Alejandra Cárdenas Rosales, José Alberto Delgado Atencio, Margarita Cunill Rodríguez, Enrique González Gutiérrez
It is known that the harmful presence of the wild cochineal (Dactylopius opuntiae), unlike the fine cochineal (Dactylopius coccus), in prickly pear crops of farmers leads to consider it as one of the major pests for this crop. In this study, we present the implementation of an optical setup that ensures the measurement of the in-vivo fluorescence spectra of wild cochineals ranging in size from 440 to 1190 µm in their natural habitat achieved by developing a reproduction model adopted from available literature...
January 11, 2021: Scientific Reports
Kayoko Suzuki, Kyoko Futamura, Nayu Sato, Masashi Nakamura, Kayoko Matsunaga, Akiko Yagami
No abstract text is available yet for this article.
December 27, 2020: Contact Dermatitis
Rahmeth Radjack
The Maison de Solenn at Cochin hospital in Paris provides transcultural care to a local migrant population. The transcultural approach consists in taking into account the cultural dimension in care and favours, through a specific technique, the sharing of cultural representations between professionals and families. The therapists can move around the hospital to provide advice as and when required, notably to facilitate care and compliance and to ensure there are no misunderstandings regarding treatments. In some situations, we recommend a transcultural consultation which consists in forming a group of several therapists from diverse professional and cultural backgrounds, to discuss a complex situation with the patient and their family...
November 2020: Soins; la Revue de Référence Infirmière
Malak Abu-Hussien, Guru Krishnakumar Viswanathan, Lia Borisover, Michael Mimouni, Hamutal Engel, Shiri Zayit-Soudry, Ehud Gazit, Daniel Segal
γD-crystallin is among the most abundant γ-crystallins in the human eye lens which are essential for preserving its transparency. Aging, and environmental changes, cause crystallins to lose their native soluble structure and aggregate, resulting in the formation of cataract. Current treatment of cataract is surgical removal which is costly. Pharmaceutical therapeutics of cataract is an unmet need. We report a screen for small molecules capable of inhibiting aggregation of human γD-crystallin. Using a highly amyloidogenic hexapeptide model 41 GCWMLY46 derived from the full-length protein, we screened a library of 68 anthraquinone molecules using ThT fluorescence assay...
December 18, 2020: International Journal of Biological Macromolecules
Vassilis Tsatsaris, Alice-Andrée Mariaggi, Odile Launay, Camille Couffignal, Jessica Rousseau, Pierre Yves Ancel, Estelle Marcault, Yves Ville, Anne-Gaël Cordier, Alexandre Vivanti, Julie Carrara, Dominique Luton, Marc Dommergues, Constance Borie, Gilles Kayem, Vivien Alessandrini, Laurence Lecomte, Jean François Meritet, Marianne Leruez-Ville, François Goffinet, Claire Dubois, Olivier Picone, Christelle Vauloup Fellous
BACKGROUND: The prevalence of COVID-19 infection during pregnancy is not known. COVIPREG is a prospective French multicenter study to assess the seroprevalence at the time of delivery and the maternal and neonatal impact of COVID-19 infection during pregnancy. In order to study factors associated with poor outcomes after COVID-19 Infection during pregnancy and adapt the sample size of the study, a preliminary assessment of the prevalence of SARS-CoV-2 IgG was planned after 500 inclusions in a one perinatal center of Paris area...
December 10, 2020: Journal of Gynecology Obstetrics and Human Reproduction
Laurence Maulin, Stéphanie Martinez
OBJECTIVE: To assess the effectiveness of corticosteroids on outcomes of patients with COVID-19 pneumonia requiring oxygen without mechanical ventilation. METHODS: We used routine care data from 51 hospitals in France and Luxembourg to assess the effectiveness of corticosteroids at 0.8 mg/kg/day eq. prednisone (CTC group) versus standard of care (no-CTC group) among adults 18 to 80 years old with confirmed COVID-19 pneumonia requiring oxygen without mechanical ventilation...
December 7, 2020: Clinical Microbiology and Infection
Anusree V Nair, Praveen N K, Leo Antony M, K K Vijayan
Antimicrobial compounds from the natural source have gained greater relevance because of their wide spectrum of possible applications, especially in the aquaculture industry where pathogenic threat and antibacterial resistance are serious concerns. In this regard, Pseudomonas aeruginosa MBTDCMFRI Ps04 (P. aeruginosa Ps04) strain isolated from the tropical estuarine habitats of Cochin was evaluated for its antibacterial potential against major aquaculture pathogens. The physiological conditions for the maximum production of the active metabolite were also optimized...
