Herpes 6

Danielle Vitali, Puja Bagri, Jocelyn M Wessels, Meenakshi Arora, Raghu Ganugula, Ankit Parikh, Talveer Mandur, Allison Felker, Sanjay Garg, M N V Ravi Kumar, Charu Kaushic
Herpes Simplex Virus Type 2 (HSV-2) is one of the most prevalent sexually transmitted viruses and is a known risk factor for HIV acquisition in the Female Genital Tract (FGT). Previously, we found that curcumin can block HSV-2 infection and abrogate the production of inflammatory cytokines and chemokines by genital epithelial cells in vitro. In this study, we investigated whether curcumin, encapsulated in nanoparticles and delivered by various in vivo routes, could minimize inflammation and prevent or reduce HSV-2 infection in the FGT...
January 4, 2020: International Journal of Molecular Sciences
Maria Francesca Piazza, Chiara Paganino, Daniela Amicizia, Cecilia Trucchi, Andrea Orsi, Matteo Astengo, Paolo Romairone, Simona Simonetti, Giancarlo Icardi, Filippo Ansaldi
The effect of severe Herpes Zoster (HZ) on chronic diseases is a component of the real burden of this vaccine-preventable disease that is not commonly considered. A retrospective cohort study was conducted to assess the health burden of severe HZ in adults ≥50 years residing in Liguria Region from 2015 to 2017. Subjects hospitalized with and without HZ were matched (1:6 ratio). 437 subjects in the HZ cohort and 2622 subjects in the non-HZ cohort were enrolled. Previous immunodeficiency, autoimmune, and rare diseases are identified as main chronic conditions related to HZ hospitalization...
January 10, 2020: Vaccines
Hee Yong Kang, Chung Hun Lee, Sang Sik Choi, Mi Kyoung Lee, Yeon Joo Lee, Jong Sun Park
Background and Objectives : Currently, few studies have reported the effects of opioids during continuous epidural infusion (CEI) to control pain owing to herpes zoster (HZ). This study aimed to retrospectively compare the effectiveness of epidural opioids in the treatment of acute HZ pain. Materials and Methods : We reviewed medical records of 105 patients who were divided into two groups: R group (CEI with ropivacaine) and RF group (CEI with ropivacaine and fentanyl). Clinical efficacy was evaluated using the numeric rating scale (NRS) score for 6 months after the procedures...
January 8, 2020: Medicina
M Bahena-Román, M A Sánchez-Alemán, C O Contreras-Ochoa, A Lagunas-Martínez, M Olamendi-Portugal, Guillermina López-Estrada, Karina Delgado-Romero, E Guzmán-Olea, V Madrid-Marina, K Torres-Poveda
BACKGROUND: To determine the prevalence of active infection by herpes simplex virus type-2 (HSV-2) among Mexican women with high-risk human papillomavirus (HR-HPV) cervical infection, recruited from public gynecology and colposcopy services. METHODS: In a cross-sectional study, HSV-2 antibodies, HSV-2 DNA, and HR-HPV DNA were quantified. RESULTS: Significant differences in HSV-2 seroprevalence and HSV-2 active infection rates were found between negative and positive HR-HPV cases...
January 11, 2020: Journal of Medical Virology
Lukas Schuierer, Michael Gebhard, Hans-Georg Ruf, Ulrich Jaschinski, Thomas M Berghaus, Michael Wittmann, Georg Braun, Dirk H Busch, Reinhard Hoffmann
BACKGROUND: Herpes simplex virus (HSV) replication can be detected in the respiratory secretions of a high proportion of ventilated intensive care unit (ICU) patients. However, the clinical significance remains poorly defined. We investigated whether patients with ventilator-associated pneumonia not responding to antibiotics and in whom high levels of HSV could be detected in respiratory secretions benefit from acyclovir treatment. METHODS: Respiratory secretions (bronchoalveolar lavage fluid or tracheal aspirates) were tested for HSV replication by quantitative real-time PCR...
