keyword
https://read.qxmd.com/read/32723113/relevance-and-perspectives-of-the-use-of-chitosan-in-winemaking-a-review
#1
Antonio Castro Marín, Donato Colangelo, Milena Lambri, Claudio Riponi, Fabio Chinnici
Chitosan is a natural polymer that has quite recently been approved as an aid for microbial control, metal chelation, clarification, and reduction of contaminants in enology. In foods other than wine, chitosan has also been evidenced to have some other activities such as antioxidant and antiradical properties. Nevertheless, the actual extent of its activities in must and wines has not been fully established. This review aimed to gather and discuss the available scientific information on the efficacy of chitosan as a multifaceted aid in winemaking, including antimicrobial, chelating, clarifying and antioxidant activities, while summarizing the chemical mechanisms underlying its action...
July 29, 2020: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/32533108/author-correction-complement-as-a-target-in-covid-19
#2
Antonio M Risitano, Dimitrios C Mastellos, Markus Huber-Lang, Despina Yancopoulou, Cecilia Garlanda, Fabio Ciceri, John D Lambris
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
June 12, 2020: Nature Reviews. Immunology
https://read.qxmd.com/read/32511554/erythrocytes-reveal-complement-activation-in-patients-with-covid-19
#3
Lk Metthew Lam, Sophie J Murphy, Leticia Kuri-Cervantes, Ariel R Weisman, Caroline A G Ittner, John P Reilly, M Betina Pampena, Michael R Betts, E John Wherry, Wen-Chao Song, John D Lambris, Douglas B Cines, Nuala J Meyer, Nilam S Mangalmurti
COVID-19, the disease caused by the SARS-CoV-2 virus, can progress to multi-organ failure characterized by respiratory insufficiency, arrhythmias, thromboembolic complications and shock. The mortality of patients hospitalized with COVID-19 is unacceptably high and new strategies are urgently needed to rapidly identify and treat patients at risk for organ failure. Clinical epidemiologic studies demonstrate that vulnerability to organ failure is greatest after viral clearance from the upper airway, which suggests that dysregulation of the host immune response is a critical mediator of clinical deterioration and death...
May 22, 2020: medRxiv: the preprint server for health sciences
https://read.qxmd.com/read/32360516/the-first-case-of-covid-19-treated-with-the-complement-c3-inhibitor-amy-101
#4
Sara Mastaglio, Annalisa Ruggeri, Antonio M Risitano, Piera Angelillo, Despina Yancopoulou, Dimitrios C Mastellos, Markus Huber-Lang, Simona Piemontese, Andrea Assanelli, Cecilia Garlanda, John D Lambris, Fabio Ciceri
Acute respiratory distress syndrome (ARDS) is a devastating clinical manifestation of COVID-19 pneumonia and is mainly based on an immune-driven pathology. Mounting evidence suggests that COVID-19 is fueled by a maladaptive host inflammatory response that involves excessive activation of innate immune pathways. While a "cytokine storm" involving IL-6 and other cytokines has been documented, complement C3 activation has been implicated as an initial effector mechanism that exacerbates lung injury in preclinical models of SARS-CoV infection...
April 29, 2020: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/32327719/complement-as-a-target-in-covid-19
#5
Antonio M Risitano, Dimitrios C Mastellos, Markus Huber-Lang, Despina Yancopoulou, Cecilia Garlanda, Fabio Ciceri, John D Lambris
No abstract text is available yet for this article.
April 23, 2020: Nature Reviews. Immunology
https://read.qxmd.com/read/32229292/prolonged-intraocular-residence-and-retinal-tissue-distribution-of-a-fourth-generation-compstatin-based-c3-inhibitor-in-non-human-primates
#6
Sarah Hughes, Justin Gumas, Rebecca Lee, Merita Romano, Nadja Berger, Avneesh Kumar Gautam, Georgia Sfyroera, Anna Lorena Chan, Gopalan Gnanaguru, Kip M Connor, Benjamin J Kim, Joshua L Dunaief, Daniel Ricklin, George Hajishengallis, Despina Yancopoulou, Edimara S Reis, Dimitrios C Mastellos, John D Lambris
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss among the elderly population. Genetic studies in susceptible individuals have linked this ocular disease to deregulated complement activity that culminates in increased C3 turnover, retinal inflammation and photoreceptor loss. Therapeutic targeting of C3 has therefore emerged as a promising strategy for broadly intercepting the detrimental proinflammatory consequences of complement activation in the retinal tissue. In this regard, a PEGylated second-generation derivative of the compstatin family of C3-targeted inhibitors is currently in late-stage clinical development as a treatment option for geographic atrophy, an advanced form of AMD which lacks approved therapy...
March 27, 2020: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/31819218/therapeutic-targeting-of-the-complement-system
#7
Daniel Ricklin, Dimitrios C Mastellos, John D Lambris
No abstract text is available yet for this article.
