George Sakoulas, Matthew Geriak, Ravina Kullar, Kristina L Greenwood, MacKenzie Habib, Anuja Vyas, Mitra Ghafourian, Venkata Naga Kiran Dintyala, Fadi Haddad
Dysregulated neutrophil and platelet interactions mediate immunothrombosis and cause lung injury in coronavirus disease 2019. IV immunoglobulin modulates neutrophil activation through FcγRIII binding. We hypothesized that early therapy with IV immunoglobulin would abrogate immunothrombosis and improve oxygenation and reduce progression to mechanical ventilation in coronavirus disease 2019 pneumonia. Design: Prospective randomized open label. Setting: Inpatient hospital...
November 2020: Critical care explorations
Arunjit Takhar, Pavol Surda, Imran Ahmad, Nikul Amin, Asit Arora, Luigi Camporota, Poppy Denniston, Kariem El-Boghdadly, Miroslav Kvassay, Denisa Macekova, Michal Munk, David Ranford, Jan Rabcan, Chysostomos Tornari, Duncan Wyncoll, Elena Zaitseva, Nicholas Hart, Stephen Tricklebank
Objectives: To propose the optimal timing to consider tracheostomy insertion for weaning of mechanically ventilated patients recovering from coronavirus disease 2019 pneumonia. We investigated the relationship between duration of mechanical ventilation prior to tracheostomy insertion and in-hospital mortality. In addition, we present a machine learning approach to facilitate decision-making. Design: Prospective cohort study. Setting: Guy's & St Thomas' Hospital, London, United Kingdom...
November 2020: Critical care explorations
Steffen B Wiegand, Bijan Safaee Fakhr, Ryan W Carroll, Warren M Zapol, Robert M Kacmarek, Lorenzo Berra
Treatment options are limited for patients with respiratory failure due to coronavirus disease 2019. Conventional oxygen therapy and awake proning are options, but the use of high-flow nasal cannula and continuous positive airway pressure are controversial. There is an urgent need for effective rescue therapies. Our aim is to evaluate the role of inhaled nitric oxide 160 ppm as a possible rescue therapy in nonintubated coronavirus disease 2019 patients. Design: Retrospective evaluation of coronavirus disease 2019 patients in respiratory distress receiving nitric oxide gas as rescue therapy...
November 2020: Critical care explorations
Ming Han Lincoln Liow, Kenny Xian Khing Tay, Nicholas Eng Meng Yeo, Darren Keng Jin Tay, Seo Kiat Goh, Joyce Suang Bee Koh, Tet Sen Howe, Andrew Hwee Chye Tan
The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented challenges to healthcare systems worldwide. Orthopaedic departments have adopted business continuity models and guidelines for essential and non-essential surgeries to preserve hospital resources as well as protect patients and staff. These guidelines broadly encompass reduction of ambulatory care with a move towards telemedicine, redeployment of orthopaedic surgeons/residents to the frontline battle against COVID-19, continuation of education and research through web-based means, and cancellation of non-essential elective procedures...
June 2020: Bone & joint open
Sean H S Lai, Camelia Q Y Tang
No abstract text is available yet for this article.
June 2020: Bone & joint open
Karen Chui, Amit Thakrar, Shivakumar Shankar
Aims: Hip fracture patients are at higher risk of severe COVID-19 illness, and admission into hospital puts them at further risk. We implemented a two-site orthopaedic trauma service, with 'COVID' and 'COVID-free' hubs, to deliver urgent and infection-controlled trauma care for hip fracture patients, while increasing bed capacity for medical patients during the COVID-19 pandemic. Methods: A vacated private elective surgical centre was repurposed to facilitate a two-site, 'COVID' and 'COVID-free', hip fracture service...
June 2020: Bone & joint open
Pietro Domenico Giorgi, Enrico Gallazzi, Paolo Capitani, Giuseppe Antiono D'Aliberti, Federico Bove, Osvaldo Chiara, Giuseppe Peretti, Giuseppe Rosario Schirò
The COVID-19 virus is a tremendous burden for the Italian health system. The regionally-based Italian National Health System has been reorganized. Hospitals' biggest challenge was to create new intensive care unit (ICU) beds, as the existing system was insufficient to meet new demand, especially in the most affected areas. Our institution in the Milan metropolitan area of Lombardy, the epicentre of the infection, was selected as one of the three regional hub for major trauma, serving a population of more than three million people...
