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Sex Addiction

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https://read.qxmd.com/read/32217364/biological-intersection-of-sex-age-and-environment-in-the-corticotropin-releasing-factor-crf-system-and-alcohol
#1
REVIEW
Abigail E Agoglia, Elizabeth J Crofton, Melissa A Herman
The neuropeptide corticotropin-releasing factor (CRF) is critical in neural circuit function and behavior, particularly in the context of stress, anxiety, and addiction. Despite a wealth of preclinical evidence for the efficacy of CRF receptor 1 antagonists in reducing behavioral pathology associated with alcohol exposure, several clinical trials have had disappointing outcomes, possibly due to an underappreciation of the role of biological variables. Although he National Institutes of Health (NIH) now mandate the inclusion of sex as a biological variable in all clinical and preclinical research, the current state of knowledge in this area is based almost entirely on evidence from male subjects...
March 7, 2020: Neuropharmacology
https://read.qxmd.com/read/32215539/hiv-and-syphilis-infections-and-associated-factors-among-patients-in-treatment-at-a-specialist-alcohol-tobacco-and-drugs-center-in-s%C3%A3-o-paulo-s-cracol%C3%A3-ndia
#2
Ariadne Ribeiro, Alisson Trevizol, Oladunni Oluwoye, Sterling McPherson, Michael G McDonnel, Viviane Briese, André Miguel, Rosana C Fratzinger, Ronaldo R Laranjeira, Ana L Alonso, Ana L Karasin, Marcelo Ribeiro, Clarice S Madruga
INTRODUCTION: This study describes the epidemiological scenario of human immunodeficiency virus (HIV) and syphilis at the biggest specialist drug addiction center in Brazil. The great challenge is to find strategies to reduce the impact of inequality and discrimination and develop policies to protect individuals living with - or at risk of - infections. METHODS: During the period from January 1 to May 31, 2016, a cross-sectional study was conducted on which all patients (N = 806) seeking inpatient treatment were enrolled...
March 20, 2020: Trends in Psychiatry and Psychotherapy
https://read.qxmd.com/read/32206828/intermittent-access-cocaine-self-administration-produces-psychomotor-sensitization-effects-of-withdrawal-sex-and-cross-sensitization
#3
Crystal C Carr, Carrie R Ferrario, Terry E Robinson
RATIONALE: With repeated administration, the psychomotor activating effects of drugs such as cocaine or amphetamine can change in very different ways-showing sensitization or tolerance-depending on whether they are administered more or less intermittently. This behavioral plasticity is thought to reflect, at least in part, changes in dopamine (DA) neurotransmission, and therefore, may provide insights into the development of substance use disorders. Indeed, the most widely used preclinical model of cocaine addiction, which involves Long Access (LgA) self-administration procedures, is reported to produce tolerance to cocaine's psychomotor activating effects and effects on DA activity...
March 24, 2020: Psychopharmacology
https://read.qxmd.com/read/32197021/effectiveness-of-opiate-substitution-treatment-in-reducing-hiv-risk-behaviors-among-african-caribbean-and-black-people-a-systematic-review-protocol
#4
Joseph B Nguemo Djiometio, Hodan Mohamud, Irene Njoroge, LaRon E Nelson, Meldon Kahan
OBJECTIVE: This systematic review aims to identify, appraise and synthesize the best available evidence on the effectiveness of methadone maintenance treatment or buprenorphine therapy in reducing sex- and drug-related HIV risk among African, Caribbean and black people. INTRODUCTION: Substance use plays an important role in HIV transmission and acquisition among African, Caribbean and black people by increasing risky sexual behavior and the risk of HIV acquisition...
March 2020: JBI Database of Systematic Reviews and Implementation Reports
https://read.qxmd.com/read/32186745/cognitive-outcomes-of-young-children-after-prenatal-exposure-to-medications-for-opioid-use-disorder-a-systematic-review-and-meta-analysis
#5
Leah F Nelson, Victoria K Yocum, Keisha D Patel, Fares Qeadan, Andrew Hsi, Sherry Weitzen
Importance: The number of children with prenatal opioid exposure to medication for addiction treatment (MAT) with methadone and buprenorphine for maternal opioid use disorder is increasing, but the associations of this exposure with cognitive outcomes are not well understood. Objective: To examine the strength and consistency of findings in the medical literature regarding the association of prenatal exposure to MAT with early childhood cognitive development, particularly when accounting for variables outside MAT exposure...
