Dara V F Albert, Margie Ream, Nicole Verbeck, Todd Lash, Pedro Weisleder
BACKGROUND: The purpose of this study was to implement an objective structured clinical examination for child neurology trainees for formative feedback regarding communication skills. Effective communication skills are essential and teachable, but tools to formally assess them are limited. An objective structured clinical examination is one such tool, but these examinations have not been developed for child neurology residents. METHODS: We developed nine standardized scenarios that highlighted communication challenges commonly encountered in child neurology...
September 15, 2020: Pediatric Neurology
G Montrucchio, S Corcione, G Sales, A Curtoni, F G De Rosa, L Brazzi
We report the cases of 7 ICU patients with COVID-19 related ARDS, who developed positive rectal swab and invasive infections due to CP-Kp. Notwithstanding the infection prevention measures introduced during COVID-19 pandemic and the changes in the hospitalized population, attention to CP-Kp infections must remain high, especially in critically ill setting.
November 23, 2020: Journal of Global Antimicrobial Resistance
Caroline Bleakley, Suveer Singh, Benjamin Garfield, Marco Morosin, Elena Surkova, Ms Sundhiya Mandalia, Bernardo Dias, Emmanouil Androulakis, Laura C Price, Colm McCabe, Stephen John Wort, Ms Cathy West, Wei Li, Rajdeep Khattar, Roxy Senior, Brijesh V Patel, Susanna Price
AIMS: Comprehensive echocardiography assessment of right ventricular (RV) impairment has not been reported in critically ill patients with COVID-19. We detail the specific phenotype and clinical associations of RV impairment in COVID-19 acute respiratory distress syndrome (ARDS). METHODS: Transthoracic echocardiography (TTE) measures of RV function were collected in critically unwell patients for associations with clinical, ventilatory and laboratory data. RESULTS: Ninety patients (25...
November 23, 2020: International Journal of Cardiology
Annika Reintam Blaser, Adam M Deane, Jean-Charles Preiser, Yaseen M Arabi, Stephan M Jakob
Enteral feeding intolerance (EFI) is a common feature in critically ill patients worldwide. However, there is no clear, widely agreed-upon definition available, with various studies rarely using the same definition. The term EFI is frequently used to describe vomiting or large gastric residual volumes associated with enteral feeding as a result of gastroparesis/delayed gastric emptying. However, the syndrome of EFI may represent the consequence of various pathophysiological mechanisms, and this heterogeneity may explain varying associations with outcomes...
November 26, 2020: Nutrition in Clinical Practice
Ahmed Anwar Khattab, Ashraf Abd El Raouf Dawood, Nagwan Yossery Saleh
OBJECTIVE: Pediatric sepsis is altered organ function in critically ill children and a main etiology of mortality for children. Therefore, the authors aimed to assess the role of serum thrombomodulin as valuable biomarker in the diagnosis and prognosis of sepsis in acutely ill pediatrics in the intensive unit. METHODS: This prospective clinical study conducted on 140 acutely ill patients admitted to the Pediatric Intensive Care Unit (PICU) of Menoufia University Hospital and 50 apparently healthy controls from October 2018 through September 2019...
November 26, 2020: Indian Journal of Pediatrics
Yie Hui Lau, Chee Hong Loh, Wee Kim Fong, Shahla Siddiqui, Chee Keat Tan, Jonathan Je Tan, Kay Choong See
INTRODUCTION: Point of care ultrasound (POCUS) has become essential in the management of critically ill patients. Multiple POCUS training courses exist, but are not widely adopted in Singapore. Given the discordance between training supply and demand, we aimed to uncover the learning needs and barriers among intensive care medicine (ICM) doctors locally. MATERIALS AND METHODS: An anonymous online survey was carried out from January to April 2019 among ICM doctors from 6 major teaching hospitals in Singapore...
September 2020: Annals of the Academy of Medicine, Singapore
Tianwen Zhu, Xiaohui Gong, Fei Bei, Li Ma, Yan Chen, Yonghong Zhang, Xia Wang, Jingjing Sun, Jian Wang, Gang Qiu, Jianhua Sun, Yu Sun, Yongjun Zhang
To identify next-generation-sequencing (NGS) clinical usability and to propose a standard diagnostic routine for critically ill infants, aged less than 100 days and suspected of having a genetically heterogeneous condition, a retrospective study was conducted between January 2016 and December 2018 at neonatal intensive care units (NICUs) of three tertiary hospitals in Shanghai, China. Whole-exome sequencing (WES) or panel sequencing was performed on 307 patients. Trio-WES, trio-panel, proband-WES, and proband-panel diagnostic yields were 39...
