Colitis Associated Cancer

Mahsa Sadat Hashemi Doulabi, Reza Goleyjani Moghaddam, Ali Salehzadeh
Ulcerative colitis is a form of inflammatory bowel disease characterized by chronic inflammation of the colon and rectum. The abnormal lesions in the digestive system caused by ulcerative colitis and intermittent colitis are of major clinical importance. MDM2 is a phospho-protein that functions as a ubiquitin ligase for p53. Recently, a T>G substitution in the promoter of the MDM2 gene (rs309) has been identified. In this case-control study, 174 ulcerative colitis biopsy samples and 82 control samples were collected from colonoscopy centers, hospitals, and clinics in Mazandaran and Gilan Provinces in Iran from October 2014 to May 2015...
March 2020: Genomics & Informatics
Tim Cooksley, Avinash Gupta, Tamer Al-Sayed, Paul Lorigan
INTRODUCTION: Immune-mediated toxicities are potentially fatal and can affect virtually any organ system. The prevalence of immune-mediated toxicity in patients being treated with immune checkpoint inhibitors (ICIs) is well described. However, the reasons for presentation and the prevalence of immune-mediated toxicity in acutely unwell patients being treated with ICIs is less well described. MATERIALS AND METHODS: A prospective analysis of all emergency presentations in patients being treated with ICIs was performed at a specialist oncology hospital in England from 20th May 2018 to 19th May 2019...
March 27, 2020: European Journal of Cancer
Bruna Damásio Moutinho, Jaqueline Ribeiro de Barros, Julio Pinheiro Baima, Rogerio Saad-Hossne, Ligia Yukie Sassaki
BACKGROUND The treatment of inflammatory bowel disease aims to induce and maintain disease remission, avoid complications, and restore quality of life. The treatments include the use of immunosuppressants and biological therapy. Despite the effectiveness of these treatments in controlling disease activity and in limiting complications, there remains an increased risk of developing malignancies. CASE REPORT A 70-year-old male patient with ulcerative colitis who had pancolitis was initially treated with mesalazine...
March 27, 2020: American Journal of Case Reports
Lianjie Lin, Dongxu Wang, Suxuan Qu, Hong Zhao, Yan Lin
Introduction: Ulcerative colitis (UC) is a chronic and inflammatory bowel disease. UC-associated colorectal cancer (UC-CRC) is one of the most severe complications of long-standing UC. In the present study, we explored the effects of miR-370-3p on UC-CRC in vivo and investigated its underlying mechanisms in vivo and in vitro. Methods: Azoxymethane (AOM) and dextran sodium sulfate (DSS) were used to induce UC-CRC in C57BL/6 mice. AOM/DSS-induced mice were treated with 5×108 pfu miR-370-3p overexpressing-adenovirus via tail-vein injection every two weeks...
2020: Drug Design, Development and Therapy
Wenhan Yang, Peng Men, Huimin Xue, Mingyan Jiang, Qiuhua Luo
Background: The combination of immune checkpoint inhibitors (ICIs) and chemotherapy can improve clinical outcomes in the treatment of various tumors, but may also be associated with more adverse events (AEs). We performed a systematic review and meta-analysis to characterize the risk of gastrointestinal AEs in cancer patients treated with ICI plus chemotherapy. Methods: This review was based on comprehensive search through PubMed, EMBASE, and the Cochrane Library for randomized controlled trials (RCTs) that reported gastrointestinal AEs following the use of ICI plus chemotherapy...
2020: Frontiers in Oncology
Elena Lo Presti, Filippo Mocciaro, Roberto Di Mitri, Anna Maria Corsale, Marta Di Simone, Salvatore Vieni, Nunzia Scibetta, Elettra Unti, Francesco Dieli, Serena Meraviglia
Inflammatory bowel disease (IBD) remains a global health problem with a significant percentage of patients progressing to chronic inflammation and colitis-associated cancer (CAC). Whether or not γδ T cells contribute to initiation and maintenance of inflammation in IBD and in the development of CAC is not known. We have evaluated the frequency, phenotype, and functions of γδ T cells among tissue-infiltrating lymphocytes in healthy donors and IBD and CAC patients. Results show that Vδ1 T cells are the dominant γδ T-cell population in healthy tissue, whereas Vδ2 T significantly abound in chronic IBD...
