Cuneyt Yilmaz, D Merrill Dane, Nicholas Tustison, Gang Song, James C Gee, Connie C W Hsia
Mechanical stresses on the lung impose the major stimuli for developmental and compensatory lung growth and remodeling. We used computed tomography (CT) to noninvasively characterize the factors influencing lobar mechanical deformation in relation to posture, pneumonectomy (PNX), and exogenous pro-angiogenic factor supplementation. Post-PNX adult canines received weekly inhalations of nebulized nanoparticles loaded with recombinant human erythropoietin (EPO) or control (empty nanoparticles) for 16 weeks. Supine and prone CT were performed at two transpulmonary pressures pre- and post-PNX following treatment...
January 16, 2020: Journal of Applied Physiology
Gail M Comer, Mark A Bush, Evan S Dellon, Mark T Marino
Eosinophilic esophagitis is a common atopic disease of the esophagus. APT-1011 is an orally disintegrating tablet formulation of fluticasone propionate under development for the treatment of eosinophilic esophagitis. The objective of this study was to evaluate the pharmacokinetics, safety, and tolerability of APT-1011 under fed or fasted conditions in the morning (am) or at bedtime (hs) in the supine position. The study was a randomized, single-dose, 3-way, crossover design in healthy adult volunteers. In each study period participants received 2 3-mg orally disintegrating APT-1011 tablets...
January 15, 2020: Journal of Clinical Pharmacology
Eun Mi Lee, Tae Hoon Lee, Ol Lim Park, Jung Gwon Nam
BACKGROUND AND PURPOSE: The aim of this study was to determine how the sleep stage and body position influence the effective pressure (Peff) in standard upward titration and experimental downward titration. METHODS: This study applied successful manual titration of continuous positive airway pressure over 3 hours [including at least 15 min in supine rapid eye movement (REM) sleep] followed by consecutive downward titration for at least 1 hour to 22 patients with moderate-to-severe obstructive sleep apnea...
January 2020: Journal of Clinical Neurology
Julian M Stewart, Marvin S Medow, Paul Visintainer, Richard Sutton
Background - Upright posture reduces venous return, stroke volume and cardiac output (CO) while causing reflex sinus rate (HR) increase. Yet, in inappropriate sinus tachycardia (IST), postural tachycardia syndrome (POTS), and vasovagal syncope (VVS) symptomatic excessive HR occurs. We hypothesized CO reaches maximum as function of HR in all. Methods - We recruited 12 healthy controls, 9 IST, 30 VVS and 30 POTS patients (13-23years) selected randomly by disorder not by HR, each fulfilled appropriate diagnostic criteria...
January 15, 2020: Circulation. Arrhythmia and Electrophysiology
F Xing, S Li, J J Zhang, C Y Sun, J R Huang, Z L Gao, T T Zhu, Q Zhao, H Zhang, C H Liu
Objective: To observe the therapeutic effect of terlipressin on refractory ascites (RA) in cirrhosis, and its role and impact on acute kidney injury (AKI). Methods: A non-randomized controlled clinical trial data of 111 hospitalized cases of liver cirrhosis accompanied with RA was collected from Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Zhongshan Hospital of Hubei Province, The First Affiliated Hospital of Zhengzhou University, The First Affiliated Hospital of Medical School of Zhejiang University, and People's Hospital of Pudong New Area of Shanghai between March 2015 and March 2017...
December 20, 2019: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Tülin Aktürk, Yaşar Turan, Nermin Tanik, Müjgan Ercan Karadağ, Hikmet Sacmaci, Levent Ertugrul Inan
OBJECTIVES: Vitamin D is a pleiotropic steroid hormone that modulates the autonomic balance. Its deficiency has been described as an environmental risk factor for multiple sclerosis (MS). The aim of this study was to investigate the serum levels of vitamin D, vitamin D binding protein (VDBP) and vitamin D receptors (VDR) and to evaluate cardiac dysautonomia in MS patients due to bidirectional interaction between vitamin D and the autonomic nervous system. METHODS: The current cross-sectional study was conducted on 26 patients with relapsing-remitting MS and on 24 healthy controls...
December 2019: Arquivos de Neuro-psiquiatria
Iramar Baptistella do Nascimento, Raquel Fleig
The objectives of the study were to identify the factors that limit diaphragmatic mobility and evaluate the therapeutic results of the monitoring methods previously used in patients with chronic obstructive pulmonary disease. The PubMed, Web of Science, Scopus, and LILACS databases were used. A gray literature search was conducted with Google scholar. PRISMA was used, and the bias risk analysis adapted from the Cochrane Handbook for clinical trials and, for other studies, the Downs and Black checklist were used...
