Lin Wang, Xiaoyu Zhang, Jiayan Shen, Yuanyuan Wei, Ting Zhao, Niqin Xiao, Xiaoman Lv, Dongdong Qin, Yundong Xu, Yang Zhou, Jing Xie, Zhaofu Li, Zhaohu Xie
Gouty nephropathy (GN) is a metabolic disease with persistently elevated blood uric acid levels. The main manifestations of GN are crystalline kidney stones, chronic interstitial nephritis, and renal fibrosis. Understanding the mechanism of the occurrence and development of GN is crucial to the development of new drugs for prevention and treatment of GN. Currently, most studies exploring the pathogenesis of GN are primarily based on animal and cell models. Numerous studies have shown that inflammation, oxidative stress, and programmed cell death mediated by uric acid and sodium urate are involved in the pathogenesis of GN...
2024: Frontiers in Medicine