Tingting Shen, Weihua Zhang, Rongyu Lan, Zhihui Wang, Jie Qin, Jiayang Chen, Jiaxing Wang, Zhuotan Wu, Yangyang Shen, Qikai Lin, Yudong Xu, Yuan Chen, Yi Wei, Yiwen Liu, Yuance Ning, Haixuan Deng, Zhenbin Cao, Xiaoping Ren
BACKGROUND: Spinal cord injury (SCI) is a severe impairment of the central nervous system, leading to motor, sensory, and autonomic dysfunction. The present study investigates the efficacy of the polyethylene glycol (PEG)-mediated spinal cord fusion (SCF) techniques, demonstrating efficacious in various animal models with complete spinal cord transection at the T10 level. This research focuses on a comparative analysis of three SCF treatment models in beagles: spinal cord transection (SCT), vascular pedicle hemisected spinal cord transplantation (vSCT), and vascularized allograft spinal cord transplantation (vASCT) surgical model...
June 2024: IBRO neuroscience reports