keyword
https://read.qxmd.com/read/38547058/nsun5-tet2-directed-chromatin-associated-rna-modification-of-5-methylcytosine-to-5-hydroxymethylcytosine-governs-glioma-immune-evasion
#1
JOURNAL ARTICLE
Ruixin Wu, Chunming Sun, Xi Chen, Runyue Yang, Yuxuan Luan, Xiang Zhao, Panpan Yu, Rongkui Luo, Yingyong Hou, Ruotong Tian, Shasha Bian, Yuli Li, Yinghua Dong, Qian Liu, Weiwei Dai, Zhuoyang Fan, Rucheng Yan, Binyang Pan, Siheng Feng, Jing Wu, Fangzhen Chen, Changle Yang, Hanlin Wang, Haochen Dai, Minfeng Shu
Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5-methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA metabolism remains unclear, as does the contribution of m5C-modified RNA to the glioma immune microenvironment. In this study, we demonstrate that the canonical 28SrRNA methyltransferase NSUN5 down-regulates β-catenin by promoting the degradation of its mRNA, leading to enhanced phagocytosis of tumor-associated macrophages (TAMs)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38546944/a-phase-1-study-of-intravenous-egfr-erbituxedvsmit-in-children-with-solid-or-cns-tumours-expressing-epidermal-growth-factor-receptor
#2
JOURNAL ARTICLE
Louise Evans, Rick Walker, Jennifer MacDiarmid, Himanshu Brahmbhatt, Antoinette Anazodo, Geoffrey McCowage, Andrew J Gifford, Maria Kavallaris, Toby Trahair, David S Ziegler
BACKGROUND: Recurrent or refractory solid and central nervous system (CNS) tumours in paediatric patients have limited treatment options and carry a poor prognosis. The EnGeneIC Dream Vector (EDV) is a novel nanocell designed to deliver cytotoxic medication directly to the tumour. The epidermal growth factor receptor is expressed in several CNS and solid tumours and is the target for bispecific antibodies attached to the EDV. OBJECTIVE: To assess the safety and tolerability of EGFR-Erbitux receptor EnGeneIC Dream Vector with mitoxantrone (E EDVsMit ) in children with recurrent / refractory solid or CNS tumours expressing EGFR...
March 28, 2024: Targeted Oncology
https://read.qxmd.com/read/38546941/novel-clinical-trials-and-approaches-in-the-management-of-glioblastoma
#3
REVIEW
Allison R Valerius, Lauren M Webb, Ugur Sener
PURPOSE OF REVIEW: The purpose of this review is to discuss a wide variety of novel therapies recently studied or actively undergoing study in patients with glioblastoma. This review also discusses current and future strategies for improving clinical trial design in patients with glioblastoma to maximize efficacy in discovering effective treatments. RECENT FINDINGS: Over the years, there has been significant expansion in therapy modalities studied in patients with glioblastoma...
March 28, 2024: Current Oncology Reports
https://read.qxmd.com/read/38546389/identification-of-a-novel-disulfideptosis-related-gene-signature-for-prognostic-implication-in-lower-grade-gliomas
#4
JOURNAL ARTICLE
Fuqiang Zhang, Meihong Lv, Yi He
Lower-grade gliomas (GBMLGG) are common, fatal, and difficult-to-treat cancers. The current treatment choices have impressive efficacy constraints. As a result, the development of effective treatments and the identification of new therapeutic targets are urgent requirements. Disulfide metabolism is the cause of the non-apoptotic programmed cell death known as disulfideptosis, which was only recently discovered. The mRNA expression data and related clinical information of GBMLGG patients downloaded from public databases were used in this study to investigate the prognostic significance of genes involved in disulfideptosis...
March 27, 2024: Aging
https://read.qxmd.com/read/38545470/dna-damage-induced-apoptosis-suppressor-triggers-progression-and-stemness-of-glioma-by-enhancing-lymphoid-enhancer-binding-factor-1-expression
#5
JOURNAL ARTICLE
You Lin Chen, Yi Liu, Yan Xu, An Qiang Yang, Gui Jie Chen, Jin Shan Xing, Hong Wei Su, Li Shang Liao
BACKGROUND: DNA damage-induced apoptosis suppressor (DDIAS) has recently been discovered to induce cancer progression, but its functions and mechanisms in glioma have not been well studied. METHODS: DDIAS expression in glioma tissues was analyzed by the Gene Expression Profiling Interactive Analysis server (GEPIA) and the Gene Expression database of Normal and Tumor tissue 2 (GENT2) databases. The role of DDIAS in glioma progression was studied by short hairpin RNA (shRNA) targeting DDIAS...
