keyword
https://read.qxmd.com/read/38518961/epigenetic-mechanisms-of-cancer-progression-and-therapy-resistance-in-estrogen-receptor-er-breast-cancer
#21
REVIEW
Eneda Toska
Estrogen receptor-positive (ER+) breast cancer is the most frequent breast cancer subtype. Agents targeting the ER signaling pathway have been successful in reducing mortality from breast cancer for decades. However, mechanisms of resistance to these treatments arise, especially in the metastatic setting. Recently, it has been recognized that epigenetic dysregulation is a common feature that facilitates the acquisition of cancer hallmarks across cancer types, including ER+ breast cancer. Alterations in epigenetic regulators and transcription factors coupled with changes to the chromatin landscape have been found to orchestrate breast oncogenesis, metastasis, and the development of a resistant phenotype...
March 20, 2024: Biochimica et Biophysica Acta. Reviews on Cancer
https://read.qxmd.com/read/38517641/impact-of-visceral-adipose-tissue-on-longevity-and-metabolic-health-a-comparative-study-of-gene-expression-in-perirenal-and-epididymal-fat-of-ames-dwarf-mice
#22
JOURNAL ARTICLE
Agnieszka Zaczek, Andrzej Lewiński, Małgorzata Karbownik-Lewińska, Andrea Lehoczki, Adam Gesing
Emerging research underscores the pivotal role of adipose tissue in regulating systemic aging processes, particularly when viewed through the lens of the endocrine hypotheses of aging. This study delves into the unique adipose characteristics in an important animal model of aging - the long-lived Ames dwarf (df/df) mice. Characterized by a Prop1df gene mutation, these mice exhibit a deficiency in growth hormone (GH), prolactin, and TSH, alongside extremely low circulating IGF-1 levels. Intriguingly, while surgical removal of visceral fat (VFR) enhances insulin sensitivity in normal mice, it paradoxically increases insulin resistance in Ames dwarfs...
March 22, 2024: GeroScience
https://read.qxmd.com/read/38517066/a-new-strategy-for-immunotherapy-of-microsatellite-stable-mss-type-advanced-colorectal-cancer-multi-pathway-combination-therapy-with-pd-1-pd-l1-inhibitors
#23
REVIEW
Lingli Cai, Anqi Chen, Dong Tang
Colorectal cancer (CRC) is a frequent gastrointestinal malignancy with high rates of morbidity and mortality; 85% of these tumours are proficient mismatch repair (pMMR)-microsatellite instability-low (MSI-L)/microsatellite stable (MSS) CRC known as 'cold' tumours that are resistant to immunosuppressive drugs. Monotherapy with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors is ineffective for treating MSS CRC, making immunotherapy for MSS CRC a bottleneck. Recent studies have found that the multi-pathway regimens combined with PD-1/PD-L1 inhibitors can enhance the efficacy of anti-PD-1/PD-L1 in MSS CRC by increasing the number of CD8+ T cells, upregulating PD-L1 expression and improving the tumour microenvironment...
March 22, 2024: Immunology
https://read.qxmd.com/read/38516266/methylome-wide-and-meqtl-analysis-helps-to-distinguish-treatment-response-from-non-response-and-pathogenesis-markers-in-schizophrenia
#24
JOURNAL ARTICLE
Binithamol K Polakkattil, Neetha N Vellichirammal, Indu V Nair, Chandrasekharan M Nair, Moinak Banerjee
Schizophrenia is a complex condition with entwined genetic and epigenetic risk factors, posing a challenge to disentangle the intermixed pathological and therapeutic epigenetic signatures. To resolve this, we performed 850K methylome-wide and 700K genome-wide studies on the same set of schizophrenia patients by stratifying them into responders, non-responders, and drug-naïve patients. The key genes that signified the response were followed up using real-time gene expression studies to understand the effect of antipsychotics at the gene transcription level...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38516191/emerging-roles-of-long-non-coding-rnas-in-osteosarcoma
#25
REVIEW
Xun Liao, Rong Wei, Junxiu Zhou, Ke Wu, Jiao Li
Osteosarcoma (OS) is a highly aggressive and lethal malignant bone tumor that primarily afflicts children, adolescents, and young adults. However, the molecular mechanisms underlying OS pathogenesis remain obscure. Mounting evidence implicates dysregulated long non-coding RNAs (lncRNAs) in tumorigenesis and progression. These lncRNAs play a pivotal role in modulating gene expression at diverse epigenetic, transcriptional, and post-transcriptional levels. Uncovering the roles of aberrant lncRNAs would provide new insights into OS pathogenesis and novel tools for its early diagnosis and treatment...