March 23, 2020: Journal of Leukocyte Biology
Yu Xin, Hongjuan Wang, Yanan Wang, Weihua Xu, Guoxin Teng, Fuyan Han, Jianqiang Guo
Vitamin D3 is beneficial in ameliorating or preventing inflammation and carcinogenesis. CCL20 is a potential therapeutic target in carcinogenesis, which mediates the protective effect of vitamin D or vitamin D analogue in autoimmune and cancer diseases. Here we aim to evaluate whether vitamin D3 plays a protective role in colitis-associated colorectal cancer (CAC) by affecting CCL20 and the molecular mechanism. Administration of azoxymethane (AOM) followed with dextran sulfate sodium (DSS) was used to simulate CAC in mouse...
March 16, 2020: European Journal of Cancer Prevention
Shashuang Zhang, Wenhua Liang, Lingjie Luo, Shan Sun, Feng Wang
BACKGROUND: Immune checkpoint inhibitor (ICPI) can augment the anti-tumour response by blocking negative immunoregulators with monoclonal antibodies. The anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibody is the first ICPI which has shown remarkable benefits in the clinical treatment of cancers. However, the increased activity of the immune system also causes some side effects called immune-related adverse events (irAEs). Colitis is one of the most common irAEs related to anti-CTLA-4 immunotherapy...
March 17, 2020: BMC Biology
Iago Rodríguez-Lago, Jesús Castro-Poceiro, Agnès Fernández-Clotet, Francisco Mesonero, Antonio López-Sanromán, Alicia López-García, Lucía Márquez, Ariadna Clos-Parals, Fiorella Cañete, Miren Vicuña, Óscar Nantes, Olga Merino, Virginia Matallana, Jordi Gordillo, Ainara Elorza, Raquel Vicente, María José Casanova, Rocío Ferreiro-Iglesias, Pablo Pérez-Galindo, José Manuel Benítez, Carlos Taxonera, María José García, Eduardo Martín, Urko Aguirre, Javier P Gisbert
BACKGROUND: Tacrolimus is a calcineurin inhibitor commonly used for prophylaxis of rejection in renal and liver transplantation. There are limited but favourable data regarding its possible use in patients with inflammatory bowel disease (IBD). AIMS: To evaluate the efficacy and safety of tacrolimus in patients with IBD in clinical practice. METHODS: We performed a retrospective, multicentre study in 22 centres in Spain. All adult patients who received oral tacrolimus for luminal or perianal IBD were included...
March 17, 2020: Alimentary Pharmacology & Therapeutics
Robert Plummer, Guo-Fu Hu, Tiegang Liu, James Yoo
INTRODUCTION: The myofibroblast is a gastrointestinal stromal cell that is a target of tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine strongly implicated in colitis-associated cancer. Crosstalk between TNF-α and other pro-inflammatory mediators amplify inflammatory signaling but the mechanism is unknown. Angiogenin (ANG) is a 14-kDa angiogenesis protein that is regulated in patients with inflammatory bowel disease. However, the role of ANG on inflammatory mediator crosstalk in the myofibroblast is unknown...
