Testosterone and food

Petra Kretzschmar, Hailie Auld, Peter Boag, Udo Gansloßer, Candace Scott, Peter John Van Coeverden de Groot, Alexandre Courtiol
Improving our sparse knowledge of the mating and reproductive behaviour of white rhinoceros ( Ceratotherium simum Burchell, 1817) is essential for the effective conservation of this iconic species. By combining morphological, physiological and habitat data with paternity assignments of 104 known mother-offspring pairs collected over a period of 13 years, we provide the most comprehensive analysis of the mating system in this species. We show that while the overall mating system was promiscuous, and both males and females produced more offspring when mating with several partners, half of all females with multiple offspring were monogamous...
April 2020: Evolutionary Applications
H Rehman, S Jahan, I Ullah, P-O Thörnqvist, M Jabbar, M Shoaib, F Aman, N John
The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats. Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg-1 for 10 weeks (males) and 2 weeks (females) and then mated. Results of F0 indicated that in the furan-treated groups (5 mg kg-1 and 10 mg kg-1 ), body weight (bw) gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at 10 mg kg-1 ...
March 16, 2020: Human & Experimental Toxicology
Rajesh Kumar Kharwar, Vaishali Singh, Chandana Haldar
The role of circulatory steroid hormone along with melatonin in lung of any seasonally breeding bird has never been explored so far. This could be interesting because steroid hormones are immunosuppressive while melatonin is immunostimulatory in nature. In our present study, we report the effect of exogenous melatonin and testosterone on expression of melatonin receptor subtypes (Mel1a and Mel1b ) and androgen receptor in lung of a tropical bird Perdicula asiatica. Birds were collected from vicinity of Varanasi and acclimatized in laboratory with sufficient food and water...
March 15, 2020: Anatomia, Histologia, Embryologia
Michael S Irwig, Maria Fleseriu, Jacqueline Jonklaas, Nicholas A Tritos, Kevin C J Yuen, Ricardo Correa, Georges Elhomsy, Vishnu Garla, Sina Jasim, Kyaw Soe, Stephanie E Baldeweg, Cesar Luiz Boguszewski, Irina Bancos
Over the past few decades, there has been an unprecedented rise in off-label use and misuse of testosterone, growth hormone, thyroid hormone, and adrenal supplements. Testosterone therapy is often promoted to men for the treatment of low energy, lower libido, erectile dysfunction, and other symptoms. Growth hormone is used in attempts to improve athletic performance in athletes and to attenuate aging in older adults. Thyroid hormone and/or thyroid supplements or boosters are taken to treat fatigue, obesity, depression, cognitive impairment, impaired physical performance, and infertility...
March 2020: Endocrine Practice
Achraf Ammar, MounaTurki, Khaled Trabelsi, Nicola Luigi Bragazzi, Omar Boukhris, Mohamed Bouaziz, Fatma Ayadi, Kais El Abed, Tarak Driss, Nizar Souissi, Hamdi Chtourou, Stephen J Bailey, Anita Hoekelmann
BACKGROUND: Maximal strength-speed exercise is a powerful stimulus to acutely increase concentrations of circulating steroid hormones and homocysteine [Hcy]. There is some evidence that antioxidant beverages rich in polyphenols can attenuate [Hcy] levels and modulate endocrine responses in favor of an anabolic environment. Polyphenols-rich pomegranate (POM) have been reported to possess one of the highest antioxidant capacities compared to other purported nutraceuticals and other food stuffs...
March 6, 2020: Journal of the International Society of Sports Nutrition
Autumn N Harris, Hyun-Wook Lee, Jill W Verlander, I David Weiner
There are substantial sex differences in renal structure and ammonia metabolism that correlate with differences in expression of proteins involved in ammonia generation and transport. This study determined the role of testis-derived testosterone in these differences. We studied 4 month-old C57BL/6 male mice 4 and 8 weeks after either bilateral orchiectomy (ORCH) or sham-operated control (SOC) surgery, and we determined the effect of testosterone replacement to reverse the effects of ORCH (ORCH+T). Finally, we determined the cellular expression of androgen receptor (AR), testosterone's canonical target receptor...
March 2, 2020: American Journal of Physiology. Renal Physiology
Jeroen Gerritsen, Jos Bloemers, Kim van Rooij, Leo de Leede, Ronald van der Geest, Henderik W Frijlink, Hans P F Koppeschaar, Berend Olivier, Adriaan Tuiten
INTRODUCTION: A new combination tablet containing sublingual testosterone and oral buspirone (T+B) was developed to benefit a subgroup of women suffering from female sexual interest/arousal disorder, caused by dysfunctionally overactive sexual inhibition. AIM: The aim of this study was to compare the effect of food intake on the pharmacokinetics of buspirone, administered as a dual-route, dual-release combination tablet containing 0.5 mg testosterone (T) and 10 mg buspirone (B)...