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38515565/ferroptosis-in-lung-cancer-dual-role-multi-level-regulation-and-new-therapeutic-strategies
#26
REVIEW
Yunbin Li, Xiaosong Li, Jian Li
Lung cancer is a highly prevalent malignant tumor worldwide, with high incidence and death rates. Recently, there has been increasing recognition of the role of ferroptosis, a unique cell death mechanism, in lung cancer. This review aims to summarize the current research progress on the relationship between ferroptosis and lung cancer. It also provides a comprehensive analysis of the regulatory processes of ferroptosis in various stages, including epigenetics, transcription, post-transcription, translation, and post-translation...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38514598/revealing-a-novel-methylated-integrin-alpha-8-related-to-extracellular-matrix-and-anoikis-resistance-using-proteomic-analysis-in-the-immune-microenvironment-of-lung-adenocarcinoma
#27
JOURNAL ARTICLE
Tingting Liu, Wen Ji, Xue Cheng, Lin Lv, Xiaohui Yu, Na Wang, Mengcong Li, Tinghua Hu, Zhihong Shi
Genomic epigenetics of extracellular matrix (ECM) play an important role in lung adenocarcinoma (LUAD). Our study identified a signature of potential prognostic genes associated with ECM and constructed immune risk-related prognosis model in LUAD. We downloaded mRNAs transcriptome data, miRNAs expression data, and clinical patient information for LUAD based on The Cancer Genome Atlas. "Limma, clusterProfiler, ggplot2" R packages and GSEA were used to analyze meaningful genes and explore potential biological function...
March 21, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38513802/epigenetic-regulation-of-hepatocellular-carcinoma-progression-micrornas-as-therapeutic-diagnostic-and-prognostic-factors
#28
JOURNAL ARTICLE
Mehrdad Hashemi, Pouria Daneii, Mahya Asadalizadeh, Kiana Tabari, Arash Matinahmadi, Seyed Shahabadin Bidoki, Yasamin Sadat Mousavi Motlagh, Ali Moghadas Jafari, Amin Ghorbani, Amir Dehghanpour, Noushin Nabavi, Shing Cheng Tan, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Mohammad Ali Sheikhbeig Goharrizi
Hepatocellular carcinoma (HCC), a significant challenge for public healthcare systems in developed Western countries including the USA, Canada, and the UK, is influenced by different risk factors including hepatitis virus infections, alcoholism, and smoking. The disruption in the balance of microRNAs (miRNAs) plays a vital function in tumorigenesis, given their function as regulators in numerous signaling networks. These miRNAs, which are mature and active in the cytoplasm, work by reducing the expression of target genes through their impact on mRNAs...
March 19, 2024: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/38513088/mechanisms-of-resistance-to-bispecific-t-cell-engagers-in-multiple-myeloma-and-their-clinical-implications
#29
JOURNAL ARTICLE
Eric Letouzé, Philippe Moreau, Nikhil C Munshi, Mehmet K Samur, Stephane Minvielle, Cyrille Touzeau
Bispecific T cell engagers (TCE) are revolutionizing patient care in multiple myeloma (MM). These monoclonal antibodies, that redirect T cells against cancer cells, are now approved for the treatment of triple-class exposed relapsed refractory multiple myeloma (RRMM). They are currently tested in earlier lines of the disease, including in first line. Yet, primary resistance occurs in about one third of RRMM patients, and most responders eventually develop acquired resistance. Understanding the mechanisms of resistance to bispecific TCE is thus essential to improve immunotherapies in MM...
March 21, 2024: Blood Advances
https://read.qxmd.com/read/38510251/functional-significance-of-dna-methylation-epigenetic-insights-into-sj%C3%A3-gren-s-syndrome
#30
REVIEW
Yanqing Wang, Farooq Riaz, Wei Wang, Jincheng Pu, Yuanyuan Liang, Zhenzhen Wu, Shengnan Pan, Jiamin Song, Lufei Yang, Youwei Zhang, Huihong Wu, Fang Han, Jianping Tang, Xuan Wang
Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with a significant global prevalence. It is a complex condition that requires careful management and monitoring. Recent research indicates that epigenetic mechanisms contribute to the pathophysiology of SjS by modulating gene expression and genome stability. DNA methylation, a form of epigenetic modification, is the fundamental mechanism that modifies the expression of various genes by modifying the transcriptional availability of regulatory regions within the genome...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38508940/prostatic-adenocarcinoma-molecular-underpinnings-and-treatment-related-options
#31
REVIEW
Divyangi Paralkar, Amir Akbari, Manju Aron
Prostate cancer is heterogeneous with varied pathologic features and presents with a wide spectrum of clinical manifestations from indolent to advanced cancer. Interrogation of the molecular landscape of prostate cancer has unveiled the complex genomic alterations in these tumors, which significantly impacts tumor biology. The documented array of chromosomal alterations, gene fusions, and epigenetic changes not only play a crucial role in oncogenesis and disease progression, but also impacts response and resistance to various therapeutic modalities...
