Rocío Romero, Rocío Penas, Ana García-Conde, Pilar Llombart, Sandra Pérez, José H Marco
OBJECTIVES: The aim of this study is to analyse whether MBCT will reduce the general level of psychopathology, increase the quality of life, and increase meta-knowledge about their emotional state in Spanish participants with cancer. METHOD: The sample consisted of n = 88 Spanish oncology patients. This was a non-randomized, two-group (experimental vs waiting list) trial conducted in a naturalistic setting. We evaluated psychological distress (BSI-18), quality of life (FACT-G), and meta-knowledge of emotions (TMMS-24)...
November 2020: Psicothema
Demián E Rodante, Marcela I Kaplan, Ramiro Olivera Fedi, Pablo Gagliesi, Agustina Pascali, Paula S José Quintero, Emilio J Compte, Ana I Perez, Melina Weinstein, Luciana C Chiapella, Federico M Daray
The present study was aim to evaluate the acceptability and preliminary effectiveness of a mobile-health application, CALMA, based on dialectical behavioral therapy skills. CALMA was proposed as an adjunct to therapy for the reduction of non-suicidal and suicidal self-injury behaviors. A parallel design was used to compare the intervention group (DBT + CALMA) and the comparison group (DBT). Patients were randomized based on their groups following a randomized cluster design. After treatment, patients completed a follow-up assessment four weeks later...
October 18, 2020: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
Andressa Oliveira Barros Dos Santos, Juliana Brandão Pinto de Castro, Vicente Pinheiro Lima, Elirez Bezerra da Silva, Rodrigo Gomes de Souza Vale
Aim: To verify the effects of physical exercise on low back pain (LBP) and serum cortisol levels in individuals with chronic LBP. Materials & methods: Randomized controlled trials evaluating the effects of exercise on LBP perception and cortisol levels in adults with nonspecific chronic LBP were included. Results: Four randomized controlled trials were included, with a total of 85 participants in the exercise group and 84 in the control group. The interventions reduced -1.61 (95% CI: -2.36 to -0.85) with inconsistency I2  = 72% (p = 0...
October 19, 2020: Pain Management
Meagan O'Neill, Dominic Samaroo, Christian Lopez, George Tomlinson, Daniel Santa Mina, Catherine Sabiston, Nicole Culos-Reed, Shabbir M H Alibhai
BACKGROUND: Women with breast cancer (BC) are living longer with debilitating side effects such as cancer-related fatigue (CRF) that affect overall well-being. Yoga promotes health, well-being and may be beneficial in reducing CRF. Although there have been previous systematic reviews and meta-analyses, the effects of yoga on CRF and quality of life (QOL) remain unclear, particularly in comparison with other types of physical activity (PA). Our objective is to carry out a systematic review and meta-analysis of the effects of yoga on CRF and QOL in women with BC...
January 2020: Integrative Cancer Therapies
Kevin Mertz, Sarah E Lindsay, Arden Morris, Robin N Kamal
BACKGROUND: The purpose of this systematic review was to determine the metrics used to assess outcomes after treatment for carpal tunnel syndrome. METHODS: We performed a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines of level I and II randomized controlled trials of treatment for carpal tunnel syndrome. We searched the PubMed/MEDLINE electronic database for studies on treatment of carpal tunnel syndrome from January 2008 to January 2018...
October 19, 2020: Hand: Official Journal of the American Association for Hand Surgery
Catherine Y S Cheung, Jash Parikh, Ashley Farrell, Melissa Lefebvre, Claudia Summa-Sorgini, Marisa Battistella
OBJECTIVE: To evaluate how treatment with DOACs for VTE affects thrombosis and bleeding outcomes compared to warfarin in CKD and dialysis patients. DATA SOURCES: A literature search was conducted for studies evaluating VTE and bleeding outcomes with DOAC use in CKD and dialysis patients. Searches conducted through EMBASE, MEDLINE/PubMed, Scopus, and Cochrane Central Register of Controlled Trials, from inception to September 22, 2020. STUDY SELECTION AND DATA EXTRACTION: Randomized controlled trials, cohort studies, and case series with ≥10 patients included...