January 10, 2020: Critical Care: the Official Journal of the Critical Care Forum
Raina N Fichorova, Charles S Morrison, Pai-Lien Chen, Hidemi S Yamamoto, Yashini Govender, Damilola Junaid, Stanthia Ryan, Cynthia Kwok, Tsungai Chipato, Robert A Salata, Gustavo F Doncel
Sexually transmitted infections (STIs) and vaginal dysbiosis (disturbed resident microbiota presenting with abnormal Nugent score or candidiasis) have been associated with mucosal inflammation and risk of HIV-1 infection, cancer and poor reproductive outcomes. To date, the temporal relationships between aberrant cervical innate immunity and the clinical onset of microbial disturbance have not been studied in a large population of reproductive age women. We examined data from a longitudinal cohort of 934 Ugandan and Zimbabwean women contributing 3,274 HIV-negative visits who had complete laboratory, clinical and demographic data...
2020: PloS One
Leonardo Silva de Araujo, Kevin Pessler, Kurt-Wolfram Sühs, Natalia Novoselova, Frank Klawonn, Maike Kuhn, Volkhard Kaever, Kirsten Müller-Vahl, Corinna Trebst, Thomas Skripuletz, Martin Stangel, Frank Pessler
BACKGROUND: The timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible. Moreover, the differentiation from other causes of meningitis/encephalitis is critical because of differences in management such as the need for antiviral or immunosuppressive treatments. Considering our previously reported association between free membrane phospholipids in cerebrospinal fluid (CSF) and CNS involvement in neuroinfections we evaluated phosphatidylcholine PC ae C44:6, an integral constituent of cell membranes, as diagnostic biomarker for bacterial meningitis...
January 7, 2020: Journal of Translational Medicine
Riikka Nivajärvi, Venla Olsson, Viivi Hyppönen, Sean Bowen, Hanna M Leinonen, Hanna P Lesch, Jan Henrik Ardenkjaer-Larsen, Olli H J Gröhn, Seppo Ylä-Herttuala, Mikko I Kettunen
Hyperpolarised [1-13 C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus-1 thymidine kinase with the prodrug ganciclovir (HSV-TK/GCV) in C6 rat glioma and compared it with traditional MR therapy markers. Female Wistar rats were inoculated with 106 C6 glioma cells. Treated animals received intratumoural lentiviral HSV-TK gene transfers on days 7 and 8 followed by 2-week GCV therapy starting on day 10...
January 7, 2020: NMR in Biomedicine
Isabelle Souza de Mélo Silva, Livia Maria do Amorim Costa Gaspar, Adriely Maria Oliveira Rocha, Luiz Pereira da Costa, Dayane Batista Tada, Elton Franceschi, Francine Ferreira Padilha
Microbial biofilms, structured communities of microorganisms, have been often associated to the infection and bacterial multiresistance problem. Conventional treatment of infection involves the use of antibiotics, being an alternative approach is the use of red propolis, a natural product, to prepare polymer nanoparticles. The aim of the present study was to encapsulate red propolis extract in poly(lactic-co-glycolic acid) (PLGA) nanoparticles for destruction in vitro of pathogenic biofilms. Poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) containing red propolis hydroethanolic extract (2 mg/mL) were produced by emulsification solvent diffusion method...
January 3, 2020: AAPS PharmSciTech
Anthony Grondin, Eloïse Baudou, Marlène Pasquet, Sonia Pelluau, Karim Jamal-Bey, Cécile Bermot, Frederic Villega, Emmanuel Cheuret
Seventeen-day-old twins were hospitalized for neonatal herpes simplex virus 1 (HSV-1) with central nervous system disease and internal capsule and thalamic lesions on magnetic resonance imaging (MRI). They were treated with the usual intravenous (IV) treatment and oral therapy for 6 months. The clinical course was good in both children with negative HSV polymerase chain reaction on completion of IV therapy. The neurological condition recurred in one child with new radiological lesions at 7 months of age, 2 weeks after discontinuation of oral treatment...