March 19, 2024: Urologic Oncology
https://read.qxmd.com/read/38504783/hijacking-the-epigenetic-mechanisms-of-a-baumannii
#32
REVIEW
S A Smiline Girija
Epigenetic mechanisms attribute to the resistance and virulence of Acinetobacter baumannii sparking a renewed area of research. Unveiling the targets pertained to the epigenetic modulation in the bacterium would aid in the curbing its complications in various recalcitrant infections. This review thus throws light on the various epigenetic mechanisms exhibited by A. bauamnnii , urging the need to implement epigenetic based novel strategies in precision medicine.
2024: Molecular Biology Research Communications
https://read.qxmd.com/read/38503962/mechanistic-insights-into-dna-damage-recognition-and-checkpoint-control-in-plants
#33
REVIEW
Josephine Herbst, Qian-Qian Li, Lieven De Veylder
The plant DNA damage response (DDR) pathway safeguards genomic integrity by rapid recognition and repair of DNA lesions that, if unrepaired, may cause genome instability. Most frequently, DNA repair goes hand in hand with a transient cell cycle arrest, which allows cells to repair the DNA lesions before engaging in a mitotic event, but consequently also affects plant growth and yield. Through the identification of DDR proteins and cell cycle regulators that react to DNA double-strand breaks or replication defects, it has become clear that these proteins and regulators form highly interconnected networks...
March 19, 2024: Nature Plants
https://read.qxmd.com/read/38502584/vascular-aging-and-atherosclerosis-a-perspective-on-aging
#34
JOURNAL ARTICLE
Shudong Ma, Xuena Xie, Rong Yuan, Qiqi Xin, Yu Miao, Sean Xiao Leng, Keji Chen, Weihong Cong
Vascular aging (VA) is recognized as a pivotal factor in the development and progression of atherosclerosis (AS). Although various epidemiological and clinical research has demonstrated an intimate connection between aging and AS, the candidate mechanisms still require thorough examination. This review adopts an aging-centric perspective to deepen the comprehension of the intricate relationship between biological aging, vascular cell senescence, and AS. Various aging-related physiological factors influence the physical system's reactions, including oxygen radicals, inflammation, lipids, angiotensin II, mechanical forces, glucose levels, and insulin resistance...
March 6, 2024: Aging and Disease
https://read.qxmd.com/read/38499886/severe-induction-of-aberrant-dna-methylation-by-nodular-gastritis-in-adults
#35
JOURNAL ARTICLE
Akiko Sasaki, Hideyuki Takeshima, Satoshi Yamashita, Chikamasa Ichita, Jun Kawachi, Wataru Naito, Yui Ohashi, Chihiro Takeuchi, Masahide Fukuda, Yumi Furuichi, Nobutake Yamamichi, Takayuki Ando, Hideki Kobara, Tohru Kotera, Takao Itoi, Chihiro Sumida, Akinobu Hamada, Kazuya Koizumi, Toshikazu Ushijima
BACKGROUND: Nodular gastritis (NG) is characterized by marked antral lymphoid follicle formation, and is a strong risk factor for diffuse-type gastric cancer in adults. However, it is unknown whether aberrant DNA methylation, which is induced by atrophic gastritis (AG) and is a risk for gastric cancer, is induced by NG. Here, we analyzed methylation induction by NG. METHODS: Gastric mucosal samples were obtained from non-cancerous antral tissues of 16 NG and 20 AG patients with gastric cancer and 5 NG and 6 AG patients without, all age- and gender-matched...