May 2020: Bone & joint open
Xiaoming Qi, Kristin A Keith, Jason H Huang
COVID-19 patients have presented with a wide range of neurological disorders, among which stroke is the most devastating. We have reviewed current studies, case series, and case reports with a focus on COVID-19 patients complicated with stroke, and presented the current understanding of stroke in this patient population. As evidenced by increased D-dimer, fibrinogen, factor VIII and von Willebrand factor, SARS-CoV-2 infection induces coagulopathy, disrupts endothelial function, and promotes hypercoagulative state...
November 17, 2020: Brain hemorrhages
Özkan Görgülü, Murat Duyan
Coronavirus disease 2019 (COVID-19) is a new zoonotic infectious disease that was first reported to the World Health Organization (WHO) on December 31, 2019, and declared as a pandemic by WHO on March 11, 2020. Due to the increased incidence of multimorbidity in geriatric age groups, COVID-19 disease leads to more severe consequences in the elderly. We aimed to determine the effects of age, comorbidity factors, symptoms, laboratory findings, and radiological results on prognosis by dividing our patients into 3 different geriatric age groups, using a retrospective descriptive analysis method...
November 18, 2020: SN comprehensive clinical medicine
Sherif M Shoieb, Mahmoud A El-Ghiaty, Ayman O S El-Kadi
In March 2020, The World Health Organization (WHO) has declared that the coronavirus disease 2019 (COVID-19) is characterized as a global pandemic. As of September 2020, infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to 213 countries and territories around the world, affected more than 31.5 million people, and caused more than 970,000 deaths worldwide. Although COVID-19 is a respiratory illness that mainly targets the lungs, it is currently well established that it is a multifactorial disease that affects other extra-pulmonary systems and strongly associated with a detrimental inflammatory response...
November 17, 2020: Emergent materials
Kolin Rubel, Dhruv Sharma, Vincent Campiti, Grace Yedlicka, Sarah J Burgin, Elisa A Illing, Kurt Kroenke, Jonathan Y Ting
Objective: The symptoms and long-term sequelae of SARS-CoV-2 infection have yet to be determined, and evaluating possible early signs is critical to determine which patients should be tested and treated. The objective of this ongoing study is to evaluate initial and short-term rhinologic symptoms, olfactory ability, and general quality of life in patients undergoing SARS-CoV-2 testing. Study Design: Prospective case-control. Setting: Academic institute...
October 2020: OTO Open
Theodore Kolokolnikov, David Iron
When using SIR and related models, it is common to assume that the infection rate is proportional to the product of susceptible and infected individuals. While this assumption works at the onset of the outbreak, the infection force saturates as the outbreak progresses, even in the absence of any interventions. We use a simple agent-based model to illustrate this saturation effect. Its continuum limit leads a modified SIR model with exponential saturation. The derivation is based on first principles incorporating the spread radius and population density...
November 16, 2020: Infectious Disease Modelling
Hironori Yamamoto, Kouichi Miura, Koichi Hagiwara, Yuji Morisawa, Alan Kawarai Lefor, Naohiro Sata, Ryozo Nagai
The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses serious health and economic problems worldwide. One of the worst scenarios is the collapse of the medical care system due to nosocomial infections. SARS-CoV-2 quickly spreads in closed spaces, crowded areas, and close physical distances, which frequently occur in Japanese medical facilities. Although we are making efforts to avoid such situations, healthcare workers always face the risk of developing a SARS-CoV-2 infection in the workplace because of proximity...