October 19, 2020: Annals of Pharmacotherapy
Pinky Kotecha, Alexander Light, Enrico Checcucci, Daniele Amparore, Cristian Fiori, Francesco Porpiglia, Prokar Dasgupta, Oussama Elhage
OBJECTIVE: The aim of this systematic review is to evaluate the data currently available regarding the repurposing of different drugs for Covid-19 treatment. Participants with suspected or diagnosed Covid-19 will be included. The interventions being considered are drugs being repurposed, and comparators will include standard of care treatment or placebo. METHODS: We searched Ovid-MEDLINE, EMBASE, Cochrane library, clinical trial registration site in the UK(NIHR), Europe (clinicaltrialsregister...
October 19, 2020: Panminerva Medica
Hyuck Hoon Kwon, Steven Hoseong Yang, Joon Lee, Byung Chul Park, Kui Young Park, Jae Yoon Jung, Youin Bae, Gyeong-Hun Park
A variety of applications of human adipose tissue stem cell-derived exosomes have been suggested as novel cell-free therapeutic strategies in the regenerative and aesthetic medical fields. This study evaluated the clinical efficacy and safety of adipose tissue stem cell-derived exosomes as an adjuvant therapy after application of fractional CO2 laser for acne scars. A 12-week prospective, double-blind, randomized, split-face trial was performed. A total of 25 patients received 3 consecutive treatment sessions of fractional CO2 laser to the whole face, with a follow-up evaluation...
October 19, 2020: Acta Dermato-venereologica
Katia Abarca, Emma Rey-Jurado, Natalia Muñoz-Durango, Yaneisi Vázquez, Jorge A Soto, Nicolás M S Gálvez, Javier Valdés-Ferrada, Carolina Iturriaga, Marcela Urzúa, Arturo Borzutzky, Jaime Cerda, Luis Villarroel, Victoria Madrid, Pablo A González, José V González-Aramundiz, Susan M Bueno, Alexis M Kalergis
Background: Respiratory syncytial virus (RSV) is responsible for most respiratory tract infections and hospitalizations in infants and represents a significant economic burden for public health. The development of a safe, effective, and affordable vaccine is a priority for the WHO. Methods: We conducted a double-blinded, escalating-dose phase 1 clinical trial in healthy males aged 18-50 years to evaluate safety, tolerability, and immunogenicity of a recombinant Mycobacterium bovis BCG vaccine expressing the nucleoprotein of RSV (rBCG-N-hRSV)...
October 2020: EClinicalMedicine
Mario Rivera-Izquierdo, María Del Carmen Valero-Ubierna, Juan Luis R-delAmo, Miguel Ángel Fernández-García, Silvia Martínez-Diz, Arezu Tahery-Mahmoud, Marta Rodríguez-Camacho, Ana Belén Gámiz-Molina, Nicolás Barba-Gyengo, Pablo Gámez-Baeza, Celia Cabrero-Rodríguez, Pedro Antonio Guirado-Ruiz, Divina Tatiana Martín-Romero, Antonio Jesús Láinez-Ramos-Bossini, María Rosa Sánchez-Pérez, José Mancera-Romero, Miguel García-Martín, Luis Miguel Martín-delosReyes, Virginia Martínez-Ruiz, Eladio Jiménez-Mejías
Background and objectives: In the last months great efforts have been developed to evaluate the more efficient therapeutic agents in the management of patients with COVID-19. Currently, no specific drug combination has consistently demonstrated an association with mortality. The aim of this study was to assess the pattern of associations observed between the different in-hospital treatments administered to a series of 238 patients admitted for COVID-19 and their relationship with mortality...
