keyword
https://read.qxmd.com/read/32950632/acquired-pellicle-protein-based-engineering-protects-against-erosive-demineralization
#1
Thamyris Souza Carvalho, Tamara Teodoro Araújo, Talita Mendes Oliveira Ventura, Aline Dionizio, João Victor Frazão Câmara, Samanta Mascarenhas Moraes, Vinicius Taioqui Pelá, Tatiana Martini, Julia Chaparro Leme, Ana Luiza Bogaz Derbotolli, Larissa Tercilia Grizzo, Edson Crusca, Priscila Yumi Tanaka Shibao, Reinaldo Marchetto, Flavio Henrique-Silva, Juliano Pelim Pessan, Marília Afonso Rabelo Buzalaf
OBJECTIVES: To evaluate, in vivo: 1) proteomic alterations in the acquired enamel pellicle (AEP) after treatment with sugarcane-derived cystatin (CaneCPI-5), hemoglobin (HB), statherin-derived peptide (StN15) or their combination before the formation of the AEP and subsequent erosive challenge; 2) the protection of these treatments against erosive demnineralization. MATERIALS AND METHODS: In 5 crossover phases, after prophylaxis, 10 volunteers rinsed (10 mL, 1 min) with: deionized water-1, 0...
September 17, 2020: Journal of Dentistry
https://read.qxmd.com/read/32947498/biomedical-beliefs-explain-the-clinical-decisions-made-by-exercise-based-practitioners-for-people-with-chronic-low-back-pain
#2
Mitchell T Gibbs, Natalie Morrison, Paul W M Marshall
STUDY DESIGN: Cross-sectional survey. OBJECTIVE: This study surveyed the attitudes and beliefs of Physiotherapists and Accredited Exercise Physiologists (AEP) toward chronic low back pain (CLBP), in Australia. The objective of this study was to investigate the effect of biomedical and biopsychosocial attitudes and beliefs toward CLBP on clinical decision making in exercise-based practitioners. SUMMARY OF BACKGROUND DATA: The attitudes and beliefs of AEPs toward CLBP have not been studied...
September 16, 2020: Spine
https://read.qxmd.com/read/32937551/gut-dysbiosis-contributes-to-amyloid-pathology-associated-with-c-ebp%C3%AE-aep-signaling-activation-in-alzheimer-s-disease-mouse-model
#3
Chun Chen, Eun Hee Ahn, Seong Su Kang, Xia Liu, Ashfaqul Alam, Keqiang Ye
The gut-brain axis is bidirectional, and gut microbiota influence brain disorders including Alzheimer's disease (AD). CCAAT/enhancer binding protein β/asparagine endopeptidase (C/EBPβ/AEP) signaling spatiotemporally mediates AD pathologies in the brain via cleaving both β-amyloid precursor protein and Tau. We show that gut dysbiosis occurs in 5xFAD mice, and is associated with escalation of the C/EBPβ/AEP pathway in the gut with age. Unlike that of aged wild-type mice, the microbiota of aged 3xTg mice accelerate AD pathology in young 3xTg mice, accompanied by active C/EBPβ/AEP signaling in the brain...
July 2020: Science Advances
https://read.qxmd.com/read/32937414/elucidating-ecological-complexity-unsupervised-learning-determines-global-marine-eco-provinces
#4
Maike Sonnewald, Stephanie Dutkiewicz, Christopher Hill, Gael Forget
An unsupervised learning method is presented for determining global marine ecological provinces (eco-provinces) from plankton community structure and nutrient flux data. The systematic aggregated eco-province (SAGE) method identifies eco-provinces within a highly nonlinear ecosystem model. To accommodate the non-Gaussian covariance of the data, SAGE uses t-stochastic neighbor embedding (t-SNE) to reduce dimensionality. Over a hundred eco-provinces are identified with the density-based spatial clustering of applications with noise (DBSCAN) algorithm...
