Qiuhan Huang, Caroline Trumpff, Anna S Monzel, Shannon Rausser, Rachel Haahr, Jack Devine, Cynthia C Liu, Catherine Kelly, Elizabeth Thompson, Mangesh Kurade, Jeremy Michelson, Evan D Shaulson, Shufang Li, Kris Engelstad, Kurenai Tanji, Vincenzo Lauriola, Tian Wang, Shuang Wang, Faris M Zuraikat, Marie-Pierre St-Onge, Brett A Kaufman, Richard Sloan, Robert-Paul Juster, Anna L Marsland, Gilles Gouspillou, Michio Hirano, Martin Picard
GDF15 (growth differentiation factor 15) is a marker of cellular energetic stress linked to physical-mental illness, aging, and mortality. However, questions remain about its dynamic properties and measurability in human biofluids other than blood. Here, we examine the natural dynamics and psychobiological regulation of plasma and saliva GDF15 in four human studies representing 4,749 samples from 188 individuals. We show that GDF15 protein is detectable in saliva (8% of plasma concentration), likely produced by salivary glands secretory duct cells...
April 21, 2024: bioRxiv