Testosterone and food

Nermin I Rizk, Mohamed S Rizk, Asmaa S Mohamed, Yahya M Naguib
PURPOSE: Male fertility is multifaceted and its integrity is as well multifactorial. Normal spermatogenesis is dependent on competent testicular function; namely normal anatomy, histology, physiology and hormonal regulation. Lifestyle stressors, including sleep interruption and even deprivation, have been shown to seriously impact male fertility. We studied here both the effects and the possible underlying mechanisms of vitamin C on male fertility in sleep deprived rats. METHODS: Thirty male Wistar albino rats were used in the present study...
January 11, 2020: Reproductive Biology and Endocrinology: RB&E
Susan J Diem, Nancy L Greer, Roderick MacDonald, Lauren G McKenzie, Philipp Dahm, Nacide Ercan-Fang, Allison Estrada, Laura S Hemmy, Christina E Rosebush, Howard A Fink, Timothy J Wilt
Background: Testosterone treatment rates in adult men have increased in the United States over the past 2 decades. Purpose: To assess the benefits and harms of testosterone treatment for men without underlying organic causes of hypogonadism. Data Sources: English-language searches of multiple electronic databases (January 1980 to May 2019) and reference lists from systematic reviews. Study Selection: 38 randomized controlled trials (RCTs) of at least 6 months' duration that evaluated transdermal or intramuscular testosterone therapies versus placebo or no treatment and reported prespecified patient-centered outcomes, as well as 20 long-term observational studies, U...
January 7, 2020: Annals of Internal Medicine
Mohammad Parastesh, Ali Heidarianpour, Mehdi Sadegh
Purpose: Diabetes mellitus type 2 with damaging effects on reproductive hormones and sperm quality parameters can often cause infertility in men. The aim of this study was to evaluate the effects of endurance, resistance and concurrent training on reproductive hormones, sperm parameter in the diabetic type 2 male rats. Methods: In this experimental study 60 Wistar rats (200 ± 50 g) were randomly assigned into 5 groups: control; diabetic; diabetic endurance training; diabetic resistance training and diabetic concurrent training...
December 2019: Journal of Diabetes and Metabolic Disorders
Mery Giantin, Minna Rahnasto-Rilla, Roberta Tolosi, Lorena Lucatello, Marianna Pauletto, Giorgia Guerra, Francesca Pezzato, Rosa M Lopparelli, Roberta Merlanti, Paolo Carnier, Francesca Capolongo, Paavo Honkakoski, Mauro Dacasto
Cytochrome P450 3A is the most important CYP subfamily in humans, and CYP3A4/CYP3A5 genetic variants contribute to inter-individual variability in drug metabolism. However, no information is available for bovine CYP3A (bCYP3A). Here we described bCYP3A missense single nucleotide variants (SNVs) and evaluated their functional effects. CYP3A28, CYP3A38 and CYP3A48 missense SNVs were identified in 300 bulls of Piedmontese breed through targeted sequencing. Wild-type and mutant bCYP3A cDNAs were cloned and expressed in V79 cells...
December 23, 2019: Scientific Reports
Mahmoud Mustafa Ali Abulmeaty, Ali Madi Almajwal, Mohamed Farouk ElSadek, Mohamed Y Berika, Suhail Razak
Background and Aim: Changes in total energy expenditure (TEE) and substrate metabolism may help explain the metabolic actions of testosterone (T). This study measured respiratory quotient (RQ), TEE, ghrelin, insulin, and key lipolysis enzyme concentrations in relation to body weight (wt) and food intake (FI) in both normal and bilaterally orchiectomized rats with/without T treatment. Methods: In total, thirty-two male Wistar rats (300-400 g) were divided into four groups ( n  = 8/group), including (a) sham-operated and vehicle-injected group (Sham), (b) T-treated sham group (T-Sham) for which sham-operated rats were injected with IM testosterone undecanoate (100 mg/kg, for one week), (c) orchiectomy and vehicle-injected group (Orch), and (d) T-replaced orchiectomy group (T-Orch)...
2019: International Journal of Endocrinology
Ralf Jäger, Alex E Mohr, Katie C Carpenter, Chad M Kerksick, Martin Purpura, Adel Moussa, Jeremy R Townsend, Manfred Lamprecht, Nicholas P West, Katherine Black, Michael Gleeson, David B Pyne, Shawn D Wells, Shawn M Arent, Abbie E Smith-Ryan, Richard B Kreider, Bill I Campbell, Laurent Bannock, Jonathan Scheiman, Craig J Wissent, Marco Pane, Douglas S Kalman, Jamie N Pugh, Jessica A Ter Haar, Jose Antonio
Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of probiotic supplementation to optimize the health, performance, and recovery of athletes. Based on the current available literature, the conclusions of the ISSN are as follows: 1)Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host (FAO/WHO).2)Probiotic administration has been linked to a multitude of health benefits, with gut and immune health being the most researched applications...