April 2024: World Journal of Oncology
https://read.qxmd.com/read/38545061/whole-tumor-histogram-analysis-of-synthetic-magnetic-resonance-imaging-predicts-isocitrate-dehydrogenase-mutation-status-in-gliomas
#6
JOURNAL ARTICLE
Xin Ge, Tiejun Gan, Zhihua Yang, Guangyao Liu, Wanjun Hu, Wenfu Ma, Yuping Bai, Yuhui Xiong, Min Li, Jianguo Zhao, Liang Zhou, Jiachen Li, Darui Li, Xiaodong Wang, Jing Zhang
BACKGROUND: An accurate assessment of isocitrate dehydrogenase (IDH) status in patients with glioma is crucial for treatment planning and is a key factor in predicting patient outcomes. In this study, we investigated the potential value of whole-tumor histogram metrics derived from synthetic magnetic resonance imaging (MRI) in distinguishing IDH mutation status between astrocytoma and glioblastoma. METHODS: In this prospective study, 80 glioma patients were enrolled from September 2019 to June 2022...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38544831/corrigendum-glioblastoma-survival-is-associated-with-distinct-proteomic-alteration-signatures-post-chemoirradiation-in-a-large-scale-proteomic-panel
#7
Andra Valentina Krauze, Michael Sierk, Trinh Nguyen, Qingrong Chen, Chunhua Yan, Ying Hu, William Jiang, Erdal Tasci, Theresa Cooley Zgela, Mary Sproull, Megan Mackey, Uma Shankavaram, Daoud Meerzaman, Kevin Camphausen
[This corrects the article DOI: 10.3389/fonc.2023.1127645.].
2024: Frontiers in Oncology
https://read.qxmd.com/read/38544404/comparison-of-dynamic-susceptibility-contrast-dsc-using-gadolinium-and-iron-based-contrast-agents-in-high-grade-glioma-at-high-field-mri
#8
JOURNAL ARTICLE
Doonyaporn Wongsawaeng, Daniel Schwartz, Xin Li, Leslie L Muldoon, Jared Stoller, Cooper Stateler, Samantha Holland, Laszlo Szidonya, William D Rooney, Cory Wyatt, Prakash Ambady, Rongwei Fu, Edward A Neuwelt, Ramon F Barajas
PURPOSE: To compare DSC-MRI using Gadolinium (GBCA) and Ferumoxytol (FBCA) in high-grade glioma at 3T and 7T MRI field strengths. We hypothesized that using FBCA at 7T would enhance the performance of DSC, as measured by contrast-to-noise ratio (CNR). METHODS: Ten patients (13 lesions) were assigned to 3T (6 patients, 6 lesions) or 7T (4 patients, 7 lesions). All lesions received 0.1 mmol/kg of GBCA on day 1. Ten lesions (4 at 3T and 6 at 7T) received a lower dose (0...
March 27, 2024: Neuroradiology Journal
https://read.qxmd.com/read/38544395/casc19-an-oncogenic-long-non-coding-rna-in-different-cancers
#9
JOURNAL ARTICLE
Yinxin Wu, Jie Mou, Gang Zhou, Chengfu Yuan
A 324 bp lncRNA called CASC19 is found on chromosome 8q24.21. Recent research works have revealed that CASC19 is involved in the prognosis of tumors and related to the regulation of the radiation tolerance mechanisms during tumor radiotherapy (RT). This review sheds light on the changes and roles that CASC19 plays in many tumors and diseases, such as nasopharyngeal carcinoma (NPC), cervical cancer, colorectal cancer (CRC), non-small cell lung cancer (NSCLC), clear cell renal cell carcinoma (ccRCC), gastric cancer (GC), pancreatic cancer (PC), hepatocellular carcinoma (HCC), glioma, and osteoarthritis (OA)...
March 27, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38544393/effects-of-glutamine-synthetase-on-neovascularization-in-glioma-in-vivo-mr-vessel-size-imaging-and-histology
#10
JOURNAL ARTICLE
Tianwei Song, Dandan Wang, Yanan Zhang, Hong Hao, Guodong Li, Xiping Ding, Zongtao Hu, Zhi Zhang, Yan Liu, Hongzhi Wang, Xianglin Li, Junchao Qian
BACKGROUND: Glutamine Synthetase (GS) could induce vascular sprouting through the improvement of endothelial cell migration in inflammatory diseases. MR vessel-size imaging has been proposed as a valuable approach for visualizing the underlying angiogenic processes in the brain. OBJECTIVE: This study aims to investigate the role of GS in the neovascularization of gliomas through the utilization of MR vessel-size imaging and histopathological techniques. METHODS: In this exploratory animal study, we randomly divided the C6 glioma rat models into a control group and an L-methionine sulfoximine (MSO) treatment group...
March 27, 2024: Current medical imaging
https://read.qxmd.com/read/38543223/navigating-the-nose-to-brain-route-a-systematic-review-on-lipid-based-nanocarriers-for-central-nervous-system-disorders
#11
REVIEW
Edoardo Agosti, Marco Zeppieri, Sara Antonietti, Luigi Battaglia, Tamara Ius, Caterina Gagliano, Marco Maria Fontanella, Pier Paolo Panciani
BACKGROUND: The blood-brain barrier (BBB) regulates brain substance entry, posing challenges for treating brain diseases. Traditional methods face limitations, leading to the exploration of non-invasive intranasal drug delivery. This approach exploits the direct nose-to-brain connection, overcoming BBB restrictions. Intranasal delivery enhances drug bioavailability, reduces dosage, and minimizes systemic side effects. Notably, lipid nanoparticles, such as solid lipid nanoparticles and nanostructured lipid carriers, offer advantages like improved stability and controlled release...
February 27, 2024: Pharmaceutics
https://read.qxmd.com/read/38543086/magnetic-hyperthermia-therapy-for-high-grade-glioma-a-state-of-the-art-review
#12
REVIEW
Benjamin Rodriguez, Daniel Rivera, Jack Y Zhang, Cole Brown, Tirone Young, Tyree Williams, Sakibul Huq, Milena Mattioli, Alexandros Bouras, Constantinos G Hadjpanayis
Magnetic hyperthermia therapy (MHT) is a re-emerging treatment modality for brain tumors where magnetic nanoparticles (MNPs) are locally delivered to the brain and then activated with an external alternating magnetic field (AMF) to generate localized heat at a site of interest. Due to the recent advancements in technology and theory surrounding the intervention, clinical and pre-clinical trials have demonstrated that MHT may enhance the effectiveness of chemotherapy and radiation therapy (RT) for the treatment of brain tumors...
February 26, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542334/bone-morphogenic-proteins-in-pediatric-diffuse-midline-gliomas-how-to-make-new-out-of-old
#13
REVIEW
Clément Berthelot, Paul Huchedé, Adrien Bertrand-Chapel, Pierre-Aurélien Beuriat, Pierre Leblond, Marie Castets
The BMP pathway is one of the major signaling pathways in embryonic development, ontogeny and homeostasis, identified many years ago by pioneers in developmental biology. Evidence of the deregulation of its activity has also emerged in many cancers, with complex and sometimes opposing effects. Recently, its role has been suspected in Diffuse Midline Gliomas (DMG), among which Diffuse Intrinsic Pontine Gliomas (DIPG) are one of the most complex challenges in pediatric oncology. Genomic sequencing has led to understanding part of their molecular etiology, with the identification of histone H3 mutations in a large proportion of patients...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542198/repurposed-drugs-celecoxib-and-fmoc-l-leucine-alone-and-in-combination-as-temozolomide-resistant-antiglioma-agents-comparative-studies-on-normal-and-immortalized-cell-lines-and-on-c-elegans
#14
JOURNAL ARTICLE
Łukasz Uram, Natalia Pieńkowska, Maria Misiorek, Żaneta Szymaszek, Magdalena Twardowska, Michał Siorek, Stanisław Wołowiec
Glioblastoma multiforme therapy remains a significant challenge since there is a lack of effective treatment for this cancer. As most of the examined gliomas express or overexpress cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptors γ (PPARγ), we decided to use these proteins as therapeutic targets. Toxicity, antiproliferative, proapoptotic, and antimigratory activity of COX-2 inhibitor (celecoxib-CXB) and/or PPARγ agonist (Fmoc-L-Leucine-FL) was examined in vitro on temozolomide resistant U-118 MG glioma cell line and comparatively on BJ normal fibroblasts and immortalized HaCaT keratinocytes...
March 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542090/abcg2-expression-as-a-potential-survival-predictor-in-human-gliomas
#15
JOURNAL ARTICLE
Marina Raguž, Marko Tarle, Danko Müller, Čedna Tomasović-Lončarić, Hana Chudy, Tonko Marinović, Darko Chudy
Gliomas are notably challenging to treat due to their invasive nature and resistance to conventional therapies. The ABCG2 protein has attracted attention for its role in multidrug resistance, complicating treatment effectiveness. This study scrutinized the relationship between ABCG2 expression and glioma grade and the role of ABCG2 in the process of glioma progression, aiming to evaluate ABCG2 expression as a predictive factor of tumor progression and patient survival. Conducted at Dubrava University Hospital, Zagreb, Croatia, the study analyzed 152 glioma specimens from 2013 to 2022, assessing ABCG2 expression alongside standard clinical markers...