2020: Frontiers in Genetics
Yinhua Zhang, Yuanyuan Chen, Zhongji Meng
COVID-19 has become a worldwide pandemic caused by the novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severe cases of COVID-19 have accounted for 10-20% of all infections, leading to more than 500,000 deaths. Increasing evidence has suggested that the inflammatory cytokine storm originating from the anti-SARS-CoV-2 immune response plays an important role in the pathogenesis of critically ill patients with COVID-19, which leads to mixed antagonistic response syndrome (MARS)...
2020: Frontiers in Immunology
Kathy C Richards, Yan-Yan Wang, Jeehye Jun, Lichuan Ye
Background: Clinical trialists and clinicians have used a number of sleep quality measures to determine the outcomes of interventions to improve sleep and ameliorate the neurobehavioral consequences of sleep deprivation in critically ill patients, but findings have not always been consistent. To elucidate the source of these consistencies, an important consideration is responsiveness of existing sleep measures. The purpose of an evaluative measure is to describe a construct of interest in a specific population, and to measure the extent of change in the construct over time...
2020: Frontiers in Neurology
Monty B Mazer, Charles Caldwell, Jodi Hanson, Daniel Mannion, Isaiah R Turnbull, Anne Drewry, Dale Osborne, Andrew Walton, Tessa Blood, Lyle L Moldawer, Scott Brakenridge, Kenneth E Remy, Richard S Hotchkiss
Sepsis initiates simultaneous pro- and anti-inflammatory processes, the pattern and intensity of which vary over time. The inability to evaluate the immune status of patients with sepsis in a rapid and quantifiable manner has undoubtedly been a major reason for the failure of many therapeutic trials. Although there has been considerable effort to immunophenotype septic patients, these methods have often not accurately assessed the functional state of host immunity, lack dynamic range, and are more reflective of molecular processes rather than host immunity...
November 25, 2020: Journal of Immunology
Hany M Elsheikha, Christina M Marra, Xing-Quan Zhu
SUMMARY Toxoplasma gondii is known to infect a considerable number of mammalian and avian species and a substantial proportion of the world's human population. The parasite has an impressive ability to disseminate within the host's body and employs various tactics to overcome the highly regulatory blood-brain barrier and reside in the brain. In healthy individuals, T. gondii infection is largely tolerated without any obvious ill effects. However, primary infection in immunosuppressed patients can result in acute cerebral or systemic disease, and reactivation of latent tissue cysts can lead to a deadly outcome...
March 17, 2021: Clinical Microbiology Reviews
Christian Koch, Fabian Edinger, Tobias Fischer, Florian Brenck, Andreas Hecker, Christian Katzer, Melanie Markmann, Michael Sander, Emmanuel Schneck
BACKGROUND: It is crucial to rapidly identify sepsis so that adequate treatment may be initiated. Accordingly, the Sequential Organ Failure Assessment (SOFA) and the quick SOFA (qSOFA) scores are used to evaluate intensive care unit (ICU) and non-ICU patients, respectively. As demand for ICU beds rises, the intermediate care unit (IMCU) carries greater importance as a bridge between the ICU and the regular ward. This study aimed to examine the ability of SOFA and qSOFA scores to predict suspected infection and mortality in IMCU patients...
November 25, 2020: World Journal of Emergency Surgery: WJES
Ludwig Scheffenbichler, Bijan Teja, Flora Scheffenbichler, Manfred Blobner, Timothy Houle, Matthias Eikermann
No abstract text is available yet for this article.
November 25, 2020: Critical Care: the Official Journal of the Critical Care Forum
Tanvir M Huda, Ashraful Alam, Tazeen Tahsina, Mohammad Mehedi Hasan, Afrin Iqbal, Jasmin Khan, Gulshan Ara, Nazia Binte Ali, Saad Ullah Al Amin, Elizabeth K Kirkwood, Tracey-Lea Laba, Nicholas Goodwin, Sumithra Muthayya, Munirul Islam, Kingsley Emwinyore Agho, John Hoddinott, Shams El Arifeen, Michael J Dibley
BACKGROUND: Undernutrition is strongly associated with poverty - levels of undernutrition are higher in poor countries than in better-off countries. Social protection especially cash transfer is increasingly recognized as an important strategy to accelerate progress in improving maternal and child nutrition. A critical method to improve nutrition knowledge and influence feeding practices is through behaviour change communication intervention. The Shonjibon Cash and Counselling study aims to assess the effectiveness of unconditional cash transfers combined with a mobile application on nutrition counselling and direct counselling through mobile phone in reducing the prevalence of stunting in children at 18 months...
