Mattia Campana, Vladislav Yakimov, Joanna Moussiopoulou, Isabel Maurus, Lisa Löhrs, Florian Raabe, Iris Jäger, Matin Mortazavi, Michael E Benros, Rose Jeppesen, Gerd Meyer Zu Hörste, Michael Heming, Eloi Giné-Servén, Javier Labad, Ester Boix, Belinda Lennox, Ksenija Yeeles, Johann Steiner, Gabriela Meyer-Lotz, Henrik Dobrowolny, Berend Malchow, Niels Hansen, Peter Falkai, Spyridon Siafis, Stefan Leucht, Sean Halstead, Nicola Warren, Dan Siskind, Wolfgang Strube, Alkomiet Hasan, Elias Wagner
Neuroinflammation and blood-cerebrospinal fluid barrier (BCB) disruption could be key elements in schizophrenia-spectrum disorderś(SSDs) etiology and symptom modulation. We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases...
April 10, 2024: Brain, Behavior, and Immunity