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JOURNAL ARTICLE
Sabrina Helena da Cruz Araujo, Javier Guillermo Mantilla-Afanador, Thiago Svacina, Tarciza Fernandes Nascimento, Aldilene da Silva Lima, Marcos Bispo Pinheiro Camara, Luis Oswaldo Viteri Jumbo, Gil Rodrigues Dos Santos, Cláudia Quintino da Rocha, Eugênio Eduardo de Oliveira
The γ-aminobutyric acid (GABA) receptors play pivotal roles in the transmission of neuronal information in the nervous system of insects, which has led these proteins to be targeted by synthetic and natural products. Here, we assessed the insecticidal potential of the essential oil of Pectis brevipedunculata (Gardner) Sch. Bip., a neotropical Asteraceae plant used in traditional medicine, for controlling Drosophila suzukii (Matsumura) adults by feeding exposure. By using in silico approaches, we disentangle the contribution of GABA receptors and other potential neuronal targets (e...
May 17, 2024: Plants (Basel, Switzerland)
#22
REVIEW
Amanda Bahiano Passos Sousa, Anelita de Jesus Rocha, Wanderley Diaciso Dos Santos Oliveira, Leandro de Souza Rocha, Edson Perito Amorim
Bananas are a staple food that considerably contributes to both food security and income generation, especially in countries of Africa, Asia, and Central and South America. The banana plant ( Musa spp.) is affected by various pathogens, of main concern being the plant-parasitic nematodes associated with the rhizosphere, the most important of which are Radopholus similis (burrowing nematode), Helicotylenchus sp. (spiral nematode), Pratylenchus sp. (root lesion nematode), and Meloidogyne sp. (gall nematode). Infected plants reduce their ability to absorb water and nutrients, which can lead to delayed flowering, fewer bunches, and lower fruit mass...
May 8, 2024: Plants (Basel, Switzerland)
#23
JOURNAL ARTICLE
Aida Maaz, Ian S Blagbrough, Paul A De Bank
A general procedure to prepare gold nanourchins (GNUs) via a seed-mediated method was followed using dopamine hydrochloride as a reducing agent and silver nitrate salt (AgNO3 ) as a shape-directing agent. The novelty of this study comes from the successful incorporation of the prepared gold urchins as an aqueous suspension in a nasal pressurized metered dose inhaler (pMDI) formulation and the investigation of their potential for olfactory targeting for direct nose-to-brain drug delivery (NTBDD). The developed pMDI formulation was composed of 0...
May 16, 2024: Pharmaceutics
#24
REVIEW
Júlio Abreu Miranda, Yasmin Ferreira da Cruz, Ícaro Chaves Girão, Fabia Julliana Jorge de Souza, Wógenes Nunes de Oliveira, Éverton do Nascimento Alencar, Lucas Amaral-Machado, Eryvaldo Sócrates Tabosa do Egito
Sunscreen products are essential for shielding the skin from ultraviolet (UV) radiation, a leading cause of skin cancer. While existing products serve this purpose, there is a growing need to enhance their efficacy while minimizing potential systemic absorption of UV filters and associated toxicological risks. Liposomal-based formulations have emerged as a promising approach to address these challenges and develop advanced photoprotective products. These vesicular systems offer versatility in carrying both hydrophilic and lipophilic UV filters, enabling the creation of broad-spectrum sunscreens...
May 15, 2024: Pharmaceutics
#25
JOURNAL ARTICLE
Teresa De Toni, Teodora Dal Buono, Chris M Li, Grisell C Gonzalez, Sung-Ting Chuang, Peter Buchwald, Alice A Tomei, Diana Velluto
The need for chronic systemic immunosuppression, which is associated with unavoidable side-effects, greatly limits the applicability of allogeneic cell transplantation for regenerative medicine applications including pancreatic islet cell transplantation to restore insulin production in type 1 diabetes (T1D). Cell transplantation in confined sites enables the localized delivery of anti-inflammatory and immunomodulatory drugs to prevent graft loss by innate and adaptive immunity, providing an opportunity to achieve local effects while minimizing unwanted systemic side effects...
May 13, 2024: Pharmaceutics
#26
JOURNAL ARTICLE
Guillermo De Grau-Bassal, Mireia Mallandrich, Lilian Sosa, Lupe Espinoza, Ana Cristina Calpena, Núria Bozal-de Febrer, María J Rodríguez-Lagunas, María L Garduño-Ramírez, María Rincón
Recently, the number of people acquiring tattoos has increased, with tattoos gaining significant popularity in people between 20 and 40 years old. Inflammation is a common reaction associated with tattooing. The purpose of this study was to evaluate a nanostructured lipid carrier loading pranoprofen (PRA-NLC) as a tattoo aftercare formulation to reduce the inflammation associated with tattooing. In this context, the in vitro drug release and the ex vivo permeation-through-human-skin tests using Franz cells were appraised...