March 19, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/38494898/cross-talk-between-cells-and-the-current-bioceramics-in-bone-regeneration-a-comprehensive-review
#36
REVIEW
Danial Khayatan, Asal Bagherzadeh Oskouei, Mostafa Alam, Meysam Mohammadikhah, Ashkan Badkoobeh, Mohsen Golkar, Kamyar Abbasi, Shahryar Karami, Reza Sayyad Soufdoost, Lotfollah Kamali Hakim, Ahmed Hussain, Hamid Tebyaniyan, Artak Heboyan
The conventional approach for addressing bone defects and stubborn non-unions typically involves the use of autogenous bone grafts. Nevertheless, obtaining these grafts can be challenging, and the procedure can lead to significant morbidity. Three primary treatment strategies for managing bone defects and non-unions prove resistant to conventional treatments: synthetic bone graft substitutes (BGS), a combination of BGS with bioactive molecules, and the use of BGS in conjunction with stem cells. In the realm of synthetic BGS, a multitude of biomaterials have emerged for creating scaffolds in bone tissue engineering (TE)...
2024: Cell Transplantation
https://read.qxmd.com/read/38494532/important-role-of-dna-methylation-hints-at-significant-potential-in-tuberculosis
#37
REVIEW
Yuexuan Qin, Tianyue Li, Peiyan An, Zhi Ren, Jun Xi, Bikui Tang
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, has persisted as a major global public health threat for millennia. Until now, TB continues to challenge efforts aimed at controlling it, with drug resistance and latent infections being the two main factors hindering treatment efficacy. The scientific community is still striving to understand the underlying mechanisms behind Mtb's drug resistance and latent infection. DNA methylation, a critical epigenetic modification occurring throughout an individual's growth and development, has gained attention following advances in high-throughput sequencing technologies...
March 18, 2024: Archives of Microbiology
https://read.qxmd.com/read/38490329/chromatin-activation-with-h3k36me2-and-compartment-shift-in-metastatic-castration-resistant-prostate-cancer
#38
JOURNAL ARTICLE
Sanji Kanaoka, Atsushi Okabe, Manato Kanesaka, Bahityar Rahmutulla, Masaki Fukuyo, Motoaki Seki, Takayuki Hoshii, Hiroaki Sato, Yusuke Imamura, Shinichi Sakamoto, Tomohiko Ichikawa, Atsushi Kaneda
Epigenetic modifiers are upregulated during the process of prostate cancer, acquiring resistance to castration therapy and becoming lethal metastatic castration-resistant prostate cancer (CRPC). However, the relationship between regulation of histone modifications and chromatin structure in CRPC has yet not fully been validated. Here, we reanalyzed publicly available clinical transcriptome and clinical outcome data and identified NSD2, a histone methyltransferase that catalyzes H3K36me2, as an epigenetic modifier that was upregulated in CRPC and whose increased expression in prostate cancer correlated with higher recurrence rate...
March 13, 2024: Cancer Letters
https://read.qxmd.com/read/38488824/pharmacotherapeutic-advances-for-chronic-myelogenous-leukemia-beyond-tyrosine-kinase-inhibitors
#39
REVIEW
Alessandro Costa, Emilia Scalzulli, Ida Carmosino, Claudia Ielo, Maria Laura Bisegna, Maurizio Martelli, Massimo Breccia
INTRODUCTION: Despite the notable success of tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML), a subset of patients experiences resistance, or relapse after discontinuation. This challenge is attributed to the Ph+ leukemia stem cells (LSCs) pool not fully involved in the inhibition process due to the current therapeutic approach. AREAS COVERED: Current pharmacological advancements in CML therapy focus on targeting LSCs, intervening in self-renewal pathways, and exploiting biological vulnerabilities...
March 15, 2024: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/38488434/improving-therapeutic-potential-in-breast-cancer-via-histone-deacetylase-inhibitor-loaded-nanofibrils
#40
JOURNAL ARTICLE
Praveetha Senthilkumar, Bhaskar Gogoi, Swati Smita Dhan, Ramesh Subramani, Charumathi Pushparaj, Ayyavu Mahesh
Epigenetic modifications play a significant role in cancer progression, making them potential targets for therapy. Histone deacetylase inhibitors have shown promise in inhibiting cancer cell growth, including in breast cancer (BC). In this research, we examined the potential of using suberoyl anilide hydroxamic acid (SAHA)-loaded β-lg nanofibrils as a drug delivery system for triple-negative BC cell lines. We assessed their impact on cell cycle progression, apoptosis, levels of reactive oxygen species, and mitochondrial membrane potential in cancer cells...
April 2024: Drug Development Research
keyword
keyword
22285
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.