Casey Wells, Anne Carrington Warren, Mollie Ashe Scott
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: This report describes the step-by-step process that led to expansion of ambulatory care pharmacy services at a newly established internal medicine clinic within a patient-centered medical home in North Carolina...
April 13, 2024: American Journal of Health-system Pharmacy: AJHP
Anaas Moncef Mergoum, Abigail Rebecca Rhone, Nicholas James Larson, David J Dries, Benoit Blondeau, Frederick Bolles Rogers
Shock is a life-threatening circulatory failure that results in inadequate tissue perfusion and oxygenation. Vasopressors and inotropes are vasoactive medications that are vital in increasing systemic vascular resistance and cardiac contractility, respectively, in patients presenting with shock. To be well versed in using these agents is an important skill to have in the critical care setting where patients can frequently exhibit symptoms of shock. In this review, we will discuss the pathophysiological mechanisms of shock and evaluate the current evidence behind the management of shock with an emphasis on vasopressors and inotropes...
April 13, 2024: Journal of Intensive Care Medicine
Nangorgo J Coulibaly, Mohammed H Elgouhari, Muhammad H Arshad, Muhammad Waqas, Hussain Shallwani, Hakeem J Shakir
Thromboembolism is a complication of neurointerventional procedures that requires patients to be placed under antiplatelet therapy. Current options for antiplatelet therapies have a delayed onset of action that prevents a rapid door to puncture transition for patents presenting in acute settings. Cangrelor (Kengreal, Chiesi, USA) is an intravenous P2Y12 platelet inhibitor approved in percutaneous coronary interventions that has an immediate onset of action and half-life between 2 and 6 min. Thus, the goal of this study is to report on the safety, effectiveness, and indications for using Cangrelor in neurointerventional procedures...
April 13, 2024: Interventional Neuroradiology
Christine Lawson, Daniel J McCabe, Ryan Feldman
Aconite poisoning refers to toxicity resulting from plants belonging to the Aconitum genus, which comprises over 350 different species of perennial flowering plants that grow in temperate mountainous areas of the northern hemisphere (North America, Europe, Asia). These plants contain a group of toxins known as aconite alkaloids, which encompass numerous closely related toxic compounds. Conventional teaching from toxicology textbooks has broadly classified these alkaloids based on their mechanism of action, often simplifying them as substances that prevent sodium channel inactivation...
April 13, 2024: Journal of Intensive Care Medicine
Saad Moughal, Fathallah Ismail Islim, Hamed Nejadhamzeeigilani, Nayyar Saleem, Tony Goddard, Tufail Patankar
INTRODUCTION: Endovascular treatment of wide neck aneurysms remains complicated with a determined and continuous technological effort towards treatment options that can offer safer and efficacious outcomes. The Woven Endobridge device was introduced in 2010 and has become a mainstay endovascular treatment for wide neck and large intracranial aneurysms. A recent review of the Woven Endobridge Clinical Assessment of Intrasaccular Aneurysm Therapy (WEBCAST) and WEBCAST2 trials and the five-year follow-up of patients was published...
April 13, 2024: Interventional Neuroradiology
Sabrina B Sholts
In 2021, amid surging activism in the Movement for Black Lives, the Smithsonian Institution's possession of the remains of thousands of African Americans drew widespread attention. In response, the Smithsonian and its National Museum of Natural History undertook a series of steps to assess these remains and to develop a policy for returning as many as possible to descendants and descendant communities, under changes that would apply to all non-Native American remains in Smithsonian collections. This paper reviews the actions taken to date and the work that is still in progress or planned...
April 13, 2024: American journal of biological anthropology
Jacqueline Crawford, Cassie McFarlane, Anita N Datta
Introduction: Frontal-predominant epileptiform discharges (EDs) include generalized spike-wave (GSW) and frontal spikes (FS). However, negative bi-frontal ED with simultaneous occipital positivity (BFOD) are rare, leading to questions regarding physiological generators. Methods: To determine the clinical significance of BFOD, electroclinical features of children with BFOD (n = 40) were compared to control patients with GSW (n = 102) and FS (n = 100). Results: Results are presented in the following order: BFOD, GSW, and FS...
