Mueez U-Din, Basma A Ahmed, Saad A Syed, Frank J Ong, Stephan M Oreskovich, Elizabeth Gunn, Micheal G Surette, Zubin Punthakee, Gregory R Steinberg, Katherine M Morrison
CONTEXT: Compared to the relatively benign effects of increased subcutaneous adipose tissue (SAT), increased visceral adipose tissue (VAT) volume is a causal risk factor for hypertension, hyperlipidaemia, type 2 diabetes and cardiovascular disease. In rodents, increased VAT volume and triglyceride density and ectopic lipid accumulation in kidneys and liver have been induced by alterations in the gut microbiome. However, few studies have characterized these relationships in humans. OBJECTIVE: To evaluate the tissue triglyceride content of VAT and SAT, liver, kidneys and pancreas in male and female adults and assess associations with markers of glucose tolerance, serum insulin and lipids and characteristics of the gut microbiome...
October 14, 2023: Journal of Clinical Endocrinology and Metabolism