February 19, 2020: Sexual Medicine
Feiby L Nassan, Tina K Jensen, Lærke Priskorn, Thorhallur I Halldorsson, Jorge E Chavarro, Niels Jørgensen
Importance: Diet may play a role in testicular function, but data on how adherence to different diet patterns influences human testicular function are scarce. Objective: To determine whether adherence to specific dietary patterns is associated with testicular function in young men. Design, Setting, and Participants: This cross-sectional study included 2935 young Danish men unselected regarding fertility status who were enrolled from April 1, 2008, through May 31, 2017...
February 5, 2020: JAMA Network Open
Muhammad Zubair, Maqbool Ahmad, Muhammad Kashif Saleemi, Shafia Tehseen Gul, Mushtaq Ahmad, Christopher Joseph Martyniuk, Qudrat Ullah, Saqib Umar
Arsenic is a major environmental toxicant of concern, affecting both female and male reproductive systems. The present study was conducted to investigate the toxic effects of arsenic on semen quality and reproductive hormones of Teddy bucks, an important domestic species in regions of Pakistan. In addition to arsenic, vitamin C was fed to a subset of animals to determine if there were ameliorative effects on reproductive parameters. Sixteen adult Teddy bucks were randomly divided into four experimental groups: A (control), B (arsenic 5 mg/kg BW/day orally), and C (arsenic 5 mg/kg BW/day plus vitamin C of an oral dose of 200 mg/kg BW/day)...
February 18, 2020: Environmental Science and Pollution Research International
Ahmed M Kabel, Samir A Salama, Amal A Alghorabi, Remon S Estfanous
Cyclosporine is an immunosuppressive agent that is used to prevent organ rejection after organ transplantation. Due to the widespread use of this type of surgery, the effect of cyclosporine on reproduction and fertility should have a specific interest. Our aim was to assess the effect of carvedilol and/or alpha-lipoic acid on cyclosporine-induced testicular toxicity in rats. Sixty male Wistar rats were divided into six equal groups: Control; cyclosporine; cyclosporine + carvedilol; cyclosporine + alpha-lipoic acid; cyclosporine + carboxymethyl cellulose; and cyclosporine + carvedilol +alpha-lipoic acid...
February 13, 2020: Clinical and Experimental Pharmacology & Physiology
Chioma Izzi-Engbeaya, Sophie Jones, Yoshibye Crustna, Pratibha C Machenahalli, Deborah Papadopoulou, Manish Modi, Christos Panayi, Jessica Starikova, Pei Chia Eng, Maria Phylactou, Edouard Mills, Lisa Yang, Risheka Ratnasabapathy, Mark Sykes, Isabella Plumptre, Ben Coumbe, Victoria C Wing, Ewa Pacuszka, Paul Bech, James Minnion, George Tharakan, Tricia Tan, Johannes Veldhuis, Ali Abbara, Alexander N Comninos, Waljit S Dhillo
CONTEXT: Glucagon-like peptide-1 (GLP-1) potently reduces food intake and augments glucose-stimulated insulin secretion. Recent animal data suggest that GLP-1 may also influence reproduction. As GLP-1 receptor agonists are currently widely used in clinical practice to treat obesity/type 2 diabetes, it is necessary to determine the effects of GLP-1 on the reproductive system in humans. OBJECTIVE: To investigate the effects of GLP-1 administration on the reproductive axis in humans...
February 13, 2020: Journal of Clinical Endocrinology and Metabolism
Omowumi T Kayode, Damilare E Rotimi, Abolanle A A Kayode, Tomilola D Olaolu, Oluyomi S Adeyemi
Reproductive dysfunction is often characterized by malfunction of the reproductive tissues, which may lead to disruption of the synergistic rhythm that should bring about a progression of sexual events and the conception of new life. This may therefore result in the sexual dysfunction and infertility that can be seen in couples having prolonged biological difficulty in reproducing their offspring after having unrestricted sexual intercourse for at least twelve months. Several factors have been implicated in the cause and progression of reproductive dysfunction, including poor nutrition, drug side effects, disease states, and toxicant ingestion...
January 22, 2020: Toxics
Ila Mishra, Twinkle Batra, Abhilash Prabhat, Neha Agarwal, Sanjay Kumar Bhardwaj, Vinod Kumar
Food availability is a major ecological factor and affects body condition and sexual traits. Here, we investigated whether males' song behaviour, a trait for female mate choice, was sensitive to the food availability period and its timing in songbirds. We manipulated daily food availability to 4 h in the morning or evening, with controls on food ad libitum, and assessed its effects on song behaviour and forebrain song control system in male zebra finches that were held as adult (parent) or offspring (since birth) at 24 ± 2 °C under 12 h daily photoperiod...
January 21, 2020: Behavioural Brain Research
Nermin I Rizk, Mohamed S Rizk, Asmaa S Mohamed, Yahya M Naguib
PURPOSE: Male fertility is multifaceted and its integrity is as well multifactorial. Normal spermatogenesis is dependent on competent testicular function; namely normal anatomy, histology, physiology and hormonal regulation. Lifestyle stressors, including sleep interruption and even deprivation, have been shown to seriously impact male fertility. We studied here both the effects and the possible underlying mechanisms of vitamin C on male fertility in sleep deprived rats. METHODS: Thirty male Wistar albino rats were used in the present study...
