Makoto Sasaki, Hiroyasu Tamamura, Yuji Tameshige, Yuya Azuma, Yoshikazu Maeda, Keiichiro Matsushita, Yoshitaka Sato, Shigeyuki Takamatsu, Kazuya Inoue, Yoji Tabata, Hitoshi Yoshimura, Kazutaka Yamamoto
PURPOSE: In concurrent chemoradiotherapy for advanced esophageal cancer, a 2-phase method consisting of initial irradiation of a wide elective nodal region and boost irradiation of the primary lesion is commonly employed. Although dose escalation to the primary lesion may be required to achieve higher local control rates, the radiation dose to critical organs must not exceed dose constraints. To achieve an optimum balance of dose prescription and dose reduction to surrounding organs, such as the lungs and heart, we compared hybrid dose distributions and investigated the best combination of the following recent irradiation techniques: volumetric modulation arc therapy (VMAT), proton broad-beam irradiation, and intensity-modulated proton beam therapy (IMPT)...
March 2024: International Journal of Particle Therapy