Thierry Gilbert, Camille Gorlt, Merlin Barbier, Benjamin Duployer, Marianna Plozza, Ophélie Dufrancais, Laure-Elene Martet, Elisa Dalbard, Loelia Segot, Christophe Tenailleau, Laurence Haren, Christel Vérollet, Christiane Bierkamp, Andreas Merdes
Ninein is a centrosome protein that has been implicated in microtubule anchorage and centrosome cohesion. Mutations in the human NINEIN gene have been linked to Seckel syndrome and to a rare form of skeletal dysplasia. However, the role of ninein in skeletal development remains unknown. Here, we describe a ninein knockout mouse with advanced endochondral ossification during embryonic development. Although the long bones maintain a regular size, the absence of ninein delays the formation of the bone marrow cavity in the prenatal tibia...
June 5, 2024: ELife