keyword
https://read.qxmd.com/read/38905376/inflammatory-proteins-may-mediate-the-causal-relationship-between-gut-microbiota-and-inflammatory-bowel-disease-a-mediation-and-multivariable-mendelian-randomization-study
#1
JOURNAL ARTICLE
Yu-Liang Huang, Jin-Min Zheng, Zheng-Yi Shi, Huan-Huan Chen, Xiao-Tong Wang, Fan-Biao Kong
This research investigates the causal relationships among gut microbiota, inflammatory proteins, and inflammatory bowel disease (IBD), including crohn disease (CD) and ulcerative colitis (UC), and identifies the role of inflammatory proteins as potential mediators. Our study analyzed gut microbiome data from 13,266 samples collected by the MiBioGen alliance, along with inflammatory protein data from recent research by Zhao et al, and genetic data on CD and UC from the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)...
June 21, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38905343/resistance-to-freezing-conditions-of-endemic-antarctic-polychaetes-is-enhanced-by-cryoprotective-proteins-produced-by-their-microbiome
#2
JOURNAL ARTICLE
Emanuela Buschi, Antonio Dell'Anno, Michael Tangherlini, Marco Candela, Simone Rampelli, Silvia Turroni, Giorgia Palladino, Erika Esposito, Marco Lo Martire, Luigi Musco, Sergio Stefanni, Cristina Munari, Jessica Fiori, Roberto Danovaro, Cinzia Corinaldesi
The microbiome plays a key role in the health of all metazoans. Whether and how the microbiome favors the adaptation processes of organisms to extreme conditions, such as those of Antarctica, which are incompatible with most metazoans, is still unknown. We investigated the microbiome of three endemic and widespread species of Antarctic polychaetes: Leitoscoloplos geminus , Aphelochaeta palmeri , and Aglaophamus trissophyllus . We report here that these invertebrates contain a stable bacterial core dominated by Meiothermus and Anoxybacillus , equipped with a versatile genetic makeup and a unique portfolio of proteins useful for coping with extremely cold conditions as revealed by pangenomic and metaproteomic analyses...
June 21, 2024: Science Advances
https://read.qxmd.com/read/38905325/mait-cells-monitor-intestinal-dysbiosis-and-contribute-to-host-protection-during-colitis
#3
JOURNAL ARTICLE
Yara El Morr, Mariela Fürstenheim, Martin Mestdagh, Katarzyna Franciszkiewicz, Marion Salou, Claire Morvan, Thierry Dupré, Alexey Vorobev, Bakhos Jneid, Virginie Premel, Aurélie Darbois, Laetitia Perrin, Stanislas Mondot, Ludovic Colombeau, Hélène Bugaut, Anastasia du Halgouet, Sophie Richon, Emanuele Procopio, Mathieu Maurin, Catherine Philippe, Raphael Rodriguez, Olivier Lantz, François Legoux
Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors and responds to such changes remains unclear. Here, we describe a protective mechanism by which mucosal-associated invariant T (MAIT) cells detect microbiota metabolites produced upon intestinal inflammation and promote tissue repair. At steady state, MAIT ligands derived from the riboflavin biosynthesis pathway were produced by aerotolerant bacteria residing in the colonic mucosa. Experimental colitis triggered luminal expansion of riboflavin-producing bacteria, leading to increased production of MAIT ligands...
June 21, 2024: Science Immunology
https://read.qxmd.com/read/38905245/gut-microbiota-diversity-in-a-dung-beetle-catharsius-molossus-across-geographical-variations-and-brood-ball-mediated-microbial-transmission
#4
JOURNAL ARTICLE
Hao-Yu Chen, Cheng-Ye Wang, Bin Zhang, Zhao He, Ren-Can Yang, Hong-Hui Zhang, Qing-Quan Hu, Zhi-Yong Zhao, Min Zhao
The dung beetle primarily feeds on the feces of herbivorous animals and play a crucial role in ecological processes like material cycles and soil improvement. This study aims to explore the diversity and composition of the gut microbiota of Catharsius molossus (a renowned dung beetle originating from China and introduced to multiple countries for its ecological value) and exploring whether these gut microbes are transmitted vertically across generations. Using 16S rRNA and ITS rRNA gene sequencing techniques, we described the diversity and composition of gut microbes in C...
