Michael Iskedjian, Edward De Vol, Mahmoud Elshenawy, Shouki Bazarbashi
PURPOSE: Health utilities (HUs) are quantitative measures of quality of life that are used to derive outcomes such as quality-adjusted life years in cost-effectiveness analyses. In the Kingdom of Saudi Arabia, there are no HUs for cancer. This study aimed to generate HU estimates for various health states associated with cancer in the Kingdom of Saudi Arabia. METHODS: Adult citizens of the Kingdom of Saudi Arabia, patients with cancer, and patients without cancer were recruited to participate in an online version of the Time Trade-Off (TTO) survey, a direct method that asks participants to indicate the amount of time they are willing to trade off in return for full health...
October 2020: JCO global oncology
Yuta Maruki, Chigusa Morizane, Yasuhito Arai, Masafumi Ikeda, Makoto Ueno, Tatsuya Ioka, Atsushi Naganuma, Masayuki Furukawa, Nobumasa Mizuno, Tadashi Uwagawa, Naminatsu Takahara, Masashi Kanai, Akinori Asagi, Satoshi Shimizu, Atsushi Miyamoto, Seigo Yukisawa, Makoto Kadokura, Yasushi Kojima, Junji Furuse, Takako Eguchi Nakajima, Kentaro Sudo, Noritoshi Kobayashi, Natsuko Hama, Takeharu Yamanaka, Tatsuhiro Shibata, Takuji Okusaka
BACKGROUND: Fibroblast growth factor receptor 2 (FGFR2) rearrangement is expected to be a novel therapeutic target in advanced/recurrent biliary tract cancer (BTC). However, efficient detection and the exact frequency of FGFR2 rearrangements among patients with advanced/recurrent BTC have not been determined, and the clinical characteristics of FGFR2 rearrangement-positive patients have not been fully elucidated. We aimed to determine the frequency of FGFR2 rearrangement-positive patients among those with advanced/recurrent BTC and elucidate their clinicopathological characteristics...
October 26, 2020: Journal of Gastroenterology
Zongyan Li, Xiaofeng Jiang, Hua Xiao, Shaoyi Chen, Wenfeng Zhu, Haiwu Lu, Liangqi Cao, Ping Xue, Haiyan Li, Dawei Zhang
BACKGROUND: Photodynamic therapy (PDT) can be performed as palliative therapy for cholangiocarcinoma, while there is currently insufficient evidence for the efficacy. The aim of this study was to explore the clinical efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP)- or percutaneous transhepatic cholangioscopy (PTCS)-directed PDT combined with stent placement for unresectable hilar cholangiocarcinoma. METHODS: A retrospective analysis was conducted on 62 patients with unresectable hilar cholangiocarcinoma...
October 26, 2020: Surgical Endoscopy
Ikuma Shioi, Yusuke Yamaoka, Akio Shiomi, Hiroyasu Kagawa, Hitoshi Hino, Shoichi Manabe, Daisuke Aizawa
An 85-year-old woman was admitted to a hospital with abdominal pain. Five years prior to admission, she had a history of hilar cholangiocarcinoma of pStage IIIC. Contrast-enhanced computed tomography showed a mass between the rectum and uterus as well as bowel obstruction due to the lesion. Colonoscopy showed severe stenosis at the lower rectum and elevation of the submucosal layer with linear erosion. Rectal cancer was suspected, and pelvic recurrence of hilar cholangiocarcinoma or endometrial carcinoma infiltrating the rectum was considered as differential diagnosis...
October 2020: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
Alexander A Azizi, Andreas V Hadjinicolaou, Carla Goncalves, Adam Duckworth, Bristi Basu
Combined hepatocellular-cholangiocarcinoma (cHCC-ICC) is an uncommon and aggressive form of primary liver cancer. Currently, there are no international guidelines for optimal management. For localized tumors, radical resection represents the preferred treatment option, whereas for advanced tumors, systemic therapies recommended for intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are often selected. Emerging information from comparative cohort studies, genomic and transcriptomic data sets are starting to build a case for rationalized approaches to systemic treatment in the advanced setting specific to cHCC-ICC...
2020: Frontiers in Oncology
Helen Hoi Lam Ng, Lynn Ling, Peter Lodge, Christopher Hammond, Tze Min Wah
Image-guided radiofrequency ablation is frequently used to treat small hepatocellular carcinoma and metastases. Complications associated with this thermal-based technology for liver cancers arise via direct mechanical injury by the electrodes or collateral thermal damage to surrounding structures. This case report describes an unusual presentation of hepatic arterial mycotic pseudoaneurysm as melaena after percutaneous image-guided radiofrequency ablation for liver metastases in a patient with a previous surgical history of hepaticojejunostomy for cholangiocarcinoma...
