Adem Sümen, Selma Öncel
AIMS: This study aims to examine the effect of the 'I am Protecting my Child from the Sun' program based on the social cognitive theory, on parental use of sun protection products and sun avoidance behaviours. DESIGN: Cluster randomized controlled trial. METHODS: The study was conducted with three groups using a pre-test, post-test, and follow-up design. The study included 185 parents, of which 63 were in the education group, 62 were in the education + SMS group, and 60 were in the control group...
October 22, 2020: Journal of Advanced Nursing
Tetsuro Sakai
Despite the lack of large randomized clinical studies, viscoelastic tests (VETs) have been a critical armamentarium for hemostatic control in liver transplantation (LT) since the 1960s. Many transplant institutions have adopted VETs in their clinical practice. Several small-size randomized clinical trials on LT patients have suggested that VET-guided hemostatic treatment algorithms have led to decreased indications for and amounts of transfused blood products, especially fresh-frozen plasma, compared to standard laboratory-based hemostatic management...
October 2020: Transfusion
Chathura B B Ratnayake, Cameron I Wells, Phillip Atherton, John S Hammond, Steve White, Jeremy J French, Derek Manas, Sanjay Pandanaboyana
BACKGROUND: Controversy exists regarding the optimal management of colorectal lung metastases (CRLM). This meta-analysis compared surgical (Surg) versus interventional (chemotherapy and/or radiotherapy) and observational non-surgical (NSurg) management of CRLM. METHODS: A systematic review of the major databases including Medline, Embase, SCOPUS and the Cochrane library was performed. RESULTS: One randomized and nine observational studies including 2232 patients: 1551 (69%) comprised the Surg cohort, 521 (23%) the interventional NSurg group and 160 (7%) the observational NSurg group...
October 22, 2020: ANZ Journal of Surgery
Rosa G Simonetti, Giovanni Perricone, Helen L Robbins, Narendra R Battula, Martin O Weickert, Robert Sutton, Saboor Khan
BACKGROUND: People with liver cirrhosis who have had one episode of variceal bleeding are at risk for repeated episodes of bleeding. Endoscopic intervention and portosystemic shunts are used to prevent further bleeding, but there is no consensus as to which approach is preferable. OBJECTIVES: To compare the benefits and harms of shunts (surgical shunts (total shunt (TS), distal splenorenal shunt (DSRS), or transjugular intrahepatic portosystemic shunt (TIPS)) versus endoscopic intervention (endoscopic sclerotherapy or banding, or both) with or without medical treatment (non-selective beta blockers or nitrates, or both) for prevention of variceal rebleeding in people with liver cirrhosis...
October 22, 2020: Cochrane Database of Systematic Reviews
Arthur José Barbosa de França, Rayanna Thayse Florêncio Costa, João Luiz Gomes Carneiro Monteiro, Nelson Studart Rocha, Belmiro Cavalcanti do Egito Vasconcelos, Sandra Lúcia Dantas de Moraes
OBJECTIVES: The present systematic review aimed to evaluate whether the IANB (conventional inferior alveolar nerve block) technique is superior to the VA (Vazirani-Akinosi) or GG (Gow-Gates) techniques for anesthesia in the removal of posterior mandibular teeth. MATERIALS AND METHODS: This systematic review was structured according to the PICO strategy, adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist, and was recorded on the international prospective register of systematic reviews (PROSPERO-CRD42020153130)...
October 22, 2020: Clinical Oral Investigations
Dominic Fisher, Quinette Louw, Lehana Thabane
BACKGROUND: Despite growing evidence of deleterious health outcomes associated with sedentary behaviour, prolonged static sitting in classrooms remains ubiquitous in primary school classrooms. Sedentary behaviour is associated with the development of cardio-metabolic conditions and poor back health. Preventative strategies to reduce sedentary behaviour and its negative health effects may be required in a resource-constrained environment such as South Africa. OBJECTIVE: Primary: To assess the feasibility of conducting a full trial to evaluate the effects of a multi-faceted intervention comprising novel multi-functional classroom furniture and a video-based curriculum versus usual care on sedentary behaviour among students aged between 10 and 11 years old in primary schools...
September 8, 2020: JMIR Research Protocols
Wenbo Guo, Song Chen, Zhiqiang Wu, Wenquan Zhuang, Jianyong Yang
OBJECTIVE: This study aimed to explore the efficacy and safety of using transarterial chemoembolization (TACE) combined with anlotinib in patients with unresectable hepatocellular carcinoma, compared with TACE alone. METHODS: This was a single-center study, retrospectively recruited 82 unresectable HCC patients who received either TACE alone (TA group; n = 46) or TACE combined with anlotinib (TC group; n = 36) between Jan 2018 and Jan 2019. The primary outcomes were progression-free survival (PFS) and overall survival (OS)...
