Sanjeev Pathak, Ying Jiang, Lauren DiPetrillo, Mark S Todtenkopf, Yan Liu, Christoph U Correll
OBJECTIVE: Patients with schizophrenia and comorbid alcohol use disorder remain understudied. This post hoc analysis evaluated data from Phase 1 of the Clinical Antipsychotic Trials of Intervention Effectiveness in Schizophrenia study (January 2001-December 2004). METHODS: Patients without substance abuse (except marijuana use) in the month before study entry were categorized into those with a history of alcohol use disorder (SZ + AUD) within 5 years before study entry and those without alcohol use disorder (SZ-only) per DSM-IV criteria...
March 17, 2020: Journal of Clinical Psychiatry
João Gama Marques
Objective: To identify the prevalence of secondary schizophrenia (organic psychosis causing a schizophrenia-like syndrome) in patients with a prior diagnosis of schizophrenia presenting to Centro Hospitalar Psiquiátrico de Lisboa, Lisbon, Portugal. Methods: Two hundred files were retrospectively assessed through paper and electronic records of patients admitted to the hospital with an International Classification of Diseases, Ninth Edition diagnosis of schizophrenia (eg, code 295...
March 12, 2020: Primary Care Companion to CNS Disorders
Yuki Takahashi, Katsunaka Mikami, Fumiaki Akama, Yuichi Onishi, Kenji Yamamoto, Hideo Matsumoto
The condition of periodic psychosis of adolescence based on the clinical features of recurrent depressive symptoms, sub-stupor, and psychotic symptoms whose features return to a normal state within 2 weeks with no residual symptoms has been often seen during adolescence. However, international recognition of periodic psychosis of adolescence is low and the condition is not recognized as an independent disease in ICD-10 or DSM-5. We presented a case report of a depressive episode central to periodic psychosis of adolescence in a 16-year old female...
April 20, 2020: Tokai Journal of Experimental and Clinical Medicine
Julia M Sheffield, Anna S Huang, Baxter P Rogers, Monica Giraldo-Chica, Bennett A Landman, Jennifer Urbano Blackford, Stephan Heckers, Neil D Woodward
BACKGROUND: Anatomical connectivity between the thalamus and cortex, including the prefrontal cortex (PFC), is abnormal in schizophrenia. Overlapping phenotypes, including deficits in executive cognitive abilities dependent on PFC-thalamic circuitry, suggest dysrupted thalamocortical anatomical connectivity may extend to psychotic bipolar disorder. We tested this hypothesis and examined the impact of illness stage to inform when in the illness course thalamocortical dysconnectivity emerges...
March 27, 2020: Schizophrenia Bulletin
Wai Tong Chien, Ka Ming Chow, Yuen Yu Chong, Daniel Bressington, Kai Chow Choi, Carmen Wing Han Chan
Objective: This study aimed to examine how five facets of mindfulness may be associated with the changes in psychotic patients' health outcomes after participating in a mindfulness-based psychoeducation group (MBPEG) program. Methods: Longitudinal follow-up data from two pragmatic randomized controlled trials of MBPEG for psychotic patients were used for this study. A total of 124 patients who completed the MBPEG program were included in this analysis. Patient outcomes (psychotic symptoms, functioning, insight into illness/treatment, subjective recovery) and five facets of mindfulness were assessed at baseline and six, 12 and 24 months post-intervention...
2020: Frontiers in Psychiatry
Dong-Ni Pan, Delhii Hoid, Zhen-Hao Wang, Yi Wang, Xuebing Li
Although impaired ability to regulate emotion is commonly reported in schizophrenic patients, the exact pattern of regulation of negative emotions in high-risk individuals remains unclear. In the current study, 26 high-schizotypy individuals paired with 26 controls completed an emotion regulation questionnaire (ERQ) and a laboratory emotion regulation task with electroencephalogram (EEG) recording. Two emotion regulation strategies, namely, reappraisal and expression suppression, were concurrently examined...
March 26, 2020: Scientific Reports
Lamia Sid-Otmane, Philippe Huot, Michel Panisset
OBJECTIVES: The treatment of Parkinson disease (PD) psychosis remains a challenge. Only a few treatments eliciting significant relief of psychotic symptoms have passed the test of randomized controlled trials. METHODS: Here, we conducted a review of the literature on the effect of antidepressants on PD psychosis. Because there is no randomized controlled trial that assessed the antipsychotic effects of antidepressants in PD, only case reports, case series, and open-label trials were available to review...