November 25, 2020: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Anusree V Nair, Leo Antony M, N K Praveen, Sayooj P, T Raja Swaminathan, K K Vijayan
Bacillus subtilis MBTDCMFRI Ba37 (B. subtilis Ba37), an antibacterial strain isolated from the tropical estuarine habitats of Cochin, was evaluated for in vitro and in vivo potential, and its application as a candidate probiont in fish health management. Thus B. subtilis Ba37 was characterized using their morphological and biochemical properties. It exhibited exoenzymatic activities, tolerance to various physiological conditions and a wide spectrum of antibacterial activity against aquaculture pathogens such as Vibrio and Aeromonas...
November 16, 2020: Microbial Pathogenesis
Mattia Del Maestro, Dele Rampini Angela, Simone Mauramati, Alice Giotta Lucifero, Giulia Bertino, Antonio Occhini, Marco Benazzo, Renato Galzio, Sabino Luzzi
BACKGROUND: Human placenta is recognized as a valuable vascular microneurosurgery training model because of its abundant availability, ethical acceptance, and analogous vasculature with other vessels of the human body; however, human placenta laboratory preparation techniques are not well described in the literature. This study outlines a detailed and standardized laboratory protocol for preparation of a color-perfused human placenta model. Survey-based validation of the model is also reported herein...
November 13, 2020: World Neurosurgery
Pauline Eymard, Melvin Gerardy, Lucas Bouys, Chadi Mehanna, Jérôme Bertherat, Francine Behar-Cohen, Elodie Bousquet
AIMS: Glucocorticoid intake is a well-established risk factor for central serous chorioretinopathy that belongs to the pachychoroid spectrum disease (PSD). The study aimed to assess the prevalence of PSD and analyse the choroidal phenotype in patients with Cushing syndrome. METHODS: A cross-sectional study was performed in Ophtalmopôle hôpital Cochin, Paris, France, with a systematic evaluation of hospitalized patients with Cushing syndrome, between November 2017 and July 2018...
November 16, 2020: Acta Ophthalmologica
P A Grange, A Jary, C Isnard, S Burrel, D Boutolleau, A Touati, C Bébéar, J Saule, P Martinet, J-L Robert, D Moulene, A Vermersch-Langlin, N Benhaddou, M Janier, N Dupin
We evaluated the utility of the commercial Allplex™ Genital Ulcer real-time PCR multiplex Assay for detecting Treponema pallidum (TPA), herpes simplex virus 1 (HSV-1) and 2 (HSV-2), and Chlamydia trachomatis serovar L (lymphogranuloma venereum; LGV) DNA in mucosal and genital ulcers in the context of suspected syphilis. In total, 374 documented genital and mucosal ulcers from patients with and without syphilis presenting at several sexually transmitted infection (STI) centers in France from October 2010 to December 2016 were analyzed at the National Reference Center for bacterial STIs at Cochin Hospital in Paris...
November 11, 2020: Journal of Clinical Microbiology
Sarah Breton
A cognitive therapy program based on mindfulness meditation has been offered at the "maison des adolescents" of Cochin Hospital for the past year and a half. After their participation, the adolescents were able to talk about their experiences in this group. The latter allows a different, innovative and interesting approach to clinical nursing.
October 2020: Revue de L'infirmière
Chiara Masi, Gaelle Couraud, Camille Daste, Jennifer Jouffriault, Serge Poiraudeau, Marie-Martine Lefevre-Colau, Francois Rannou, Christelle Nguyen
BACKGROUND: Lumbar spinal stenosis (LSS) is the leading cause of spinal surgery in people over 65-years old. In people with LSS, generic self-administered questionnaires are the most commonly used PROs to assess health-related quality of life, global activity limitation, and low back pain-located activity limitation. AIM: To develop of a new patient-reported outcome measure assessing activities and participation in people with LSS. DESIGN: Observation, prospective and qualitative study...
October 28, 2020: European Journal of Physical and Rehabilitation Medicine
Jérémy Béguin, Johann Foloppe, Christelle Maurey, Eve Laloy, Julie Hortelano, Virginie Nourtier, Christelle Pichon, Sandrine Cochin, Pascale Cordier, Hélène Huet, Eric Quemeneur, Bernard Klonjkowski, Philippe Erbs
Oncolytic virotherapy is a promising therapeutic approach for the treatment of cancer. TG6002 is a recombinant oncolytic vaccinia virus deleted in the thymidine kinase and ribonucleotide reductase genes and armed with the suicide gene FCU1 , which encodes a bifunctional chimeric protein that efficiently catalyzes the direct conversion of the nontoxic 5-fluorocytosine into the toxic metabolite 5-fluorouracil. In translational research, canine tumors and especially mammary cancers are relevant surrogates for human cancers and can be used as preclinical models...
