Filippo Migliorini, Federico Cocconi, Gianluca Vecchio, Luise Schäefer, Julian Koettnitz, Nicola Maffulli
INTRODUCTION: Pharmacological strategies might influence bone healing in terms of time to union or quality of mature bone. This expert opinion discussed the current level I evidence on the experimental pharmacological agents used to favor bone fracture healing. AREAS COVERED: This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the 2020 PRISMA statement. In April 2023, the following databases were accessed: PubMed, Web of Science, Google Scholar, Embase...
September 23, 2023: Expert Opinion on Investigational Drugs
Mohamed Zouari, Rim Dghaies, Wiem Rhaiem, Manel Belhajmansour, Emna Krichen, Amel Ben Hamad, Mariem Boukattaya, Mahdi Ben Dhaou, Riadh Mhiri
PURPOSE: To identify the risk factors for adverse outcomes after pediatric pyeloplasty. METHODS: We conducted a retrospective review of all children under the age of 14 years who underwent primary pyeloplasty for unilateral ureteropelvic junction (UPJ) obstruction at a single teaching hospital in Tunisia between January 1, 2013, and December 31, 2022. RESULTS: A total of 103 patients were included. Median age of patients at surgery was 27 months (interquartile range [IQR], 13-44)...
September 23, 2023: International Journal of Urology: Official Journal of the Japanese Urological Association
Yunxia Wang, Xiaolin Liu, Luyao Gong, Weihong Ding, Wenjing Hao, Yeheng Peng, Jun Zhang, Weimin Cai, Yuan Gao
Sunitinib is the first-line drug for renal cell carcinoma (RCC) treatment. However, patients who received sunitinib treatment will ultimately develop drug resistance after 6-15 months, creating a huge obstacle to the current treatment of RCC. Therefore, it is urgent to clarify the mechanisms of sunitinib resistance and develop new strategies to overcome it. In this review, the mechanisms of sunitinib resistance in RCC have been summarized based on five topics: activation of bypass or alternative pathway, inadequate drug accumulation, tumor microenvironment, metabolic reprogramming and epigenetic regulation...
September 23, 2023: British Journal of Pharmacology
JunYi Qiao, Yujiao Wang, Weimin He
Neuroendocrine neoplasms (NENs) originate from neuroendocrine cells, and mainly occur in the gastrointestinal tract and lungs, rarely occurring in the orbit. Here, the clinicopathologic factors, treatments and prognosis of three cases of orbital NENs are described. The mean age of the three patients (two females and one male) was 59 years. Two cases exhibited ocular symptoms, including unilateral proptosis and eyelid mass, while the third case presented systemic symptoms exhibited as Cushing's syndrome. The tumours were surgically resected in all three patients...
September 2023: Journal of International Medical Research
Aslıhan Gürün Kaya, Deniz Doğan
Over the past two decades, endobronchial ultrasound (EBUS) has become a crucial tool for diagnosing pulmonary diseases. The most common indication of EBUS usage is the diagnosis and staging of lung cancer. Additionally, there have been significant improvements in the application of convex probe EBUS in line with the increase in experience and knowledge about EBUS and the developments in medicine and technology. To enhance diagnostic accuracy and acquire larger tissue samples, techniques such as cryo-biopsy guided by endobronchial ultrasound (EBUS) and intranodal forceps biopsy have been developed...
September 2023: Tüberküloz Ve Toraks
Shang Wang, Yi Yan, Jian Zhang, Ping Yuan, Ci-Jun Luo, Hong-Ling Qiu, Hui-Ting Li, Jian Xu, Lan Wang, Tian-Lan Li, Rong Jiang
BACKGROUND: The maintenance dosage of selexipag is categorized as low, medium or high. In order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension (PAH), we performed a systematic review and meta-analysis. METHODS: Studies assessing PAH risk stratification indices, such as the World Health Organization functional class (WHO-FC), six-minute walk distance (6MWD), N-terminal pro-B-type natriuretic peptide (NT-proBNP) level, right atrial pressure (RAP), cardiac index (CI) and mixed venous oxygen saturation (SvO2 ), were included...
September 23, 2023: Animal Models and Experimental Medicine
Maureen A Smythe, Wendy Wu, Candice L Garwood
INTRODUCTION: This systematic review evaluates the extent to which the effect of anticoagulants may be altered in the presence of cannabinoids. METHODS: The following databases were searched: EMBASE, PubMed, Web of Science, Scopus, PscycINFO, and CINAHL from database inception through May 2023. Search terms included cannabis AND anticoagulant AND drug interactions, and related key words. The major outcome was hemorrhage or thrombosis and if available, the relative change in quantitative intensity of anticoagulation after cannabinoid exposure...