December 9, 2019: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/31717543/changes-in-antioxidants-and-sensory-properties-of-italian-chocolates-and-related-ingredients-under-controlled-conditions-during-an-eighteen-month-storage-period
#8
Arianna Roda, Milena Lambri
BACKGROUND: While there has been an increasing interest in the health properties of chocolate, limited research has looked into the changes of antioxidants occurring in the time span from production to the best before date, which was a period of 18 months in this study. METHODS: Humidity, ash, pH, acidity, fiber, carotenoids, retinols, tocopherols, sugars, proteins, theobromine, caffeine, polyphenols, fats, the peroxide value, organic acids, and volatile compounds, along with the sensory profile, were monitored at 18-week intervals for 18 months under conditions simulating a factory warehouse or a point of sale...
November 9, 2019: Nutrients
https://read.qxmd.com/read/31605100/author-correction-stealth-corporate-innovation-an-emerging-threat-for-therapeutic-drug-development
#9
Dimitrios C Mastellos, Anna M Blom, E Sander Connolly, Mohamed R Daha, Brian V Geisbrecht, Berhane Ghebrehiwet, Piet Gros, George Hajishengallis, V Michael Holers, Markus Huber-Lang, Taroh Kinoshita, Tom E Mollnes, Robert A Montgomery, B Paul Morgan, Bo Nilsson, Ruben Pio, Daniel Ricklin, Antonio M Risitano, Ronald P Taylor, Alberto Mantovani, John P A Ioannidis, John D Lambris
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
October 11, 2019: Nature Immunology
https://read.qxmd.com/read/31562490/-stealth-corporate-innovation-an-emerging-threat-for-therapeutic-drug-development
#10
Dimitrios C Mastellos, Anna M Blom, E Sander Connolly, Mohamed R Daha, Brian V Geisbrecht, Berhane Ghebrehiwet, Piet Gros, George Hajishengallis, V Michael Holers, Markus Huber-Lang, Taroh Kinoshita, Tom E Mollnes, Robert A Montgomery, B Paul Morgan, Bo Nilsson, Ruben Pio, Daniel Ricklin, Antonio M Risitano, Ronald P Taylor, Alberto Mantovani, John P A Ioannidis, John D Lambris
No abstract text is available yet for this article.
September 27, 2019: Nature Immunology
https://read.qxmd.com/read/31542608/complement-activation-on-neutrophils-initiates-endothelial-adhesion-and-extravasation
#11
Antonina Akk, Luke E Springer, Lihua Yang, Samantha Hamilton-Burdess, John D Lambris, Huimin Yan, Ying Hu, Xiaobo Wu, Dennis E Hourcade, Mark J Miller, Christine T N Pham
Neutrophils are essential to the pathogenesis of many inflammatory diseases. In the autoantibody-mediated K/BxN model of inflammatory arthritis, the alternative pathway (AP) of complement and Fc gamma receptors (FcγRs) are required for disease development while the classical pathway is dispensable. The reason for this differential requirement is unknown. We show that within minutes of K/BxN serum injection complement activation (CA) is detected on circulating neutrophils, as evidenced by cell surface C3 fragment deposition...
October 2019: Molecular Immunology
https://read.qxmd.com/read/31514048/first-trials-to-assess-the-feasibility-of-grape-seed-powder-gsp-as-a-novel-and-sustainable-bentonite-alternative
#12
Elia Romanini, Jacqui M McRae, Donato Colangelo, Milena Lambri
Grape pathogenesis-related proteins can cause haze in wine that is undesirable for consumers. Bentonite is used to remove these proteins but is a non-renewable natural material and reduces wine volume due to poor settling. As a potential bentonite alternative, grape seeds powder (GSP) was added to four wines and two grape juice varieties. Addition to wine required high doses (25-32 g/L) for protein removal and haze prevention and this induced changes to wine composition. By contrast, addition to grape juice prior to fermentation required substantially lower doses of GSP (5 g/L) to prevent haze formation...
September 6, 2019: Food Chemistry
https://read.qxmd.com/read/31324874/clinical-promise-of-next-generation-complement-therapeutics
#13
REVIEW
Dimitrios C Mastellos, Daniel Ricklin, John D Lambris
The complement system plays a key role in pathogen immunosurveillance and tissue homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of inflammatory damage that exacerbates pathology. The clinical merit of targeting the complement system has been established for rare clinical disorders such as paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome. Evidence from preclinical studies and human genome-wide analyses, supported by new molecular and structural insights, has revealed new pathomechanisms and unmet clinical needs that have thrust a new generation of complement inhibitors into clinical development for a variety of indications...