March 11, 2020: Biochemical and Biophysical Research Communications
Seth E Karol, Thomas B Alexander, Amit Budhraja, Stanley B Pounds, Kristin Canavera, Lei Wang, Joshua Wolf, Jeffery M Klco, Paul E Mead, Soumyasri Das Gupta, Su Y Kim, Ahmed Hamed Salem, Tammy Palenski, Norman J Lacayo, Ching-Hon Pui, Joseph T Opferman, Jeffrey E Rubnitz
BACKGROUND: Outcomes for children with relapsed or refractory acute myeloid leukaemia remain poor. The BCL-2 inhibitor, venetoclax, has shown promising activity in combination with hypomethylating agents and low-dose cytarabine in older adults for whom chemotherapy is not suitable with newly diagnosed acute myeloid leukaemia. We aimed to determine the safety and explore the activity of venetoclax in combination with standard and high-dose chemotherapy in paediatric patients with relapsed or refractory acute myeloid leukaemia...
March 11, 2020: Lancet Oncology
Lijuan Wang, Lei Tang, Yiming Feng, Suying Zhao, Mei Han, Chuan Zhang, Gehui Yuan, Jun Zhu, Shuyuan Cao, Qian Wu, Lei Li, Zhan Zhang
OBJECTIVE: Gut microbiota have been linked to inflammatory bowel disease (IBD) and colorectal cancer (CRC). Akkermansia muciniphila ( A. muciniphila ) is a gram-negative anaerobic bacterium that is selectively decreased in the faecal microbiota of patients with IBD, but its causative role and molecular mechanism in blunting colitis-associated colorectal cancer (CAC) remain inconclusive. This study investigates how A. muciniphila engages the immune response in CAC. DESIGN: Mice were given dextran sulfate sodium to induce colitis, followed by azoxymethane to establish CAC with or without pasteurised A...
March 13, 2020: Gut
H M Zhang, W Han, H Yang, L Wang, X Y Bai, G C Ruan, M X Wu, X F Chen, M Y Guo, R N Zhou, Q Y Zhou, J M Qian
Objective: To analyze the clinical features of ulcerative colitis associated colorectal cancer (UC-CRC). Methods: A total of 869 inpatients with Ulcerative Colitis (UC) in Peking Union Medical Hospital from January 1998 to January 2018 were continuously enrolled. Clinical data and the outcome of colorectal cancer (CRC) were collected via medical records and telephone follow-up. Chi-square test and logistic regression model were used to analyze the data. Results: There were 16 patients in 869 UC inpatients who were diagnosed with CRC during a period of 7 548 person years and the incidence rate of UC-CRC was 1...
March 3, 2020: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Olivia V Yvellez, Victoria Rai, Philip H Sossenheimer, John Hart, Jerrold R Turner, Christopher Weber, Katia El Jurdi, David T Rubin
BACKGROUND: Chronic inflammation in ulcerative colitis (UC) is associated with the development of colorectal neoplasia (CRN). A group at St. Mark's Hospital reported a novel cumulative inflammatory index that predicted the development of CRN in UC patients that we validated with an independent, well-described, matched, case-controlled cohort from the University of Chicago. METHODS: Cumulative inflammatory burden (CIB) was calculated by summing each histological inflammatory activity (HIA) score and multiplying it by the length of the surveillance interval...
March 10, 2020: Inflammatory Bowel Diseases
Farzad Rahmani, Fereshteh Asgharzadeh, Amir Avan, Farnaz Barneh, Mohammad Reza Parizadeh, Gordon A Ferns, Mikhail Ryzhikov, Mohammad Reza Ahmadian, Elisa Giovannetti, Mohieddin Jafari, Majid Khazaei, Seyed Mahdi Hassanian
AIMS: Rigosertib (RGS) is a PI3K inhibitor that exerts protective effects against tumor progression and cancer-related inflammation. This study was aimed to explore the regulatory effects of RGS on proliferative, pro-fibrotic and inflammatory factors in DSS- induced colitis mice model. MATERIALS AND METHODS: The present study integrates systems and molecular biology approaches to investigate the therapeutic potency of RGS in an experimental model of colitis specifically examining its effects on the PI3K/AKT and NF-κB signaling pathways...