September 23, 2023: Pharmacotherapy
Yaning Yang, Guangjian Yang, Weihua Li, Xuezhi Hao, Shuyang Zhang, Xin Ai, Siyu Lei, Haiyan Xu, Yan Wang
BACKGROUND: Although some targeted therapies have been shown to be effective in treating HER2-altered non-small cell lung cancer (NSCLC), the survival demands have not yet been met due to the high cost and limited availability. This study aimed to assess the effectiveness and safety of pyrotinib plus antiangiogenic agents, including apatinib, anlotinib, and bevacizumab, in previously treated patients with HER2-altered advanced NSCLC. METHODS: In this retrospective real-world study, patients with HER2-altered NSCLC who received pyrotinib plus antiangiogenic agents as a second- or later-line treatment between November 2015 and January 2022 were reviewed...
September 23, 2023: Thoracic Cancer
Brittany Roman, Sydney Collette, Abigail M Smith, Amy Theos
A retrospective chart review of 332 pediatric psoriasis patients seen at a single academic institution from 2012 to 2022 was conducted to examine the risk factors associated with palmoplantar psoriasis (PP), a painful and treatment-resistant subtype of plaque psoriasis affecting hands and feet. Black patients have a 6.386-fold increase in the odds of having PP compared to White patients and males have a 2.241-fold increase in the odds of having PP. Black and Hispanic/Latino patients displayed a higher prevalence of nail and palm/sole involvement (p < ...
September 23, 2023: Pediatric Dermatology
Zhenhua Liu, Xinyu Wang, Yao Ma, Yiting Lin, Gang Wang
Artificial intelligence (AI) is a field of computer science that involves the development of programs designed to replicate human cognitive processes and the analysis of complex data. In dermatology, which is predominantly a visual-based diagnostic field, AI has become increasingly important in improving professional processes, particularly in the diagnosis of psoriasis. In this review, we summarized current AI applications in psoriasis: (i) diagnosis, including identification, classification, lesion segmentation, lesion severity and area scoring; (ii) treatment, including prediction treatment efficiency and prediction candidate drugs; (iii) management, including e-health and preventive medicine...
September 23, 2023: Experimental Dermatology
Nicolette Casarcia, Patrick Rogers, Emma Guld, Samvit Iyer, Yutong Li, Jack T Burcher, Lindsay K DeLiberto, Sabyasachi Banerjee, Anupam Bishayee
Pancreatic cancer is the third leading cause of cancer-related deaths in the United States, owing to its aggressive nature and suboptimal treatment options, emphasizing the need for novel therapeutic approaches. Emerging studies have exhibited promising results regarding the therapeutic utility of plant-derived compounds (phytochemicals) in pancreatic cancer. The purpose of this review is to evaluate the potential of phytochemicals in the treatment and prevention of pancreatic cancer. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses was applied to collect articles for this review...
September 23, 2023: British Journal of Pharmacology
Grace Haynes, Fauziyya Muhammad, Ali F Khan, Esmaeil Mohammadi, Zachary A Smith, Lei Ding
Since its development, spinal cord functional magnetic resonance imaging (fMRI) has utilized various methodologies and stimulation protocols to develop a deeper understanding of a healthy human spinal cord that lays a foundation for its use in clinical research and practice. In this review, we conducted a comprehensive literature search on spinal cord fMRI studies and summarized the recent advancements and resulting scientific achievements of spinal cord fMRI in the following three aspects: the current state of spinal cord fMRI methodologies and stimulation protocols, knowledge about the healthy spinal cord's functions obtained via spinal cord fMRI, and fMRI's exemplary usage in spinal cord diseases and injuries...
September 23, 2023: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Kazuya Takeda, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Keiichi Jingu
To investigate radiation-induced cytopenia and establish predictive nomograms for hematological toxicity, we reviewed 3786 patients aged 18 or older who received radiation monotherapy between 2010 and 2021 for non-hematologic malignancies. We collected data on patient background, treatment content and hematologic toxicities for 12 weeks after the start of radiotherapy. The patients were randomly divided into training and test groups in 7:3 ratio. In the training group, we conducted ordered logistic regression analysis to identify predictive factors for neutropenia, lymphocytopenia, anemia and thrombocytopenia...
