Testosterone and food

Zhihui Jiang, Lingbiao Gu, Xiuli Liang, Baorui Cao, Jingmiao Zhang, Xiao Guo
Selenium is an essential nutrient in diets; however, the effects of selenium on enzyme metabolic activation are not currently clear. Cytochromes P450 (CYP450) are major phase I metabolic enzymes involved in the biotransformation of xenobiotics and endogenous compounds to form electrophilic reactive metabolites. To investigate the effect of selenium on CYP450 isoform activity, the Landrace pigs were divided into three groups: the control group (containing Se 0.15 mg/kg), the Se-deficient group (Se 0.03 mg/kg), and the Se-supply group (Se 0...
November 13, 2019: Biological Trace Element Research
Lawrence M Schell
OBJECTIVES: The goal of this article is to review a body of research around water contamination conducted in the Akwesasne Mohawk Nation between 1995 and 2016, place these findings in a biocultural context, and consider implications for a human biology of water. METHODS: This review draws on research projects conducted in partnership with the Akwesasne Mohawk Nation living along the St. Lawrence River as well as published research by others on water contamination at Akwesasne...
November 12, 2019: American Journal of Human Biology: the Official Journal of the Human Biology Council
Camila Ferreira Sales, Ana Paula Barbosa Pinheiro, Yves Moreira Ribeiro, André Alberto Weber, Fabíola de Oliveira Paes-Leme, Ronald Kennedy Luz, Nilo Bazzoli, Elizete Rizzo, Rafael Magno Costa Melo
Food restriction is part of the life cycle of many fish species; however, nutritional deficiency may negatively influence gametogenesis and gonadal maturation. The aim of this study was to evaluate the effects of food restriction on the spermatogenesis of Nile tilapia. For this, adult males were submitted to starvation and refeeding cycles (alternating periods of starvation and feeding) for 7, 14, 21, and 28 days. After 7 days of starvation, glycaemic and lipid levels were significantly reduced, followed by reduction of plasma testosterone (T) and 11-ketotestosterone (11-KT)...
November 8, 2019: Molecular and Cellular Endocrinology
Liat Morgan, Beata Itin-Shwartz, Lee Koren, Jerrold S Meyer, Devorah Matas, Ahmad Younis, Shiri Novak, Nathalie Weizmann, Olja Rapaic, Weissam Abu Ahmad, Eyal Klement, Tal Raz
Food-animal welfare is a major ethical and social concern. Pork is the most consumed meat worldwide, with over a billion pigs slaughtered annually. Most of these pigs routinely undergo painful surgical procedures (surgical castration, tail docking, teeth clipping), which farmers often reluctant to avoid, claiming it would increase cost and reduce production efficiency. Herein, this study indicates that these procedures compromise pigs' health and condition. Replacing surgical castration with immunocastration, avoiding tail docking and teeth clipping, and providing environmental enrichment, resulted in significant increase in weight gain, lowered risks for injuries and death, and reduced saliva and hair cortisol, both biomarkers for stress...
November 6, 2019: Scientific Reports
Suneela Vegunta, Juliana M Kling, Ekta Kapoor
Androgens are believed to have an important biologic role in women, particularly in regulation of libido and sexual arousal, although much about their function on other systems in women is unknown. Testosterone, the primary ovarian androgen, has been used to treat carefully selected postmenopausal women with hypoactive sexual desire disorder (HSDD). However, testosterone use in women has not been approved by the United States Food and Drug Administration (FDA) because of uncertainties regarding the effectiveness and long-term safety of this strategy...
November 5, 2019: Journal of Women's Health
Marta C Soares, Renata Mazzei, Sónia C Cardoso, Cândida Ramos, Redouan Bshary
Mathematical modelling regarding evolutionary theory typically assumes that optimal strategies are not constrained through mechanistic processes. In contrast, recent studies on brain anatomy and neurobiology suggest that flexibility in social behaviour is rather constrained by the physiological state of the social decision-making network. Changing its state may yield selective advantages in some social contexts but neutral or even detrimental effects in others. Here we provide field evidence for such physiological trade-offs...
November 1, 2019: Scientific Reports
Chiagoziem A Otuechere, Adewale Adewuyi, Tanitoluwa Oluwabayo, Folashade Afolayan, Oghenetega Avwioroko, Uche Abazuh
There is a current interest from the food packaging, biomedical and agricultural sectors in hybrid materials formed from clays and natural polymeric compounds. However, research investigating the toxicity of vermiculite-cellulose nanocrystal (VERN) hybrid on the testes of Wistar rats is rare. Twenty rats, divided into control and treatment groups, were orally administered distilled water, 5, 10, and 20 mg/kg bw VERN daily for two consecutive weeks. At the termination of experiments, the testicular organo-somatic index, superoxide dismutase, catalase, and gamma-glutamyl transferase activities were not significantly changed by VERN relative to the controls...
