Tristram A Lett, Nilakshi Vaidya, Tianye Jia, Elli Polemiti, Tobias Banaschewski, Arun L W Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brüh, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomáš Paus, Luise Poustka, Argyris Stringaris, Lea Waller, Zuo Zhang, Lauren Robinson, Jeanne Winterer, Yuning Zhang, Sinead King, Michael N Smolka, Robert Whelan, Ulrike Schmidt, Julia Sinclair, Henrik Walter, Jianfeng Feng, Trevor W Robbins, Sylvane Desrivières, Andre Marquand, Gunter Schumann
Current psychiatric diagnoses are not defined by neurobiological measures which hinders the development of therapies targeting mechanisms underlying mental illness 1,2 . Research confined to diagnostic boundaries yields heterogeneous biological results, whereas transdiagnostic studies often investigate individual symptoms in isolation. There is currently no paradigm available to comprehensively investigate the relationship between different clinical symptoms, individual disorders, and the underlying neurobiological mechanisms...
May 7, 2024: medRxiv