April 13, 2024: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
Ajmain Chowdhury, Assim Saad Eddin, Su Kim Hsieh, Fabiana C Policeni
Gender diversity, especially pertaining to transgender and gender-diverse (TGD) populations, is often stigmatized. A small but not insignificant number of adults in the United States identify as TGD, including transgender, nonbinary, and other gender identities than cisgender. Accessing health care remains a significant challenge for TGD individuals because many health care systems adhere to a gender binary model and many TGD individuals experience negative interactions when interfacing with health care. There is also a scarcity of literature addressing their unique health care needs, limiting our current understanding of breast cancer risks and screening recommendations for TGD patients...
April 13, 2024: Journal of breast imaging
Sevinç İnan, Emre Barış
Autophagy is a cellular process that is evolutionarily conserved, involving the sequestration of damaged organelles and proteins into autophagic vesicles, which subsequently fuse with lysosomes for degradation. Autophagy controls the development of many diseases by influencing apoptosis, inflammation, the immune response and different cellular processes. Autophagy plays a significant role in the aetiology of disorders associated with dentistry. Autophagy controls odontogenesis. Furthermore, it is implicated in the pathophysiology of pulpitis and periapical disorders...
April 2024: Journal of Cellular and Molecular Medicine
Yuxiang Du
The Hippo signalling pathway, an evolutionarily conserved kinase cascade, has been shown to be crucial for cell fate determination, homeostasis and tissue regeneration. Recent experimental and clinical studies have demonstrated that the Hippo signalling pathway is involved in the pathophysiology of ocular diseases. This article provides the first systematic review of studies on the regulatory and functional roles of mammalian Hippo signalling systems in eye diseases. More comprehensive studies on this pathway are required for a better understanding of the pathophysiology of eye diseases and the development of effective therapies...
April 2024: Journal of Cellular and Molecular Medicine
Håvard Ulsaker, Henrik Halvorsen, Audun Ole Braaten, Eric Dorenberg, Beate Rikken Lindberg, Kåre Christian Nordhus, Øyvind Jakobsen, Reidar Brekken, Arne Seternes, Frode Manstad-Hulaas
Objective : The multibranched off-the-shelf Zenith® t-Branch (Cook Medical, Bloomington, IN) device is commonly chosen for endovascular repair of thoracoabdominal aortic aneurysms. The aim of this study was to report early and mid-term outcomes in all patients treated with the t-Branch in Norway; Design and Methods : A retrospective multicenter study with Norwegian centers performing complex endovascular aortic repair was undertaken. T-Branch patients from 2014 to 2020 were included. All postoperative computed tomography angiography images were reviewed, and demographic, anatomical, perioperative and follow-up data were analyzed; Results: Seventy patients were treated in a single-step ( n  = 55) or staged ( n  = 15) procedure...
December 2024: Scandinavian Cardiovascular Journal: SCJ
J Adrián Rivera-Alcántara, Natalia Esparza-Hurtado, Gabriela A Galán-Ramírez, Ivette Cruz-Bautista, Roopa Mehta, Carlos A Aguilar-Salinas, Alexandro J Martagon
Biobanks are valuable tools for developing and applying scientific research and international cooperation through the collection of biological materials and their associated data. Systematic research following the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines was conducted in late 2022 in PubMed and Scopus, and generated 17 articles to be reviewed in depth and critically assessed using the Critical Appraisal Skills Programme Checklist due to the limited available data; 12 relevant health organizations and government websites outside of peer-reviewed journals were also included...
April 13, 2024: International Journal of Biological Markers
Grace Baek, Miryoung Kim, Madison Lee, Shan O'Connor, Lauren Held, Lars van der Laan, Ryan D Cassaday
INTRODUCTION: Pegaspargase (PEG) is a key component of standard regimens for acute lymphoblastic leukemia/lymphoma (ALL) and extranodal natural killer/T-cell lymphoma (NKTCL). Emerging evidence suggests an opportunity to decrease incidence of PEG-associated toxicities with dose capping, but evidence is limited. This study aims to evaluate whether a significant difference in PEG-associated toxicities related to dosing strategy exists and to identify patient-specific or regimen-specific factors for PEG-related toxicity...