October 31, 2019: Andrologia
Maricel V Maffini, Ryan D Canatsey
Tetramethyl bisphenol F (TMBPF) has been shown to impart unique physical properties critical for high performance of epoxy can coatings without the estrogenic activity concerns associated with other bisphenols. To further characterize the toxicological profile of TMBPF, additional endocrine-related endpoints including in vitro aromatase inhibition and steroidogenesis assays, and in vivo androgen agonism/antagonism were performed. Systemic toxicity was also assessed by a repeat dose 90-day dietary toxicity study followed by 28-day recovery period...
October 17, 2019: Food and Chemical Toxicology
Wakae Murata, Yoshihiro Yamaguchi, Ken-Ichi Fujita, Ken Yamauchi, Toshio Tanaka, Akira Ogita
Parabens have been widely used as antimicrobial preservatives in cosmetics, pharmaceuticals, foods, and beverages. Commonly, methyl-, ethyl-, propyl-, and butylparaben are used independently or in combination to maintain the quality of industrial products, and they are considered to have low toxicity. However, recent evidence has suggested that parabens are toxic in mammalian cells, and parabens have been associated with allergic-contact dermatitis, breast cancer, and changes in testosterone levels. Sulforaphane, a cruciferous vegetable-derived isothiocyanate, was effective in decreasing the growth inhibitory concentrations of ethyl-, propyl-, butyl-, and methylparaben in the yeast Saccharomyces cerevisiae...
October 9, 2019: Letters in Applied Microbiology
Dorte Glintborg, Richard Christian Jensen, Anne Vibeke Schmedes, Ivan Brandslund, Henriette Boye Kyhl, Tina Kold Nielsen, Marianne Skovsager Andersen
STUDY QUESTION: Are higher testosterone levels during pregnancy in women with polycystic ovary syndrome (PCOS) associated with longer offspring anogenital distance (AGD)? SUMMARY ANSWER: AGD was similar in 3-month-old children born of mothers with PCOS compared to controls. WHAT IS KNOWN ALREADY: AGD is considered a marker of prenatal androgenization. STUDY DESIGN, SIZE, DURATION: Maternal testosterone levels were measured by mass spectrometry at Gestational Week 28 in 1127 women...
September 27, 2019: Human Reproduction
Meghan A Rice, Sanjay V Malhotra, Tanya Stoyanova
Prostate cancer is the most commonly diagnosed cancer affecting men in the United States. The prostate is a hormone-dependent gland in which androgen hormones testosterone and dihydrotestosterone bind to and activate the androgen receptor, initiating nuclear translocation of androgen receptor and a subsequent signaling cascade. Due to the androgen dependency of the prostate, androgen deprivation therapies have emerged as first line treatment for aggressive prostate cancer. Such therapies are effective until the point at which prostate cancer, through a variety of mechanisms including but not limited to generation of ligand-independent androgen receptor splice variants, or intratumoral androgen production, overcome hormone deprivation...
2019: Frontiers in Oncology
Katelyn Ann Bruno, Jessica Elizabeth Mathews, Alex Lingyun Yang, J Augusto Frisancho, Ashley Jennie Scott, Henry David Greyner, Frank Anthony Molina, Merci Shekinah Greenaway, George Maxwell Cooper, Adriana Bucek, Andrea Carolina Morales-Lara, Anneliese Ruth Hill, Anna Alisa Mease, Damian Nicolas Di Florio, John Michael Sousou, Alexandria Christine Coronado, Allison Ray Stafford, DeLisa Fairweather
Myocarditis is an inflammatory heart disease that leads to dilated cardiomyopathy (DCM) and heart failure. Sex hormones play an important role in the development of myocarditis with testosterone driving disease in males and estrogen being cardioprotective in females. The human population is widely exposed to the endocrine disruptor bisphenol A (BPA) from plastics such as water bottles, plastic food containers, copy paper, and receipts. Several clinical and numerous animal studies have found an association between elevated BPA levels and cardiovascular disease...
2019: Frontiers in Endocrinology
Luigi Barrea, Angela Arnone, Giuseppe Annunziata, Giovanna Muscogiuri, Daniela Laudisio, Ciro Salzano, Gabriella Pugliese, Annamaria Colao, Silvia Savastano
Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder and is characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries. Obesity, low-grade chronic inflammatory status, and insulin-resistance (IR) often coexist in PCOS. The Mediterranean diet (MD) is an anti-inflammatory dietary pattern, which is rich in complex carbohydrates and fiber, and high in monounsaturated fat. There is a close association among obesity, low-grade chronic inflammation, IR, and hormonal derangements in PCOS...
September 23, 2019: Nutrients
Elizabeth A Platz, John R Barber, Susan Chadid, Jiayun Lu, Adrian S Dobs, Norma F Kanarek, William G Nelson, Gary Bradwin, Katherine A McGlynn, Sabine Rohrmann
Context: Testosterone deficiency prevalence increases with age, comorbidities, and obesity. Objective: To inform clinical guidelines for testosterone deficiency management and development of targets for nonpharmacologic intervention trials for these men, we determined serum testosterone in never-smoking, lean men without select comorbidities in nationally representative surveys. Design Setting Participants: We used cross-sectional data for never-smoking, lean men ≥20 years without diabetes, myocardial infarction, congestive heart failure, stroke, or cancer, without use of hormone-influencing medications, and participated in morning sessions of National Health and Nutrition Examination Survey (NHANES) III (phase I 1988-1991) or continuous NHANES (1999-2004)...