January 11, 2020: Reproductive Biology and Endocrinology: RB&E
Susan J Diem, Nancy L Greer, Roderick MacDonald, Lauren G McKenzie, Philipp Dahm, Nacide Ercan-Fang, Allison Estrada, Laura S Hemmy, Christina E Rosebush, Howard A Fink, Timothy J Wilt
Background: Testosterone treatment rates in adult men have increased in the United States over the past 2 decades. Purpose: To assess the benefits and harms of testosterone treatment for men without underlying organic causes of hypogonadism. Data Sources: English-language searches of multiple electronic databases (January 1980 to May 2019) and reference lists from systematic reviews. Study Selection: 38 randomized controlled trials (RCTs) of at least 6 months' duration that evaluated transdermal or intramuscular testosterone therapies versus placebo or no treatment and reported prespecified patient-centered outcomes, as well as 20 long-term observational studies, U...
January 7, 2020: Annals of Internal Medicine
Mohammad Parastesh, Ali Heidarianpour, Mehdi Sadegh
Purpose: Diabetes mellitus type 2 with damaging effects on reproductive hormones and sperm quality parameters can often cause infertility in men. The aim of this study was to evaluate the effects of endurance, resistance and concurrent training on reproductive hormones, sperm parameter in the diabetic type 2 male rats. Methods: In this experimental study 60 Wistar rats (200 ± 50 g) were randomly assigned into 5 groups: control; diabetic; diabetic endurance training; diabetic resistance training and diabetic concurrent training...
December 2019: Journal of Diabetes and Metabolic Disorders
Mery Giantin, Minna Rahnasto-Rilla, Roberta Tolosi, Lorena Lucatello, Marianna Pauletto, Giorgia Guerra, Francesca Pezzato, Rosa M Lopparelli, Roberta Merlanti, Paolo Carnier, Francesca Capolongo, Paavo Honkakoski, Mauro Dacasto
Cytochrome P450 3A is the most important CYP subfamily in humans, and CYP3A4/CYP3A5 genetic variants contribute to inter-individual variability in drug metabolism. However, no information is available for bovine CYP3A (bCYP3A). Here we described bCYP3A missense single nucleotide variants (SNVs) and evaluated their functional effects. CYP3A28, CYP3A38 and CYP3A48 missense SNVs were identified in 300 bulls of Piedmontese breed through targeted sequencing. Wild-type and mutant bCYP3A cDNAs were cloned and expressed in V79 cells...
December 23, 2019: Scientific Reports
Mahmoud Mustafa Ali Abulmeaty, Ali Madi Almajwal, Mohamed Farouk ElSadek, Mohamed Y Berika, Suhail Razak
Background and Aim: Changes in total energy expenditure (TEE) and substrate metabolism may help explain the metabolic actions of testosterone (T). This study measured respiratory quotient (RQ), TEE, ghrelin, insulin, and key lipolysis enzyme concentrations in relation to body weight (wt) and food intake (FI) in both normal and bilaterally orchiectomized rats with/without T treatment. Methods: In total, thirty-two male Wistar rats (300-400 g) were divided into four groups ( n  = 8/group), including (a) sham-operated and vehicle-injected group (Sham), (b) T-treated sham group (T-Sham) for which sham-operated rats were injected with IM testosterone undecanoate (100 mg/kg, for one week), (c) orchiectomy and vehicle-injected group (Orch), and (d) T-replaced orchiectomy group (T-Orch)...
2019: International Journal of Endocrinology
Ralf Jäger, Alex E Mohr, Katie C Carpenter, Chad M Kerksick, Martin Purpura, Adel Moussa, Jeremy R Townsend, Manfred Lamprecht, Nicholas P West, Katherine Black, Michael Gleeson, David B Pyne, Shawn D Wells, Shawn M Arent, Abbie E Smith-Ryan, Richard B Kreider, Bill I Campbell, Laurent Bannock, Jonathan Scheiman, Craig J Wissent, Marco Pane, Douglas S Kalman, Jamie N Pugh, Jessica A Ter Haar, Jose Antonio
Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of probiotic supplementation to optimize the health, performance, and recovery of athletes. Based on the current available literature, the conclusions of the ISSN are as follows: 1)Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host (FAO/WHO).2)Probiotic administration has been linked to a multitude of health benefits, with gut and immune health being the most researched applications...
December 21, 2019: Journal of the International Society of Sports Nutrition
Hai-Tao Gao, Hong-Yi Shi, Qi-Meng Dai, An-Qi Li, Liu Yang, Yue Sun, Si-Yi Jin, Ling-Zi Xia
Human beings are increasingly exposed to phthalates, which are a group of chemicals used to make plastics more flexible and harder to break, and simultaneously ingesting abundant food emulsifiers via daily diet. The purpose of this study was to investigate the effect of the food emulsifier glycerin monostearate (GMS) on male reproductive toxicity caused by di(2-ethylhexyl) phthalate (DEHP, one of the phthalates) and explore the underlying mechanism. Thirty male Sprague-Dawley rats were randomly divided into control group, DEHP group and DEHP+GMS group...
December 2019: Current Medical Science
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