Giulia Ferrannini, Dirk De Bacquer, Pieter Vynckier, Guy De Backer, Viveca Gyberg, Kornelia Kotseva, Linda Mellbin, Anna Norhammar, Jaakko Tuomilehto, David Wood, Lars Rydén
BACKGROUND: Gender disparities in the management of dysglycaemia, defined as either impaired glucose tolerance (IGT) or type 2 diabetes (T2DM), in coronary artery disease (CAD) patients are a medical challenge. Recent data from two nationwide cohorts of patients suggested no gender difference as regards the risk for diabetes-related CV complications but indicated the presence of a gender disparity in risk factor management. The aim of this study was to investigate gender differences in screening for dysglycaemia, cardiovascular risk factor management and prognosis in dysglycemic CAD patients...
February 11, 2021: Cardiovascular Diabetology
Ohad Gluck, Hadas Ganer Herman, Nataly Fainstein, Neri Katz, Jacob Bar, Michal Kovo
OBJECTIVE: To investigate the association between gestational impaired glucose tolerance (GIGT), and laboratory and clinical hyperglycemic markers. METHODS: A prospective study in Holon between 2017 and 2019. Women with a singleton term delivery and one abnormal value in their last three oral glucose tolerance test measurements (OGTTs; GIGT group, n = 60) were compared with control women with normal glucose challenge test (GCT) and/or OGTT measurements (n = 60)...
January 23, 2021: International Journal of Gynaecology and Obstetrics
Nobuko Sera, Takeshi Nakamura, Ichiro Horie, Rumi Higashi, Reiko Tominaga, Hiromi Yamamoto, Aya Nozaki, Shoko Natsuda, Haruko Takashima, Akie Kamada, Norio Abiru, Takeshi Nagayasu, Susumu Eguchi, Atsushi Kawakami
Background: New-onset diabetes mellitus (DM) often develops after partial pancreatectomy. Little is known regarding how soon patients develop glucose intolerance after partial pancreatectomy. We investigated the incidence of and factors contributing to the development of glucose intolerance during hospitalization after partial pancreatectomy. Patients and methods: We retrospectively analyzed the cases of 38 patients with normal glucose tolerance pre-surgery who underwent a partial pancreatectomy (pancreaticoduodenectomy, n  = 23; distal pancreatectomy, n  = 15)...
January 2021: Diabetology International
Diederik Esser, Juri Matualatupauw, Ric C H de Vos, Ron Wehrens, Jos van der Stappen, Ingrid van der Meer, Lydia A Afman
The increased usage of alternative Ayurvedic treatments as potential health-beneficial therapies emphasizes the importance of studying its efficacy in sound placebo-controlled intervention trials. An example of such a traditional Ayurvedic herbal preparation is Mohana Choorna, a mixture composed of 20 different herbs and used to prevent and treat type 2-diabetes (T2D). We studied the efficacy of "Mohana Choorna" on T2D-related parameters in subjects with impaired glucose tolerance. In a double blind, placebo-controlled cross-over trial, 19 overweight (BMI > 27 kg/m2 ) subjects aged 50-70 years with an impaired glucose tolerance received two four-week interventions, i...
January 18, 2021: Nutrients
Cristina Bianchi, Giovanni de Gennaro, Alex Brocchi, Elisa Minaldi, Stefano Del Prato, Alessandra Bertolotto
AIMS: For women with previous gestational diabetes (GDM), international guidelines recommend 75 g oral glucose tolerance test (OGTT) at 4-12 weeks after delivery to assess glucose tolerance, considering their increased risk of type 2 diabetes. We evaluated prevalence of postpartum impaired glucose regulation (IGR) and identified associated risk factors. METHODS: We retrospectively collected data from 749 women with previous GDM (IADPSG criteria) who underwent postpartum OGTT for type 2 diabetes screening between 2011 and 2019...
January 9, 2021: Journal of Diabetes and its Complications
Masato Iida, Yuko Ishiguro
AIM: Prediabetes defined by HbA1c 5.7-6.4 has been shown to be associated with left ventricular (LV) hypertrophy and diastolic dysfunction in hypertensive patients. We hypothesized HbA1c prediabetes may be related to the alterations of LA contractility or volume in nondiabetic hypertension. METHODS: Nondiabetic individuals on sinus rhythm were enrolled; 107 patients with never-treated hypertension, 134 patients with treated hypertension, and 71 normotensive subjects...
December 31, 2020: Journal of Diabetes and its Complications
Arzu Or Koca, Hüseyin Samet Koca, Cüneyd Anil
Context: Hyperinsulinemia is the most common metabolic change associated with cochleovestibular diseases. Aim: We aimed to investigate the auditory functions in hyperinsulinemic individuals. Settings and Design: A total of 164 patients were included in this case-control study. While 76 patients with insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] of ≥2.5) constituted the case group, 88 patients with HOMA-IR values of <2...