March 24, 2020: Clinical Neuropharmacology
Christopher M Jones, Wilson M Compton, Desiree Mustaquim
Methamphetamine is a highly addictive central nervous system stimulant. Methamphetamine use is associated with a range of health harms, including psychosis and other mental disorders, cardiovascular and renal dysfunction, infectious disease transmission, and overdose (1,2). Although overall population rates of methamphetamine use have remained relatively stable in recent years (3), methamphetamine availability and methamphetamine-related harms (e.g., methamphetamine involvement in overdose deaths and number of treatment admissions) have increased in the United States* (4,5); however, analyses examining methamphetamine use patterns and characteristics associated with its use are limited...
March 27, 2020: MMWR. Morbidity and Mortality Weekly Report
Scott D Blain, Julia M Longenecker, Rachael G Grazioplene, Bonnie Klimes-Dougan, Colin G DeYoung
Positive symptoms of schizophrenia and its extended phenotype-often termed psychoticism or positive schizotypy-are characterized by the inclusion of novel, erroneous mental contents. One promising framework for explaining positive symptoms involves apophenia, conceptualized here as a disposition toward false-positive errors. Apophenia and positive symptoms have shown relations to openness to experience (more specifically, to the openness aspect of the broader openness/intellect domain), and all of these constructs involve tendencies toward pattern seeking...
April 2020: Journal of Abnormal Psychology
(no author information available yet)
Reports an error in "Temporal associations between sleep quality and paranoia across the paranoia continuum: An experience sampling study" by Zuzana Kasanova, Michal Hajdúk, Viviane Thewissen and Inez Myin-Germeys ( Journal of Abnormal Psychology , 2020[Jan], Vol 129[1], 122-130). In the article, the affiliation for Inez Myin-Germeys should have included the School for Mental Health and Neuroscience, Maastricht University. In addition, the following acknowledgment of funding was missing from the author note: "This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 777084...
April 2020: Journal of Abnormal Psychology
Craig Cumming, Stuart A Kinner, Rebecca McKetin, Ian Li, David Preen
ISSUES: Methamphetamine use is a problem for health and criminal justice systems (CJS) worldwide. Methamphetamine is used at higher rates in CJS-involved populations than the general community. This systematic review synthesises the evidence for health and CJS outcomes post-CJS contact for people reporting pre-CJS methamphetamine use. APPROACH: Academic databases were searched to identify peer-reviewed original studies using a longitudinal design that investigated associations between pre-CJS methamphetamine use and health and criminal justice outcomes after CJS contact...
March 24, 2020: Drug and Alcohol Review
Tineke Grent-'t-Jong, Ruchika Gajwani, Joachim Gross, Andrew I Gumley, Rajeev Krishnadas, Stephen M Lawrie, Matthias Schwannauer, Frauke Schultze-Lutter, Peter J Uhlhaas
Importance: Psychotic disorders are characterized by impairments in neural oscillations, but the nature of the deficit, the trajectory across illness stages, and functional relevance remain unclear. Objectives: To examine whether changes in spectral power, phase locking, and functional connectivity in visual cortex are present during emerging psychosis and whether these abnormalities are associated with clinical outcomes. Design, Setting, and Participants: In this cross-sectional study, participants meeting clinical high-risk criteria for psychosis, participants with first-episode psychosis, participants with affective disorders and substance abuse, and a group of control participants were recruited...
March 25, 2020: JAMA Psychiatry
Angie Ho Yan Lam, Sau Fong Leung, Jessie Jingxia Lin, Wai Tong Chien
Background: Emotion dysregulation has emerged as a transdiagnostic factor that potentially exacerbates the risk of early-onset, maintenance, and relapse of psychosis. Mindfulness is described as the awareness that emerges from paying attention to the present moment without judgment. It gently pulls the mind out of the negative emotions induced by the disparity between expectation and reality by focusing on the present moment, instead of worrying about the future or regretting the past...
2020: Neuropsychiatric Disease and Treatment
David Kimhy, Amanda Lister, Ying Liu, Julia Vakhrusheva, Philippe Delespaul, Dolores Malaspina, Luz H Ospina, Vijay A Mittal, James J Gross, Yuanjia Wang
Emotion regulation (ER) difficulties are ubiquitous among individuals with schizophrenia and have been hypothesized to contribute to stress sensitivity and exacerbation of psychotic symptoms in this population. However, the evidence supporting this link is equivocal, potentially due to previous studies' reliance on retrospective assessments of ER and psychosis, as well as lack of consideration of putative moderators such as emotion awareness. To address these limitations, we employed experience sampling method using mobile electronic devices to investigate the links between momentary in vivo use of ER strategies (m ER), emotion awareness, and psychotic symptoms during daily functioning...