2020: Clinics
Mingdong Li, Jianfei Chen, Yetao Ma, Zaomin Li, Junjun Qin
Objective: To compare the effectiveness of proximal femoral nail anti-rotation (PFNA) in the treatment of intertrochanteric fracture of femur in traction bed supine position and non-traction bed lateral position. Methods: A retrospective analysis of 102 elderly patients with intertrochanteric fracture of femur who met the selection criteria between January 2013 and April 2018 was made. According to the different operative positions, the patients were divided into two groups: group A (50 cases, PFNA internal fixation in traction bed supine position) and group B (52 cases, PFNA internal fixation in non-traction bed lateral position)...
January 15, 2020: Chinese Journal of Reparative and Reconstructive Surgery
Nelson Francisco Serrão, Alberto Porta, Vinicius Minatel, Antônio A M Castro, Aparecida Maria Catai, Luciana Maria Malosá Sampaio, Ross Arena, Audrey Borghi-Silva
PURPOSE: Chronic obstructive pulmonary disease (COPD) negatively impacts autonomic control of the heart rate, as assessed by time and frequency domains of heart rate variability (HRV) analysis. However, it is unknown whether symbolic dynamic analysis may identify cardiac autonomic impairment, and whether such nonlinear indices may be associated with disease severity, prognostic markers, perceived dyspnea and functional capacity in patients with COPD. The current study assessed cardiac autonomic modulation by symbolic analysis of HRV in patients with COPD compared with healthy controls...
January 14, 2020: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
Navid Moghadam, Maryam Selk Ghaffari, Pardis Noormohammadpour, Mohsen Rostami, Mohammad Zarei, Mersad Moosavi, Ramin Kordi
There are many proposed core stability exercises in a variety of positions; however, it is not clear that in which position, activation of transverse abdominis muscle is utmost. We aimed to compare the activation of transverse abdominis muscle in different core stability exercise positions through ultrasound imaging. in a 20 subjects' study we compared the effectiveness of drawing-in and bracing maneuvers on transverse abdominis in different core stability exercise positions (supine, hook lying, supine with 90° flexed knee and hip, supine with stretched knees and 90° flexed hips, bridge, bridge with one stretched knee and Bird dog)...
December 2019: Journal of Exercise Rehabilitation
Davide Chiumello, Paolo Formenti, Luca Bolgiaghi, Giovanni Mistraletti, Miriam Gotti, Francesco Vetrone, Alessandro Baisi, Luciano Gattinoni, Michele Umbrello
BACKGROUND: During thoracic surgery, patients are usually positioned in lateral decubitus and only the dependent lung ventilated. The ventilated lung is thus exposed to the weight of the contralateral hemithorax and restriction of the dependent chest wall. We hypothesized that mechanical power would increase during one-lung ventilation in the lateral position. METHODS: We performed a prospective, observational, single-center study from December 2016 to May 2017...
February 2020: Anesthesia and Analgesia
Kristine Rabben Amundsen, Kari Anne I Evensen
No studies have described physical therapy treatment for children with congenital Zika virus syndrome. In this case report, the authors aimed to improve postural control, mobility, and social skills in a 17- to 18-month-old child with congenital Zika virus syndrome through a period of 6-week home-based, intensive physical therapy intervention. Outcome measures were the Posture and Postural Ability Scale, Pediatric Evaluation of Disability Inventory, and Caregiver Priorities and Child Health Index of Life With Disabilities...
January 2020: Child Neurology Open
Imola Fejes, György Ábrahám, Péter Légrády
Purpose: Authors investigated the effect of a university exam period on blood pressure (BP) and baroreflex-sensitivity (BRS) among healthy students. Materials and methods: Fifty-three healthy normotensive university students participated in the test. BP values and BRS were recorded once during a 14-week long semester and once during a 6-week long exam period with a Finometer device. The time-domain spontaneous BRS in lying position and after standing up was calculated with Nevrokard software. Students were divided into optimal, normal, high-normal and hypertension (HT) groups by BP values...