October 9, 2020: Medicina clínica
Francesco Salton, Paola Confalonieri, G Umberto Meduri, Pierachille Santus, Sergio Harari, Raffaele Scala, Simone Lanini, Valentina Vertui, Tiberio Oggionni, Antonella Caminati, Vincenzo Patruno, Mario Tamburrini, Alessandro Scartabellati, Mara Parati, Massimiliano Villani, Dejan Radovanovic, Sara Tomassetti, Claudia Ravaglia, Venerino Poletti, Andrea Vianello, Anna Talia Gaccione, Luca Guidelli, Rita Raccanelli, Paolo Lucernoni, Donato Lacedonia, Maria Pia Foschino Barbaro, Stefano Centanni, Michele Mondoni, Matteo Davì, Alberto Fantin, Xueyuan Cao, Lucio Torelli, Antonella Zucchetto, Marcella Montico, Annalisa Casarin, Micaela Romagnoli, Stefano Gasparini, Martina Bonifazi, Pierlanfranco D'Agaro, Alessandro Marcello, Danilo Licastro, Barbara Ruaro, Maria Concetta Volpe, Reba Umberger, Marco Confalonieri
Background: In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated with significant morbidity and mortality. Severe dysregulated systemic inflammation is the putative mechanism. We hypothesize that early prolonged methylprednisolone (MP) treatment could accelerate disease resolution, decreasing the need for intensive care unit (ICU) admission and mortality. Methods: We conducted a multicenter observational study to explore the association between exposure to prolonged, low-dose MP treatment and need for ICU referral, intubation, or death within 28 days (composite primary end point) in patients with severe COVID-19 pneumonia admitted to Italian respiratory high-dependency units...
October 2020: Open Forum Infectious Diseases
Craig S Charron, Bryan T Vinyard, Elizabeth H Jeffery, Sharon A Ross, Harold E Seifried, Janet A Novotny
Introduction: Preclinical studies suggest that brassica vegetable diets decrease cancer risk, but epidemiological studies show varied effects, resulting in uncertainty about any health impact of brassicas. Factors controlling absorption of glucosinolate metabolites may relate to inconsistent results. We reported previously that subjects with BMI > 26 kg/m2 (HiBMI), given cooked broccoli plus raw daikon radish (as a source of plant myrosinase) daily for 17 days, had lower glucosinolate metabolite absorption than subjects given a single broccoli meal...
2020: Frontiers in Nutrition
Catherine Schwinger, Ram K Chandyo, Manjeswori Ulak, Mari Hysing, Merina Shrestha, Suman Ranjitkar, Tor A Strand
Introduction: There is an increase in the double burden of malnutrition globally, with a particular rise documented in Asia. In Nepal, undernutrition has been prevalent for decades. Today, however, the incidence of overweight and obesity (OWOB) in the country has increased substantially. There is a need to conduct local studies reporting on the concurrent burden of both underweight and OWOB across adult populations. This study addresses this need by describing the distribution of body mass index (BMI) in a defined population of adults living in the peri-urban community of Bhaktapur, Nepal...
2020: Frontiers in Nutrition
Edward H Munson, Samuel T Orange, James W Bray, Shane Thurlow, Philip Marshall, Rebecca V Vince
This study examined the dose-response effects of ingesting different sodium concentrations on markers of hydration and tennis skill. Twelve British nationally-ranked tennis players (age: 21.5 ± 3.1 years; VO2peak : 45.5 ± 4.4 ml. kg. min-1 ) completed four identical in-door tennis training sessions in a cluster randomized, single-blind, placebo-controlled, crossover design. Twenty-minutes prior to each training session, participants consumed a 250 ml sodium-containing beverage (10, 20, 50 mmol/L) or a placebo (0 mmol/L), and continued to consume 1,000 ml of the same beverage at set periods during the 1-h training session...
2020: Frontiers in Nutrition
Alain Fraisse, Carles Bautista-Rodriguez, Margarita Burmester, Mary Lane, Yogen Singh
Persistent patent ductus arteriosus (PDA) is very common in preterm infants, especially in extremely preterm infants. Despite significant advances in management of these vulnerable infants, there has been no consensus on management of PDA-when should we treat, who should we treat, how should we treat and in fact there is no agreement on how we should define a hemodynamically significant PDA. Medical management with non-steroidal anti-inflammatory drugs (NSAIDs) remains the first line of therapy with moderate success rate in closing the PDA...