November 25, 2020: BMC Public Health
Urooj Fatima, Syed Saif Abbas Rizvi, Neha Raina, Saher Fatima, Safikur Rahman, Mohammad Amjad Kamal, Md Imtaiyaz Hassan
Coronavirus disease-2019 (COVID-19) is a respiratory tract infection, accompanied with severe or fatal pneumonia like symptoms and sometime death. It has posed to be an ongoing global health emergency caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to a sudden outbreak and a large number of infections and deaths, it became a major concern all over the world. The options available as effective therapeutic, should be urgently exercised to handle this pandemic disease. So far, no specific and accurate anti-SARS-CoV-2 treatment is recommended because of the absence of sufficient clinical evidence...
November 24, 2020: Current Pharmaceutical Design
Theresa H Wirtz, Lukas Buendgens, Ralf Weiskirchen, Sven H Loosen, Nina Haehnsen, Tobias Puengel, Samira Abu Jhaisha, Jonathan F Brozat, Philipp Hohlstein, Ger Koek, Albrecht Eisert, Raphael Mohr, Christoph Roderburg, Tom Luedde, Christian Trautwein, Frank Tacke, Alexander Koch
Background: Calprotectin is present in the cytosol of neutrophil granulocytes and released upon activation. Fecal calprotectin is applied in the clinical management of inflammatory bowel disease whereas serum calprotectin has been discussed as a biomarker in inflammatory disorders. However, its long-term prognostic relevance in critical illness remains unclear. Our aim was to investigate serum calprotectin concentrations as a prognostic biomarker in critically ill and septic patients. Methods: Serum calprotectin concentrations were analyzed in 165 critically ill patients (108 with sepsis, 57 without sepsis) included in our observational study...
November 23, 2020: Diagnostics
Fiona Lynch, Amy Nisselle, Clara L Gaff, Belinda McClaren
Genomic medicine in pediatric acute care is showing great promise, with rapid results from exome and genome sequencing returned within days providing critically important information for treatment and management of seriously ill children. Many have suggested that rapid acute care genomics presents novel genetic counseling issues. This is due to the need for rapid response to referrals, the immense emotional distress that parents are likely to experience when their child is in acute care, and the unfamiliar environment of the acute care setting...
November 25, 2020: Journal of Genetic Counseling
Faeq Husain-Syed, István Vadász, Jochen Wilhelm, Hans-Dieter Walmrath, Werner Seeger, Horst-Walter Birk, Birgit Jennert, Hartmut Dietrich, Susanne Herold, Janina Trauth, Khodr Tello, Michael Sander, Rory E Morty, Heiko Slanina, Christian G Schüttler, John Ziebuhr, Shadi Kassoumeh, Claudio Ronco, Fiorenza Ferrari, Klaus Warnatz, Klaus Stahl, Benjamin Seeliger, Marius M Hoeper, Tobias Welte, Sascha David
Despite the pandemic status of COVID-19, there is limited information about host risk factors and treatment beyond supportive care. Immunoglobulin G (IgG) could be a potential treatment target. Our aim was to determine the incidence of IgG deficiency and associated risk factors in a cohort of 62 critical ill COVID-19 patients admitted to two German ICUs (72.6% male, median age: 61 years). 13 (21.0%) of the patients displayed IgG deficiency (IgG <7 g/L) at baseline (predominant for the IgG1, IgG2, and IgG4 subclasses)...
November 25, 2020: American Journal of Physiology. Lung Cellular and Molecular Physiology
Mathijs R Wirtz, Jiri Moekotte, Kirsten Balvers, Marjolein M Admiraal, Jean-Francois Pittet, Joe Colombo, Brant M Wagener, J Carel Goslings, Nicole Juffermans
PURPOSE: Nosocomial infection contributes to adverse outcome after brain injury. This study investigates whether autonomic nervous system activity is associated with a decreased host immune response in patients following stroke or traumatic brain injury (TBI). METHODS: A prospective study was performed in adult patients with TBI or stroke who were admitted to the Intensive Care Unit of our tertiary university hospital between 2013 and 2016. Heart rate variability (HRV) was recorded daily and assessed for autonomic nervous system activity...
November 25, 2020: Intensive Care Medicine Experimental
Figen Esen, Perihan E Özcan, Günseli Orhun, Özlem Polat, İlkay Anaklı, Gülçin Alay, Verda Tuna, Emre Çeliksoy, Mehmet Kılıç, Mutlu Mercan, Tufan Tukek
Objectives: To evaluate the effect of adjunct treatment with Octagam, an intravenous immunoglobulin (IVIG) product, on clinical outcomes and biomarkers in critically ill COVID-19 patients. Methods: Data from a single center was analyzed retrospectively. Patients had received preliminary standard of intensive care (SIC) according to a local treatment algorithm, either alone or along with Octagam 5% at 30 g/day for 5 days. Both groups were compared regarding baseline characteristics, survival, and changes in inflammation markers...
November 25, 2020: Current Medical Research and Opinion
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