December 2020: Radiology Case Reports
Felix Hahn, Lukas Müller, Aline Mähringer-Kunz, Yasemin Tanyildizi, Daniel Pinto Dos Santos, Christoph Düber, Peter R Galle, Arndt Weinmann, Roman Kloeckner
Background: Intrahepatic cholangiocarcinoma (ICC) is an aggressive tumor entity, and distant metastases are common. However, studies investigating patterns and clinical relevance of distant metastases are rare. Therefore, we aimed to analyze occurrence, location, and prognostic impact of distant metastases on overall survival (OS). Methods: Between 1997 and 2018, 417 patients with ICC were treated at our tertiary care center. Distant metastases and intrahepatic tumor burden were retrospectively evaluated in a longitudinal approach using volumetric assessment of cross-sectional imaging studies and all available medical/histopathological reports...
2020: Journal of Oncology
Satoshi Nagaoka, Daisaku Yamada, Hidetoshi Eguchi, Yuki Yokota, Yoshifumi Iwagami, Tadafumi Asaoka, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Eiji Miyoshi, Yuichiro Doki, Masaki Mori
Interleukin-33 (IL-33), an alarmin released during tissue injury, facilitates the development of cholangiocarcinoma (CCA) in a murine model. However, it is unclear whether IL-33 is associated with human CCA. The aim of this study was to support the following hypothesis: IL-33 is released during hepatectomy for CCA, subsequently facilitating the development of subclinical CCA and eventually leading to recurrent disease. IL-33 expression was assessed in various samples from both humans and mice including resected liver and paired plasma samples collected at hepatectomy and after surgery, and its influences on recurrent disease and patient prognosis were determined...
October 24, 2020: Cancer Science
Ximin Shi, Haiqun Xing, Xiaobo Yang, Fang Li, Shaobo Yao, Jia Congwei, Haitao Zhao, Marcus Hacker, Li Huo, Xiang Li
PURPOSE: This study aimed to compare the performance of 68 Ga-labelled fibroblast activating protein inhibitor (FAPI) PET and 18 F-FDG PET for imaging of hepatic tumours. METHODS: We prospectively assessed 20 patients with suspected intrahepatic lesions. Tumour radiological features, pathology, or follow-up examinations were assessed as ground truth in correlation with PET scans. Semiquantitative analysis was additionally performed by measuring the standardised uptake value (SUV)...
October 24, 2020: European Journal of Nuclear Medicine and Molecular Imaging
Zeyu Zhang, Yufan Zhou, Kuan Hu, Yun Huang
INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) stands as the second most common malignant tumor in the liver with poor patient prognosis. Increasing evidences have shown that inflammation plays a significant role in tumor progression, angiogenesis, and metastasis. However, the prognosis significance of inflammatory biomarkers on recurrence-free survival (RFS) and overall survival (OS) in ICC patients is poorly recognized. METHODS: ICC patients who underwent curative hepatectomy and diagnosed pathologically were retrospectively analyzed...
October 23, 2020: World Journal of Surgical Oncology
Mai Ly Thi Nguyen, Khac Cuong Bui, Tim Scholta, Jun Xing, Vikas Bhuria, Bence Sipos, Ludwig Wilkens, Nguyen Linh Toan, Thirumalaisamy P Velavan, Przemyslaw Bozko, Ruben R Plentz
BACKGROUND AND AIM: Cholangiocarcinoma has an unimproved prognosis. Interleukin 6 (IL-6) has an oncogenic potential in some cancer diseases. However, the role of IL-6 in cholangiocarcinoma carcinogenesis is not well understood. The current study investigated the role of IL-6 signaling in cholangiocarcinoma carcinogenesis and efficacy of siltuximab treatment on Cholangiocarcinoma in vitro and in vivo. METHODS: The expression of IL-6 was analyzed on human cholangiocarcinoma cell lines, murine and human cholangiocarcinoma tissues, using reverse transcription real time PCR and immunohistochemistry...
October 22, 2020: Journal of Gastroenterology and Hepatology
Jin-Xing Zhang, Ye Ding, Hai-Tao Yan, Chun-Gao Zhou, Jin Liu, Sheng Liu, Qing-Quan Zu, Hai-Bin Shi
BACKGROUND: Sarcopenia is emerging as a prognostic factor in patients with malignant diseases. The prognostication of perihilar cholangiocarcinoma (PHC) with obstructive jaundice was complex, because these patients suffered compete mortality events beyond cancer itself. Our study was to investigate the association between low skeletal-muscle index and overall survival (OS) after percutaneous transhepatic biliary drainage (PTBD) for obstructive jaundice due to PHC. METHODS: We performed a retrospective survival analysis of patients undergoing PTBD for PHC-related obstructive jaundice between January 2016 and March 2019...
October 22, 2020: Surgical Endoscopy
Wen-Long Yu, Guanzhen Yu, Hui Dong, Ke Chen, Jun Xie, Hua Yu, Yuan Ji, Guang-Shun Yang, Ai-Jun Li, Wen-Ming Cong, Guang-Zhi Jin
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is the second most common tumor in primary liver cancer, but the prognostic factors associated with long-term outcomes after surgical resection remain poorly defined. This study aimed to develop a novel prognostic classifier for patients with ICC after surgery. METHODS: Using a proteomics approach, we screened tumor markers that up-regulated in ICC tissues, and narrowed down by bioinformatics analysis, western blot and immunohistochemistry...