December 21, 2019: Journal of the International Society of Sports Nutrition
Hai-Tao Gao, Hong-Yi Shi, Qi-Meng Dai, An-Qi Li, Liu Yang, Yue Sun, Si-Yi Jin, Ling-Zi Xia
Human beings are increasingly exposed to phthalates, which are a group of chemicals used to make plastics more flexible and harder to break, and simultaneously ingesting abundant food emulsifiers via daily diet. The purpose of this study was to investigate the effect of the food emulsifier glycerin monostearate (GMS) on male reproductive toxicity caused by di(2-ethylhexyl) phthalate (DEHP, one of the phthalates) and explore the underlying mechanism. Thirty male Sprague-Dawley rats were randomly divided into control group, DEHP group and DEHP+GMS group...
December 2019: Current Medical Science
Muhammad U Sohail, Mohamed A Elrayess, A A Al Thani, M Al-Asmakh, Hadi M Yassine
The present study is designed to compare demographic characteristics, plasma biochemistry, and the oral microbiome in obese ( N = 37) and lean control ( N = 36) subjects enrolled at Qatar Biobank, Qatar. Plasma hormones, enzymes, and lipid profiles were analyzed at Hamad Medical Cooperation Diagnostic Laboratory. Saliva microbiome characterization was carried out by 16S rRNA amplicon sequencing using Illumina MiSeq platform. Obese subjects had higher testosterone and sex hormone-binding globulin (SHBG) concentrations compared to the control group...
December 3, 2019: Microorganisms
Flora Bacopoulou, Despoina Apostolaki, Aimilia Mantzou, Artemis Doulgeraki, Artur Pałasz, Pantelis Tsimaris, Eleni Koniari, Vasiliki Efthymiou
The Spexin gene is considered the most dysregulated in obese human fat. Limited data suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity. The aim of this case-control study was to compare fasting serum spexin concentrations between normal weight (NW) and overweight/obese (OB/OW) adolescent females and explore the relationship between circulating spexin and anthropometric, bone and fat mass, metabolic and hormonal parameters. Eighty post-menarcheal females (mean age ± SD 16...
December 2, 2019: Journal of Clinical Medicine
Yansen Li, Zhaojian Li, Yun Cao, Xin Zhou, Chunmei Li
Zinc (Zn) can accumulate in the body of wild animal and human through bio-magnification effects in the food chain to pose chronic toxicity. Male spermatogenesis was sensitive to excessive Zn and elevated temperature. This study aimed to examine whether or not excessive Zn intake caused testicular toxicity and estimate the interaction between Zn and high temperature (HT) in testes of Bama miniature pigs. Six-month-old pigs were pre-fed with or without additional Zn at 1500 mg/kg diet for 30 d and afterward subjected to HT at 40 °C for 5 h daily for 8 consecutive days...
November 21, 2019: Environmental Pollution
Susanne Jenni-Eiermann, Lukas Jenni, Juanita Olano Marin, Benjamin Homberger
Yolk hormones are substances which transmit non-genetic factors from the mother to the next generation. The systematic changes of yolk hormone concentrations within asynchronously hatching clutches have been interpreted as a means to adaptively shape the offspring's phenotype. However, in synchronously hatching clutches the role of yolk hormones is less understood. We investigated whether seasonal changes between eggs in the yolk hormones testosterone (Testo), progesterone (Prog) and corticosterone (Cort) also occur in the grey partridge, a synchronously hatching precocial species without direct food competition between siblings...
November 29, 2019: General and Comparative Endocrinology
Zhihui Jiang, Lingbiao Gu, Xiuli Liang, Baorui Cao, Jingmiao Zhang, Xiao Guo
Selenium is an essential nutrient in diets; however, the effects of selenium on enzyme metabolic activation are not currently clear. Cytochromes P450 (CYP450) are major phase I metabolic enzymes involved in the biotransformation of xenobiotics and endogenous compounds to form electrophilic reactive metabolites. To investigate the effect of selenium on CYP450 isoform activity, the Landrace pigs were divided into three groups: the control group (containing Se 0.15 mg/kg), the Se-deficient group (Se 0.03 mg/kg), and the Se-supply group (Se 0...
November 13, 2019: Biological Trace Element Research
Lawrence M Schell
OBJECTIVES: The goal of this article is to review a body of research around water contamination conducted in the Akwesasne Mohawk Nation between 1995 and 2016, place these findings in a biocultural context, and consider implications for a human biology of water. METHODS: This review draws on research projects conducted in partnership with the Akwesasne Mohawk Nation living along the St. Lawrence River as well as published research by others on water contamination at Akwesasne...