2020: Frontiers in Pediatrics
Priya Brahmbhatt, Catherine M Sabiston, Christian Lopez, Eugene Chang, Jack Goodman, Jennifer Jones, David McCready, Ian Randall, Sarah Rotstein, Daniel Santa Mina
Background: Breast cancer surgery results in numerous acute and long-term adverse outcomes; the degree to which these can be mitigated or prevented through prehabilitation is unknown. Methods: We conducted a longitudinal, single-arm, mixed-methods study to examine the feasibility of prehabilitation in 22 women undergoing breast cancer surgery. All participants received an individualized exercise prescription including upper quadrant-specific resistance and mobility training and aerobic exercise for the duration of their surgical wait time...
2020: Frontiers in Oncology
You-Meng Sun, Ying Wang, Xin-Xing Sun, Jing Chen, Zhi-Ping Gong, Hai-Yan Meng
Background: Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape among non-small-cell lung cancer (NSCLC) patients. The efficacy of ICI therapy in older patients (≥65 years) is controversial and not fully clarified. We performed a systematic review and meta-analysis to evaluate the efficacy of ICIs in patients with advanced or metastatic NSCLC based on age (<65 years vs. ≥65 years). Methods: A comprehensive literature search for eligible randomized control phase II/III trials that compared the efficacy of anti-PD-1/PD-L1 agents against chemotherapy in advanced or metastatic NSCLC patients...
2020: Frontiers in Oncology
Jinze Li, Lei Peng, Dehong Cao, Bo Cheng, Haocheng Gou, Yunxiang Li, Qiang Wei
Background: The use of robot-assisted radical nephrectomy (RARN) for renal cell carcinoma (RCC) has increased in recent years, but the advantages of RARN over laparoscopic radical nephrectomy (LRN) remain controversial. This study aimed to compare the perioperative outcomes between RARN and LRN. Methods: We systematically searched the EMBASE, PubMed, Web of Science, and CNKI databases to identify eligible comparative studies. The parameters were perioperative outcomes including operating time (OT), estimated blood loss (EBL), length of stay (LOS), conversion rate, and complications...
2020: Frontiers in Oncology
Dongxu Zhang, Kai Sun, Tianqi Wang, Gang Wu, Jipeng Wang, Yuanshan Cui, Jitao Wu
Background and objective: Radical cystectomy has been characterized as the most difficult operation in urology because of the complex surgical procedures and postoperative complications. Enhanced recovery after surgery (ERAS), which reduces the incidence of perioperative complications, has been widely used in clinical surgery. Herein, we performed a meta-analysis to evaluate the efficacy and safety of ERAS vs. conventional recovery after surgery (CRAS) on perioperative outcomes of radical cystectomy. Methods: We performed a systematic search of randomized controlled trials (RCTs) in the following databases: Medline, Embase, and the Cochrane Controlled Trials Register, based on the PICOS strategy...
2020: Frontiers in Oncology
Xin Yan, Xuan Tian, Zhiqiang Wu, Weidong Han
Background: Despite the acknowledged benefits of immune checkpoint inhibitor (ICI)-based combination therapy (either with other checkpoint inhibitors, chemotherapy, targeted therapy, or radiotherapy), little is known about the impact of age on the efficacy of ICI -based combination therapy in non-small-cell lung cancer (NSCLC) patients. We conducted a systematic review and meta-analysis to investigate the differences in the benefits of ICI-based combination therapy for NSCLC by age (cut-off age, 65 years). Methods: We systematically searched randomized controlled trials (RCTs) of ICI plus other therapies including other ICIs, chemotherapies, targeted therapies, or radiotherapies, in the PubMed, Embase, and Cochrane databases with available hazard ratios (HRs) and 95% confidence intervals (CIs) for death and disease progression according to patient age...
2020: Frontiers in Oncology
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