Herpes 6

Itaru Hayakawa, Osamu Nomura, Kazuhiro Uda, Yu Funakoshi, Hiroshi Sakakibara, Yuho Horikoshi
AIM: While the incidence and aetiology of serious bacterial infections among febrile infants younger than 90 days old are well studied, those concerning viral infection are not. There are severe life-threatening viral infections requiring immediate intense therapy. The objective of the study is to describe the incidence and aetiology of serious viral infections (SVI) among young febrile infants. METHODS: A retrospective audit was performed covering all the febrile infants younger than 90 days old admitted to a paediatric emergency department in Japan from 2011 to 2013...
November 15, 2019: Journal of Paediatrics and Child Health
Ying-Chou Chen, Dae Hyun Yoo, Chang Keun Lee, Ko-Jen Li, Ji-Eon Won, Wen-Shuo Wu, Jinglin Zhong, Claudia Nicolay, Chad Daniel Walls, Yoshiya Tanaka
AIM: We evaluated the safety of baricitinib in an East Asian (EA) patient population with moderate-to-severely active rheumatoid arthritis (RA), through an integrated sub-analysis of data from the overall baricitinib RA clinical program. METHODS: Data from EA patients who received any dose of baricitinib from five completed studies (1 Phase 2, 4 Phase 3) and an ongoing long-term extension study were pooled up to 1 September, 2016. Exposure-adjusted incidence rates (EAIR) and incidence rates (IRs), both per 100 patient-years (PY), were calculated...
November 14, 2019: International Journal of Rheumatic Diseases
Marzieh Jamalidoust, Nasrin Aliabadi, Mandana Namayandeh, Mazyar Ziyaeyan
OBJECTIVES: Human β-herpes viruses, including cytomegalovirus and human herpesvirus 6, can become activated in liver transplant patients. Here, we evaluated the effects of human herpesvirus 6 infection as an independent factor on cytomegalovirus infection and the occurrence of associated diseases in liver transplant patients. MATERIALS AND METHODS: In this cross-sectional study, 46 patients who underwent deceased-donor liver transplant at Nemazi Hospital, Shiraz University of Medical Sciences (Shiraz, Iran) were prospectively monitored for cytomegalovirus and human herpesvirus 6 infections during 3 months posttransplant...
November 13, 2019: Experimental and Clinical Transplantation
Jennifer Eriksson, Matthias Hunger, François Bourhis, Robyn Thorén, Zoran Popmihajlov, Lynn Finelli, Yiling Jiang
OBJECTIVES: Immunocompromised subjects are at increased risk for herpes zoster (HZ) and HZ-related complications, such as post herpetic neuralgia (PHN). We describe health utilities, health care resource utilization (HCRU), productivity loss and health care costs in recipients of autologous hematopoietic stem cell transplantation (Auto-HSCT) who developed confirmed HZ in the phase 3 clinical trial. METHODS: HCRU, costs, and EQ-5D-3L utility were assessed for 155 confirmed HZ cases observed after receiving inactivated varicella zoster virus (VZV) vaccine (ZVIN ) or placebo...
November 13, 2019: Expert Review of Pharmacoeconomics & Outcomes Research
Marine Cailleaux, Benoît Pilmis, Assaf Mizrahi, Julie Lourtet-Hascoet, Jean-Claude Nguyen Van, Lilian Alix, Carine Couzigou, Barbara Vidal, Pierre Tattevin, Alban Le Monnier
Microbiological diagnosis of central nervous system (CNS) infections is challenging due to limited access to CNS samples, overlap between meningitis and encephalitis, and the multiplicity of pathogens potentially involved. We aimed to estimate the impact of a commercial multiplex PCR assay (FilmArray® meningitis/encephalitis) on the management of patients with suspicion of meningitis or encephalitis, in terms of time to diagnosis, antimicrobial agents use, duration of hospitalization, and costs. This prospective observational study was conducted at Saint Joseph Hospital (Paris, France) from December 2016 to December 2017...
November 12, 2019: European Journal of Clinical Microbiology & Infectious Diseases
Andy K H Lim, Sahira Paramaswaran, Lucy J Jellie, Ralph K Junckerstorff
Hyponatremia can occur with central nervous system (CNS) infections, but the frequency and severity may depend on the organism and nature of CNS involvement. In this cross-sectional study at a large Australian hospital network from 2015 to 2018, we aimed to determine the prevalence and severity of hyponatremia associated with CNS infection clinical syndromes, and the association with specific organisms. We examined the results of cerebrospinal fluid analysis from lumbar punctures performed in 184 adult patients with a serum sodium below 135 mmol/L who had abnormal cerebrospinal fluid analysis and a clinical syndrome consistent with an acute CNS infection (meningitis or encephalitis)...