March 2, 2020: Life Sciences
Christine Verdon, Achuthan Aruljothy, Peter L Lakatos, Talat Bessissow
Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with an increased risk of colorectal cancer (CRC). This has led to the implementation of surveillance programmes to minimise this risk. Overall, these proactive programmes in association with better medical therapies have reduced the incidence of CRC in this population. Specific populations remain at increased risk, such as younger age at diagnosis, primary sclerosing cholangitis, colonic strictures and pseudopolyps. The majority of gastrointestinal international societies favour chromoendoscopy with targeted biopsies or random biopsies...
March 2020: Frontline Gastroenterology
Baosheng Chen, David M Alvarado, Micah Iticovici, Nathan S Kau, Haeseong Park, Parag J Parikh, Dinesh Thotala, Matthew A Ciorba
Colorectal cancer is a major cause of mortality worldwide. Chemotherapy and radiation remain standard treatment for locally advanced disease, with current immune-targeting therapies applying to only a small subset of patients. Expression of the immuno-oncology target indoleamine 2,3 dioxygenase 1 (IDO1) is associated with poor colorectal cancer clinical outcomes but is understudied as a potential treatment target. In this study, we examined the interaction between the IDO1 pathway and radiotherapy in colorectal cancer...
March 3, 2020: Cancer Immunology Research
Ji Hyun Choi, Chang Mo Moon, Tae-Seop Shin, Eun Kyoung Kim, Andrea McDowell, Min-Kyung Jo, Yang Hee Joo, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim, Sung-Ae Jung, Yoon-Keun Kim
Lactobacillus paracasei is a major probiotic and is well known for its anti-inflammatory properties. Thus, we investigated the effects of L. paracasei-derived extracellular vesicles (LpEVs) on LPS-induced inflammation in HT29 human colorectal cancer cells and dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice. ER stress inhibitors (salubrinal or 4-PBA) or CHOP siRNA were utilized to investigate the relationship between LpEV-induced endoplasmic reticulum (ER) stress and the inhibitory effect of LpEVs against LPS-induced inflammation...
March 2, 2020: Experimental & Molecular Medicine
Joyce Wing Yan Mak, Jacqueline So, Whitney Tang, Terry Cheuk Fung Yip, Wai Keung Leung, Michael Li, Fu Hang Lo, Ka Man Ng, Shun Fung Sze, Chi Man Leung, Steven Woon Choy Tsang, Edwin Hok Shing Shan, Kam Hon Chan, Belsy C Y Lam, Aric J Hui, Wai Hung Chow, Francis Ka Leung Chan, Siew Chien Ng
Background and aim: Role of 5-aminosalicylic acid (5-ASA), statin and aspirin in reducing cancer risks in inflammatory bowel disease (IBD) remains controversial. We aimed to examine chemo-preventive effects of these drugs in all cancers in IBD in population-based setting. Methods: IBD patients diagnosed between 2000 and 2016 were identified from the Hong Kong IBD Registry and followed from IBD diagnosis until first cancer occurrence. Primary outcome was cancer development ≥6 months after IBD diagnosis. Adjusted hazard ratio (aHR) with 95% confidence interval (CI) was estimated with Cox proportional hazards model...
March 2, 2020: Scandinavian Journal of Gastroenterology
Feng Jiang, Minghao Liu, Haidan Wang, Guoping Shi, Biqing Chen, Tuo Chen, Xiaomin Yuan, Ping Zhu, Jinyong Zhou, Qiong Wang, Yugen Chen
BACKGROUND: Colorectal cancer (CRC) has a high incidence and mortality rate worldwide. Colitis-associated CRC (CAC) is used for describing the relationship between inflammation and CRC. No chemopreventive agents have been found to be both effective and safe in CRC. Therefore, the prevention and treatment of CAC are extremely urgent. Wu Mei Wan (WMW) has been used for the clinical treatment of enteritis with a remarkable efficacy. Here, we aim to investigate the underlying mechanism of WMW in the prevention of CAC...
February 24, 2020: Biomedicine & Pharmacotherapy
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