Kathy Liu, Mario Russo, Joshua S Ellis, John Di Capua, Sara Zhao, Sanjeeva Kalva, Ronald S Arellano, Zubin Irani, Raul Uppot, Stephen W Linderman, Joanna Aizenberg, Shriya Srinivasan, Avik Som
Image-guided tumor ablative therapies are mainstay cancer treatment options, but often require intra-procedural protective tissue displacement to reduce the risk of collateral damage to neighboring organs. Standard of care (SoC) strategies, such as hydrodissection (fluidic injection), are limited by rapid diffusion of fluid and poor retention time, risking injury to adjacent organs, increased cancer recurrence rates from incomplete tumor ablations, and limited patient qualification. Herein, we developed "gel-dissection," a technique leveraging injectable hydrogels for longer-lasting, shapeable, and transient tissue separation, empowering clinicians with improved ablation operation windows and greater control...
April 28, 2024: Advanced Healthcare Materials