March 2, 2020: JAMA Network Open
https://read.qxmd.com/read/32184278/knowledge-attitudes-and-practices-of-canadian-pediatric-emergency-physicians-regarding-short-term-opioid-use-a-descriptive-cross-sectional-survey
#6
Megan Fowler, Samina Ali, Serge Gouin, Amy L Drendel, Naveen Poonai, Maryna Yaskina, Mithra Sivakumar, Esther Jun, Kathryn Dong
BACKGROUND: In the midst of the current opioid crisis, physicians are caught between balancing children's optimal pain management and the risks of opioid therapy. This study describes pediatric emergency physicians' practice patterns for prescribing, knowledge and attitudes regarding, and perceived barriers to and facilitators of short-term use of opioids. METHODS: We created a survey tool using published methodology guidelines and distributed it from October to December 2017 to all physicians in the Pediatric Emergency Research Canada database using Dillman's tailored design method for mixed-mode surveys...
January 2020: CMAJ Open
https://read.qxmd.com/read/32173404/sex-differences-in-the-glutamate-system-implications-for-addiction
#7
REVIEW
L L Giacometti, J M Barker
Clinical and preclinical research have identified sex differences in substance use and addiction-related behaviors. Historically, substance use disorders are more prevalent in men than women, though this gap is closing. Despite this difference, women appear to be more susceptible to the effects of many drugs and progress to substance abuse treatment more quickly than men. While the glutamate system is a key regulator of addiction-related behaviors, much of the work implicating glutamate signaling and glutamatergic circuits has been conducted in men and male rodents...
March 12, 2020: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/32172240/problematic-smartphone-use-screen-time-and-chronotype-correlations-in-university-students
#8
Pavle Randjelovic, Nenad Stojiljkovic, Niko Radulovic, Nikola Stojanovic, Ivan Ilic
BACKGROUND: Besides numerous advantages and commodities offered by smartphones, there are obvious unhealthy effects. The global trend of an increase in the frequency of usage of smartphones, that is, prolonged screen time, is closely related to problematic smartphone use. The aim of our study was to measure the level of problematic smartphone use in a student population through the assessment of the smartphone screen time and the determination of the student chronotype, as well as through the correlation between these variables...
March 13, 2020: European Addiction Research
https://read.qxmd.com/read/32165100/the-link-between-boredom-and-hypersexuality-a-systematic-review
#9
Leonor de Oliveira, Joana Carvalho
BACKGROUND: Some conceptualizations of hypersexuality posit boredom as a possible trigger of hypersexual behavior. AIM: This work aims to review published articles addressing the link between boredom and hypersexuality to investigate if this relationship can yet be established based on current empirical data. METHODS: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies, published until September 2019, were retrieved from EBSCO, Scopus, Web of Science, and PubMed...
March 9, 2020: Journal of Sexual Medicine
https://read.qxmd.com/read/32160970/sex-specific-outcomes-in-a-substance-use-intervention-program
#10
Alexandra M Amaducci, Marna Rayl Greenberg, Andrew W Sheen, Hanna R Warren, Pratik M Parikh, Paige Roth, Kevin R Weaver, David M Richardson, David B Burmeister, Jennifer L Stephens, Robert D Cannon
PURPOSE: We performed an emergency department (ED)-based substance use screening, motivational interview-based intervention, and treatment referral program with the goal of determining sex-specific outcomes. Specifically, in this quality improvement project, we aimed to determine whether there was a difference among sexes in the type of substances used; the frequency of positive screening results for substance use disorder; agreeing to an intervention; the type of follow-up evaluation, participation, and referral; and attempts to change substance use after intervention...
