Wei E Gordon, Seungbyn Baek, Hai P Nguyen, Yien-Ming Kuo, Rachael Bradley, Sarah L Fong, Nayeon Kim, Alex Galazyuk, Insuk Lee, Melissa R Ingala, Nancy B Simmons, Tony Schountz, Lisa Noelle Cooper, Ilias Georgakopoulos-Soares, Martin Hemberg, Nadav Ahituv
Frugivory evolved multiple times in mammals, including bats. However, the cellular and molecular components driving it remain largely unknown. Here, we use integrative single-cell sequencing (scRNA-seq and scATAC-seq) on insectivorous (Eptesicus fuscus; big brown bat) and frugivorous (Artibeus jamaicensis; Jamaican fruit bat) bat kidneys and pancreases and identify key cell population, gene expression and regulatory differences associated with the Jamaican fruit bat that also relate to human disease, particularly diabetes...
January 9, 2024: Nature Communications