Mallikarjun Patil, Sarojini Singh, John Henderson, Prasanna Krishnamurthy
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has reached a pandemic level, spreading across the globe by affecting over 33 million people and causing over 1,009,270 deaths. SARS-CoV-2 is highly infectious with a high basic reproduction number (R0 ) of 2.2-5.7 that has led to its exponential spread. Besides, very little is known about it in terms of immunogenicity and its molecular targets. SARS-CoV-2 causes acute respiratory distress syndrome, followed by multiple organ failure and death in a small percentage of individuals...
October 20, 2020: Journal of Cellular Physiology
Linlin Cheng, Haolong Li, Liubing Li, Chenxi Liu, Songxin Yan, Haizhen Chen, Yongzhe Li
OBJECTIVE: The coronavirus disease 2019 (COVID-19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID-19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID-19. METHODS: Studies investigating ferritin in COVID-19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta-analysis was performed to compare the ferritin level between different patient groups: non-survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non-ICU; with mechanical ventilation versus without mechanical ventilation...
October 19, 2020: Journal of Clinical Laboratory Analysis
Flavia Pigliacelli, Maria Gabriella Donà, Amalia Giglio, Norma Cameli, Aldo Morrone, Mauro Zaccarelli, Alessandra Latini
No abstract text is available yet for this article.
October 19, 2020: International Journal of Dermatology
Philippe Garcia, Alexis Revet, Antoine Yrondi, Vanessa Rousseau, Yannick Degboe, François Montastruc
INTRODUCTION: In the stressful context of the coronavirus disease 2019 (COVID-19) pandemic, some reports have raised concerns regarding psychiatric disorders with the use of hydroxychloroquine. In this study, we reviewed all psychiatric adverse effects with hydroxychloroquine in COVID-19 patients, as well as in other indications, reported in VigiBase, the World Health Organization's (WHO) global database of individual case safety reports. METHODS: First, we analyzed all psychiatric adverse effects, including suicide, of hydroxychloroquine in COVID-19 patients reported to 16 June 2020...
October 19, 2020: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Tsuriel Rashi
Doctors have been treating infectious diseases for hundreds of years, but the risk they and other medical professionals are exposed to in an epidemic has always been high. At the front line of the present war against COVID-19, medical teams are endangering their lives as they continue to treat patients suffering from the disease. What is the degree of danger that a medical team must accept in the face of a pandemic? What are the theoretical justifications for these risks? This article offers answers to these questions by citing opinions based on Jewish ethical thought that has been formulated down through the ages...
October 19, 2020: Medicine, Health Care, and Philosophy
Tracy H T Lai, Monica Lee, Alvin K H Au, Heather H Y Tang, Emily W H Tang, Kenneth K W Li
PURPOSE: In order to minimize the risk of transmission of coronavirus disease 2019 (COVID-19), many clinic appointments were postponed to lower patient attendance. Actively calling patients to postpone appointments is a labour-intensive process. We were the first ophthalmic clinics in Hong Kong to use short message service (SMS) to dispatch messages simultaneously to a large number of patients to offer postponement of appointments. The aim of this study is to evaluate whether SMS is an effective method to reduce outpatient attendance during the COVID-19 pandemic...
October 19, 2020: International Ophthalmology
Dennis Lapuente, Clara Maier, Pascal Irrgang, Julian Hübner, Antonia Sophia Peter, Markus Hoffmann, Armin Ensser, Katharina Ziegler, Thomas H Winkler, Torsten Birkholz, Andreas E Kremer, Philipp Steininger, Klaus Korn, Frank Neipel, Klaus Überla, Matthias Tenbusch
SARS-CoV-2 has emerged as a previously unknown zoonotic coronavirus that spread worldwide causing a serious pandemic. While reliable nucleic acid-based diagnostic assays were rapidly available, only a limited number of validated serological assays were available in the early phase of the pandemic. Here, we evaluated a novel flow cytometric approach to assess spike-specific antibody responses.HEK 293T cells expressing SARS-CoV-2 spike protein in its natural confirmation on the surface were used to detect specific IgG and IgM antibody responses in patient sera by flow cytometry...
