Coronavirus | Page 19

John R Greenland, Marilyn D Michelow, Linlin Wang, Martin J London
Healthcare systems worldwide are responding to Coronavirus Disease 2019 (COVID-19), an emerging infectious syndrome caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Patients with COVID-19 can progress from asymptomatic or mild illness to hypoxemic respiratory failure or multisystem organ failure, necessitating intubation and intensive care management. Healthcare providers, and particularly anesthesiologists, are at the frontline of this epidemic, and they need to be aware of the best available evidence to guide therapeutic management of patients with COVID-19 and to keep themselves safe while doing so...
March 19, 2020: Anesthesiology
Mohamed E El Zowalaty, Josef D Järhult
Human coronaviruses continue to pose a threat to human health. The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 which causes coronavirus disease-2019 (COVID-19), an acute respiratory disease marked the third introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. This recent emergence of a previously unknown coronavirus in China leads to huge impacts on humans globally. Covid-19 is a challenge to global public health...
June 2020: One Health
Weilong Shang, Yi Yang, Yifan Rao, Xiancai Rao
The outbreak of 2019-novel coronavirus disease (COVID-19) that is caused by SARS-CoV-2 has spread rapidly in China, and has developed to be a Public Health Emergency of International Concern. However, no specific antiviral treatments or vaccines are available yet. This work aims to share strategies and candidate antigens to develop safe and effective vaccines against SARS-CoV-2.
2020: NPJ vaccines
Yadi Zhou, Yuan Hou, Jiayu Shen, Yin Huang, William Martin, Feixiong Cheng
Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality. However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, representing as an effective drug discovery strategy from existing drugs, could shorten the time and reduce the cost compared to de novo drug discovery. In this study, we present an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV-host interactome and drug targets in the human protein-protein interaction network...
2020: Cell Discovery
Yu Wai Chen, Chin-Pang Bennu Yiu, Kwok-Yin Wong
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CL pro ) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding and dimerisation are 100% conserved. Comparison of the polyprotein PP1AB sequences showed 86% identity. The 3C-like cleavage sites on the coronaviral polyproteins are highly conserved. Based on the near-identical substrate specificities and high sequence identities, we are of the opinion that some of the previous progress of specific inhibitors development for the SARS-CoV enzyme can be conferred on its SARS-CoV-2 counterpart...
2020: F1000Research
Han Xiao, Yan Zhang, Desheng Kong, Shiyue Li, Ningxi Yang
BACKGROUND From the end of December 2019, coronavirus disease 2019 (COVID-19) began to spread in central China. Social capital is a measure of social trust, belonging, and participation. This study aimed to investigate the effects of social capital on sleep quality and the mechanisms involved in people who self-isolated at home for 14 days in January 2020 during the COVID-19 epidemic in central China. MATERIAL AND METHODS Individuals (n=170) who self-isolated at home for 14 days in central China, completed self-reported questionnaires on the third day of isolation...
March 20, 2020: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Bruno Tilocca, Alessio Soggiu, Vincenzo Musella, Domenico Britti, Maurizio Sanguinetti, Andrea Urbani, Paola Roncada
Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of "unconventional" biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province...
March 17, 2020: Microbes and Infection
Peng Li, Ji-Bo Fu, Ke-Feng Li, Yan Chen, Hong-Ling Wang, Lei-Jie Liu, Jie-Nan Liu, Yong-Li Zhang, She-Lan Liu, An Tang, Zhen-Dong Tong, Jian-Bo Yan
We report a familial cluster of 2019 novel coronavirus disease (COVID-19) to evidence that a potential transmission of the COVID-19 during the incubation period. The first patient in this familial cluster was identified in presymptomatic period, as a close contact of a confirmed patient. Five family members had close contact with the first patient during his incubation period, four of them were confirmed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the subsequent sampling test...
March 16, 2020: International Journal of Infectious Diseases: IJID
Zahra Sahraei, Minoosh Shabani, Shervin Shokouhi, Ali Saffaei
No abstract text is available yet for this article.
March 16, 2020: International Journal of Antimicrobial Agents
Young June Choe, Eun Hwa Choi
No abstract text is available yet for this article.
March 23, 2020: Journal of Korean Medical Science
Ji Young Park, Mi Seon Han, Kyoung Un Park, Ji Young Kim, Eun Hwa Choi
The large outbreak of coronavirus disease 2019 (COVID-19) that started in Wuhan, China has now spread to many countries worldwide. Current epidemiologic knowledge suggests that relatively few cases are seen among children, which limits opportunities to address pediatric specific issues on infection control and the children's contribution to viral spread in the community. Here, we report the first pediatric case of COVID-19 in Korea. The 10-year-old girl was a close contact of her uncle and her mother who were confirmed to have COVID-19...