January 2020: Technology in Cancer Research & Treatment
Chiara Buizza, Herald Cela, Clarissa Ferrari, Claudia Goss, Alessandro Bottacini, Maria Angela Mazzi, Lidia Del Piccolo, Alberto Ghilardi
OBJECTIVES: This study is based on a multi-centered RCT conducted on breast cancer patients during their first consultation with an oncologist. The main aim was to evaluate whether the introduction of a communication tool (i.e., the Question Prompt Sheet or Question Listing), with or without a companion, impacted the number of questions asked by patients during the consultation, and subsequent psychological and relational outcomes. METHODS: The sample consisted of 324 breast cancer patients who were randomly placed into one of the two intervention groups: Question Prompt Sheet or Question Listing...
October 22, 2020: Journal of Psychosocial Oncology
S Salvatore, E Pitsouni, T Grigoriadis, D Zacharakis, G Pantaleo, M Candiani, S Athanasiou
PURPOSE: This study aimed to clarify the efficacy of intravaginal CO2 -laser treatment in postmenopausal women with genitourinary syndrome of menopause (GSM). MATERIALS AND METHODS: This double - blind, randomized, sham-controlled trial included postmenopausal women diagnosed with GSM and bothersome dryness and dyspareunia. Treatment consisted of three sessions. Active CO2 -laser treatments (active group) were compared to sham treatments (sham group) with the primary endpoints being changes in dryness and dyspareunia intensity, as assessed by the 10-cm visual analog scale...
October 22, 2020: Climacteric: the Journal of the International Menopause Society
G Alvares-Pereira, M V Silva-Nunes, A Spector
BACKGROUND: Cognitive Stimulation Therapy (CST) is considered a gold-standard, evidence-based and cost-effective approach to improve cognitive function and quality of life of people with mild to moderate dementia. AIMS: To validate CST for the Portuguese population and test its effectiveness. METHODS: A single-blind, multi-center, randomized controlled trial recruited 112 older people with dementia. The primary outcome measure was cognition and secondary measures were quality of life, communication, autonomy, anxiety, depression, and global functioning...
October 22, 2020: Aging & Mental Health
Haoran Ke, Jing Li, Bingyun Lu, Chenghai Yang, Jiamin Wang, Zhiqing Wang, Le Liu, Ye Chen
BACKGROUND: This study aimed to investigate whether an increased proton pump inhibitor (PPI) dose enhanced the efficacy of Helicobacter pylori (H. pylori) eradication and determine the appropriate cutoff intragastric pH value that could predict H. pylori eradication with bismuth-based quadruple therapy. MATERIALS AND METHODS: A total of 207 H. pylori infected, treatment naive patients were enrolled in this prospective, open-label, randomized controlled trial...
October 21, 2020: Helicobacter
Emily Brooks, Megan Spokas, Deborah Goldschmidt
There has been a lack of consensus regarding whether to include or exclude participants with suicidal ideation (SI) from posttraumatic stress disorder (PTSD) psychotherapy clinical trials and, until recently, how best to report adverse events related to suicide risk. Without consistent reporting or evaluation of SI as an outcome, clinical practice guidelines are limited in their ability to recommend interventions for this common co-occurrence. In the present meta-analysis, we compared randomized controlled trials (RCTs) of PTSD psychotherapies, based on their suicide exclusion criteria...
October 21, 2020: Journal of Traumatic Stress
Thippawan Bunsanong, Nujjaree Chaimongkol
AIM: To determine the effectiveness of a self-management support intervention on knee functional status and health-related quality of life among middle-age women with knee osteoarthritis. DESIGN: Randomized controlled trial. METHODS: The participants were 40 middle-aged women who had been clinically diagnosed with knee osteoarthritis for more than 3 months and randomly assigned into intervention and control groups equally. After IRB approval code 02-05-2562 was obtained, data collection was carried out from July - November 2019 at the Outpatient Department of Orthorpedics, Thasala Hospital, Thailand...
October 21, 2020: Journal of Advanced Nursing
Gan Mi Wang, Liang Jin Li, Wen Lu Tang, James M Wright
BACKGROUND: Renin inhibitors (RIs) reduce blood pressure more than placebo, with the magnitude of this effect thought to be similar to that for angiotensin converting enzyme (ACE) inhibitors. However, a drug's efficacy in lowering blood pressure cannot be considered as a definitive indicator of its effectiveness in reducing mortality and morbidity. The effectiveness and safety of RIs compared to ACE inhibitors in treating hypertension is unknown. OBJECTIVES: To evaluate the benefits and harms of renin inhibitors compared to ACE inhibitors in people with primary hypertension...