October 20, 2020: European Journal of Clinical Microbiology & Infectious Diseases
Rodolfo Buselli, Martina Corsi, Gabriele Necciari, Piero Pistolesi, Sigrid Baldanzi, Martina Chiumiento, Elena Del Lupo, Paolo Del Guerra, Alfonso Cristaudo
In December 2019, clusters of atypical pneumonia with unknown etiology emerged in the city of Wuhan in China. In early January 2020, the Center for Disease Control in China announced that it was identified a new coronavirus, first tentatively named 2019-nCoV and officially named SARS-CoV-2 by the International Committee on Taxonomy of Viruses. On 11 February 2020 the WHO identified the disease caused by SARS-CoV-2 as COVID-19 (COronaVIrus Disease-19 based on the year of appearance). Although only a few months have passed since the beginning of this pandemic, numerous studies, case reports, reviews by leading international scientific and medical journals have been published...
October 15, 2020: Brain, behavior, & immunity health
Susana Fernández-Raga, Alba Fidalgo-Navarro, Joaquín Bernardo-Cofiño
No abstract text is available yet for this article.
October 15, 2020: Medicina clínica
Osama Abdalla Mabrouk Kheiralla, Abdulrahman Amin Tajaldeen, Adel Osman Bakheet
Since the outbreak of Coronavirus Disease-19 (COVID-19) infection in December 2019 in Wuhan, the capital Hubei province, central of China, more than 4 million people have contracted the virus worldwide. Despite the imposed precautions, coronavirus disease-19 is rapidly spreading with human-to-human transmission resulting in more than 290,000 death as of May 13, 2020 according to World Health Organization (WHO). The aim of this study was to revise the characteristic imaging features of Sever Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) during their outbreak, and to compare them with that of COVID-19, to familiarize radiologists with the imaging spectrum of corona-virus syndromes...
2020: European Journal of Radiology Open
Stephen Lam Chan, Masatoshi Kudo
Background: The pandemic of coronavirus disease 2019 (COVID-19) has diverted resources from healthcare services for patients with chronic medical illness such as cancer. COVID-19 also causes organ dysfunction, complicating cancer treatment. In most countries with an outbreak of COVID-19, modifications of cancer management have been adopted to accommodate the crisis and minimize the exposure of cancer patients to the infection. In countries where COVID-19 numbers are subsiding, medical teams should also be prepared to resume normal practices gradually...
September 2020: Liver Cancer
T D Subash, T D Subha, I Titus, Alsufiyan Nazim, Eugene Peter
The virus which is called as corona spoiling many of human lives as well as countries growth. Coronavirus is an infectious disease, so spreading from one person to other easily. Till now there is no medicine for corona. World Health Organization (WHO) taking lot of steps to control it. In India many of them get affected by coronavirus called COVID-19. A household survey is conducted nationally through online. This survey is a method for checking knowledge about the infectious virus. In this online survey some questionnaires were asked...
October 14, 2020: Materials Today: Proceedings
Janga Vijay Kumar, A Harshavardhan, Hanumanthu Bhukya, A V Krishna Prasad
The domain of medical diagnosis and predictive analytics is one of the key domains of research with enormous dimensions whereby the diseases of different types can be predicted. Nowadays, there is a huge panic of impact and rapid mutation of the COVID-19 virus impression. The world is getting affected by this virus to a huge extent and there is no vaccine developed so far. India is also having more than 10,000 patients with than 300 deceased. The global human community is having around 20 lacs of Coronavirus patients...
October 14, 2020: Materials Today: Proceedings
Rahim Ud Din, Aly R Seadawy, Kamal Shah, Aman Ullah, Dumitru Baleanu
The theme of this paper focuses on the mathematical modeling and transmission mechanism of the new Coronavirus shortly noted as (COVID-19), endangering the lives of people and causing a great menace to the world recently. We used a new type epidemic model composed on four compartments that is susceptible, exposed, infected and recovered (SEIR), which describes the dynamics of COVID-19 under convex incidence rate. We simulate the results by using nonstandard finite difference method (NSFDS) which is a powerful numerical tool...