October 27, 2019: Journal of Clinical Medicine
Josef Georg Heckmann, Peter Paul Urban, Susanne Pitz, Orlando Guntinas-Lichius, Ildikό Gágyor
BACKGROUND: Peripheral facial nerve palsy is the most com- mon functional disturbance of a cranial nerve. 60-75% of cases are idiopathic. METHODS: This review is based on a selective literature search proceeding from the current, updated German-language guideline on the diagnosis and treatment of idiopathic facial nerve palsy. RESULTS: The recommended drug treatment consists of prednisolone 25 mg bid for 10 days, or 60 mg qd for 5 days followed by a taper to off in decrements of 10 mg per day...
October 11, 2019: Deutsches Ärzteblatt International
Wei Wang, Cuijing Xu, Jianqiang Zhang, Jinpeng Wang, Rilei Yu, Dongping Wang, Ruijuan Yin, Wenmiao Li, Tao Jiang
BACKGROUND AND PURPOSE: The worldwide prevalence of herpes simplex virus (HSV) and shortage of efficient therapeutic strategies to counteract it are global concerns. In terms of treatment, the widely-utilized anti-HSV drugs such as acyclovir have serious limitations, e.g. drug resistance and side effects. Herein, we identified that the guanidine-modified (E, E)-4,6-bis (styryl)-pyrimidine (BS-pyrimidine) derivative 5d was an inhibitor of HSV and further elucidated the anti-HSV mechanisms of 5d both in vitro and in vivo...
November 10, 2019: British Journal of Pharmacology
Seilesh Kadambari, Andrew J Pollard, Michael J Goldacre, Raphael Goldacre
BACKGROUND: Congenital viral infections cause substantial long-term morbidity but population-based data about diagnosis rates are scarce. The aim of this study was to assess the long-term trends in congenital viral infections in England and to report on how the rates of these infections might have changed with improved methods for detection, the introduction of the two-dose measles-mumps-rubella (MMR) vaccine in 1996, and the implementation of the Newborn Hearing Screening Programme (NHSP) in 2006...
November 7, 2019: Lancet Infectious Diseases
Jin-Ik Kim, Randal J Kaufman, Sung Hoon Back, Ja-Young Moon
When endoplasmic reticulum (ER) functions are perturbed, the ER induces several signaling pathways called unfolded protein response to reestablish ER homeostasis through three ER transmembrane proteins: inositol-requiring enzyme 1 (IRE1), PKR-like ER kinase (PERK), and activating transcription factor 6 (ATF6). Although it is important to measure the activity of ATF6 that can indicate the status of the ER, no specific cell-based reporter assay is currently available. Here, we report a new cell-based method for monitoring ER stress based on the cleavage of ATF6α by sequential actions of proteases at the Golgi apparatus during ER stress...
November 11, 2019: Molecules and Cells
Rong-Mei Peng, Yu-Xin Guo, Ge-Ge Xiao, Chen-Di Li, Jing Hong
Objectives : To explore the cellular morphological characteristics and changes in corneal endotheliitis among different viruses by in vivo confocal microscopy (IVCM). Methods : Corneal confocal images of 44 eyes of 44 patients with HSV, VZV, CMV and EBV corneal endotheliitis were studied retrospectively. Corneal confocal images of 44 normal eyes were used as controls. Results : The pathogens included cytomegalovirus (n = 20), herpes simplex virus (n = 8), varicella zoster virus (n = 10), and Epstein Barr virus (n = 6)...
November 7, 2019: Ocular Immunology and Inflammation
Anna Mz Gagliardi, Brenda Ng Andriolo, Maria Regina Torloni, Bernardo Go Soares, Juliana de Oliveira Gomes, Regis B Andriolo, Eduardo Canteiro Cruz
BACKGROUND: Herpes zoster, commonly known as shingles, is a neurocutaneous disease caused by the reactivation of the virus that causes varicella (chickenpox). After resolution of the varicella episode, the virus can remain latent in the sensitive dorsal ganglia of the spine. Years later, with declining immunity, the varicella zoster virus (VZV) can reactivate and cause herpes zoster, an extremely painful condition that can last many weeks or months and significantly compromise the quality of life of the affected person...
November 7, 2019: Cochrane Database of Systematic Reviews
Hena S Cheema, Aloise M Diedrich, Briana M Kyne, Mona Toeque
Varicella-zoster is the causative virus underlying varicella or "chickenpox" and herpes zoster or "shingles." Cases of disseminated disease have been widely reported in immunocompromised patients. We describe an interesting case of tri-segmental cranial nerve V herpes zoster here with discussion of the salient clinical features as well as brief discussion about ongoing trials for herpes zoster ophthalmicus prophylaxis. This case also highlights the importance of timely treatment and diagnosis, as the patient presented 6 days prior to hospitalization with a mild vesicular facial rash but was lost to follow up without filling a prescription for acyclovir, returning with severe facial involvement...
