Tae-Hwi Schwantes-An, John B Whitfield, Guruprasad P Aithal, Stephen R Atkinson, Ramon Bataller, Greg Botwin, Naga P Chalasani, Heather J Cordell, Ann K Daly, Rebecca Darlay, Christopher P Day, Florian Eyer, Tatiana Foroud, Samer Gawrieh, Dermot Gleeson, David Goldman, Paul S Haber, Jean-Marc Jacquet, Craig S Lammert, Tiebing Liang, Suthat Liangpunsakul, Steven Masson, Philippe Mathurin, Romain Moirand, Andrew McQuillin, Christophe Moreno, Marsha Y Morgan, Sebastian Mueller, Beat Müllhaupt, Laura E Nagy, Pierre Nahon, Bertrand Nalpas, Sylvie Naveau, Pascal Perney, Munir Pirmohamed, Helmut K Seitz, Michael Soyka, Felix Stickel, Andrew Thompson, Mark R Thursz, Eric Trépo, Timothy R Morgan, Devanshi Seth
BACKGROUND: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-associated cirrhosis by comparing single-nucleotide polymorphisms among patients with alcohol-associated cirrhosis (ALC) versus drinkers who did not have evidence of liver fibrosis/cirrhosis. METHODS: Using a data-driven approach, a PRS for ALC was generated using a meta-genome-wide association study of ALC (N=4305) and an independent cohort of heavy drinkers with ALC and without significant liver disease (N=3037)...
June 1, 2024: Hepatology Communications