December 30, 2019: Neuropediatrics
Sami Hraiech, Eline Bonnardel, Christophe Guervilly, Cyprien Fabre, Anderson Loundou, Jean-Marie Forel, Mélanie Adda, Gabriel Parzy, Guilhem Cavaille, Benjamin Coiffard, Antoine Roch, Laurent Papazian
BACKGROUND: Herpesviridae reactivation among non-immunocompromised critically ill patients is associated with impaired prognosis, especially during acute respiratory distress syndrome (ARDS). However, little is known about herpes simplex virus (HSV) and Cytomegalovirus (CMV) reactivation occurring in patients with severe ARDS under veno-venous extracorporeal membrane oxygenation (ECMO). We tried to determine the frequency of Herpesviridae reactivation and its impact on patients' prognosis during ECMO for severe ARDS...
December 23, 2019: Annals of Intensive Care
Yu-Chi Tsai, Judit Hohmann, Mohamed El-Shazly, Li-Kwan Chang, Balázs Dankó, Norbert Kúsz, Chi-Ting Hsieh, Attila Hunyadi, Fang-Rong Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Lindernia crustacea (L.) F.Muell. (Scrophulariaceae) was selected for phytochemical investigation owing to its traditional use against human herpes virus infection and its anti-Epstein-Barr virus (EBV) effect. AIMS OF THE STUDY: The present study focused on the phytochemical investigation of L. crustacea including the isolation and structure determination of its biologically active compounds. Compounds with anti-EBV effects were also investigated...
December 18, 2019: Journal of Ethnopharmacology
Kozue Kasai, Naoko Kato, Seika Den, Kenji Konomi, Megumi Shinzawa, Jun Shimazaki
BACKGROUND: We compared the clinical outcomes of accelerated corneal collagen crosslinking (CXL) and 5% NaCl hypertonic saline (HS) for the treatment of symptomatic bullous keratopathy (BK). METHODS: A randomized controlled trial was held at Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan. Twenty-three eyes of 23 consecutive patients with symptomatic BK were enrolled. The etiology of BK included pseudophakic BK, previous keratoplasty, previous endotheliitis, previous glaucoma surgery, trauma, herpes infection, as well as unknown causes...
December 2019: Medicine (Baltimore)
Mwita Wambura, Mary Drake, Evodius Kuringe, Esther Majani, Daniel Nyato, Caterina Casalini, Jacqueline Materu, Deusdedit Mjungu, Soori Nnko, Gaspar Mbita, Esther Kalage, Amani Shao, John Changalucha, Albert Komba
BACKGROUND: The HIV epidemic in Eastern and Southern Africa is characterized by a high incidence and prevalence of HIV infection among adolescent girls and young women (AGYW) aged 15-24 years. For instance, in some countries, HIV prevalence in AGYW aged 20-24 years exceeds that in AGYW aged 15-19 years by 2:1. Sauti (meaning voices), a project supported by the United States Agency for International Development, is providing HIV combination prevention interventions to AGYW in the Shinyanga region, Tanzania...
December 20, 2019: JMIR Research Protocols
Dan Wang, Li Wang, Rui Xu, Xing'an Wu, Yunlan Li
To explore the antiviral activity of nano-realgar against herpes simplex virus Type II (HSV-2) in vitro.
 Methods: Acyclovir (ACV) as a positive control, the cytotoxicity of nano-realgar at different concentrations (including 200.00, 150.00, 100.00, 50.00, 25.00, 12.50, 6.25, 3.13, 1.54, 0.78, 0.39 and 0 mg/L) on normal Vero cells were determined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay. HSV-2 virus titer was determined by plaque assay, and the Vero cells model of HSV-2 infection was established...
