Arterial compliance supplement

Julia C Kuszewski, Rachel H X Wong, Lisa G Wood, Peter R C Howe
BACKGROUND AND AIMS: Chronic conditions such as obesity, which contribute to endothelial dysfunction in older adults, can cause impairments in cerebrovascular perfusion, which is associated with accelerated cognitive decline. Supplementing the diet with bioactive nutrients that can enhance endothelial function, such as fish oil or curcumin, may help to counteract cerebrovascular dysfunction. METHODS AND RESULTS: A 16-week double-blind, randomized placebo-controlled trial was undertaken in 152 older sedentary overweight/obese adults (50-80 years, body mass index: 25-40 kg/m2 ) to investigate effects of fish oil (2000 mg docosahexaenoic acid + 400 mg eicosapentaenoic acid/day), curcumin (160 mg/day) or a combination of both on cerebrovascular function (measured by Transcranial Doppler ultrasound), systemic vascular function (blood pressure, heart rate and arterial compliance) and cardiometabolic (fasting glucose and blood lipids) and inflammatory (C-reactive protein) biomarkers...
December 30, 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Vladimir V Lomivorotov, Gleb Moroz, Samandar Ismoilov, Vladimir Shmyrev, Sergey Efremov, Marat Abubakirov, Vasily Batalov, Giovanni Landoni, Rosalba Lembo, Alexander Bogachev-Prokophiev, Andrey Sapegin, Rinaldo Bellomo
OBJECTIVE: To test the feasibility and investigate possible cardiovascular effects of a sustained high-dose intravenous thiamine protocol in patients undergoing combined valvular and coronary artery bypass graft surgery. DESIGN: Randomized, placebo-controlled, pilot feasibility trial. SETTING: Cardiac surgery department of a tertiary hospital. PARTICIPANTS: Forty patients undergoing combined valvular and coronary artery bypass surgery...
September 4, 2019: Journal of Cardiothoracic and Vascular Anesthesia
S R Zwakenberg, P A de Jong, J W Bartstra, R van Asperen, J Westerink, H de Valk, R H J A Slart, G Luurtsema, J M Wolterink, G J de Borst, J A van Herwaarden, M A van de Ree, L J Schurgers, Y T van der Schouw, J W J Beulens
BACKGROUND: Vitamin K occurs in the diet as phylloquinone and menaquinones. Observational studies have shown that both phylloquinone and menaquinone intake might reduce cardiovascular disease (CVD) risk. However, the effect of vitamin K on vascular calcification is unknown. OBJECTIVES: The aim of this study was to assess if menaquinone supplementation, compared to placebo, decreases vascular calcification in people with type 2 diabetes and known CVD. METHODS: In this double-blind, randomized, placebo-controlled trial, we randomly assigned men and women with type 2 diabetes and CVD to 360 µg/d menaquinone-7 (MK-7) or placebo for 6 mo...
October 1, 2019: American Journal of Clinical Nutrition
Erin Victoria McGillick, Indya M Davies, Stuart B Hooper, Lauren T Kerr, Marta Thio, Philip DeKoninck, Shigeo Yamaoka, Ryan Hodges, Karyn Rodgers, Valerie A Zahra, Alison Maree Moxham, Aidan J Kashyap, Kelly J Crossley
Newborns with lung hypoplasia (LH) commonly have limited respiratory function and often require ventilatory assistance after birth. We aimed to characterize the cardiorespiratory transition and respiratory function in newborn lambs with LH. LH was induced by draining fetal lung liquid in utero (110-133d, term=147d, n=6). At ~133d gestation, LH and Control lambs (n=6) were instrumented and ventilated for 3 hours to monitor blood gas status, oxygenation, ventilator requirements and hemodynamics during the transition from fetal to newborn life...
June 13, 2019: Journal of Applied Physiology
Josefine S Baekgaard, Dan Isbye, Camilla Ikast Ottosen, Mo Haslund Larsen, Jakob Hessel Andersen, Lars S Rasmussen, Jacob Steinmetz
INTRODUCTION: Hyperoxaemia is commonly observed in trauma patients but has been associated with pulmonary complications and mortality in some patient populations. The objectives of this study were to evaluate whether maintenance of normoxia is feasible using a restrictive oxygen strategy in the initial phase after trauma and to evaluate the incidence of 30-day mortality and/or major pulmonary complications. METHODS: Forty-one adult trauma patients admitted to our trauma centre were randomised to 24 hours of restrictive oxygen therapy (no supplemental oxygen if the arterial oxyhaemoglobin saturation (SpO2 ) was at least 94%, n = 21) or liberal oxygen therapy (intubated patients: FiO2 1...
August 2019: Acta Anaesthesiologica Scandinavica
S Zhorzholiani, S Krasheninnikov, A Shepelev, T Tenchurin, A Gorodkov, L Bokeria
Previously, the pattern of changes in the radial elasticity of the aortic wall in the longitudinal direction has been shown, which poses new challenges in the selection of the biomechanical properties of synthetic prostheses for replacing arterial vessels. The aim of the work was to develop a system of methods for assessing the biomechanical properties of vascular implants, allowing supplementing the known methods of testing on thromboresistance and healing. Samples of blood vessels prostheses were prepared using electrospinning technology with the polymer composition and the conditions of prosthesis formation so that their elastic properties in the physiological pressure range were as close as possible to the properties of native blood vessels...