October 1, 2019: Journal of the Endocrine Society
Chanarat Kiriya, Ranchana Yeewa, Chakkrit Khanaree, Teera Chewonarin
The preventive effects of purple rice crude ethanolic extract (PRE) were firstly investigated on testosterone-induced benign prostatic hyperplasia (BPH) in castrated rats. As compared to vehicle-treated rats, lower prostate weights were found in the BPH rats that received PRE 1 g/kg bw. In addition, the PRE treatment down-regulated the androgen receptor (AR) expression in the dorsolateral prostate of those rats. In human prostate cancer cell line, LNCaP, PRE could reduce the cell growth, down-regulate the expression of AR and suppress prostate-specific antigen (PSA) secretion...
September 2019: Journal of Food Biochemistry
Jos Bloemers, Jeroen Gerritsen, Kim van Rooij, Leo de Leede, Ronald van der Geest, Henderik W Frijlink, Hans P F Koppeschaar, Berend Olivier, Adriaan Tuiten
INTRODUCTION: Female sexual interest/arousal disorder (FSIAD) affects many women worldwide, but pharmacological treatment options are scarce. A new medicine being developed for FSIAD is an on-demand, dual-route, dual-release drug combination product containing 0.5 mg testosterone (T) and 50 mg sildenafil (S), referred to here as T+S. AIM: The aim of this study was to compare the effect of a fed and a fasted state on the pharmacokinetics of sildenafil following administration of T+S...
September 2019: Journal of Sexual Medicine
Kelton Tremellen, Amy Hill, Karma Pearce
Obesity is known to be associated with impaired testicular function potentially resulting in androgen deficiency and subfertility. While the underlying cause of obesity-related male hypogonadism is multi-factorial, here, we investigated the impact of dietary fat on testicular endocrine function. Ingestion of a high-fat "fast food" mixed meal, a common practice for obese men, produced a 25% fall in serum testosterone within an hour of eating, with levels remaining suppressed below fasting baseline for up to 4 hr...
September 2, 2019: Andrologia
Itzel Y López-Pacheco, Arisbe Silva-Núñez, Carmen Salinas-Salazar, Alejandra Arévalo-Gallegos, Laura A Lizarazo-Holguin, Damiá Barceló, Hafiz M N Iqbal, Roberto Parra-Saldívar
Existence of anthropogenic contaminants (ACs) in different environmental matrices is a serious and unresolved concern. For instance, ACs from different sectors, such as industrial, agricultural, and pharmaceutical, are found in water bodies with considerable endocrine disruptors potency and can damage the biotic components of the environment. The continuous ACs exposure can cause cellular toxicity, apoptosis, genotoxicity, and alterations in sex ratios in human beings. Whereas, aquatic organisms show bioaccumulation, trophic chains, and biomagnification of ACs through different entry route...
November 10, 2019: Science of the Total Environment
Juan Carlos Rodríguez-Escamilla, Estefany I Medina-Reyes, Carolina Rodríguez-Ibarra, Alejandro Déciga-Alcaraz, José O Flores-Flores, Adriana Ganem-Rondero, Miriam Rodríguez-Sosa, Luis I Terrazas, Norma L Delgado-Buenrostro, Yolanda I Chirino
Food-grade titanium dioxide labeled as E171 has been approved for human consumption by the Food and Drug Administration (USA) and by the European Union for five decades. However, titanium dioxide has been classified as a possible carcinogen for humans by the International Agency of Research in Cancer raising concerns of its oral intake and the translocation to bloodstream, which could disturb barriers such as the blood-testis barrier. There is evidence that titanium dioxide by intragastric/intraperitoneal/intravenous administration induced alterations on testosterone levels, testicular function and architecture, but studies of the E171 effects on the testicle structure and blood-testis barrier are limited...
August 15, 2019: Journal of Applied Toxicology: JAT
Cristina Daniela Possenti, Alexandra Bea Bentz, Andrea Romano, Marco Parolini, Manuela Caprioli, Diego Rubolini, Kristen Navara, Nicola Saino
Predators have both direct, consumptive effects on their prey and non-lethal effects on physiology and behavior, including reproductive decisions, with cascading effects on prey ecology and evolution. Here, we experimentally tested such non-lethal effects of exposure to increased predation risk on clutch size, egg mass, and the concentration of yolk steroid hormones in the yellow-legged gull Larus michahellis . We simulated increased predation risk by displaying stuffed predators (adult fox Vulpes vulpes , and adult buzzard Buteo buteo ) to breeding adults before egg laying...
August 2019: Current Zoology
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