October 28, 2019: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Eric F Morand, Richard Furie, Yoshiya Tanaka, Ian N Bruce, Anca D Askanase, Christophe Richez, Sang-Cheol Bae, Philip Z Brohawn, Lilia Pineda, Anna Berglind, Raj Tummala
BACKGROUND: Anifrolumab, a human monoclonal antibody to type I interferon receptor subunit 1 investigated for the treatment of systemic lupus erythematosus (SLE), did not have a significant effect on the primary end point in a previous phase 3 trial. The current phase 3 trial used a secondary end point from that trial as the primary end point. METHODS: We randomly assigned patients in a 1:1 ratio to receive intravenous anifrolumab (300 mg) or placebo every 4 weeks for 48 weeks...
December 18, 2019: New England Journal of Medicine
Martin Michaelis, Malte C Kleinschmidt, Denisa Bojkova, Holger F Rabenau, Mark N Wass, Jindrich Cinatl
Omeprazole was shown to improve the anti-cancer effects of the nucleoside analogue 5-fluorouracil. Here, we combined omeprazole with the antiviral nucleoside analogues ribavirin and acyclovir. Omeprazole did not affect the antiviral effects of ribavirin in non-toxic concentrations up to 80 μg/mL but increased the acyclovir-mediated effects on herpes simplex virus 1 and 2 (HSV-1 and -2) replication in a dose-dependent manner. Omeprazole alone reduced HSV-1 and -2 titers [but not HSV-induced formation of cytopathogenic effects (CPE)] at concentrations ≥40 μg/mL...
2019: Frontiers in Microbiology
Janin Chandra, Wai-Ping Woo, Julie L Dutton, Yan Xu, Bo Li, Sally Kinrade, Julian Druce, Neil Finlayson, Paul Griffin, Kerry J Laing, David M Koelle, Ian H Frazer
BACKGROUND: Genital herpes simplex infection affects more than 500 million people worldwide. We have previously shown that COR-1, a therapeutic HSV-2 polynucleotide vaccine candidate, is safe and well tolerated in healthy subjects. OBJECTIVE: Here, we present a single center double-blind placebo-controlled, randomized phase I/IIa trial of COR-1 in HSV-2 positive subjects in which we assessed safety and tolerability as primary endpoints, and immunogenicity and therapeutic efficacy as exploratory endpoints...
2019: PloS One
Andrea E Murmann, Elizabeth T Bartom, Matthew J Schipma, Jacob Vilker, Siquan Chen, Marcus E Peter
MicroRNAs (miRNAs) are short double-stranded noncoding RNAs (19-23 nucleotides) that regulate gene expression by suppressing mRNAs through RNA interference. Targeting is determined by the seed sequence (position 2-7/8) of the mature miRNA. A minimal G-rich seed of just six nucleotides is highly toxic to cells by targeting genes essential for cell survival. A screen of 215 miRNAs encoded by 17 human pathogenic viruses (v-miRNAs) now suggests that a number of v-miRNAs can kill cells through a G-rich 6mer sequence embedded in their seed...
December 5, 2019: IScience
Xiaojun Hu, Suranjana Goswami, Ju Qiu, Qian Chen, Sylvain Laverdure, Brad T Sherman, Tomozumi Imamichi
Macrophages play an essential role in the immune system. Recent studies have shown that long non-coding RNAs (lncRNAs) can regulate genes encoding products involved in the immune response. Interleukin (IL)-27 is a member of the IL-6/IL-12 family of cytokines with broad anti-viral effects that inhibits human immunodeficiency virus (HIV) type-1 and herpes simplex virus (HSV). However, little is known about the role of lncRNAs in macrophages affected by IL-27. Therefore, we investigated the expression profiles of mRNA and lncRNA in human monocyte-derived macrophages (MDMs) regulated by IL-27...
December 9, 2019: International Journal of Molecular Sciences
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