October 15, 2020: JMA journal
Julian Woolley, Christopher Donnell, Stuart Worthington
Introduction/Objectives: As a result of the coronavirus disease 2019 (COVID-19) pandemic, primary care specialist orthodontic practices have been limited to providing emergency treatment only. This has resulted in a cessation of normal face-to-face services and patient advice can only be offered by remote means. A service evaluation was carried out to assess the quality of information published on websites and social media pages of specialist orthodontic practices in London, against General Dental Council guidance on communication and advertising and the British Orthodontic Society (BOS) COVID-19 specific guidance for orthodontics in primary care in relation to Coronavirus Disease 2019 (COVID-19) pandemic...
November 2020: Heliyon
Arpita Basu, Rachel Patzer, Darya Hosein, Zhensheng Wang, Nitika Sharma, Harold Franch, Frederic Rahbari Oskoui, Divya Gupta, Ram Subramanian, Lakshmi Sridharan, Wanda Allison, Stephen Pastan, Christian Larsen
Background: The current surge of coronavirus 2019 (COVID-19) cases in certain parts of the country has burdened the healthcare system, limiting access to tertiary centers for many. As a result, COVID-19-positive Solid Organ Transplant (SOT) recipients are increasingly being managed by local healthcare providers. It is crucial for community providers to understand disease severity and know if COVID-19-impacted SOT recipients have a different clinical course compared with COVID-19-negative SOT recipients with a similar presentation...
December 2020: Transplantation Direct
Clara Pizzuti, Annalisa Socievole, Bastian Prasse, Piet Van Mieghem
Initially emerged in the Chinese city Wuhan and subsequently spread almost worldwide causing a pandemic, the SARS-CoV-2 virus follows reasonably well the Susceptible-Infectious-Recovered (SIR) epidemic model on contact networks in the Chinese case. In this paper, we investigate the prediction accuracy of the SIR model on networks also for Italy. Specifically, the Italian regions are a metapopulation represented by network nodes and the network links are the interactions between those regions. Then, we modify the network-based SIR model in order to take into account the different lockdown measures adopted by the Italian Government in the various phases of the spreading of the COVID-19...
2020: Applied Network Science
Yong Lin, Jun Yuan, Quanxin Long, Jieli Hu, Haijun Deng, Zhenyu Zhao, Juan Chen, Mengji Lu, Ailong Huang
To date, it remains unclear if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection exacerbates liver injury in patients with chronic hepatitis B virus (HBV) infection. In this study, we present a retrospective study of 133 hospitalized confirmed mild coronavirus disease 2019 (COVID-19) cases, including 116 patients with COVID-19 with negative serum hepatitis B antigen and 17 HBV inactive carriers with COVID-19. We found that there were no significant differences for the discharge rate or duration of hospitalization between the two groups...
November 18, 2020: Genes & Diseases
Irma Huayanay, Stephanie Luu
The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had overwhelmed the healthcare system worldwide with multiple ethical dilemmas. Several tools have been used to assess risk factors in these patients. One of them, the Clinical Frailty scale, has shown good correlation between the patient functional status and hospital stay with overall mortality. We present a case were the Clinical Frailty Scale was used to assess patient management and goals of care.
January 2020: Gerontology & Geriatric Medicine
Mohsen Poursadeqiyan, Edris Bazrafshan, Maryam Feiz Arefi
INTRODUCTION: Spread of novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) has become a global and pandemic crisis. Some measures such as excessive use of disinfectants, increased production of nonbiodegradable waste, and water pollution will be the consequences of fighting against coronavirus disease 2019 (COVID-19), which harms the environment. Due to the fact that these effects will be identified in the long term, they may be neglected in the current situation...
2020: Journal of Education and Health Promotion
Sana Saffiruddin Shaikh, Anooja P Jose, Disha Anil Nerkar, Midhuna Vijaykumar Kv, Saquib Khaleel Shaikh
Background: Coronavirus (SARS-CoV-2), the cause of COVID-19, a fatal disease emerged from Wuhan, a large city in the Chinese province of Hubei in December 2019. Main body of abstract: The World Health Organization declared COVID-19 as a pandemic due to its spread to other countries inside and outside Asia. Initial confirmation of the pandemic shows patient exposure to the Huanan seafood market. Bats might be a significant host for the spread of coronaviruses via an unknown intermediate host...
2020: Future journal of pharmaceutical sciences
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