Gul Pelin Odabas, Kubra Aslan, Pinar Alisan Suna, Perihan Kader Kendirli, Şerife Erdem, Mustafa Çakır, Alper Özcan, Ebru Yılmaz, Musa Karakukcu, Hamiyet Donmez-Altuntas, Arzu Hanim Yay, Kemal Deniz, Derya Altay, Duran Arslan, Halit Canatan, Ahmet Eken, Ekrem Unal
The anti-inflammatory and immunosuppressive drugs which are used in the treatment of Graft-versus-Host Disease (GVHD) have limited effects in controlling the severity of the disease. In this study, we aimed to investigate the prophylactic effect of Alantolactone (ALT) in a murine model of experimental GVHD. The study included 4 BALB/c groups as hosts: Naïve (n = 7), Control GVHD (n = 16), ALT-GVHD (n = 16), and Syngeneic transplantation (n = 10). Busulfan (20 mg/kg/day) for 4 days followed by cyclophosphamide (100 mg/kg/day) were administered for conditioning...
January 20, 2024: International Immunopharmacology