April 13, 2024: Journal of Oncology Pharmacy Practice
Francesco Sgadari, Alessandro Vaglica, Antonella Porrello, Dario Savoca, Rosario Schicchi, Maurizio Bruno
In the present study, the chemical composition of the essential oil from aerial parts of two populations of Paeonia mascula subsp. russoi , collected in Sicily, was evaluated by GC-MS. No previously phytochemical investigation has been reported for this subspecies. The main components of the essential oil of the population with pink flowers were salicylaldehyde (34.31%), nonanal (16.95%) and 2-hexenal (10.17%), whereas essential oil of the population with white flowers, was shown to be rich of myrtanal (14...
April 13, 2024: Natural Product Research
Alan R Vazquez, Weng-Kee Wong
Modern randomization methods in clinical trials are invariably adaptive, meaning that the assignment of the next subject to a treatment group uses the accumulated information in the trial. Some of the recent adaptive randomization methods use mathematical programming to construct attractive clinical trials that balance the group features, such as their sizes and covariate distributions of their subjects. We review some of these methods and compare their performance with common covariate-adaptive randomization methods for small clinical trials...
April 13, 2024: Pharmaceutical Statistics
Lotte Colson, Simon Vanhentenrijk, Theodoros Kalpakos, Bram Roosens, Berlinde Von Kemp, Tim Balthazar, Stijn Lochy, Frederik H Verbrugge
AIMS: To provide real-world data on post-diuretic spot urine sodium concentration (UNa) assessment in acute heart failure (AHF) and its implications for treatment. METHODS AND RESULTS: Automated query of the electronic medical record identified patients admitted to the cardiac intensive care unit of a single tertiary care hospital between November 2018 and December 2021, who received intravenous loop diuretics. Detailed manual chart review confirmed the AHF diagnosis...
April 13, 2024: Acta Clinica Belgica
C Hebborn, F M Nunes, A E Lovell
This corrects the article DOI: 10.1103/PhysRevLett.131.212503.
March 29, 2024: Physical Review Letters
Hiroaki Tanaka, Shota Okazaki, Masaru Kobayashi, Yuto Fukushima, Yosuke Arai, Takushi Iimori, Mikk Lippmaa, Kohei Yamagami, Yoshinori Kotani, Fumio Komori, Kenta Kuroda, Takao Sasagawa, Takeshi Kondo
We investigate the electronic structure of 2H-NbS_{2} and h-BN by angle-resolved photoemission spectroscopy (ARPES) and photoemission intensity calculations. Although in bulk form, these materials are expected to exhibit band degeneracy in the k_{z}=π/c plane due to screw rotation and time-reversal symmetries, we observe gapped band dispersion near the surface. We extract from first-principles calculations the near-surface electronic structure probed by ARPES and find that the calculated photoemission spectra from the near-surface region reproduce the gapped ARPES spectra...
March 29, 2024: Physical Review Letters
Iman Marvian, Hanqing Liu, Austin Hulse
Universality of local unitary transformations is one of the cornerstones of quantum computing with many applications and implications that go beyond this field. However, it has recently been shown that this universality does not hold in the presence of continuous symmetries: generic symmetric unitaries on a composite system cannot be implemented, even approximately, using local symmetric unitaries on the subsystems. In this Letter, we show that, despite these constraints, any SU(2) rotationally invariant unitary can be realized with the Heisenberg exchange interaction, which is 2-local and rotationally invariant, provided that the system interacts with a pair of ancilla qubits...
March 29, 2024: Physical Review Letters
Xanda C Kolesnikow, Raditya W Bomantara, Andrew C Doherty, Arne L Grimsmo
The Gottesman-Kitaev-Preskill (GKP) code may be used to overcome noise in continuous variable quantum systems. However, preparing GKP states remains experimentally challenging. We propose a method for preparing GKP states by engineering a time-periodic Hamiltonian whose Floquet states are GKP states. This Hamiltonian may be realized in a superconducting circuit comprising a SQUID shunted by a superinductor and a capacitor, with a characteristic impedance twice the resistance quantum. The GKP Floquet states can be prepared by adiabatically tuning the frequency of the external magnetic flux drive...
March 29, 2024: Physical Review Letters
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