2024: PloS One
https://read.qxmd.com/read/38904949/island-biogeography-theory-provides-a-plausible-explanation-for-why-larger-vertebrates-and-taller-humans-have-more-diverse-gut-microbiomes
#5
JOURNAL ARTICLE
Katherine Ramos Sarmiento, Alex Carr, Christian Diener, Kenneth J Locey, Sean M Gibbons
Prior work has shown a positive scaling relationship between vertebrate body size, human height, and gut microbiome alpha diversity. This observation mirrors commonly observed species area relationships (SAR) in many other ecosystems. Here, we expand these observations to several large data sets, showing that this size-diversity scaling relationship is independent of relevant covariates, like diet, body mass index, age, sex, bowel movement frequency, antibiotic usage, and cardiometabolic health markers. Island biogeography theory (IBT), which predicts that larger islands tend to harbor greater species diversity through neutral demographic processes, provides a simple mechanism for positive SARs...
June 21, 2024: ISME Journal
https://read.qxmd.com/read/38904934/the-role-of-the-microbiome-in-allergy-asthma-and-occupational-lung-disease
#6
REVIEW
Ashley Peer, Derrick R Samuelson
PURPOSE OF REVIEW: The human commensal microbiota is now widely accepted as a key regulator of human health and disease. The composition of the mucosal associated microbiota has been shown to play a critical role in the lung health. The role of the mucosal microbiota in the development and severity of allergy, asthma, and occupational lung disease is only beginning to take shape. However, advances in our understanding of these links have tremendous potential to led to new clinical interventions to reduce allergy, asthma, and occupational lung disease morbidity...
June 21, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38904897/dietary-supplementation-of-compound-probiotics-improves-intestinal-health-by-modulated-microbiota-and-its-scfa-products-as-alternatives-to-in-feed-antibiotics
#7
JOURNAL ARTICLE
Wenxing Wang, Guoqi Dang, Wei Hao, Anping Li, Hongfu Zhang, Shu Guan, Teng Ma
Enterococcus faecium, Bifidobacterium, and Pediococcus acidilactici, as intestinal probiotics, have been proved to play a positive role in treating intestinal diseases, promoting growth and immune regulation in poultry. The aim of this study was to evaluate the effect of compound probiotics on growth performance, digestive enzyme activity, intestinal microbiome characteristics, as well as intestinal morphology in broiler chickens. Treatment diets with chlortetracycline and compound probiotics were used for two groups of sixty broilers each throughout the feeding process...
June 21, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38904896/integrative-analysis-of-the-microbiome-and-metabolome-of-broiler-intestine-insights-into-the-mechanisms-of-probiotic-action-as-an-antibiotic-substitute
#8
JOURNAL ARTICLE
Yang Li, Jian-Ling Zhang, Jia-Qi Chen, Zhuang Chen, Shi Liu, Jing Liu, Wen-Jie Huang, Jia-Zhou Li, Dong Ruan, Jun-Jin Deng, Zhi-Lin Wang
Antibiotic substitutes have become a research focus due to restrictions on antibiotic usage. Among the antibiotic substitutes on the market, probiotics have been extensively researched and used. However, the mechanism by which probiotics replace antibiotics remains unclear. In this study, we aimed to investigate this mechanism by comparing the effects of probiotics and antibiotics on broiler growth performance and intestinal microbiota composition. Results shown that both probiotics and antibiotics increased daily weight gain and reduced feed conversion rate in broilers...
June 21, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38904672/evaluation-of-synbiotic-combinations-of-commercial-probiotic-strains-with-different-prebiotics-in-in-vitro-and-ex-vivo-human-gut-microcosm-model
#9
JOURNAL ARTICLE
Shivani D Raval, G Archana
Exploring probiotics for their crosstalk with the host microbiome through the fermentation of non-digestible dietary fibers (prebiotics) for their potential metabolic end-products, particularly short-chain fatty acids (SCFAs), is important for understanding the endogenous host-gut microbe interaction. This study was aimed at a systematic comparison of commercially available probiotics to understand their synergistic role with specific prebiotics in SCFAs production both in vitro and in the ex vivo gut microcosm model...
June 21, 2024: Archives of Microbiology
https://read.qxmd.com/read/38904411/community-interactions-among-microbes-give-rise-to-host-microbiome-mutualisms-in-an-aquatic-plant
#10
JOURNAL ARTICLE
Jason R Laurich, Emma Lash, Anna M O'Brien, Oxana Pogoutse, Megan E Frederickson
UNLABELLED: Microbiomes often benefit plants, conferring resistance to pathogens, improving stress tolerance, or promoting plant growth. As potential plant mutualists, however, microbiomes are not a single organism but a community of species with complex interactions among microbial taxa and between microbes and their shared host. The nature of ecological interactions among microbes in the microbiome can have important consequences for the net effects of microbiomes on hosts. Here, we compared the effects of individual microbial strains and 10-strain synthetic communities on microbial productivity and host growth using the common duckweed Lemna minor and a synthetic, simplified version of its native microbiome...
