Yan Shen, Zu-yi Yuan, Yan Liu, Yan Xiao, Yue Wu, Yan Zhao, Yu-ling Tian, Wei-min Liu, Li-jun Wang, Xiao Liang, Tao Chen, Tao Geng
OBJECTIVE: To establish a uremic apolipoprotein E knockout (apoE-/-) mouse model and explore the relationship between accelerated atherosclerosis and Treg/Teff balance. METHODS: Using apoE-/- mice with C57BL/6J background, uremic apoE-/- mice were created by electrocautery of the right kidney and nephrectomy of the left, and the control apoE-/- mice received a sham-operation. Two weeks after inducing uremia, the renal function of the mice were evaluated to assess the validity of the model...
February 2010: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University