November 2018: Georgian Medical News
Kerry L Hildreth, Robert S Schwartz, Joseph Vande Griend, Wendy M Kohrt, Patrick J Blatchford, Kerrie L Moreau
The cardiovascular effects of testosterone (T) are controversial. Low T has been associated with accelerated vascular aging, characterized by large elastic artery stiffening (decreased compliance), intimal-medial thickening (IMT), and endothelial dysfunction. Endurance exercise improves vascular function, but resistance training may increase arterial stiffness. We sought to determine whether T supplementation improved markers of vascular aging in men with low-normal T, and whether T supplementation prevented arterial stiffness with resistance exercise...
September 6, 2018: Journal of Applied Physiology
Elisa Damiani, Abele Donati, Massimo Girardis
PURPOSE OF REVIEW: To examine the potential harmful effects of hyperoxia and summarize the results of most recent clinical studies evaluating oxygen therapy in critically ill patients. RECENT FINDINGS: Excessive oxygen supplementation may have detrimental pulmonary and systemic effects because of enhanced oxidative stress and inflammation. Hyperoxia-induced lung injury includes altered surfactant protein composition, reduced mucociliary clearance and histological damage, resulting in atelectasis, reduced lung compliance and increased risk of infections...
April 2018: Current Opinion in Anaesthesiology
Marjan Mahdavi-Roshan, Javad Nasrollahzadeh, Ali Mohammad Zadeh, Ali Zahedmehr
BACKGROUND: Hypertension is one of the major risk factors for cardiovascular morbidities, including coronary artery disease (CAD). OBJECTIVES: With interest on the important role of hypertension in the progression of CAD, this study was designed to estimate the effect of garlic powder tablets on the blood pressure (BP) in patients with severe CAD. METHODS: A randomized, placebo-controlled, clinical trial was conducted on 56 CAD patients, aged 25 - 75 years old...
November 2016: Iranian Red Crescent Medical Journal
Hui Ding, Qi Lv, Shiman Wu, Shike Hou, Ziquan Liu, Ning Xu Landén, Ping Tian, Mengyang Yu, Zhiguang Sun, Haojun Fan
Smoke inhalation injury (SII) is associated with significant morbidity and mortality in burn patients, and effective treatments are lacking. Perfluorocarbons (PFCs) have a protective effect against acute lung injury. We aimed to assess the therapeutic effects of perfluorohexane on burn patients with SII. Patients with burns complicated by moderately severe SII were randomly divided into control (n = 11) and PFC groups (n = 12). The control group received conventional treatment (anti-infection, nutritional support, antishock measures, and supportive treatment)...
July 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
Jessica R Santos-Parker, Talia R Strahler, Candace J Bassett, Nina Z Bispham, Michel B Chonchol, Douglas R Seals
We hypothesized that curcumin would improve resistance and conduit artery endothelial function and large elastic artery stiffness in healthy middle-aged and older adults. Thirty-nine healthy men and postmenopausal women (45-74 yrs) were randomized to 12 weeks of curcumin (2000 mg/day Longvida®; n=20) or placebo (n=19) supplementation. Forearm blood flow response to acetylcholine infusions (FBFACh ; resistance artery endothelial function) increased 37% following curcumin supplementation (107±13 vs. 84±11 AUC at baseline, P=0...
January 3, 2017: Aging
Yves Lacasse, Sarah Bernard, Frédéric Sériès, Van Hung Nguyen, Jean Bourbeau, Shawn Aaron, François Maltais
BACKGROUND: Long-term oxygen therapy (LTOT) is the only component of the management of chronic obstructive pulmonary disease (COPD) that improves survival in patients with severe daytime hypoxemia. LTOT is usually provided by a stationary oxygen concentrator and is recommended to be used for at least 15-18 h a day. Several studies have demonstrated a deterioration in arterial blood gas pressures and oxygen saturation during sleep in patients with COPD, even in those not qualifying for LTOT...
January 9, 2017: BMC Pulmonary Medicine
Tamara Page, Craig Lockwood, Tiffany Conroy-Hiller
BACKGROUND: Coronary heart disease is the major cause of illness and death in Western countries and this is likely to increase as the average age of the population rises. Consumers with established coronary heart disease are at the highest risk of experiencing further coronary events. Lifestyle measures can contribute significantly to a reduction in cardiovascular mortality in established coronary heart disease. Improved management of cardiac risk factors by providing education and referrals as required has been suggested as one way of maintaining quality care in patients with established coronary heart disease...
