Madelyn G Strahan, James J Finneran, Jason Mulsow, Dorian S Houser
Differences in odontocete biosonar emissions have been reported for animals with hearing loss compared to those with normal hearing. For example, some animals with high-frequency hearing loss have been observed to lower the dominant frequencies of biosonar signals to better match a reduced audible frequency range. However, these observations have been limited to only a few individuals and there has been no systematic effort to examine how animals with varying degrees of hearing loss might alter biosonar click properties...
July 2020: Journal of the Acoustical Society of America
Rodolphe Nenert, Jane B Allendorfer, E Martina Bebin, Tyler E Gaston, Leslie E Grayson, James T Houston, Jerzy P Szaflarski
OBJECTIVE: Resting-state (rs) network dysfunction is a contributing factor to treatment resistance in epilepsy. In treatment-resistant epilepsy (TRE), pharmacological and nonpharmacological therapies have been shown to improve such dysfunction. In this study, our goal was to prospectively evaluate the effect of highly purified plant-derived cannabidiol (CBD; Epidiolex®) on rs functional magnetic resonance imaging (fMRI) functional connectivity (rs-FC). We hypothesized that CBD would change and potentially normalize the rs-FC in TRE...
July 30, 2020: Epilepsy & Behavior: E&B
Fran López-Caballero, Pablo Martin-Trias, Teresa Ribas-Prats, Natàlia Gorina-Careta, David Bartrés-Faz, Carles Escera
The frequency-following response (FFR) is an auditory evoked potential (AEP) that follows the periodic characteristics of a sound. Despite being a widely studied biosignal in auditory neuroscience, the neural underpinnings of the FFR are still unclear. Traditionally, FFR was associated with subcortical activity, but recent evidence suggested cortical contributions which may be dependent on the stimulus frequency. We combined electroencephalography (EEG) with an inhibitory transcranial magnetic stimulation protocol, the continuous theta burst stimulation (cTBS), to disentangle the cortical contribution to the FFR elicited to stimuli of high and low frequency...
2020: Frontiers in Human Neuroscience
Tomoko Tajiri, Chisako Wada, Hirotsugu Ohkubo, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu, Takehiro Uemura, Masaya Takemura, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Akio Niimi
Acute eosinophilic pneumonia (AEP) is an acute respiratory illness with diffuse pulmonary infiltrates and pulmonary eosinophilia. While the etiology of AEP remains unclear, a relationship between cigarette smoking and AEP onset has been suggested. The use of heated tobacco products (HTPs) has been growing, but the impact of these products on our health is not fully understood. We herein report a case of AEP that developed after switching from conventional cigarette to HTP smoking. The patient's condition improved after the cessation of HTP smoking and corticosteroid treatment initiation...
July 21, 2020: Internal Medicine
L L Cheng, F L Luo, Y H Xiong, F Q Jia, P Tang, W Liu, B Zhang, J H Liu, H X Wang
Objective The tests of three types of auditory evoked potentials (AEPs) were performed on normal young adults, to understand the frequency characteristics of different testing methods and the relationship between response threshold and pure tone audiometry threshold of different methods, and to discuss the forensic value of 3 types of AEPs to evaluate hearing function. Methods Twenty normal young adults were selected, their standard pure tone audiometry threshold, short-term pure tone audiometry threshold and the response threshold of 3 types of AEPs (tone burst-auditory brainstem response, 40 Hz auditory event-related potential and slow vertex response) at 0...
June 2020: Fa Yi Xue za Zhi
Mario Cebulla, Rudolf Hagen, Kristen Rak, Ute Geiger
Objective: The Carina® implant system is a fully implantable active middle ear implant, which can be coupled to various structures in the middle ear, depending on the nature of the hearing loss and the middle ear anatomy. Currently, there is only one method for determining the coupling efficiency of the actuator of this implant system, and this is limited to incus coupling. Design: The proposed method is based on the intraoperative recording and evaluation of auditory brainstem responses (ABRs) while directly stimulating the hearing system via the actuator...
July 21, 2020: International Journal of Audiology
Alejandra Lopez-Juarez, Arturo Gonzalez-Vega, Anke Kleinert-Altamirano, Valeria Piazza, Angeles Garduno-Robles, Milvia Iris Alata-Tejedo, Carlos Villaseñor-Mora, Jose Ramon Eguibar, Carmen Cortes, Luis Carlos Padierna, Victor Hugo Hernandez
Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) is a neurodegenerative disease due to mutations in TUBB4A. Patients suffer from extrapyramidal movements, spasticity, ataxia, and cognitive deficits. Magnetic resonance imaging features are hypomyelination and atrophy of the striatum and cerebellum. A correlation between the mutations and their cellular, tissue and organic effects is largely missing. The effects of these mutations on sensory functions have not been described so far. We have previously reported a rat carring a TUBB4A (A302T) mutation and sharing most of the clinical and radiological signs with H-ABC patients...
