Zili Zhang, Tao Wang, Fei Liu, Airu Zhu, Guoping Gu, Jieping Luo, Jingyi Xu, Jincun Zhao, Yiming Li, Yuanyuan Li, Xiaoqing Liu, Nanshan Zhong, Wenju Lu
BACKGROUND: The pandemic of the coronavirus disease 2019 (COVID-19) has brought a global public health crisis. However, the pathogenesis underlying COVID-19 are barely understood. METHODS: In this study, we performed proteomic analyses of airway mucus obtained by bronchoscopy from severe COVID-19 patients. In total, 2351 and 2073 proteins were identified and quantified in COVID-19 patients and healthy controls, respectively. RESULTS: Among them, 92 differentiated expressed proteins (DEPs) (46 up-regulated and 46 down-regulated) were found with a fold change >1...
January 13, 2021: Life Sciences