Qianyu Zhang, Ying Zhang, Chen Wang, Huan Tang, Ang Ma, Peng Gao, Qiaoli Shi, Guohua Wang, Shengnan Shen, Junzhe Zhang, Fei Xia, Yinhua Zhu, Jigang Wang
BACKGROUND: The pentose phosphate pathway (PPP) plays a crucial role in the material and energy metabolism in cancer cells. Targeting 6-phosphogluconate dehydrogenase (6PGD), the rate-limiting enzyme in the PPP metabolic process, to inhibit cellular metabolism is an effective anticancer strategy. In our previous study, we have preliminarily demonstrated that gambogic acid (GA) induced cancer cell death by inhibiting 6PGD and suppressing PPP at the cellular level. However, it is unclear whether GA could suppress cancer cell growth by inhibiting PPP pathway in mouse model...
April 20, 2024: Phytomedicine