October 22, 2020: Cochrane Database of Systematic Reviews
T T Favas, Priya Dev, Rameshwar Nath Chaurasia, Kamlesh Chakravarty, Rahul Mishra, Deepika Joshi, Vijay Nath Mishra, Anand Kumar, Varun Kumar Singh, Manoj Pandey, Abhishek Pathak
BACKGROUND: Coronaviruses mainly affect the respiratory system; however, there are reports of SARS-CoV and MERS-CoV causing neurological manifestations. We aimed at discussing the various neurological manifestations of SARS-CoV-2 infection and to estimate the prevalence of each of them. METHODS: We searched the following electronic databases; PubMed, MEDLINE, Scopus, EMBASE, Google Scholar, EBSCO, Web of Science, Cochrane Library, WHO database, and ClinicalTrials...
October 21, 2020: Neurological Sciences
Serdar Demirgan, Funda Gümüş Özcan, Ezgi Kargı Gemici, Hasan Cem Güneyli, Erkan Yavuz, Osman Bilgin Gülçiçek, Ayşin Selcan
The aim of this randomized controlled trial was to determine whether applying the reverse Trendelenburg position before pneumoperitoneum has a preventive effect on increased intracranial pressure using optic nerve sheath diameter (ONSD) measurement as a noninvasive parameter. Seventy-nine patients were allocated to two groups according to whether pneumoperitoneum was applied in the supine position (group S, n = 40) or in the reverse Trendelenburg position (group RT, n = 39). The ONSD was measured at the following time points: T0: before anesthesia; T1: after endotracheal intubation; T2: after pneumoperitoneum in group S and after positioning in group RT; T3: after positioning in group S and after pneumoperitoneum in group RT; T4: 30 min after endotracheal intubation, and T5: after desufflation...
October 21, 2020: Journal of Clinical Monitoring and Computing
Hyun Jin Song, Kiyon Rhew, Yoon Jae Lee, In-Hyuk Ha
BACKGROUND: Patients with cancer often receive acid-suppressive agents (ASAs) to treat common gastroesophageal reflux and peptic ulcer diseases. Our systematic review addresses the association between ASAs and survival outcomes in these patients. METHODS: We searched MEDLINE, EMBASE, and Cochrane until December 2019, including randomized controlled trials (RCTs), quasi-RCTs, and observational studies concerning ASAs that reported progression-free survival (PFS) and/or overall survival (OS)...
October 22, 2020: International Journal of Clinical Oncology
Kuo-Chuan Hung, Chao-Ting Hung, Yan-Yuen Poon, Shao-Chun Wu, Kee-Hsin Chen, Jen-Yin Chen, Ying-Jen Chang, I-Wen Chen, Cheuk-Kwan Sun, Min-Hsien Chiang
PURPOSE: This meta-analysis aimed to assess the impact of cricoid pressure (CP) application on intubation outcomes. SOURCE: Electronic databases (i.e., MEDLINE, PubMed, Embase, and Cochrane review) were searched from inception to 2 June 2020 for randomized-controlled trials that assessed the intubation outcomes in adult patients using laryngoscopic approaches with and without the application of CP (i.e., CP vs non-CP group). The primary outcome was the successful first-attempt intubation rate (SFAIR), and the secondary outcomes were intubation time, incidences of poor laryngoscopic views (i...
October 21, 2020: Canadian Journal of Anaesthesia
George Van Buren, Charles M Vollmer
Pancreatic fistula has been the defining complication and challenge of pancreatic surgery. Better awareness and mitigation of postoperative pancreatic fistulas has led to significant improvements in morbidity and mortality of pancreatic surgery. The definition and management of pancreatic fistulas has sequentially progressed over the last three decades; the literature ranges from retrospective, observational studies to prospective multicenter randomized controlled trials. The landmark literature contributions driving the perioperative management of pancreatic fistulas are detailed in this article...
October 21, 2020: Annals of Surgical Oncology
Roberto Cirocchi, Georgi Popivanov, Marina Konaktchieva, Sonia Chipeva, Guglielmo Tellan, Andrea Mingoli, Mauro Zago, Massimo Chiarugi, Gian Andrea Binda, Reinhold Kafka, Gabriele Anania, Annibale Donini, Riccardo Nascimbeni, Mohammed Edilbe, Sorena Afshar
INTRODUCTION: Damage control surgery (DCS) is the classic approach to manage severe trauma and has recently also been considered an appropriate approach to the treatment of critically ill patients with severe intra-abdominal sepsis. The purpose of the present review is to evaluate the outcomes following DCS for Hinchey II-IV complicated acute diverticulitis (CAD). METHODS: A comprehensive systematic search was undertaken to identify all randomized clinical trials (RCTs) and observational studies, irrespectively of their size, publication status, and language...
October 22, 2020: International Journal of Colorectal Disease
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