May 2020: Science Advances
https://read.qxmd.com/read/32919104/statherin-derived-peptide-protects-against-intrinsic-erosion
#5
Even Akemi Taira, Gabriel Carvalho, Carolina Ruis Ferrari, Tatiana Martini, Vinicius Taioqui Pelá, Talita Mendes Oliveira Ventura, Aline Salgado Dionizio, Edson Crusca, Reinaldo Marchetto, Marília Afonso Rabelo Buzalaf
OBJECTIVES: In the present study, we used an in vitro initial intrinsic erosion model to evaluate: (experiment 1) the influence of the degree of serine (Ser) phosphorylation of peptides containing the 15 N-terminal residues of statherin and (experiment 2) the effect of different concentrations of the peptide with the best performance in experiment 1 on initial enamel erosion. DESIGN: Bovine enamel specimens were divided into 6 groups (n = 15/group) for each experiment...
August 28, 2020: Archives of Oral Biology
https://read.qxmd.com/read/32913694/a-case-for-biopsy-injectable-naltrexone-induced-acute-eosinophilic-pneumonia
#6
Pranay R Korpole, Souad Al-Bacha, Salim Hamadeh
Naltrexone is a semi-synthetic opioid that has competitive antagonist activity at mu opioid receptors. Naltrexone has proven to be efficacious in the treatment of alcohol and opioid dependence, and a long-acting injectable form of naltrexone was developed to overcome non-compliance. Therefore, injectable naltrexone has the potential to become an important medication for the treatment of opiate and alcohol dependence. Acute eosinophilic pneumonia (AEP) is a rare acute respiratory illness of varying severity that may lead to acute respiratory distress syndrome and death...
September 3, 2020: Curēus
https://read.qxmd.com/read/32894620/can-risk-prediction-models-help-us-individualise-stillbirth-prevention-a-systematic-review-and-critical-appraisal-of-published-risk-models
#7
REVIEW
R Townsend, A Manji, J Allotey, Aep Heazell, L Jorgensen, L A Magee, B W Mol, Kie Snell, R D Riley, J Sandall, Gcs Smith, M Patel, B Thilaganathan, P von Dadelszen, S Thangaratinam, A Khalil
BACKGROUND: Stillbirth prevention is an international priority - risk prediction models could individualise care and reduce unnecessary intervention, but their use requires evaluation. OBJECTIVES: To identify risk prediction models for stillbirth, and assess their potential accuracy and clinical benefit in practice. SEARCH STRATEGY: Medline, EMBASE, DH-DATA and AMED databases were searched from inception to June 2019 using terms relevant to stillbirth, perinatal mortality and prediction models...
September 7, 2020: BJOG: An International Journal of Obstetrics and Gynaecology
https://read.qxmd.com/read/32891579/-covid-19-and-africa-surviving-between-a-rock-and-a-hard-place
#8
Maite de Aranzabal, Victoria Fumadó, Iñaki Alegria, Mercedes Rivera, Nuria Torre, Belen Guibert, María José Muñoz, Cinta Moraleda, Quique Bassat
With over 575,000 deaths and about 13.3 million cases globally, the COVID-19 pandemic has had a terrible impact globally during the 6 months since cases were first detected in China. Conscious of the many challenges presented in settings with abundance of resources and with robust health systems, where mortality has been significant and transmission difficult to control, there was a logical concern to see how the virus could impact African countries, and their fragile and weak health systems. Such an anticipated "tsunami", with potentially devastating consequences, seems however to not have yet arrived, and African countries, albeit witnessing an increasing degree of autochthonous transmission, seem to this day relatively unaffected by the pandemic...
August 3, 2020: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://read.qxmd.com/read/32877245/radiologic-and-pathologic-correlation-in-evali
#9
Prasad M Panse, Fionna F Feller, Yasmeen M Butt, Maxwell L Smith, Brandon T Larsen, Henry D Tazelaar, Howard J Harvin, Michael B Gotway
OBJECTIVE. The purpose of this article is to characterize the appearance on CT of e-cigarette or vaping product use-associated lung injury (EVALI) in a cohort with histopathologic evidence of this disorder. MATERIALS AND METHODS. Twenty-four patients with EVALI were identified. Chest CT examinations were reviewed by two radiologists for various chest CT findings. For comparison with pathologic findings, CT assessments were distilled into previously described patterns of EVALI seen on CT: acute lung injury (ALI), chronic eosinophilic pneumonia (CEP) or organizing pneumonia (OP), acute eosinophilic pneumonia (AEP), alveolar hemorrhage, hypersensitivity pneumonitis (HP), lipoid pneumonia, and mixed or unclassifiable patterns...