March 9, 2020: Clinical Therapeutics
https://read.qxmd.com/read/32159266/the-effects-of-cannabis-use-a-test-among-dual-electronic-and-combustible-cigarette-users
#11
Nubia A Mayorga, Lorra Garey, Pamella Nizio, Julia D Buckner, Michael J Zvolensky
BACKGROUND AND OBJECTIVES: Despite greater rates of cannabis use among those that smoke combustible cigarettes, it is currently unknown whether cannabis use is related to e-cigarette dependence or maladaptive beliefs about combustible cigarettes. Therefore, the current study sought to identify whether adult dual users of combustible and e-cigarettes (ie, dual users) who also used cannabis differed from dual users who did not use cannabis on e-cigarette dependence severity, perceived barriers to quitting, and perception of risks and of benefits of e-cigarettes...
March 11, 2020: American Journal on Addictions
https://read.qxmd.com/read/32155186/measuring-the-impact-of-the-capital-card%C3%A2-a-novel-form-of-contingency-management-on-substance-misuse-treatment-outcomes-a-retrospective-evaluation
#12
Antony C Moss, Devon De Silva, Sharon Cox, Caitlin Notley, Manish Nanda
BACKGROUND: The Capital Card, developed by WDP, is a digital innovation which acts as a form of contingency management, and aims to significantly improve service user outcomes. WDP is a substance misuse treatment provider commissioned by local authorities across the UK to support service users and their families affected by addiction. The Capital Card, much like commercial loyalty cards, uses a simple earn-spend points system which incentivises and rewards service users for engaging with services e...
2020: PloS One
https://read.qxmd.com/read/32146647/in-situ-regulated-dopamine-transporter-trafficking-there-s-no-place-like-home
#13
Rita R Fagan, Patrick J Kearney, Haley E Melikian
Dopamine (DA) is critical for motivation, reward, movement initiation, and learning. Mechanisms that control DA signaling have a profound impact on these important behaviors, and additionally play a role in DA-related neuropathologies. The presynaptic SLC6 DA transporter (DAT) limits extracellular DA levels by clearing released DA, and is potently inhibited by addictive and therapeutic psychostimulants. Decades of evidence support that the DAT is subject to acute regulation by a number of signaling pathways, and that endocytic trafficking strongly regulates DAT availability and function...
March 7, 2020: Neurochemical Research
https://read.qxmd.com/read/32132923/crosstalk-between-kappa-opioid-and-dopamine-systems-in-compulsive-behaviors
#14
REVIEW
Angélica Del Pilar Escobar, José Patricio Casanova, María Estela Andrés, José Antonio Fuentealba
The strength of goal-oriented behaviors is regulated by midbrain dopamine neurons. Dysfunctions of dopaminergic circuits are observed in drug addiction and obsessive-compulsive disorder. Compulsive behavior is a feature that both disorders share, which is associated to a heightened dopamine neurotransmission. The activity of midbrain dopamine neurons is principally regulated by the homeostatic action of dopamine through D2 receptors (D2R) that decrease the firing of neurons as well as dopamine synthesis and release...
2020: Frontiers in Pharmacology
https://read.qxmd.com/read/32121183/increased-resting-state-triple-network-functional-connectivity-in-undergraduate-problematic-cannabis-users-a-preliminary-eeg-coherence-study
#15
Claudio Imperatori, Chiara Massullo, Giuseppe Alessio Carbone, Angelo Panno, Marta Giacchini, Cristina Capriotti, Elisa Lucarini, Benedetta Ramella Zampa, Eric Murillo-Rodríguez, Sérgio Machado, Benedetto Farina
An increasing body of experimental data have suggested that aberrant functional interactions between large-scale networks may be the most plausible explanation of psychopathology across multiple mental disorders, including substance-related and addictive disorders. In the current research, we have investigated the association between problematic cannabis use (PCU) and triple-network electroencephalographic (EEG) functional connectivity. Twelve participants with PCU and 24 non-PCU participants were included in the study...