June 21, 2024: MBio
https://read.qxmd.com/read/38904365/molecular-surveillance-of-influenza-a-virus-in-saudi-arabia-whole-genome-sequencing-and-metagenomic-approaches
#11
JOURNAL ARTICLE
Iman Dandachi, Abdulrahman Alrezaihi, Dashty Amin, Nurah AlRagi, Bader Alhatlani, Abdulwahab Binjomah, Kholoud Aleisa, Xiaofeng Dong, Julian A Hiscox, Waleed Aljabr
Outbreaks of influenza A viruses are generally seasonal and cause annual epidemics worldwide. Due to their frequent reassortment and evolution, annual surveillance is of paramount importance to guide vaccine strategies. The aim of this study was to explore the molecular epidemiology of influenza A virus and nasopharyngeal microbiota composition in infected patients in Saudi Arabia. A total of 103 nasopharyngeal samples from 2015 and 12 samples from 2022 were collected from patients positive for influenza A...
June 21, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38904362/the-potential-of-pseudomonas-fluorescens-sbw25-to-produce-viscosin-enhances-wheat-root-colonization-and-shapes-root-associated-microbial-communities-in-a-plant-genotype-dependent-manner-in-soil-systems
#12
JOURNAL ARTICLE
Ying Guan, Frederik Bak, Rosanna Catherine Hennessy, Courtney Horn Herms, Christine Lorenzen Elberg, Dorte Bodin Dresbøll, Anne Winding, Rumakanta Sapkota, Mette Haubjerg Nicolaisen
UNLABELLED: Microorganisms interact with plant roots through colonization of the root surface, i.e., the rhizoplane or the surrounding soil, i.e., the rhizosphere. Beneficial rhizosphere bacteria such as Pseudomonas spp. can promote plant growth and protect against pathogens by producing a range of bioactive compounds, including specialized metabolites like cyclic lipopeptides (CLPs) known for their biosurfactant and antimicrobial activities. However, the role of CLPs in natural soil systems during bacteria-plant interactions is underexplored...
June 21, 2024: MSphere
https://read.qxmd.com/read/38904265/the-tumor-microbiome-reacts-to-hypoxia-and-can-influence-response-to-radiation-treatment-in-colorectal-cancer
#13
JOURNAL ARTICLE
Martin Benej, Rebecca Hoyd, McKenzie Kreamer, Caroline E Wheeler, Dennis J Grencewicz, Fouad Choueiry, Carlos H F Chan, Yousef Zakharia, Qin Ma, Rebecca D Dodd, Cornelia M Ulrich, Sheetal Hardikar, Michelle L Churchman, Ahmad A Tarhini, Lary A Robinson, Eric A Singer, Alexandra P Ikeguchi, Martin D McCarter, Gabriel Tinoco, Marium Husain, Ning Jin, Aik Choon Tan, Afaf E G Osman, Islam Eljilany, Gregory Riedlinger, Bryan P Schneider, Katarina Benejova, Martin Kery, Ioanna Papandreou, Jiangjiang Zhu, Nicholas Denko, Daniel Spakowicz
Tumor hypoxia has been shown to predict poor patient outcomes in several cancer types, partially because it reduces radiation's ability to kill cells. We hypothesized that some of the clinical effects of hypoxia could also be due to its impact on the tumor microbiome. Therefore, we examined the RNA-seq data from the Oncology Research Information Exchange Network (ORIEN) database of colorectal cancer (CRC) patients treated with radiotherapy. We identified microbial RNAs for each tumor and related them to the hypoxic gene expression scores calculated from host mRNA...
June 21, 2024: Cancer Res Commun
https://read.qxmd.com/read/38904096/modulation-of-alzheimer-s-disease-brain-pathology-in-mice-by-gut-bacterial-depletion-the-role-of-il-17a
#14
JOURNAL ARTICLE
Wenlin Hao, Qinghua Luo, Inge Tomic, Wenqiang Quan, Tobias Hartmann, Michael D Menger, Klaus Fassbender, Yang Liu
Gut bacteria regulate brain pathology of Alzheimer's disease (AD) patients and animal models; however, the underlying mechanism remains unclear. In this study, 3-month-old APP-transgenic female mice with and without knock-out of Il-17a gene were treated with antibiotics-supplemented or normal drinking water for 2 months. The antibiotic treatment eradicated almost all intestinal bacteria, which led to a reduction in Il-17a-expressing CD4-positive T lymphocytes in the spleen and gut, and to a decrease in bacterial DNA in brain tissue...