September 2, 2020: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/32874509/use-of-an-asparaginyl-endopeptidase-for-chemo-enzymatic-peptide-and-protein-labeling
#10
T M Simon Tang, Davide Cardella, Alexander J Lander, Xuefei Li, Jorge S Escudero, Yu-Hsuan Tsai, Louis Y P Luk
Asparaginyl endopeptidases (AEPs) are ideal for peptide and protein labeling. However, because of the reaction reversibility, a large excess of labels or backbone modified substrates are needed. In turn, simple and cheap reagents can be used to label N-terminal cysteine, but its availability inherently limits the potential applications. Aiming to address these issues, we have created a chemo-enzymatic labeling system that exploits the substrate promiscuity of AEP with the facile chemical reaction between N-terminal cysteine and 2-formyl phenylboronic acid (FPBA)...
June 21, 2020: Chemical Science
https://read.qxmd.com/read/32873047/latency-dependent-filtering-and-compact-representation-of-the-complete-auditory-pathway-response
#11
Angel de la Torre, Joaquin T Valderrama, Jose C Segura, Isaac M Alvarez
Auditory evoked potentials (AEPs) include the auditory brainstem response (ABR), middle latency response (MLR), and cortical auditory evoked potentials (CAEPs), each one covering a specific latency range and frequency band. For this reason, ABR, MLR, and CAEP are usually recorded separately using different protocols. This article proposes a procedure providing a latency-dependent filtering and down-sampling of the AEP responses. This way, each AEP component is appropriately filtered, according to its latency, and the complete auditory pathway response is conveniently represented (with the minimum number of samples, i...
August 2020: Journal of the Acoustical Society of America
https://read.qxmd.com/read/32859953/delta-secretase-cleavage-of-tau-mediates-its-pathology-and-propagation-in-alzheimer-s-disease
#12
REVIEW
Seong Su Kang, Eun Hee Ahn, Keqiang Ye
Alzheimer's disease (AD) is a progressive neurodegenerative disease with age as a major risk factor. AD is the most common dementia with abnormal structures, including extracellular senile plaques and intraneuronal neurofibrillary tangles, as key neuropathologic hallmarks. The early feature of AD pathology is degeneration of the locus coeruleus (LC), which is the main source of norepinephrine (NE) supplying various cortical and subcortical areas that are affected in AD. The spread of Tau deposits is first initiated in the LC and is transported in a stepwise manner from the entorhinal cortex to the hippocampus and then to associative regions of the neocortex as the disease progresses...
August 28, 2020: Experimental & Molecular Medicine
https://read.qxmd.com/read/32858993/indication-of-electromagnetic-field-exposure-via-rbf-svm-using-time-series-features-of-zebrafish-locomotion
#13
Yaqing He, Kim Fung Tsang, Richard Yuen-Chong Kong, Yuk-Tak Chow
This paper introduces a novel model based on support vector machine with radial basis function kernel (RBF-SVM) using time-series features of zebrafish ( Danio rerio ) locomotion exposed to different electromagnetic fields (EMFs) to indicate the corresponding EMF exposure. A group of 14 adult zebrafish was randomly divided into two groups, 7 in each group; the fish of each group have the novel tank test under a sham or real magnetic exposure of 6.78 MHz and about 1 A/m. Their locomotion in the tests was videotaped to convert into the x, y coordinate time-series of the trajectories for reforming time-series matrices according to different time-series lengths...
August 26, 2020: Sensors
https://read.qxmd.com/read/32845935/machine-learning-for-a-combined-electroencephalographic-anesthesia-index-to-detect-awareness-under-anesthesia
#14
Moritz Tacke, Eberhard F Kochs, Marianne Mueller, Stefan Kramer, Denis Jordan, Gerhard Schneider
Spontaneous electroencephalogram (EEG) and auditory evoked potentials (AEP) have been suggested to monitor the level of consciousness during anesthesia. As both signals reflect different neuronal pathways, a combination of parameters from both signals may provide broader information about the brain status during anesthesia. Appropriate parameter selection and combination to a single index is crucial to take advantage of this potential. The field of machine learning offers algorithms for both parameter selection and combination...