February 28, 2020: Brain Sciences
https://read.qxmd.com/read/32111696/direct-interaction-of-pp2a-phosphatase-with-gaba-b-receptors-alters-functional-signaling
#16
Xiaofan Li, Miho Terunuma, Tarek G Deeb, Shari Wiseman, Menelas N Pangalos, Angus C Nairn, Stephen J Moss, Paul A Slesinger
Addictive drugs usurp the brain's intrinsic mechanism for reward, leading to compulsive and destructive behaviors. In the ventral tegmental area (VTA), the center of the brain's reward circuit, GABAergic neurons control the excitability of dopamine (DA) projection neurons and are the site of initial psychostimulant-dependent changes in signaling. Previous work established that cocaine/methamphetamine exposure increases protein phosphatase 2A (PP2A) activity, which dephosphorylates the GABAB R2 subunit, promotes internalization of the GABAB receptor and leads to smaller GABAB R-activated G protein-gated inwardly rectifying potassium (GIRK) currents in VTA GABA neurons...
February 26, 2020: Journal of Neuroscience
https://read.qxmd.com/read/32111186/knowledge-and-attitudes-towards-e-cigarette-use-in-lebanon-and-their-associated-factors
#17
Hanan Aghar, Nathalie El-Khoury, Mahasen Reda, Wissam Hamadeh, Hussein Krayem, Mohammad Mansour, Hawraa Raouf, Miran A Jaffa
BACKGROUND: Despite the misconceptions regarding E-cigarettes (ECs), only a few studies have been conducted in the Middle East that focused on this topic. This study assesses the knowledge of and attitudes towards ECs in Lebanon, determines how these two measures are associated, and identifies the variables that explain each of these measures. METHODS: A cross sectional study was conducted on a convenience sample of Lebanese pedestrians aged between 18 and 64 inclusive...
February 28, 2020: BMC Public Health
https://read.qxmd.com/read/32087834/online-hiv-information-seeking-and-pre-exposure-prophylaxis-awareness-among-people-who-use-drugs
#18
Yerina S Ranjit, Roman Shrestha, Michael Copenhaver, Frederick L Altice
People who use drugs (PWUD) remain at high risk for acquiring human immunodeficiency virus (HIV), both from injection and from sexual risk-taking. In 2016, 9% of 39,782 new HIV diagnoses occurred among people who inject drugs in the United States. Reaching PWUD with accurate information about and motivation for initiating pre-exposure prophylaxis (PrEP) remains challenging and remains the first crucial step in the knowledge-attitude-behavior change continuum. This study seeks to contribute to closing this information gap by examining the HIV information-seeking behaviors among PWUD who are not on PrEP, so as to identify potential strategies to increase adoption of HIV prevention such as PrEP as part of overall health and related to risk-taking behaviors...
April 2020: Journal of Substance Abuse Treatment
https://read.qxmd.com/read/32079347/energy-drink-consumption-depression-and-salutogenic-sense-of-coherence-among-adolescents-and-young-adults
#19
Ákos Tóth, Rita Soós, Etelka Szovák, Noemi M Najbauer, Dalma Tényi, Györgyi Csábí, Márta Wilhelm
The prevalence of energy drink consumption has increased in Hungary over the past 10-15 years. This study assesses the frequency, motivations, and adverse effects of energy drink consumption, and examines how the process of becoming a regular consumer is connected with sense of coherence and depression symptoms. A total of 631 high school and college students were assessed using the Depression Scale (BDS-13) and Sense of Coherence Scale (SOC-13). Logistic regression models were fit to test the effect of and links between factors influencing addiction to energy drink use...
February 17, 2020: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/32072572/the-fodrat-study-food-addiction-drugs-alcohol-and-tobacco-first-data-on-food-addiction-prevalence-among-patients-with-addiction-to-drugs-tobacco-and-alcohol
#20
B Tinghino, F Lugoboni, A Amatulli, C Biasin, M Bramani Araldi, D Cantiero, M Cremaschini, G L Galimberti, S Giusti, C Grosina, G E G Mulazzani, U Nizzoli
OBJECTIVES: The main focus of this study was to evaluate the prevalence of food addiction (FA) in a population of 575 subjects, all affected by drugs, alcohol and/or tobacco addiction. METHODS: Patients were enrolled in Addiction Service Centers and 25 items YFAS questionnaire was administered. Prevalence of FA was studied among patients who already have an addiction and then this prevalence was compared between groups of abusers (by type of substance), comparing mono abusers with polyabusers, as well as regressions by age, BMI, sex, through multiple regression analysis...
February 18, 2020: Eating and Weight Disorders: EWD
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