December 2020: Results in Physics
Alabed Ali A Alabed, Asita Elengoe, Elan Selvi Anandan, Abdullah Y Almahdi
Background: There is a major public health challenge threatening the world with the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in December 2019 from Wuhan, China. Objective: The aim of this study was to assess the knowledge, attitude and practice regarding COVID-19 and its transmission, causes and prevention among people living in Malaysia. Methods: A cross-sectional study was conducted among people living in Malaysia by using an online survey in March and April 2020...
October 14, 2020: Journal of Public Health
Wei Liu, Wei-Jie Guan, Nan-Shan Zhong
Coronavirus disease 2019 (COVID-19)-the third in a series of coronavirus infections-has caused a global public health event in the 21st century, resulting in substantial global morbidity and mortality. Building on its legacy of managing severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), China has played a key role in the scientific community by revealing the viral transmission routes and clinical characteristics of COVID-19 and developing novel therapeutic interventions and vaccines...
October 15, 2020: Engineering (Beijing, China)
Lorenzo Gamberini, Tommaso Tonetti, Savino Spadaro, Gianluca Zani, Carlo Alberto Mazzoli, Chiara Capozzi, Emanuela Giampalma, Maria Letizia Bacchi Reggiani, Elisabetta Bertellini, Andrea Castelli, Irene Cavalli, Davide Colombo, Federico Crimaldi, Federica Damiani, Alberto Fogagnolo, Maurizio Fusari, Emiliano Gamberini, Giovanni Gordini, Cristiana Laici, Maria Concetta Lanza, Mirco Leo, Andrea Marudi, Giuseppe Nardi, Irene Ottaviani, Raffaella Papa, Antonella Potalivo, Emanuele Russo, Stefania Taddei, Carlo Alberto Volta, V Marco Ranieri
Background: A large proportion of patients with coronavirus disease 2019 (COVID-19) develop severe respiratory failure requiring admission to the intensive care unit (ICU) and about 80% of them need mechanical ventilation (MV). These patients show great complexity due to multiple organ involvement and a dynamic evolution over time; moreover, few information is available about the risk factors that may contribute to increase the time course of mechanical ventilation.The primary objective of this study is to investigate the risk factors associated with the inability to liberate COVID-19 patients from mechanical ventilation...
2020: Journal of Intensive Care
Olusola Samuel Makinde, Olubukola Olayemi Olusola-Makinde, Emmanuel Idowu Olamide, Gbenga Jacob Abiodun
With the current outbreak of coronavirus disease 2019 (COVID-19), countries have been on rising preparedness to detect and isolate any imported and locally transmitted cases of the disease. It is observed that mode of transmission of the disease varies from one country to the other. Recent studies have shown that COVID-19 cases are not influenced by race and weather conditions. In this study, effect of modes of transmission of COVID-19 is considered with respect to prevalence and mortality counts in World Health Organisation (WHO) regions...
December 2020: Health Information Science and Systems
Suhail Hussain, Surjith Vattoth, Khawaja Hassan Haroon, Ahmad Muhammad
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. COVID-19-associated thrombotic events are recognized. A wide variety of neurological presentations have been recently documented. We report the first case of COVID-19 presenting with generalized seizure secondary to cerebral venous sinus thrombosis.
May 2020: Case Reports in Neurology
Ali Adel Dawood, Zahra Adel Dawood
Since the first period of the virus's emergence in Iraq, the government and health-related authorities have rushed to impose home quarantine and suspend work in all facilities of the country besides prescribed the sear measures for doubtful cases. From that time, the detected cases elevated with the number of mortality. Our study aims to take an overview of the disease during the past seven months, and a general review of the effects of quarantine measures that have resulted in an altitude graphic curve for both injuries and deaths...
October 14, 2020: Vacunas
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