Benjamin A Kansy, Tim P Wehrs, Kirsten Bruderek, Yu Si, Sonja Ludwig, Freya Droege, Pia Hasskamp, Uta Henkel, Nina Dominas, Thomas K Hoffmann, Peter A Horn, Martin Schuler, Thomas C Gauler, Monika Lindemann, Stephan Lang, Agnes Bankfalvi, Sven Brandau
Patients with HPV- -localized head and neck cancer (HNC) show inferior outcomes after surgery and radiochemotherapy compared to HPV-associated cancers. The underlying mechanisms remain elusive, but differences in immune status and immune activity may be implicated. In this study, we analyzed immune profiles of CD8+ T cells and myeloid-derived suppressor cells (MDSC) in HPV+ versus HPV- disease.The overall frequency of CD8+ T cells was reduced in HNC versus healthy donors but substantially increased after curative therapy (surgery and/or radiochemotherapy)...
November 29, 2023: Cancer Immunology, Immunotherapy: CII