March 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541684/radiosensitization-of-allogenic-subcutaneous-c6-glioma-model-with-focused-ultrasound-induced-mild-hyperthermia
#16
JOURNAL ARTICLE
Zhiyuan Xu, David Schlesinger, Robert Andrew Drainville, David Moore, Patcharin Pramoonjago, Jason Sheehan, Frederic Padilla
The radiosensitization potential of focused ultrasound (FUS)-induced mild hyperthermia was assessed in an allogenic subcutaneous C6 glioma tumor model in rats. Mild hyperthermia at 42 °C was induced in tumors using a single-element 350 kHz FUS transducer. Radiation was delivered with a small animal radiation research platform using a single-beam irradiation technique. The combined treatment involved 20 min of FUS hyperthermia immediately before radiation. Tumor growth changes were observed one week post-treatment...
March 9, 2024: Life
https://read.qxmd.com/read/38540734/identification-and-validation-of-a-pex5-dependent-signature-for-prognostic-prediction-in-glioma
#17
JOURNAL ARTICLE
Xuhui Qin, Bing Wang, Xia Lu, Yanyang Song, Wei Wang
Gliomas, the most prevalent and lethal form of brain cancer, are known to exhibit metabolic alterations that facilitate tumor growth, invasion, and resistance to therapies. Peroxisomes, essential organelles responsible for fatty acid oxidation and reactive oxygen species (ROS) homeostasis, rely on the receptor PEX5 for the import of metabolic enzymes into their matrix. However, the prognostic significance of peroxisomal enzymes for glioma patients remains unclear. In this study, we elucidate that PEX5 is indispensable for the cell growth, migration, and invasion of glioma cells...
March 6, 2024: Biomolecules
https://read.qxmd.com/read/38540119/comprehensive-transcriptomic-profiling-of-diverse-brain-tumor-types-uncovers-complex-structures-of-the-brain-tumor-microenvironment
#18
JOURNAL ARTICLE
Jiin Choi, Hee Jin Cho
Various types of brain tumors occur in both children and adults. These tumors manifest with different characteristics such as malignancy, cellular lineage, location of origin, and genomic profile. Recently, immunotherapy, which manipulates immune cells in the tumor microenvironment (TME) to kill tumor cells, has attracted attention as a treatment strategy for tumors. Here, we analyzed the transcriptomic architecture of the brain tumor microenvironment to provide potential guidelines to overcome the therapeutic vulnerabilities to brain tumors...
February 23, 2024: Biomedicines
https://read.qxmd.com/read/38539663/gene-expression-of-gaba-a-receptor-subunits-and-association-with-patient-survival-in-glioma
#19
JOURNAL ARTICLE
Rafael Badalotti, Matheus Dalmolin, Osvaldo Malafaia, Jurandir M Ribas Filho, Rafael Roesler, Marcelo A C Fernandes, Gustavo R Isolan
Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABAA receptors. The GABRA5 gene, which encodes the α5 subunit of the GABAA receptor, has been implicated in an aggressive subgroup of medulloblastoma (MB), a type of pediatric brain tumor. However, the possible role of GABAA receptor subunits in glioma remains poorly understood. Here, we examined the expression of genes encoding GABAA receptor subunits in different types of glioma, and its possible association with patient prognosis assessed by overall survival (OS)...
March 14, 2024: Brain Sciences
https://read.qxmd.com/read/38539603/qualitative-and-visual-along-tract-analysis-of-diffusion-based-parameters-in-patients-with-diffuse-gliomas
#20
JOURNAL ARTICLE
Markus Fahlström, Sadia Mirza, Åsa Alberius Munkhammar, Maria Zetterling, Francesco Latini
BACKGROUND: Grade 2-3 diffuse gliomas (DGs) show extensive infiltration through white matter (WM) tracts. Along-tract analysis of WM tracts based on diffusion tensor tractography (DTI) can been performed to assess the microstructural integrity of WM tracts. The clinical implication of these DTI-related findings is still under debate, especially in tumor patients. The aim of this study was to analyze and compare diffusion-based parameters along WM tracts and variables specific to WM -tumor interactions in DGs and correlate them with preoperative neuropsychological assessment...
February 26, 2024: Brain Sciences
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