May 10, 2024: Pharmaceutics
#27
JOURNAL ARTICLE
Jeferson Ziebarth, Letícia Marina da Silva, Ariane Krause Padilha Lorenzett, Ingrid Delbone Figueiredo, Paulo Fernando Carlstrom, Felipe Nunes Cardoso, André Luiz Ferreira de Freitas, Amanda Martins Baviera, Rubiana Mara Mainardes
Liraglutide (LIRA) is a glucagon-like peptide-1 (GLP-1) receptor agonist renowned for its efficacy in treating type 2 diabetes mellitus (T2DM) and is typically administered via subcutaneous injections. Oral delivery, although more desirable for being painless and potentially enhancing patient adherence, is challenged by the peptide's low bioavailability and vulnerability to digestive enzymes. This study aimed to develop LIRA-containing zein-based nanoparticles stabilized with eudragit RS100 and chitosan for oral use (Z-ERS-CS/LIRA)...
May 9, 2024: Pharmaceutics
#28
JOURNAL ARTICLE
Celia Gómez-Labrador, Elena Ricart, Marisa Iborra, Eva Iglesias, María Dolores Martín-Arranz, Luisa de Castro, Ruth De Francisco, Francisco Javier García-Alonso, Ana Sanahuja, Carla J Gargallo-Puyuelo, Francisco Mesonero, María José Casanova, Míriam Mañosa, Montserrat Rivero, Marta Calvo, Mónica Sierra-Ausin, Carlos González-Muñoza, Xavier Calvet, Santiago García-López, Jordi Guardiola, Lara Arias García, Lucía Márquez-Mosquera, Ana Gutiérrez, Yamile Zabana, Mercè Navarro-Llavat, Rufo Lorente Poyatos, Marta Piqueras, Leyanira Torrealba, Fernando Bermejo, Ángel Ponferrada-Díaz, José L Pérez-Calle, Manuel Barreiro-de Acosta, Coral Tejido, José Luis Cabriada, Ignacio Marín-Jiménez, Óscar Roncero, Yolanda Ber, Luis Fernández-Salazar, Blau Camps Aler, Alfredo J Lucendo, Jordina Llaó, Luis Bujanda, Carmen Muñoz Villafranca, Eugeni Domènech, María Chaparro, Javier P Gisbert
Markers that allow for the selection of tailored treatments for individual patients with inflammatory bowel diseases (IBD) are yet to be identified. Our aim was to describe trends in real-life treatment usage. For this purpose, patients from the ENEIDA registry who received their first targeted IBD treatment (biologics or tofacitinib) between 2015 and 2021 were included. A subsequent analysis with Machine Learning models was performed. The study included 10,009 patients [71% with Crohn's disease (CD) and 29% with ulcerative colitis (UC)]...
May 8, 2024: Pharmaceutics
#29
JOURNAL ARTICLE
Jhony Anacleto-Santos, Elisa Vega-Ávila, Leticia Pacheco, Manuel Lacueva-Arnedo, Alicia Gómez-Barrio, Alexandra Ibáñez-Escribano, Teresa de Jesús López-Pérez, Brenda Casarrubias-Tabarez, Fernando Calzada, Perla Yolanda López-Camacho, Norma Rivera-Fernández
Pleopeltis crassinervata is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently, conducting biological and pharmacological assays is crucial to validate the therapeutic efficacy of this plant within the context of traditional medicine. In the present study, we investigated the biological activity of extracts and fractions obtained from P. crassinervata organs against bacteria ( Salmonella typhimurium , Salmonella typhi , Staphylococcus aureus , Proteus mirabilis , Shigella flexneri , Bacillus subtilis , Escherichia coli) and Trichomonas vaginalis using in vitro models...
May 7, 2024: Pharmaceutics
#30
JOURNAL ARTICLE
Daniel Figueiredo Vanzan, Ester Puna Goma, Fernanda Resende Locatelli, Thiago da Silva Honorio, Priscila de Souza Furtado, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Hilton Antônio Mata Dos Santos, Flávia Almada do Carmo, Alice Simon, Alexandre Dos Santos Pyrrho, António José Ribeiro, Lucio Mendes Cabral
Silybin (SIB) is a hepatoprotective drug known for its poor oral bioavailability, attributed to its classification as a class IV drug with significant metabolism during the first-pass effect. This study explored the potential of solid lipid nanoparticles with (SLN-SIB-U) or without (SLN-SIB) ursodeoxycholic acid and polymeric nanoparticles (PN-SIB) as delivery systems for SIB. The efficacy of these nanosystems was assessed through in vitro studies using the GRX and Caco-2 cell lines for permeability and proliferation assays, respectively, as well as in vivo experiments employing a murine model of Schistosomiasis mansoni infection in BALB/c mice...