July 17, 2020: Journal of Comparative Neurology
Yasuhiro Umekage, Shunsuke Okumura, Toshiyuki Tenma, Yoshihiro Kazebayashi, Noriko Hirai, Yoshinori Minami, Kazushi Doshita, Takaaki Sasaki, Yasushi Yamamoto, Yoshinobu Ohsaki
Acute eosinophilic pneumonia (AEP) is an eosinophilic lung disease associated with environmental substances including smoking. Although the etiology of AEP has not been fully elucidated, it has been hypothesized that IL-33 plays a central role in the pathogenesis of AEP. Turpentine oil, from resins of pine trees, is not only used in paints, but also utilized in experimental animal models of inflammation because it leads to the production of inflammatory cytokines including IL-33. Here, we report the first case of AEP following turpentine oil inhalation...
2020: Respiratory Medicine Case Reports
Gema Mondejar-Parreño, Francisco Perez-Vizcaino, Angel Cogolludo
Lung diseases constitute a global health concern causing disability. According to WHO in 2016, respiratory diseases accounted for 24% of world population mortality, the second cause of death after cardiovascular diseases. The Kv7 channels family is a group of voltage-dependent K+ channels (Kv) encoded by KCNQ genes that are involved in various physiological functions in numerous cell types, especially, cardiac myocytes, smooth muscle cells, neurons, and epithelial cells. Kv7 channel α-subunits are regulated by KCNE1-5 ancillary β-subunits, which modulate several characteristics of Kv7 channels such as biophysical properties, cell-location, channel trafficking, and pharmacological sensitivity...
2020: Frontiers in Physiology
Chantal Forristal, Evan Russell, Tamara McColl, Andrew Petrosoniak, Brent Thoma, Kyla Caners, George Mastoras, Adam Szulewski, Timothy Chaplin, James Huffman, Karen Woolfrey, Christa Dakin, Andrew K Hall
INTRODUCTION: Simulation is becoming a popular educational modality for physician continuing professional development (CPD). This study sought to characterize how simulation-based CPD (SBCPD) is being used in Canada and what academic emergency physicians (AEPs) desire in an SBCPD program. METHODS: Two national surveys were conducted from March to June 2018. First, the SBCPD Needs Assessment Survey was administered online to all full-time AEPs across 9 Canadian academic emergency medicine (EM) sites...
July 15, 2020: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
Guilherme Lepski, Analía Arévalo, Florian Roser, M Liebsch, Marcos Tatagiba
The objective of this study was to calculate the risk of postsurgical hearing deterioration as a function of changes in the amplitude and latency of the most stable components (waves III and V) of the auditory evoked potential (AEP) during petroclival meningioma resection surgery. We retrospectively analyzed intraoperative AEP monitoring results and pre- and postsurgical hearing status in 40 consecutive patients who were surgically treated for petroclival meningiomas. Statistical analyses were conducted to identify the most sensitive and specific way to predict hearing dysfunction after surgery...
July 15, 2020: Neurosurgical Review
Xuan Zhang, Jiawei Lin, Fang Pi, Tao Zhang, Chao Ai, Shujuan Yu
This work aimed to extract gelatinous chicory root pectin (CRP) and evaluated the rheological behavior of the dispersions and gels. CRP was extracted by citric acid (CEP), alkaline (AEP), ammonium oxalate (OEP) and sodium citrate (SEP). The yield, molecular weight (Mw) and the degree of esterification (DE) of pectin samples varied from 8.8 to 14.8% (w/w), 204 to 336 k Da and 4.0 to 47.4%, respectively. AFM studies showed self-organize on mica of CEP, revealing a random coil conformation due to the interaction of multiple branching, whereas, AEP exhibited long linear filamentous structures...
July 7, 2020: International Journal of Biological Macromolecules
Holly E Gray, Tony Powell, Suyoung Choi, D Scott Smith, Wayne J Parker
Non-reactive phosphorus (nRP) contains condensed phosphates and organic phosphorus (OP) species that are recalcitrant in secondary wastewater treatment and tend to remain in final effluents. To meet ultra-low effluent P discharge limits, persistent nRP must be removed. The objective of this study was to evaluate the use of an advanced oxidation process (AOP) which couples TiO2 /UV photolysis with ultrafiltration to oxidize and remove nRP species. Initial tests utilized OP model compounds, adenosine triphosphate (ATP) and aminoethylphosphonate (AEP), in a binary mixture to evaluate AOP treatment and to elucidate possible mechanisms of phosphorus removal...
May 22, 2020: Water Research
Antonio Rodríguez Núñez, Alicia Pérez Blanco
Despite being an international reference in donation and transplantation, Spain needs to improve pediatric donation, including donation after the circulatory determination of death. The present article, a summary of the consensus report prepared by the Organización Nacional de Trasplantes and the Spanish Pediatrics Association, intends the facilitation of donation procedures in newborns and children and the analysis of associated ethical dilemma. The ethical basis for donation in children, the principles of clinical assessment of possible donors, the criteria for the determination of death in children, intensive care management of donors, basic concepts of donation after the circulatory determination of death and the procedures for donation in newborns with severe nervous system's malformation incompatible with life, as well as in children receiving palliative care are commented...