2020: PloS One
https://read.qxmd.com/read/32837967/national-recommendations-on-pediatric-donation
#15
Antonio Rodríguez Núñez, Alicia Pérez Blanco
Despite being an international reference in donation and transplantation, Spain needs to improve pediatric donation, including donation after the circulatory determination of death. The present article, a summary of the consensus report prepared by the Organización Nacional de Trasplantes and the Spanish Pediatrics Association, intends the facilitation of donation procedures in newborns and children and the analysis of associated ethical dilemma. The ethical basis for donation in children, the principles of clinical assessment of possible donors, the criteria for the determination of death in children, intensive care management of donors, basic concepts of donation after the circulatory determination of death and the procedures for donation in newborns with severe nervous system's malformation incompatible with life, as well as in children receiving palliative care are commented...
July 24, 2020: Anales de pediatría
https://read.qxmd.com/read/32835030/aep-engine-of-the-specialist-s-recognition-and-guarantor-of-the-paediatric-model-generating-health-also-in-pandemic-situations
#16
María José Mellado
No abstract text is available yet for this article.
June 2020: Anales de pediatría
https://read.qxmd.com/read/32832679/gut-dysbiosis-contributes-to-amyloid-pathology-associated-with-c-ebp%C3%AE-aep-signaling-activation-in-alzheimer-s-disease-mouse-model
#17
Chun Chen, Eun Hee Ahn, Seong Su Kang, Xia Liu, Ashfaqul Alam, Keqiang Ye
The gut-brain axis is bidirectional, and gut microbiota influence brain disorders including Alzheimer's disease (AD). CCAAT/enhancer binding protein β/asparagine endopeptidase (C/EBPβ/AEP) signaling spatiotemporally mediates AD pathologies in the brain via cleaving both β-amyloid precursor protein and Tau. We show that gut dysbiosis occurs in 5xFAD mice, and is associated with escalation of the C/EBPβ/AEP pathway in the gut with age. Unlike that of aged wild-type mice, the microbiota of aged 3xTg mice accelerate AD pathology in young 3xTg mice, accompanied by active C/EBPβ/AEP signaling in the brain...
July 2020: Science Advances
https://read.qxmd.com/read/32785522/optimizing-the-formation-of-the-acquired-enamel-pellicle-in-vitro-for-proteomic-analysis
#18
Vinícius Taioqui PelÁ, Talita Mendes Oliveira Ventura, Marília Afonso Rabelo Buzalaf
Saliva is the major contributor for the protein composition of the acquired enamel pellicle (AEP), a bacteria-free organic layer formed by the selective adsorption of salivary proteins on the surface of the enamel. However, the amount of proteins that can be recovered is even smaller under in vitro condition, due to the absence of continuous salivary flow. Objective This study developed an in vitro AEP protocol for proteomics analysis using a new formation technique with different collection solutions. Methodology 432 bovine enamel specimens were prepared (4x4 mm) and divided into four groups (n=108)...
2020: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/32752763/effects-of-dolphin-hearing-bandwidth-on-biosonar-click-emissions
#19
Madelyn G Strahan, James J Finneran, Jason Mulsow, Dorian S Houser
Differences in odontocete biosonar emissions have been reported for animals with hearing loss compared to those with normal hearing. For example, some animals with high-frequency hearing loss have been observed to lower the dominant frequencies of biosonar signals to better match a reduced audible frequency range. However, these observations have been limited to only a few individuals and there has been no systematic effort to examine how animals with varying degrees of hearing loss might alter biosonar click properties...
July 2020: Journal of the Acoustical Society of America
https://read.qxmd.com/read/32745959/cannabidiol-normalizes-resting-state-functional-connectivity-in-treatment-resistant-epilepsy
#20
Rodolphe Nenert, Jane B Allendorfer, E Martina Bebin, Tyler E Gaston, Leslie E Grayson, James T Houston, Jerzy P Szaflarski
OBJECTIVE: Resting-state (rs) network dysfunction is a contributing factor to treatment resistance in epilepsy. In treatment-resistant epilepsy (TRE), pharmacological and nonpharmacological therapies have been shown to improve such dysfunction. In this study, our goal was to prospectively evaluate the effect of highly purified plant-derived cannabidiol (CBD; Epidiolex®) on rs functional magnetic resonance imaging (fMRI) functional connectivity (rs-FC). We hypothesized that CBD would change and potentially normalize the rs-FC in TRE...
July 30, 2020: Epilepsy & Behavior: E&B
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