January 14, 2020: Blood Pressure
Justin M Haller, Hunter Ross, Kimberly Jacobson, Zhining Ou, David Rothberg, Michael Githens
BACKGROUND: Supination adduction (SAD) fractures are rotational ankle fractures with a characteristic vertical medial malleolus fracture and tension failure fibula fracture. While these fractures are considered rotational injuries, they can have joint impaction that could lead to early joint degeneration. The purpose of this study was to characterize SAD ankle fractures and compare these injuries with partial articular pilon fractures. METHODS: Following IRB approval, we retrospectively reviewed ankle and pilon fractures (OTA 43 & 44) treated at two academic level-1 trauma centers from 2008-2016...
January 8, 2020: Injury
Eline G M Cox, Geert Koster, Aidan Baron, Thomas Kaufmann, Ruben J Eck, T Corien Veenstra, Bart Hiemstra, Adrian Wong, Thomas C Kwee, Jaap E Tulleken, Frederik Keus, Renske Wiersema, Iwan C C van der Horst
BACKGROUND: In critically ill patients, auscultation might be challenging as dorsal lung fields are difficult to reach in supine-positioned patients, and the environment is often noisy. In recent years, clinicians have started to consider lung ultrasound as a useful diagnostic tool for a variety of pulmonary pathologies, including pulmonary edema. The aim of this study was to compare lung ultrasound and pulmonary auscultation for detecting pulmonary edema in critically ill patients. METHODS: This study was a planned sub-study of the Simple Intensive Care Studies-I, a single-center, prospective observational study...
January 13, 2020: Critical Care: the Official Journal of the Critical Care Forum
Lilian Teddy Mselle, Lucia Eustace
BACKGROUND: Before the advent of Western medicine in Tanzania, women gave birth in an upright position either by sitting, squatting or kneeling. Birthing women would hold ropes or trees as a way of gaining strength and stability in order to push the baby with sufficient force. Despite the evidence supporting the upright position as beneficial to the woman and her unborn child, healthcare facilities consistently promote the use of the supine position. The purpose of this study was to explore the perceptions and experiences of mothers and nurse-midwives regarding the use of the supine position during labour and delivery...
January 13, 2020: BMC Pregnancy and Childbirth
Jo Armour Smith, Niklas König Ignasiak, Jesse V Jacobs
BACKGROUND: Anticipatory postural adjustments (APAs) occur in the trunk during tasks such as rapid limb movement and are impaired in individuals with musculoskeletal and neurological dysfunction. To understand APA impairment, it is important to first determine if APAs can be measured reliably and which characteristics of APAs are task-invariant. RESEARCH QUESTION: What is the test-retest reliability of latency, amplitude and muscle activation patterns (synergies) of trunk APAs during arm-raise and leg-raise tasks, and to what extent are these APA characteristics invariant across tasks at the individual and group levels? METHODS: 15 young adults (mean age: 23...
January 9, 2020: Gait & Posture
Blake E S Taylor, Irene Say, Pratit Patel, Luke D Tomycz
Dissecting pericallosal aneurysms from the falx cerebri is technically challenging, as one must release the adherent dome but minimize shearing injury, which could result in intraoperative rupture. We discuss a 51-yr-old woman with a history of hypertension and smoking who presented with severe headaches and was found to have a 6-mm unruptured, multilobulated pericallosal aneurysm abutting the falx, with anterior and superior projecting domes on either side. She also had an azygos anterior cerebral artery (ACA), a rare anatomic variant associated with pericallosal aneurysms, where both A1 segments form a single A2...
January 13, 2020: Operative Neurosurgery (Hagerstown, Md.)
Tianyao Chen, Rafael Casas, Peter S Lum
Movement impairments resulting from neurologic injuries, such as stroke, can be treated with robotic exoskeletons that assist with movement retraining. Exoskeleton designs benefit from low impedance and accurate torque control. We designed a 2 degree-of-freedom tethered exoskeleton that can provide independent torque control on elbow flexion/extension and forearm supination/pronation. Two identical series elastic actuators (SEAs) are used to actuate the exoskeleton. The two SEAs are coupled through a novel cable-driven differential...
December 2019: IEEE Transactions on Robotics
Ryohei Takada, Tetsuya Jinno, Kazumasa Miyatake, Masanobu Hirao, Toshitaka Yoshii, Atsushi Okawa
BACKGROUND: This prospective study aimed to clarify whether this novel device can evaluate the cup orientation during total hip arthroplasty (THA) more closely to that measured in postoperative computed tomography (CT) compared to the surgeon's estimate using a manual goniometer. METHODS: We prospectively performed 30 cementless THAs via the anterolateral approach in supine position between October 2018 and July 2019, wherein cup orientation was evaluated by both a portable imageless navigation system (HipAlign) and a manual goniometer during surgeries...
January 10, 2020: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
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