July 2020: Noise & Health
Saurav Khatiwada, Shipra Agarwal, Devasenathipathy Kandasamy, V P Jyotsna, Rajeev Kumar, Virinder Kumar Bansal, R M Pandey, Nandita Gupta, Nikhil Tandon
BACKGROUND AND AIMS: Pheochromocytoma and paraganglioma (PPGL) are associated with dysglycemia and diabetes mellitus (DM) much of which improves post operatively. In this study, we set out to ascertain pre and post-operative prevalence of DM in patients with PPGL based on oral glucose tolerance test (OGTT) and HbA1c and to evaluate effect of insulin secretion and sensitivity indices on DM pre-operatively. METHODS: Clinical and anthropometric data collection, HbA1c, 75 g OGTT with serum insulin estimation were done pre-operatively (n = 34) and at follow-up after successful surgery (n = 24) in patients with PPGL...
November 2020: Diabetes & Metabolic Syndrome
Nizam Ud Din Khwaja, Ganesan Arunagirinathan
Alpha Glucosidase Inhibitors (AGIs) are a group of drugs which acts on the gastrointestinal tract and helps in reducing fasting and postprandial hyperglycemia by reducing the absorption of carbohydrates. This group comprises of Acarbose, Miglitol and Voglibose. They are available in the market for almost three decades now. When used as monotherapy Glycated Haemoglobin (HBA1c) reduction can be as high as 0.77% which is predominantly noted in Eastern Asian population and those on high carbohydrate diet. There is more pronounced reduction in HbA1c in those who present with higher baseline values...
December 16, 2020: Current Drug Safety
Jie Wen, Qingjing Liu, Mengmeng Liu, Bian Wang, Mei Li, Min Wang, Xiajie Shi, Hong Liu, Jing Wu
BACKGROUND: Chronic low-grade inflammation and dysfunction of metabolism has been reported to be involved in obesity. Regulatory T cell (Treg) and helper T cell 17 (Th17) are involved in chronic inflammatory diseases. Impaired balance of Treg/Th17 is one of the major factors contributing to inflammatory status in obesity. METHODS: Overweight/obese patients (n = 80) were recruited and classified into three subgroups: normal glucose tolerance group (NGT, n = 32), impaired glucose regulation group (IGR, n = 19) and type two diabetes mellitus group (T2DM, n = 29)...
December 11, 2020: Archives of Medical Research
Lin Liu, Xiaojun Ma, Huiwen Xu, Sijie Ruan, Xiaodan Yuan
AIMS: The pathophysiology of each phenotype of prediabetes is unique that promotes different levels of diabetes and cardiovascular disease risks. Exercise guidelines for individuals with prediabetes including both aerobic and resistance training could improve metabolic control, but its effects on different prediabetes subtypes are unclear. The aim of this explorative randomized controlled trial was to evaluate the effects of aerobic training (AT) or resistance training (RT) on glucose metabolism and lipid profile by different prediabetes subtypes with...
December 10, 2020: Primary Care Diabetes
Louis Y Tee, Sharifah Munirah Alhamid, Jeriel L Tan, Theik Di Oo, Jaime Chien, Primavera Galinato, Seow Yen Tan, Shafi Humaira, Raymond Kok Choon Fong, Troy H Puar, Wann Jia Loh, Anindita Santosa, Joan Khoo, Barbara Helen Rosario
Objective: Migrant workers, a marginalized and under-resourced population, are vulnerable to coronavirus disease 2019 (COVID-19) due to limited healthcare access. Moreover, metabolic diseases-such as diabetes mellitus (DM), hypertension, and hyperlipidemia-predispose to severe complications and mortality from COVID-19. We investigate the prevalence and consequences of undiagnosed metabolic illnesses, particularly DM and pre-diabetes, in international migrant workers with COVID-19. Methods: In this retrospective analysis, we analyzed the medical records of international migrant workers with laboratory-confirmed COVID-19 hospitalized at a tertiary hospital in Singapore from April 21 to June 1, 2020...
2020: Frontiers in Public Health
Sara Parrettini, Ludovica Ranucci, Antonella Caroli, Vittorio Bini, Riccardo Calafiore, Elisabetta Torlone
BACKGROUND AND AIM: The relationship among distribution of pathological values at the Oral Glucose Tolerance Test (OGTT), metabolic risk factors and pregnancy outcomes in women with Gestational Diabetes (GDM), has not been clearly identified. We retrospectively compared metabolic and therapeutic parameters, maternal-fetal outcomes and post-partum OGTTs, with respect to the number and distribution of altered values of diagnostic OGTT in pregnancy. Secondly, we assessed whether insulin therapy predictive factors were identifiable...