October 21, 2020: Journal of Gastroenterology
Tadashi Toyohara, Takahiro Nakazawa, Kais Zakharia, Shuya Shimizu, Katsuyuki Miyabe, Kenichi Harada, Kenji Notohara, Tomohiro Yamada, Katsumi Hayashi, Itaru Naitoh, Kazuki Hayashi, Hiromi Kataoka
An 80-year-old man was admitted due to biliary stricture with autoimmune pancreatitis. Although radiographical examinations suggested Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC), punched biopsies from the bile duct revealed adenocarcinoma. In the resected specimen, abundant N-terminus of Forkhead box P3 (Foxp3)-positive cells were localized in cholangiocarcinoma (CCA) tissue, while IgG4-positive cells were spread around the entire bile duct. Therefore, the case was diagnosed with IgG4-SC accompanied by CCA, not sporadic CCA...
October 21, 2020: Internal Medicine
Jonathan J Hue, Kavin Sugumar, Sarah C Markt, Amr Mohamed, J Eva Selfridge, David Bajor, Luke D Rothermel, Jeffrey M Hardacre, John B Ammori, Jordan M Winter, Lee M Ocuin
BACKGROUND: Most data on postoperative outcomes among patients with proximal extrahepatic cholangiocarcinoma are reported by single institutions. The purpose of this study was to analyze postoperative outcomes stratified by age and comorbidities. METHODS: Patients with proximal extrahepatic cholangiocarcinoma who underwent a resection were identified in the National Cancer Database. Pathologic, postoperative, and survival outcomes were compared based on age and Charlson-Deyo comorbidity index...
October 18, 2020: Surgery
Akira Shimizu, Yuji Soejima
No abstract text is available yet for this article.
October 21, 2020: Annals of Surgical Oncology
Ruyi Zhang, Lisanne Noordam, Xumin Ou, Buyun Ma, Yunlong Li, Pronay Das, Shaojun Shi, Jiaye Liu, Ling Wang, Pengfei Li, Monique M A Verstegen, D Srinivasa Reddy, Luc J W van der Laan, Maikel P Peppelenbosch, Jaap Kwekkeboom, Ron Smits, Qiuwei Pan
BACKGROUND & AIMS: Mature transfer RNAs (tRNA) charged with amino acids decode mRNA to synthesize proteins. Dysregulation of translational machineries has a fundamental impact on cancer biology. This study aims to map the tRNAome landscape in liver cancer patients and to explore potential therapeutic targets at the interface of charging amino acid with tRNA. METHODS: Resected tumour and paired tumour-free (TFL) tissues from hepatocellular carcinoma (HCC) patients (n = 69), and healthy liver tissues from organ transplant donors (n = 21), HCC cell lines, and cholangiocarcinoma (CC) patient-derived tumour organoids were used...
October 8, 2020: Liver International: Official Journal of the International Association for the Study of the Liver
Qin-Yu Lei, De-Chao Jiao, Xin-Wei Han
BACKGROUND: Hilar cholangiocarcinoma (CC) is a common malignant tumor with high malignancy and poor prognosis. Most patients have lost the opportunity to undergo radical surgery when diagnosed. Although palliative drainage or biliary stent placement is a preferable choice, the tumor cannot be controlled. This study aimed to develop a novel brachytherapy drainage tube for low-dose-rate brachytherapy with an effective drainage, thereby prolonging the survival time of patients. CASE SUMMARY: A 54-year-old male patient had undergone choledochal stent implantation due to obstructive jaundice...
October 6, 2020: World Journal of Clinical Cases
Junichi Yoshikawa, Yutaro Kato, Atsushi Sugioka, Ichiro Uyama
BACKGROUND: In an increasing number of patients undergoing radical surgery for perihilar cholangiocarcinoma [1-3], the intrahepatic bile duct is conventionally transected after the vessels to be preserved or reconstructed are confirmed [3,4]. In patients with extremely advanced perihilar cholangiocarcinoma having massive vascular involvement, it is sometimes difficult to confirm the vessels for reconstruction because of restricted working space and/or anatomical variants, even after liver parenchymal dissection [4]...
October 13, 2020: Surgical Oncology
Shuai He, Shilei Tang
The WNT/β-catenin signaling pathway is a highly conserved and tightly controlled molecular mechanism that regulates embryonic development, cellular proliferation and differentiation. Of note, accumulating evidence has shown that the aberrant of WNT/β-catenin signaling promotes the development and/or progression of liver cancer, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), the two most prevalent primary liver tumours in adults. There are two different WNT signaling pathways have been identified, which were termed non-canonical and canonical pathways, the latter involving the activation of β-catenin...
October 17, 2020: Biomedicine & Pharmacotherapy
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