December 16, 2020: Molecular Therapy Oncolytics
Devender Bairwa, Chengappa G Kavadichanda, M B Adarsh, Aishwarya Gopal, Vir Singh Negi
OBJECTIVES: Hand dysfunction causes significant reduction in quality of life in systemic sclerosis. We assessed the validity and reliability of the culturally adapted Indian version of Cochin Hand Function Scale (I-CHFS). We determined the factors contributing to hand dysfunction and its burden on quality of life. METHOD: I-CHFS was formulated by replacing five questions (questions 7, 9, 10, 14 and 15) in CHFS which were determined as unsuitable in an Indian setting...
October 15, 2020: Clinical Rheumatology
Yu-Fang Wang, I-Wei Chen, Satishkumar Subendran, Chun-Wei Kang, Bivas Panigrahi, Tzu-Fun Fu, Chia-Yuan Chen
Food coloring is often used as a coloring agent in foods, medicines and cosmetics, and it was reported to have certain carcinogenic and mutagenic effects in living organisms. Investigation of physiological parameters using zebrafish is a promising methodology to understand disease biology and drug toxicity for various drug discovery on humans. Zebrafish (Danio rerio) is a well-acknowledged model organism with combining assets such as body transparency, small size, low cost of cultivation, and high genetic homology with humans and is used as a specimen tool for the in-vivo throughput screening approach...
October 1, 2020: Scientific Reports
Hervé Lefèvre, Chantal Stheneur, Charlotte Cardin, Lola Fourcade, Christine Fourmaux, Elise Tordjman, Marie Touati, Flore Voisard, Sevan Minassian, Pauline Chaste, Marie Rose Moro, Jonathan Lachal
The coronavirus disease 2019 pandemic presents unprecedented challenges for the health care system. The pressure on health care staff continues to intensify, accentuated by the confinement (lockdown) of the population and the unprecedented duration of this emergency. Separately and especially together, overwork, degraded conditions of care because of the never-ending emergency, and the risk of exposure to the virus can lead to acute psychological distress or signs of burnout. This original program was developed at Cochin Hospital in Paris, France to prevent these potentially dramatic psychological consequences, support the medical staff, and identify those most affected to offer them specific care...
September 19, 2020: Journal of Pain and Symptom Management
Antonia Valenzuela, Murray Baron, Tatiana S Rodriguez-Reyna, Susanna Proudman, Dinesh Khanna, Amber Young, Monique Hinchcliff, Virginia Steen, Jessica Gordon, Vivien Hsu, Flavia V Castelino, Sara Schoenfeld, Shufeng Li, Joy Y Wu, David Fiorentino, Lorinda Chung
OBJECTIVE: Calcinosis is a debilitating complication of systemic sclerosis (SSc) with no effective treatments. We sought to identify clinical correlations and to characterize complications and disability associated with calcinosis in a multi-center, international cohort of SSc patients. METHODS: We established a cohort of 568 consecutive SSc patients who fulfill 2013 revised ACR/EULAR criteria at 10 centers within North America, Australia, and Mexico. Calcinosis was defined as subcutaneous calcium deposition by imaging and/or physical examination, or a clear history of extruded calcium...
June 17, 2020: Seminars in Arthritis and Rheumatism
Kariyil Veettil Neethu, Sivasankaran Bijoy Nandan, Nelkunnassery Dominic Don Xavier, Paravanparambil Rajakumar Jayachandran, Pashnath Raghu Anu, Alungal Manikandan Midhun, Dhandapani Mohan, Shambanagouda R Marigoudar
The southwest coast of India along the Cochin region is seriously affected by metal contamination from increasing industrial activities. This contribution pertains to the chronic toxicity effects of lead and its biomarker responses on the black clam, Villorita cyprinoides, largely endemic to Southern India. The metal concentration (lead (Pb), copper (Cu), zinc (Zn), cadmium (Cd), nickel (Ni), and chromium (Cr)) and contamination indices such as geoaccumulation index and contamination factor suggests that the Cochin estuarine system (CES) is moderately to heavily polluted with metals...
August 27, 2020: Environmental Science and Pollution Research International
Jérémy Béguin, Virginie Nourtier, Murielle Gantzer, Sandrine Cochin, Johann Foloppe, Jean-Marc Balloul, Eve Laloy, Dominique Tierny, Bernard Klonjkowski, Eric Quemeneur, Christelle Maurey, Philippe Erbs
BACKGROUND: Cancer is a leading cause of mortality for both humans and dogs. As spontaneous canine cancers appear to be relevant models of human cancers, developing new therapeutic approaches could benefit both species. Oncolytic virotherapy is a promising therapeutic approach in cancer treatment. TG6002 is a recombinant oncolytic vaccinia virus deleted in the thymidine kinase and ribonucleotide reductase genes and armed with the suicide gene FCU1 that encodes a protein which catalyses the conversion of the non-toxic 5-fluorocytosine into the toxic metabolite 5-fluorouracil...
August 25, 2020: BMC Veterinary Research
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