November 27, 2020: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Diyi Zhou, Lijun Chen, Xin Mou
Pancreatic and duodenal homeobox (PDX)‑1 is a gene that plays an important role in pancreatic development and function. Type‑2 diabetes mellitus (T2DM) is a metabolic disease associated with insulin resistance and impaired islet β‑cell function. There is evidence that methylation of PDX‑1 plays a role in the development of T2DM. Acarbose is an α‑glucosidase inhibitor that can effectively delay the absorption of glucose by the body. The aim of the present study was to examine the effect of acarbose on PDX‑1 methylation in islet β‑cells in spontaneous type‑2 diabetic db/db mice...
January 2021: Molecular Medicine Reports
Alessandro Rossini, Sofia Frigerio, Elena Dozio, Roberto Trevisan, Gianluca Perseghin, Sabrina Corbetta
Background: Aromatase inhibitors in women with breast cancer have been associated with cancer treatment-induced bone loss (CTIBL), increased fracture risk, and impairment of glucose metabolism. Denosumab (Dmab), a monoclonal antibody against RANKL, which is a key regulator of the osteoclast activity, is effective as an antiresorptive agent in the treatment of CTIBL. Since RANKL/RANK pathway may contribute to the pathogenesis of glucometabolic disorders, it has been suggested that Dmab may improve glucose homeostasis...
2020: International Journal of Endocrinology
Tullaya Sitasuwan, Raweewan Lertwattanarak
OBJECTIVES: About 11%-30% of individuals with impaired fasting plasma glucose (IFG) have type 2 diabetes mellitus (T2DM), diagnosed by the 75 g oral glucose tolerance test (75 g OGTT). This study investigated (1) the prevalence and cut-off levels for fasting plasma glucose (FPG) and glycated haemoglobin A1c (HbA1c) in IFG individuals that most effectively predict the presence of T2DM diagnosed by a 75 g OGTT; (2) the predictors associated with T2DM; and (3) the pathophysiological characteristics of patients with IFG...
November 10, 2020: BMJ Open
Mohsen Marvibaigi, Seyed Morteza Hosseini, Neda Amini
ETHNOPHARMACOLOGICAL RELEVANCE: Launaea acanthodes (Boiss.) O. Kuntze is native to semiarid regions of central Iran, traditionally used in the treatment of numerous disorders including diabetes. AIM OF THE STUDY: The current study aimed to explore hypoglycemic activity of Launaea acanthodes extract in streptozotocin-induced diabetic rats. Furthermore, gene expression study was carried out to examine expression levels of key glucose metabolism-related genes. METHODS: For in vitro study, Folin-Ciocalteus, DPPH and aluminum chloride colorimetric assays were used to determine the total phenolic content, antioxidant capacity and total flavonoid content of extracts, respectively...
March 25, 2021: Journal of Ethnopharmacology
Wei Tian, Xiao-Rong Zhu, Chun-Yan Qiao, Ying-Nan Ma, Fang-Yuan Yang, Zhen Zhou, Jian-Ping Feng, Ran Sun, Rong-Rong Xie, Jing Lu, Xi Cao, Jian-Bo Zhou, Jin-Kui Yang
AIM: PAX6 is a transcription factor involved in embryonic development of many organs, including the eyes and the pancreas. Mutations of PAX6 gene is the main cause of a rare disease, congenital aniridia (CA). This case-control study aims to investigate the effects of PAX6 mutations on glucose metabolism and insulin secretion in families with CA. METHODS: Twenty-one families with CA were screened by Sanger sequencing. Patients with PAX6 mutations and CA (cases) and age-matched healthy family members (controls) were enrolled...
November 10, 2020: Diabetic Medicine: a Journal of the British Diabetic Association
Ruibin Zhang, Tingting Fu, Xin Zhao, Yao Qiu, Xiaolin Hu, Hongyan Shi, Xiao Yin
Objective: The myokine irisin has been proposed to affect obesity and metabolism disorders. However, data about the association of irisin with obesity and glucose metabolic status in humans remains controversial, and limited data are available concerning the Chinese population. This study aimed to evaluate the association between serum irisin concentrations and obesity, as well as glucose metabolic and cardiovascular factors in the middle-aged physical activity-matched Chinese Han race population...
2020: Diabetes, Metabolic Syndrome and Obesity
Latife Bozkurt, Christian S Göbl, Karoline Leitner, Giovanni Pacini, Alexandra Kautzky-Willer
INTRODUCTION: It is of current interest to assess eligibility of hemoglobin A1c (HbA1c) as a screening tool for earlier identification of women with risk for more severe hyperglycemia in pregnancy but data regarding accuracy are controversial. We aimed to evaluate if HbA1c mirrors pathophysiological precursors of glucose intolerance in early pregnancy that characterize women who develop gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: 220 pregnant women underwent an HbA1c measurement as well as an oral glucose tolerance test (OGTT) with multiple measurements of glucose, insulin and C-peptide for evaluation of insulin sensitivity and beta-cell function at 16th gestational week (IQR: 14-18)...
November 2020: BMJ Open Diabetes Research & Care
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