March 23, 2020: Journal of Korean Medical Science
Ki Tae Kwon, Jae Hoon Ko, Heejun Shin, Minki Sung, Jin Yong Kim
As the coronavirus disease 2019 (COVID-19) outbreak is ongoing, the number of individuals to be tested for COVID-19 is rapidly increasing. For safe and efficient screening for COVID-19, drive-through (DT) screening centers have been designed and implemented in Korea. Herein, we present the overall concept, advantages, and limitations of the COVID-19 DT screening centers. The steps of the DT centers include registration, examination, specimen collection, and instructions. The entire service takes about 10 minutes for one testee without leaving his or her cars...
March 23, 2020: Journal of Korean Medical Science
Alexander Gross, Dorina Thiemig, Franz-Wilhelm Koch, Martin Schwarz, Sven Gläser, Thomas Albrecht
No abstract text is available yet for this article.
March 19, 2020: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Dan Sun, Hui Li, Xiao-Xia Lu, Han Xiao, Jie Ren, Fu-Rong Zhang, Zhi-Sheng Liu
BACKGROUND: An outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was first detected in Wuhan, Hubei, China. People of all ages are susceptible to SARS-CoV-2 infection. No information on severe pediatric patients with COVID-19 has been reported. We aimed to describe the clinical features of severe pediatric patients with COVID-19. METHODS: We included eight severe or critically ill patients with COVID-19 who were treated at the Intensive Care Unit (ICU), Wuhan Children's Hospital from January 24 to February 24...
March 19, 2020: World Journal of Pediatrics: WJP
Zheng Ye, Yun Zhang, Yi Wang, Zixiang Huang, Bin Song
Coronavirus disease 2019 (COVID-19) outbreak, first reported in Wuhan, China, has rapidly swept around the world just within a month, causing global public health emergency. In diagnosis, chest computed tomography (CT) manifestations can supplement parts of limitations of real-time reverse transcription polymerase chain reaction (RT-PCR) assay. Based on a comprehensive literature review and the experience in the frontline, we aim to review the typical and relatively atypical CT manifestations with representative COVID-19 cases at our hospital, and hope to strengthen the recognition of these features with radiologists and help them make a quick and accurate diagnosis...
March 19, 2020: European Radiology
Kai Liu
No abstract text is available yet for this article.
March 20, 2020: Science
Kelly Servick, Adrian Cho, Jennifer Couzin-Frankel, Giorgia Guglielmi
No abstract text is available yet for this article.
March 20, 2020: Science
Kai-Cai Liu, Ping Xu, Wei-Fu Lv, Xiao-Hui Qiu, Jin-Long Yao, Jin-Feng Gu, Wei Wei
PURPOSE: To report CT features of coronavirus disease-2019 (COVID-19) in patients with various disease severity. METHODS: The CT manifestations and clinical data of 73 patients with COVID-19 were retrospectively collected in 6 hospitals from Jan 21 to Feb 3, 2020. We analyzed the initial and follow-up CT features of patients with disease severity, according to the Guidelines for the Diagnosis and Treatment of New Coronavirus Pneumonia. RESULTS: Six patients (8%) were diagnosed as mild type pneumonia; these patients had no obvious abnormal CT findings or manifested mild changes of lung infection...
March 12, 2020: European Journal of Radiology
Rachael Pung, Calvin J Chiew, Barnaby E Young, Sarah Chin, Mark I-C Chen, Hannah E Clapham, Alex R Cook, Sebastian Maurer-Stroh, Matthias P H S Toh, Cuiqin Poh, Mabel Low, Joshua Lum, Valerie T J Koh, Tze M Mak, Lin Cui, Raymond V T P Lin, Derrick Heng, Yee-Sin Leo, David C Lye, Vernon J M Lee
BACKGROUND: Three clusters of coronavirus disease 2019 (COVID-19) linked to a tour group from China, a company conference, and a church were identified in Singapore in February, 2020. METHODS: We gathered epidemiological and clinical data from individuals with confirmed COVID-19, via interviews and inpatient medical records, and we did field investigations to assess interactions and possible modes of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
March 16, 2020: Lancet
Chris Alderman
Pharmacists around the world can expect to be affected by the coronavirus, especially those who provide care for older people who are at a much higher risk for grave consequences from the virus. It is critical that pharmacists maintain awareness of the evolving pandemic and access reliable information to remain familiar with developments.
April 1, 2020: Senior Care Pharmacist
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