Laxmi Prasad Uprety, Chang-Gun Lee, Kang-Il Oh, Hyesoo Jeong, Subin Yeo, Yoonjoong Yong, Je Kyung Seong, Il Yong Kim, Hyesun Go, Eunkuk Park, Seon-Yong Jeong
BACKGROUND: The overstoring of surplus calories in mature adipocytes causes obesity and abnormal metabolic activity. The anti-obesity effect of a Celosia cristata (CC) total flower extract was assessed in vitro, using 3T3-L1 pre-adipocytes and mouse adipose-derived stem cells (ADSCs), and in vivo, using high-fat diet (HFD)-treated C57BL/6 male mice. METHODS: CC extract was co-incubated during adipogenesis in both 3T3-L1 cells and ADSCs. After differentiation, lipid droplets were assessed by oil red O staining, adipogenesis and lipolytic factors were evaluated, and intracellular triglyceride and glycerol concentrations were analyzed...
May 27, 2024: Biomedicine & Pharmacotherapy