September 22, 2023: Journal of Radiation Research
Abbie D Leino, John C Magee, David B Kershaw, Manjunath P Pai, Jeong M Park
Tacrolimus is widely reported to display diurnal variation in pharmacokinetic parameters with twice-daily dosing. However, the contribution of chronopharmacokinetics versus food intake is unclear, with even less evidence in the pediatric population. The objectives of this study were to summarize the existing literature by meta-analysis and evaluate the impact of food composition on 24-hour pharmacokinetics in pediatric kidney transplant recipients. For the meta-analysis, ten studies involving 253 individuals were included...
September 23, 2023: Journal of Clinical Pharmacology
Tiyani Milta Sono, Eugene Yeika, Aislinn Cook, Aubrey Kalungia, Sylvia A Opanga, Joseph Elikem Efui Acolatse, Israel Abebrese Sefah, Ana Golić Jelić, Stephen Campbell, Giulia Lorenzetti, Zia Ul Mustafa, Vanda Marković-Peković, Amanj Kurdi, Bene D Anand Paramadhas, Godfrey Mutashambara Rwegerera, Adefolarin A Amu, Mobolaji Eniola Alabi, Evelyn Wesangula, Margaret Oluka, Felix Khuluza, Ibrahim Chikowe, Joseph O Fadare, Olayinka O Ogunleye, Dan Kibuule, Ester Hango, Natalie Schellack, Nishana Ramdas, Amos Massele, Steward Mudenda, Iris Hoxha, Catrin E Moore, Brian Godman, Johanna C Meyer
INTRODUCTION: Antimicrobial resistance (AMR) is a global concern. Currently, the greatest mortality due to AMR is in Africa. A key driver continues to be high levels of dispensing of antibiotics without a prescription. AREAS COVERED: A need to document current rates of dispensing, their rationale and potential ways forward including antimicrobial stewardship programmes (ASPs). A narrative review was undertaken. The highest rates of antibiotic purchasing were in Eritrea (up to 89...
September 23, 2023: Expert Review of Anti-infective Therapy
Chenliang Wu, Beibei Liu, Caiqi Xu, Song Zhao, Yuehua Li, Junjie Xu, Jinzhong Zhao
BACKGROUND: Although Hill-Sachs lesions (HSLs) are assumed to be influenced by glenoid characteristics in the context of bipolar bone loss, little is known about how glenoid concavity influences HSL morphology. PURPOSE: To investigate the relationship between the native glenoid depth and HSL morphological characteristics. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: Computed tomography images of bilateral shoulders from 151 consecutive patients with traumatic unilateral anterior shoulder instability were retrospectively reviewed...
September 22, 2023: American Journal of Sports Medicine
Yousef S Alyousef, Venerina Johnston, Rebecca Mellor, Melanie L Plinsinga, Haroun Zerguine, Michelle D Smith
PURPOSE: Lower limb osteoarthritis (OA) is a prevalent condition that has a profound impact on an individual's life in several domains, including occupational activities. The objective of this study was to systematically describe and compare work-related outcomes (e.g., employment status, absenteeism, and productivity loss) in individuals with and without lower limb OA. MATERIALS AND METHODS: Five databases were searched until 17 June 2023. Studies were eligible for inclusion if they compared work-related outcomes between individuals with lower limb OA and healthy controls (e...
September 22, 2023: Disability and Rehabilitation
Ayman Saeed
No abstract text is available yet for this article.
June 1, 2023: Annals of Plastic Surgery
Vicente A Benites-Zapata, Enrique A Hernandez-Bustamante, Luis M Acuña-Chávez, Claudia P Escudero-Gaytan, Juan R Ulloque-Badaracco, Esteban A Alarcón-Braga, Gino Venegas, Percy Herrera-Añazco
AIM: Low- and middle-income countries represent nearly 85% of all cervical cancer cases worldwide; thereby, it is extremely important to identify methods to improve the screening process. Therefore, this study aimed to summarize the primary characteristics of studies on accessibility, coverage, patient preferences, and factors associated with patient satisfaction or acceptance of colposcopy in primary healthcare. METHODS: A search strategy, based on MeSH, Emtree, and free terms, was run through 5 databases (PubMed, Scopus, Embase, Ovid/Medline, and Web of Science)...
2023: Journal of Primary Care & Community Health
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