March 24, 2020: NPJ Schizophrenia
Stefano Damiani, Laura Fusar-Poli, Natascia Brondino, Umberto Provenzani, Helen Baldwin, Paolo Fusar-Poli, Pierluigi Politi
The psychosis spectrum comprises heterogeneous disorders characterized by both world-related and self-related symptoms. How these symptoms may arise with similar features in spite of the different aetiologies is yet an unsolved question. In behavior narrative review, we compare three conditions characterized by psychotic experiences (schizophrenia, substance-use disorder and sensory-deprivation) searching for links between their phenomenological features and the mechanisms underlying their onset. Clinically, psychotic experiences are characterized by the reciprocal contamination of world- and self-related contents, termed 'world/self ambivalence'...
March 18, 2020: Psychiatry Research. Neuroimaging
Shalini Lal, Danielle Joanna Starcevic, Rebecca Fuhrer
BACKGROUND: Youth mental health is an important public health concern affecting low-, middle-, and high-income countries, and many young people in need of mental health services do not receive the care they need when they need it. An early step in accessing mental health care is the referral process, yet most of the research done on pathways to care has focused on clinical populations (eg, first-episode psychosis) recruited from mental health care settings. There has been limited research attention on the experiences of referral to mental health services from the perspectives of youth recruited from the general population who may or may not have received the services they need...
March 24, 2020: JMIR Research Protocols
J R Zinkstok, F Velders, R Rieken, M Houben, A Fiksinski, T A M J van Amelsvoort, E Boot
The 22q11.2 deletion syndrome (22q11.2ds) is a genetic syndrome affecting multiple organ systems and is associated with increased risk of developing neuropsychiatric disorders. We describe a 15-year old female adolescent with 22q11.2ds, psychotic disorder, and catatonia. Individuals with 22q11.2ds are at increased risk of developing catatonia. Vulnerability for developing extrapyramidal symptoms and epileptic seizures may complicate pharmacological treatment for psychotic episodes. There may be a diagnostic delay of diagnosing Parkinson's disease in patients taking antipsychotics as parkinsonism may be viewed as a side effect...
2020: Tijdschrift Voor Psychiatrie
Kara Dempster, Peter Jeon, Michael MacKinley, Peter Williamson, Jean Théberge, Lena Palaniyappan
Early response to antipsychotic medications is one of the most important determinants of later symptomatic and functional outcomes in psychosis. Glutathione and glutamate have emerged as promising therapeutic targets for patients demonstrating inadequate response to dopamine-blocking antipsychotics. Nevertheless, the role of these neurochemicals in the mechanism of early antipsychotic response remains poorly understood. Using a longitudinal design and ultrahigh field 7-T magnetic resonance spectroscopy (MRS) protocol in 53 subjects, we report the association between dorsal anterior cingulate cortex glutamate and glutathione, with time to treatment response in drug naive (34...
March 24, 2020: Molecular Psychiatry
Cpt Kendra Parker-Pitts, Cpt Wells Weymouth, Maj Thomas Frawley
BACKGROUND: Intrathecal Baclofen (ITB) has become an increasingly common treatment for severe muscle spasticity associated with conditions such as cerebral palsy and spinal cord injury. Classically, withdrawal symptoms mimic symptoms of serotonin syndrome with hypertension, increased spasticity, clonus, hyperthermia, tachycardia, and possibly acute psychosis. Hypotension, muscle flaccidity, and respiratory depression are generally considered symptoms of toxicity or overdose. CASE REPORT: We present the case of a male with recent ITB pump revision who presented with autonomic features suggestive of Baclofen withdrawal, while the remainder of his physical examination suggested appropriate medication dosing...
March 20, 2020: Journal of Emergency Medicine
Bruno Romeo, Amelie Petillion, Catherine Martelli, Amine Benyamina
INTRODUCTION: Even though anomalies on brain metabolites have been found in schizophrenia, researches about subjects with high risk (HR) show heterogeneous results. Thus, this meta-analysis aims to characterize the metabolic profile of HR subjects, first, compared to controls (HC) and then compared to people with schizophrenia. METHODS: After a systematic database search, means and standard deviations were extracted to calculate standardized mean differences (SMD)...
March 16, 2020: Journal of Psychiatric Research
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