2019: IDCases
Leonid D Zamora, Ma Theresa M Collante, Sandra V Navarra
AIM: To identify clinical risk factors associated with herpes zoster (HZ) infections in systemic lupus erythematosus (SLE). METHODS: A case-control study of HZ infection was performed in SLE patients seen at the University of Santo Tomas Lupus Clinics from 2009-2014. Cases were matched 1:2 to SLE controls without HZ infection for age, sex, and disease duration. Clinical characteristics, SLE disease activity, and immunosuppressive use were compared. RESULTS: Sixty-five SLE patients (61, 93...
November 6, 2019: International Journal of Rheumatic Diseases
Caroline Kittinger, Arnita Barnes, Alan Hunter, LeeAnn Machiesky, Sandrina Phipps, Anthony Shannon, Robert Stadelman, Susan Wilson, Ellen O'Connor
Interferon-alpha receptor 1 (IFNAR1) is a target of interest for recombinant biotherapeutics that block the JAK/STAT pathway. This pathway is believed to play a role in many diseases including Hepatitis B and C, Herpes Simplex, Multiple Sclerosis, and other autoimmune disorders. By using IFNAR1 as a target to block Type I IFN from binding to the JAK/STAT pathway and prevent activation of this target, autoimmune disease progression can be modulated. Current IFNAR1 extracellular domain (ECD) expression and purification protocols are labor intensive with low product yield and limited scalability...
November 2, 2019: Protein Expression and Purification
Lisa Stockdale, Stephen Nash, Ruth Farmer, John Raynes, Suresh Malikaarjun, Robert Newton, Helen A Fletcher
BACKGROUND: Recent evidence highlights human cytomegalovirus (HCMV) and immune activation as risk factors for tuberculosis (TB) disease. It is not known whether other herpes viruses are also implicated, nor if a dose-response relationship exists between TB risk and herpes co-infection. METHODS: This nested case-control study used stored serum samples from 25 TB cases up to 10 years prior to TB diagnosis and between 3 and 6 matched non-TB controls from a rural Ugandan cohort...
November 5, 2019: Journal of Infectious Diseases
Nazila Dabestani, David A Katz, Julia Dombrowski, Amalia Magaret, Anna Wald, Christine Johnston
BACKGROUND: Genital herpes simplex virus type-1 (HSV-1) has emerged as the leading cause of first episode genital herpes among specific populations in the U.S., such as adolescents, young adult women, and men who have sex with men (MSM). We examined trends in the etiology of first episode genital herpes diagnoses over time in an STD clinic population. METHODS: Using an electronic database, we identified persons diagnosed with first episode genital herpes at Public Health Seattle & King County STD Clinic from 1993 through 2014 and compared risk factors for genital HSV-1 versus HSV-2 infection...
October 30, 2019: Sexually Transmitted Diseases
Doris M Salgado, Roció Vega, Jairo Antonio Rodríguez, Ángela Niño, Rocío Rodríguez, Ángela Ortiz, Isabel DeLaura, Irene Bosch, Carlos F Narváez
OBJECTIVE: To evaluate the clinical, laboratory and immune characteristics of ZIKV-associated encephalitis in pediatric patients after the epidemic in Huila, southern Colombia. METHODS: A pediatric neuro-surveillance hospital study was conducted in a referral health center in southern Colombia, from October 2016 to October 2017. Cases of encephalitis were confirmed by nucleic acid amplification tests and serological methods in cerebrospinal fluid (CSF), plasma and/or urine...
October 30, 2019: International Journal of Infectious Diseases: IJID
Kathlyn Laval, Jolien Van Cleemput, Jonah B Vernejoul, Lynn W Enquist
Pseudorabies virus (PRV), an alphaherpesvirus closely related to Varicella-Zoster virus (VZV) and Herpes simplex type 1 (HSV1) infects mucosa epithelia and the peripheral nervous system (PNS) of its host. We previously demonstrated that PRV infection induces a specific and lethal inflammatory response, contributing to severe neuropathy in mice. So far, the mechanisms that initiate this neuroinflammation remain unknown. Using a mouse footpad inoculation model, we found that PRV infection rapidly and simultaneously induces high G-CSF and IL-6 levels in several mouse tissues, including the footpad, PNS and central nervous system (CNS) tissues...
November 2019: PLoS Pathogens
Victoria Furer, Christien Rondaan, Marloes Heijstek, Sander van Assen, Marc Bijl, Nancy Agmon-Levin, Ferdinand C Breedveld, Raffaele D'Amelio, Maxime Dougados, Meliha Crnkic Kapetanovic, Jacob M van Laar, Annette Ladefoged de Thurah, Robert Landewé, Anna Molto, Ulf Müller-Ladner, Karen Schreiber, Leo Smolar, Jim Walker, Klaus Warnatz, Nico M Wulffraat, Ori Elkayam
Objectives: The aims of this study were to update the evidence on the incidence and prevalence rates of vaccine preventable infections (VPI) in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and compare the data to the general population when available. Methods: A literature search was performed using Medline, Embase and Cochrane library (October 2009 to August 2018). The primary outcome was the incidence or prevalence of VPI in the adult AIIRD population...
2019: RMD Open
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"