Qiaobei Ye, Yu Zhu, Meng Shi, Linxi Lv, Yuyan Gong, Luyao Zhang, Lehe Yang, Haiyang Zhao, Chengguang Zhao, Huanhai Xu
Double cortin-like kinase 1 (DCLK1) exhibits high expression levels across various cancers, notably in human colorectal cancer (CRC). Diacerein, a clinically approved interleukin (IL)-1β inhibitor for osteoarthritis treatment, was evaluated for its impact on CRC proliferation and migration, alongside its underlying mechanisms, through both in vitro and in vivo analyses. The study employed MTT assay, colony formation, wound healing, transwell assays, flow cytometry, and Hoechst 33342 staining to assess cell proliferation, migration, and apoptosis...
April 2024: Chinese Journal of Natural Medicines