2024: Gut Microbes
https://read.qxmd.com/read/38904092/effect-of-diet-on-the-evolution-of-gut-commensal-bacteria
#15
REVIEW
Tanja Dapa, Karina B Xavier
The gut microbiota, comprising trillions of diverse microorganisms inhabiting the intestines of animals, forms a complex and indispensable ecosystem with profound implications for the host's well-being. Its functions include contributing to developing the host's immune response, aiding in nutrient digestion, synthesizing essential compounds, acting as a barrier against pathogen invasion, and influencing the development or regression of various pathologies. The dietary habits of the host directly impact this intricate community of gut microbes...
2024: Gut Microbes
https://read.qxmd.com/read/38904070/airway-microbiome-signature-accurately-discriminates-mycobacterium-tuberculosis-infection-status
#16
JOURNAL ARTICLE
Alex Kayongo, Moses Levi Ntayi, Geoffrey Olweny, Edward Kyalo, Josephine Ndawula, Willy Ssengooba, Edgar Kigozi, Robert Kalyesubula, Richard Munana, Jesca Namaganda, Musiime Caroline, Rogers Sekibira, Bernard Sentalo Bagaya, David Patrick Kateete, Moses Lutaakome Joloba, Daudi Jjingo, Obondo James Sande, Harriet Mayanja-Kizza
Mycobacterium tuberculosis remains one of the deadliest infectious agents globally. Amidst efforts to control TB, long treatment duration, drug toxicity, and resistance underscore the need for novel therapeutic strategies. Despite advances in understanding the interplay between microbiome and disease in humans, the specific role of the microbiome in predicting disease susceptibility and discriminating infection status in tuberculosis still needs to be fully investigated. We investigated the impact of M.tb infection and M...
June 21, 2024: IScience
https://read.qxmd.com/read/38904067/characterizing-the-metabolome-and-microbiome-at-giant-panda-scent-marking-sites-during-the-mating-season
#17
JOURNAL ARTICLE
Jin Hou, Vanessa Hull, Masanori Fujimoto, Zejun Zhang, Xiaoyuan Chen, Shiyu Chen, Rui Chen, Thomas Connor, Dunwu Qi, Jindong Zhang
Scent marking sites served as a primary means of chemical communication for giant pandas, enabling intraspecific communication. We integrated metabolomics and high-throughput sequencing techniques to examine the non-targeted metabolome and microbial community structure of scent marking sites and feces in the field. Integrative analysis revealed a more comprehensive array of chemical compounds compared to previous investigations, including ketones, acids, heterocycles, alcohols, and aldehydes. Notably, specific compounds such as 2-decenal, (E)-, octanal, decanal, L-α-terpineol, vanillin, and nonanal emerged as potential key players in scent signaling...
June 21, 2024: IScience
https://read.qxmd.com/read/38903943/gut-microbes-improve-prognosis-of-klebsiella-pneumoniae-pulmonary-infection-through-the-lung-gut-axis
#18
JOURNAL ARTICLE
Yuxiu Tang, Liquan Chen, Jin Yang, Suqing Zhang, Jun Jin, Yao Wei
BACKGROUND: The gut microbiota plays a vital role in the development of sepsis and in protecting against pneumonia. Previous studies have demonstrated the existence of the gut-lung axis and the interaction between the gut and the lung, which is related to the prognosis of critically ill patients; however, most of these studies focused on chronic lung diseases and influenza virus infections. The purpose of this study was to investigate the effect of faecal microbiota transplantation (FMT) on Klebsiella pneumoniae -related pulmonary infection via the gut-lung axis and to compare the effects of FMT with those of traditional antibiotics to identify new therapeutic strategies...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38903937/editorial-the-interplay-of-gut-microbiome-between-infection-and-inflammation
#19
EDITORIAL
Piyush Baindara, Santi M Mandal
No abstract text is available yet for this article.
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38903799/highly-diverse-microbial-community-of-regenerated-seedlings-reveals-the-high-capacity-of-the-bulb-in-lily-lilium-brownii
#20
JOURNAL ARTICLE
Sauban Musa Jibril, Wu Yan, Yi Wang, Xishen Zhu, Zhou Yunying, Jie Wu, Ling Wang, Limin Zhang, Chengyun Li
Lily bulbs, which have both nutrient storage and reproductive functions, are a representative group of plants for studying the maintenance and transfer of plant-associated microbiomes. In this study, a comparison of the microbial composition of bulbs and their regenerated seedlings cultured under aseptic conditions, as well as subcultured seedlings that succeeded five times, was examined by amplicon sequencing. A total of 62 bacterial taxa and 56 fungal taxa were found to be transferred to the 5th generation in seedlings, which are the core microbiome of lily...
2024: Frontiers in Microbiology
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