Yusha Sun, Xin Wang, Daniel Y Zhang, Zhijian Zhang, Janardhan P Bhattarai, Yingqi Wang, Weifan Dong, Feng Zhang, Kristen H Park, Jamie Galanaugh, Abhijeet Sambangi, Qian Yang, Sang Hoon Kim, Garrett Wheeler, Tiago Goncalves, Qing Wang, Daniel Geschwind, Riki Kawaguchi, Huadong Wang, Fuqiang Xu, Zev A Binder, Isaac H Chen, Emily Ling-Lin Pai, Sara Stone, MacLean Nasrallah, Kimberly M Christian, Marc Fuccillo, Donald M O'Rourke, Minghong Ma, Guo-Li Ming, Hongjun Song
Glioblastoma (GBM), a universally fatal brain cancer, infiltrates the brain and can be synaptically innervated by neurons, which drives tumor progression 1-6 . Synaptic inputs onto GBM cells identified so far are largely short-range and glutamatergic 7-9 . The extent of integration of GBM cells into brain-wide neuronal circuitry is not well understood. Here we applied a rabies virus-mediated retrograde monosynaptic tracing approach 10-12 to systematically investigate circuit integration of human GBM organoids transplanted into adult mice...
March 4, 2024: bioRxiv