November 12, 2019: American Journal of Human Biology: the Official Journal of the Human Biology Council
Camila Ferreira Sales, Ana Paula Barbosa Pinheiro, Yves Moreira Ribeiro, André Alberto Weber, Fabíola de Oliveira Paes-Leme, Ronald Kennedy Luz, Nilo Bazzoli, Elizete Rizzo, Rafael Magno Costa Melo
Food restriction is part of the life cycle of many fish species; however, nutritional deficiency may negatively influence gametogenesis and gonadal maturation. The aim of this study was to evaluate the effects of food restriction on the spermatogenesis of Nile tilapia. For this, adult males were submitted to starvation and refeeding cycles (alternating periods of starvation and feeding) for 7, 14, 21, and 28 days. After 7 days of starvation, glycaemic and lipid levels were significantly reduced, followed by reduction of plasma testosterone (T) and 11-ketotestosterone (11-KT)...
November 8, 2019: Molecular and Cellular Endocrinology
Liat Morgan, Beata Itin-Shwartz, Lee Koren, Jerrold S Meyer, Devorah Matas, Ahmad Younis, Shiri Novak, Nathalie Weizmann, Olja Rapaic, Weissam Abu Ahmad, Eyal Klement, Tal Raz
Food-animal welfare is a major ethical and social concern. Pork is the most consumed meat worldwide, with over a billion pigs slaughtered annually. Most of these pigs routinely undergo painful surgical procedures (surgical castration, tail docking, teeth clipping), which farmers often reluctant to avoid, claiming it would increase cost and reduce production efficiency. Herein, this study indicates that these procedures compromise pigs' health and condition. Replacing surgical castration with immunocastration, avoiding tail docking and teeth clipping, and providing environmental enrichment, resulted in significant increase in weight gain, lowered risks for injuries and death, and reduced saliva and hair cortisol, both biomarkers for stress...
November 6, 2019: Scientific Reports
Suneela Vegunta, Juliana M Kling, Ekta Kapoor
Androgens are believed to have an important biologic role in women, particularly in regulation of libido and sexual arousal, although much about their function on other systems in women is unknown. Testosterone, the primary ovarian androgen, has been used to treat carefully selected postmenopausal women with hypoactive sexual desire disorder (HSDD). However, testosterone use in women has not been approved by the United States Food and Drug Administration (FDA) because of uncertainties regarding the effectiveness and long-term safety of this strategy...
November 5, 2019: Journal of Women's Health
Marta C Soares, Renata Mazzei, Sónia C Cardoso, Cândida Ramos, Redouan Bshary
Mathematical modelling regarding evolutionary theory typically assumes that optimal strategies are not constrained through mechanistic processes. In contrast, recent studies on brain anatomy and neurobiology suggest that flexibility in social behaviour is rather constrained by the physiological state of the social decision-making network. Changing its state may yield selective advantages in some social contexts but neutral or even detrimental effects in others. Here we provide field evidence for such physiological trade-offs...
November 1, 2019: Scientific Reports
Chiagoziem A Otuechere, Adewale Adewuyi, Tanitoluwa Oluwabayo, Folashade Afolayan, Oghenetega Avwioroko, Uche Abazuh
There is a current interest from the food packaging, biomedical and agricultural sectors in hybrid materials formed from clays and natural polymeric compounds. However, research investigating the toxicity of vermiculite-cellulose nanocrystal (VERN) hybrid on the testes of Wistar rats is rare. Twenty rats, divided into control and treatment groups, were orally administered distilled water, 5, 10, and 20 mg/kg bw VERN daily for two consecutive weeks. At the termination of experiments, the testicular organo-somatic index, superoxide dismutase, catalase, and gamma-glutamyl transferase activities were not significantly changed by VERN relative to the controls...
October 31, 2019: Andrologia
Maricel V Maffini, Ryan D Canatsey
Tetramethyl bisphenol F (TMBPF) has been shown to impart unique physical properties critical for high performance of epoxy can coatings without the estrogenic activity concerns associated with other bisphenols. To further characterize the toxicological profile of TMBPF, additional endocrine-related endpoints including in vitro aromatase inhibition and steroidogenesis assays, and in vivo androgen agonism/antagonism were performed. Systemic toxicity was also assessed by a repeat dose 90-day dietary toxicity study followed by 28-day recovery period...
October 17, 2019: Food and Chemical Toxicology
Wakae Murata, Yoshihiro Yamaguchi, Ken-Ichi Fujita, Ken Yamauchi, Toshio Tanaka, Akira Ogita
Parabens have been widely used as antimicrobial preservatives in cosmetics, pharmaceuticals, foods, and beverages. Commonly, methyl-, ethyl-, propyl-, and butylparaben are used independently or in combination to maintain the quality of industrial products, and they are considered to have low toxicity. However, recent evidence has suggested that parabens are toxic in mammalian cells, and parabens have been associated with allergic-contact dermatitis, breast cancer, and changes in testosterone levels. Sulforaphane, a cruciferous vegetable-derived isothiocyanate, was effective in decreasing the growth inhibitory concentrations of ethyl-, propyl-, butyl-, and methylparaben in the yeast Saccharomyces cerevisiae...
October 9, 2019: Letters in Applied Microbiology
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