July 19, 2019: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/31270150/cholesterol-crystals-induce-coagulation-activation-through-complement-dependent-expression-of-monocytic-tissue-factor
#14
Caroline S Gravastrand, Bjørg Steinkjer, Bente Halvorsen, Anne Landsem, Mona Skjelland, Eva Astrid Jacobsen, Trent M Woodruff, John D Lambris, Tom E Mollnes, Ole-Lars Brekke, Terje Espevik, Anne Mari A Rokstad
Cholesterol crystals (CC) are strong activators of complement and could potentially be involved in thromboinflammation through complement-coagulation cross-talk. To explore the coagulation-inducing potential of CC, we performed studies in lepirudin-based human whole blood and plasma models. In addition, immunohistological examinations of brain thrombi and vulnerable plaque material from patients with advanced carotid atherosclerosis were performed using polarization reflected light microscopy to identify CC...
July 3, 2019: Journal of Immunology
https://read.qxmd.com/read/31171642/complement-c3-inhibition-by-compstatin-cp40-prevents-intra-and-extravascular-hemolysis-of-red-blood-cells
#15
Inge Baas, Laura Delvasto-Nuñez, Peter Ligthart, Conny Brouwer, Claudia Folman, Edimara S Reis, Daniel Ricklin, John D Lambris, Diana Wouters, Masja de Haas, Ilse Jongerius, Sacha S Zeerleder
No abstract text is available yet for this article.
June 6, 2019: Haematologica
https://read.qxmd.com/read/31130967/corrigendum-targeting-complement-pathways-in-polytrauma-and-sepsis-induced-multiple-organ-dysfunction
#16
Ebru Karasu, Bo Nilsson, Jörg Köhl, John D Lambris, Markus Huber-Lang
[This corrects the article DOI: 10.3389/fimmu.2019.00543.].
2019: Frontiers in Immunology
https://read.qxmd.com/read/31048789/new-insights-into-the-immune-functions-of-complement
#17
REVIEW
Edimara S Reis, Dimitrios C Mastellos, George Hajishengallis, John D Lambris
The recognition of microbial or danger-associated molecular patterns by complement proteins initiates a cascade of events that culminates in the activation of surface complement receptors on immune cells. Such signalling pathways converge with those activated downstream of pattern recognition receptors to determine the type and magnitude of the immune response. Intensive investigation in the field has uncovered novel pathways that link complement-mediated signalling with homeostatic and pathological T cell responses...
August 2019: Nature Reviews. Immunology
https://read.qxmd.com/read/31045344/interlaboratory-comparison-of-hydrogen-deuterium-exchange-mass-spectrometry-measurements-of-the-fab-fragment-of-nistmab
#18
Jeffrey W Hudgens, Elyssia S Gallagher, Ioannis Karageorgos, Kyle W Anderson, James J Filliben, Richard Y-C Huang, Guodong Chen, George M Bou-Assaf, Alfonso Espada, Michael J Chalmers, Eduardo Harguindey, Hui-Min Zhang, Benjamin T Walters, Jennifer Zhang, John D Venable, Caitlin Steckler, Inhee Park, Ansgar Brock, Xiaojun Lu, Ratnesh K Pandey, Arun Chandramohan, Ganesh S Anand, Sasidhar N Nirudodhi, Justin B Sperry, Jason C Rouse, James A Carroll, Kasper D Rand, Ulrike Leurs, David D Weis, Mohammed A Al-Naqshabandi, Tyler S Hageman, Daniel Deredge, Patrick L Wintrode, Malvina Papanastasiou, John D Lambris, Sheng Li, Sarah Urata
Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is an established, powerful tool for investigating protein-ligand interactions, protein folding, and protein dynamics. However, HDX-MS is still an emergent tool for quality control of biopharmaceuticals and for establishing dynamic similarity between a biosimilar and an innovator therapeutic. Because industry will conduct quality control and similarity measurements over a product lifetime and in multiple locations, an understanding of HDX-MS reproducibility is critical...
May 2, 2019: Analytical Chemistry
https://read.qxmd.com/read/31031765/complementing-the-cancer-immunity-cycle
#19
REVIEW
Ruben Pio, Daniel Ajona, Sergio Ortiz-Espinosa, Alberto Mantovani, John D Lambris
Reactivation of cytotoxic CD8+ T-cell responses has set a new direction for cancer immunotherapy. Neutralizing antibodies targeting immune checkpoint programmed cell death protein 1 (PD-1) or its ligand (PD-L1) have been particularly successful for tumor types with limited therapeutic options such as melanoma and lung cancer. However, reactivation of T cells is only one step toward tumor elimination, and a substantial fraction of patients fails to respond to these therapies. In this context, combination therapies targeting more than one of the steps of the cancer-immune cycle may provide significant benefits...
2019: Frontiers in Immunology
https://read.qxmd.com/read/30949180/targeting-complement-pathways-in-polytrauma-and-sepsis-induced-multiple-organ-dysfunction
#20
REVIEW
Ebru Karasu, Bo Nilsson, Jörg Köhl, John D Lambris, Markus Huber-Lang
Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. However, depending on the origin and extent of the damaged macro- and micro -milieu, the complement system can also be either excessively activated or inhibited. In both cases, this can lead to a maladaptive immune response and subsequent multiple cellular and organ dysfunction...
2019: Frontiers in Immunology
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