May 4, 2024: Pharmaceutics
#31
JOURNAL ARTICLE
Timoteo Delgado-Maldonado, Alonzo González-González, Adriana Moreno-Rodríguez, Virgilio Bocanegra-García, Ana Verónica Martinez-Vazquez, Erick de Jesús de Luna-Santillana, Gerard Pujadas, Guadalupe Rojas-Verde, Edgar E Lara-Ramírez, Gildardo Rivera
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a fast-spreading viral pathogen and poses a serious threat to human health. New SARS-CoV-2 variants have been arising worldwide; therefore, is necessary to explore more therapeutic options. The interaction of the viral spike (S) protein with the angiotensin-converting enzyme 2 (ACE2) host receptor is an attractive drug target to prevent the infection via the inhibition of virus cell entry. In this study, Ligand- and Structure-Based Virtual Screening (LBVS and SBVS) was performed to propose potential inhibitors capable of blocking the S receptor-binding domain (RBD) and ACE2 interaction...
May 1, 2024: Pharmaceutics
#32
JOURNAL ARTICLE
Alessandra Rossetti, Louis Chonco, Nicolas Alegría, Veronica Zelli, Andrés J García, Carmen Ramírez-Castillejo, Alessandra Tessitore, Carlos de Cabo, Tomás Landete-Castillejos, Claudio Festuccia
Deer antlers are the fastest growing tissue. Because they are based on proto-oncogenes, to avoid the risk of cancer, antlers evolved strong anticancer mechanisms, and thus their extract (DVA) is effective also against the few human tumours studied so far. We assessed whether DVA is a general anticancer compound by testing the direct effects in cells of different tumours: glioblastoma (GBM; lines U87MG and U251), colorectal (CRC; lines DLD-1, HT-29, SW480, and SW620), breast cancer (BRCA; lines MCF7, SKBR3, and PA00), and leukaemia (THP-1)...
April 30, 2024: Pharmaceutics
#33
JOURNAL ARTICLE
Liberato De Caro, Thibaud Stoll, Arnaud Grandeury, Fabia Gozzo, Cinzia Giannini
We introduce an innovative theoretical framework tailored for the analysis of Pair Distribution Function (PDF) data derived from Small-Angle X-ray Scattering (SAXS) measurements of core-shell micelles. The new approach involves the exploitation of the first derivative of the PDF and the derivation of analytical equations to solve the core-shell micelle structure under the hypothesis of a spheroidal shape. These analytical equations enable us to determine the micelle's aggregation number, degree of ellipticity, and contrast in electron density between the core-shell and shell-buffer regions after having determined the whole micelle size and its shell size from the analysis of the first derivative of the PDF...
April 29, 2024: Pharmaceutics
#34
REVIEW
Leticia Santos Pimentel, Luciana Machado Bastos, Luiz Ricardo Goulart, Lígia Nunes de Morais Ribeiro
Since prostate cancer (PCa) relies on limited therapies, more effective alternatives are required. Essential oils (EOs) and their bioactive compounds are natural products that have many properties including anticancer activity. This review covers studies published between 2000 and 2023 and discusses the anti-prostate cancer mechanisms of the EOs from several plant species and their main bioactive compounds. It also provides a critical perspective regarding the challenges to be overcome until they reach the market...
April 24, 2024: Pharmaceutics
#35
JOURNAL ARTICLE
Aram M de Haas, Dorian A Stolk, Sjoerd T T Schetters, Laura Goossens-Kruijssen, Eelco Keuning, Martino Ambrosini, Louis Boon, Hakan Kalay, Gert Storm, Hans J van der Vliet, Tanja D de Gruijl, Yvette van Kooyk
Cancer vaccines have emerged as a potent strategy to improve cancer immunity, with or without the combination of checkpoint blockade. In our investigation, liposomal formulations containing synthetic long peptides and α-Galactosylceramide, along with a DC-SIGN-targeting ligand, Lewis Y (LeY ), were studied for their anti-tumor potential. The formulated liposomes boosted with anti-CD40 adjuvant demonstrated robust invariant natural killer (iNKT), CD4+ , and CD8+ T-cell activation in vivo. The incorporation of LeY facilitated the targeting of antigen-presenting cells expressing DC-SIGN in vitro and in vivo...
