Lin Jin, Yunjia Chen, Suhail Muzaffar, Chao Li, Carlos A Mier-Aguilar, Jasim Khan, Mahendra P Kashyap, Shanrun Liu, Ritesh Srivastava, Jessy S Deshane, Tim M Townes, Boni E Elewski, Craig A Elmets, David K Crossman, Chander Raman, Mohammad Athar
Hidradenitis suppurativa (HS) is a complex inflammatory skin disease with undefined mechanistic underpinnings. Here, we investigated HS epithelial cells and demonstrated that HS basal progenitors modulate their lineage restriction and give rise to pathogenic keratinocyte clones, resulting in epidermal hyperproliferation and dysregulated inflammation in HS. When comparing to healthy epithelial stem/progenitor cells, in HS, we identified changes in gene signatures that revolve around the mitotic cell cycle, DNA damage response and repair, as well as cell-cell adhesion and chromatin remodeling...
December 5, 2023: Proceedings of the National Academy of Sciences of the United States of America