June 30, 2020: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Thaiza S P de Souza, Fernanda F G Dias, Joana Paula S Oliveira, Juliana M L N de Moura Bell, Maria Gabriela B Koblitz
The almond cake is a protein-rich residue generated by the mechanical expression of the almond oil. The effects of the aqueous (AEP) and enzyme-assisted aqueous extraction processes (EAEP) on the biological properties of the almond cake protein were evaluated. Total phenolic content (TPC), antioxidant capacity, inhibitory effects against crucial enzymes related to metabolic syndrome, antimicrobial potential, and in vitro protein digestibility profile were assessed. EAEP provided the best results for antioxidant capacity by both ORAC (397...
July 2, 2020: Scientific Reports
Valentina Franco, Maria Paola Canevini, Giovambattista De Sarro, Cinzia Fattore, Guido Fedele, Carlo Andrea Galimberti, Giuliana Gatti, Angela La Neve, Eleonora Rosati, Luigi Maria Specchio, Salvatore Striano, Paolo Tinuper, Emilio Perucca
OBJECTIVE: To determine whether systematic screening for adverse effects of antiepileptic drugs (AEDs) reduces toxicity burden and improves health-related quality of life in patients with epilepsy. METHODS: Consecutive patients with uncontrolled seizures aged ≥16 years and a high Adverse Event Profile (AEP) score were randomized to 2 groups and followed up for 18 months at 11 referral centers. AEP scores were made available to treating physicians at all visits in the intervention group, but not in the control group...
June 29, 2020: Neurology
R Assmann, S O Breukink, S A P Caubergh, L P S Stassen, S M J van Kuijk, J Melenhorst
There is an ongoing debate as to whether or not the efficacy of Sacral Neuromodulation (SNM) is optimized by maximizing the total number of active electrode poles (AEPs) during lead placement because there are more programming options. However, this is at the cost of increased operating time. The aims of this study were to establish if a higher number of AEP's improves SNM efficacy during the trial period and after permanent implantable pulse generator (IPG) placement and if was there a correlation between number of AEPs and battery life of the first placed IPG...
June 27, 2020: Colorectal Disease
Qiyan Zhao, Pengfei Li, Mingming Wang, Wenbin Zhang, Wei Zhao, Ruijin Yang
PC (phosphatidylcholine), PE (phosphatidylethanolamine), PI (phosphatidylinositol), and PA (phosphatidic acid) in 9 peanut matrices obtained during the AEP (aqueous extraction processing) of peanut were quantified employing HPLC-ELSD analysis in this study. Phosphorus contents of crude oils obtained from different demulsification treatments were also investigated. Decantation had a larger effect than grinding in terms of phospholipids loss due to alkaline-hydrolysis, indicating this processing step was vital for the manipulation of phospholipids levels remained in oil...
June 17, 2020: Food Chemistry
T Aran Mooney, Adam Smith, Ole Næsbye Larsen, Kirstin Anderson Hansen, Marianne Rasmussen
Hearing is vital for birds as they rely on acoustic communication with parents, mates, chicks, and conspecifics. Amphibious seabirds face many ecological pressures, having to sense cues in air and underwater. Natural noise conditions have helped shape this sensory modality but anthropogenic noise is increasingly impacting seabirds. Surprisingly little is known about their hearing, despite their imperiled status. Understanding sound sensitivity is vital when we seek to manage manmade noise impacts. We measured the auditory sensitivity of nine wild Atlantic puffins, Fratercula arctica , in a capture-and-release setting in an effort to define their audiogram and compare these data to the hearing of other birds and natural rookery noise...
June 19, 2020: Journal of Experimental Biology
Xiaolong Yao, Ke Wang, Shanshan Zhang, Shan Liang, Ke Li, Chun Wang, Tingting Zhang, Hailong Li, Juncheng Wang, Liming Dong, Zhiliang Yao
Microorganisms play important roles in the degradation of volatile organic compounds. Aeromonas salmonicida strain (AEP-3) generated from biomass in the citric acid fermentation industry was screened and subjected to denaturing gradient gel electrophoresis (DGGE) fingerprinting and 16S rDNA gene sequencing. The growth conditions of AEP-3 in Luria-Bertani broth were optimized at 25 °C and approximately pH 7. AEP-3 was used to degrade ethyl formate, propionic aldehyde, or acetone alone and their mixture. The concentrations of ethyl formate, propionic aldehyde, and acetone were below 7500, 600, and 800 mg L-1 , respectively, and their maximum degradation efficiencies were 100%, 92...
June 9, 2020: Chemosphere
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