2005: JBI Library of Systematic Reviews
Bryan Heath Curry, Vernon Bond, Sudhakar Pemminati, Vasavi Rakesh Gorantla, Yulia Andreevna Volkova, Kishan Kadur, Richard Mark Millis
INTRODUCTION: Beetroot Juice (BJ) contains dietary nitrates that increase the blood Nitric Oxide (NO) level, decrease Blood Pressure (BP), increase athletic performance and improve cognitive functions but the mechanism remains unclear. Ultrasonographic measurement of middle cerebral artery blood flow velocity with computation of Cerebral Augmentation Index (CAIx) is a measure of the reflected flow signal, modulated by changes in cerebrovascular resistance and compliance. AIM: This pilot study tests the hypothesis that ingestion of an amount of BJ sufficient to raise the blood NO level two-to three-fold, decreases Transcranial Doppler (TCD) measured CAIx...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Kirk P Conrad
BACKGROUND: Important roles for G-protein-coupled receptors (GPCRs) have been identified in the maternal physiological adaptations to pregnancy and in the pathogenesis of preeclampsia. On this basis, GPCRs are potential therapeutic targets for preeclampsia. OBJECTIVES AND RATIONALE: In this review, vasopressin and apelin are initially considered in this context before the focus on the hormone relaxin and its cognate receptor, the relaxin/insulin-like family peptide receptor 1 (RXFP1)...
September 2016: Human Reproduction Update
Dimitris Georgopoulos, Nectaria Xirouchaki, Nikolaos Tzanakis, Magdy Younes
The data show respiratory variables in 108 critically ill patients with acute respiratory failure placed on proportional assist ventilation with load adjustable gain factors (PAV+) after at least 36 h on passive mechanical ventilation. PAV+ was continued for 48 h until the patients met pre-defined criteria either for switching to controlled modes or for breathing without ventilator assistance. Data during passive mechanical ventilation and during PAV+ are reported. Data are acquired from the whole population, as well as from patients with and without acute respiratory distress syndrome...
September 2016: Data in Brief
Yufuko Kataoka, Yoshi-Ichiro Kamijo, Yu Ogawa, Eri Sumiyoshi, Mari Nakae, Shigeki Ikegawa, Kazumasa Manabe, Mayuko Morikawa, Masashi Nagata, Satoshi Takasugi, Shizue Masuki, Hiroshi Nose
In Japan, the incidence of heat illness in older people has rapidly increased during midsummer in the last decade, and we suggested that whey-protein+carbohydrate supplementation during aerobic training would increased plasma volume (PV) to enhance thermoregulatory adaptation in older men (J Appl Physiol 107: 725-733, 2009); however, >60% of people age 65 and older suffer from hypertension, and the symptoms may be worsened by hypervolemia. To examine this, we randomly divided 21 older men (∼69 yr) with ∼160 mmHg for systolic and ∼90 mmHg for diastolic blood pressure at rest into two groups: Glc (n = 11) consuming glucose alone (25 g) and Pro-Glc (n = 10) consuming whey protein (10 g) + glucose (15 g), immediately after cycling exercise at 60-75% of peak aerobic capacity (V̇o2 peak ) for 60 min/day, 3 days/wk, for 8 wk...
October 1, 2016: Journal of Applied Physiology
Christos Rammos, Ulrike B Hendgen-Cotta, Matthias Totzeck, Julia Pohl, Peter Lüdike, Ulrich Flögel, René Deenen, Karl Köhrer, Brent A French, Axel Gödecke, Malte Kelm, Tienush Rassaf
AIMS: Diastolic dysfunction is highly prevalent, and ageing is the main contributor due to impairments in active cardiac relaxation, ventriculo-vascular stiffening, and endothelial dysfunction. Nitric oxide (NO) affects cardiovascular functions, and NO bioavailability is critically reduced with ageing. Whether replenishment of NO deficiency with dietary inorganic nitrate would offer a novel approach to reverse age-related cardiovascular alterations was not known. METHODS AND RESULTS: A dietary nitrate supplementation was applied to young (6 month) and old (20 month) wild-type mice for 8 weeks and compared with controls...
June 2016: European Journal of Heart Failure
Benjamin Heller, Adam Levine
This is the case of an 80-year-old female who presented for evacuation of a neck hematoma on POD#3 after a parathyroidectomy. Her medical history included coronary artery disease with a drug-eluding stent, off aspirin for 2 weeks. She had a significant hematoma from the hyoid bone extending down to below the suprasternal notch. She reported hoarseness. The anesthesiology team provided regional anesthesia with bilateral superficial cervical blocks, supplemented with minimal sedation for patient compliance. The surgical team used no adjuvant local anesthetic...
October 2015: Middle East Journal of Anesthesiology
Alexander J Rodríguez, David Scott, Velandai Srikanth, Peter Ebeling
BACKGROUND: Low vitamin D has been associated with poor arterial compliance in observational studies. Arterial stiffness has prognostic value for cardiovascular disease risk. The aim of this systematic review was to clarify the literature surrounding the use of vitamin D to ameliorate arterial stiffness. METHODS: We conducted a systematic review of the MEDLINE, Scopus and EMBASE databases for randomized controlled clinical trials investigating the effect of vitamin D supplementation on pulse wave velocity (PWV) and/or augmentation index (AI) as indicators of arterial stiffness...
May 2016: Clinical Endocrinology
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