April 24, 2024: Pharmaceutics
#36
JOURNAL ARTICLE
Marta Vicario-de-la-Torre, Virginia Puebla-García, Lidia Ybañez-García, José Javier López-Cano, Miriam Ana González-Cela-Casamayor, Marco Brugnera, Bárbara Burgos-Blasco, David Díaz-Valle, José Antonio Gegúndez-Fernández, José Manuel Benítez-Del-Castillo, Rocío Herrero-Vanrell
Compounded insulin eye drops were prepared at 1 IU/mL from commercially available subcutaneous insulin by dilution in saline solution or artificial tears. Physicochemical characterization and in vitro tolerance testing in human and conjunctival cells were followed by a 28-day short-term stability study under various conditions. The formulations were isotonic (280-300 mOsm/L), had a pH close to neutral (7-8), medium surface-tension values (<56 MN/m-1 ), and low (≈1 mPa·s) and medium (≈5 mPa·s) viscosities (compounded normal saline solution and artificial tear-based preparation, respectively)...
April 24, 2024: Pharmaceutics
#37
JOURNAL ARTICLE
Luis Otero-Millán, Brais Bea-Mascato, Jose Luis Legido Soto, Noemi Martínez-López-De-Castro, Natividad Lago-Rivero
(1) Background: Parenteral nutrition (PN) is a technique used for the administration of nutrients to patients for whom traditional routes cannot be used. It is performed using solutions with extremely complex compositions, which can give rise to a large number of interactions. These interactions can impact their stability and put the patient's life at risk. The aim of this study is to determine how changes in composition and storage protocol affect the stability of NP solutions. (2) Methods: Twenty-three samples were prepared according to routine clinical practice, with modifications to the concentration of some components...
April 23, 2024: Pharmaceutics
#38
REVIEW
Antonio Carlos Vital Júnior, Mikaelly Batista da Silva, Shênia Santos Monteiro, Matheus Augusto de Bittencourt Pasquali
This review article covers the therapeutic potential of the plants Harpagophytum procumbens and Turnera subulata in the treatment of neurodegenerative diseases. Despite the recognition of their beneficial properties, there is notable shortage of specific clinical and in vitro studies on these species regarding neurodegenerative diseases. Compounds such as harpagosides and vite-xin-2-O-rhamnoside, found in Harpagophytum procumbens and Turnera subulata , respectively, as well as other antioxidants and anti-inflammatory agents, are associated with mechanisms of action that involve reducing oxidative stress and modulating the inflammatory response, indicating their therapeutic potential in these pathologies...
May 20, 2024: Pharmaceuticals
#39
REVIEW
Isabela Frazão da Silva, Wesley Rossi Bragante, Renato Cesar Moretti Junior, Lucas Fornari Laurindo, Elen Landgraf Guiguer, Adriano Cressoni Araújo, Adriana M R Fiorini, Claudia C T Nicolau, Marie Oshiiwa, Enzo Pereira de Lima, Sandra Maria Barbalho, Luís R Silva
Smallanthus sonchifolius , popularly known as yacon, is a member of the Asteraceae family. Due to its medicinal and edible value, yacon is consumed by different populations. Yacon is unique due to its high fructo-oligosaccharide and inulin content, as well as flavonoids, sesquiterpene lactones, and phenolic acids. Roots can be used to produce flour, which is less perishable and can be applied in various industrial products. This systematic review focuses on the effects of yacon flour on metabolic parameters...
May 20, 2024: Pharmaceuticals
#40
JOURNAL ARTICLE
Yazmín K Márquez-Flores, Elizdath Martínez-Galero, José Correa-Basurto, Yudibeth Sixto-López, Isabel Villegas, María Á Rosillo, Ana Cárdeno, Catalina Alarcón-de-la-Lastra
BACKGROUND: The inflammasome is a cytosolic multiprotein complex associated with multiple autoimmune diseases. Phytochemical compounds in soy ( Glycine max ) foods, such as isoflavones, have been reported for their anti-inflammatory properties. AIM: the anti-inflammatory activity of DZ (daidzein) and EQ (equol) were investigated in an ex vivo model of LPS-stimulated murine peritoneal macrophages and by molecular docking correlation. METHODS: Cells were pre-treated with DZ (25, 50, and 100 µM) or EQ (5, 10, and 25 µM), followed by LPS stimulation...
May 16, 2024: Pharmaceuticals
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