Sabina Ranjit, Yao Wang, Jingwen Zhu, Satish B Cheepala, Erin G Schuetz, Woo Jung Cho, Beisi Xu, Camenzind G Robinson, Gang Wu, Anjaparavanda P Naren, John D Schuetz
The role of ABCC4, an ATP-binding cassette transporter, in the process of platelet formation, megakaryopoiesis, is unknown. Here, we show that ABCC4 is highly expressed in megakaryocytes (MKs). Mining of public genomic data (ATAC-seq and genome wide chromatin interactions, Hi-C) revealed that key megakaryopoiesis transcription factors (TFs) interacted with ABCC4 regulatory elements and likely accounted for high ABCC4 expression in MKs. Importantly these genomic interactions for ABCC4 ranked higher than for genes with known roles in megakaryopoiesis suggesting a role for ABCC4 in megakaryopoiesis...
November 8, 2023: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy