keyword
https://read.qxmd.com/read/38532197/expression-of-fibroblast-growth-factor-receptor-2-fgfr2-in-combined-hepatocellular-cholangiocarcinoma-and-intrahepatic-cholangiocarcinoma-clinicopathological-study
#1
JOURNAL ARTICLE
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
Genetic alterations including fusions in fibroblast growth factor receptor 2 (FGFR2) are detected in 10-20% of intrahepatic cholangiocarcinoma (iCCA), and FGFR2 inhibitors are effective for the treatment of iCCA. We examined a prevalence of FGFR2 genetic alterations and their clinicopathological significance in combined hepatocellular-cholangiocarcinoma (cHCC-CCA). FGFR2 expression, which is a surrogate marker for FGFR2 genetic alterations, was immunohistochemically assessed in the liver sections from 75 patients with cHCC-CCA, 35 with small duct-type iCCA, 30 with large duct-type iCCA, and 35 with hepatocellular carcinoma (HCC)...
March 27, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38527556/impact-of-liver-diseases-and-pharmacological-interactions-on-the-transportome-involved-in-hepatic-drug-disposition
#2
REVIEW
Jose J G Marin, Candela Cives-Losada, Rocio I R Macias, Marta R Romero, Rebeca P Marijuan, Nazaret Hortelano-Hernandez, Kevin Delgado-Calvo, Carmen Villar, Jesus M Gonzalez-Santiago, Maria J Monte, Maitane Asensio
The liver plays a pivotal role in drug disposition owing to the expression of transporters accounting for the uptake at the sinusoidal membrane and the efflux across the basolateral and canalicular membranes of hepatocytes of many different compounds. Moreover, intracellular mechanisms of phases I and II biotransformation generate, in general, inactive compounds that are more polar and easier to eliminate into bile or refluxed back toward the blood for their elimination by the kidneys, which becomes crucial when the biliary route is hampered...
March 23, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38526177/oncogenic-roles-of-laminin-subunit-gamma-2-in-intrahepatic-cholangiocarcinoma-via-promoting-egfr-translation
#3
JOURNAL ARTICLE
Jianjuan Zhang, Fubo Ji, Yaqi Tan, Lei Zhao, Yongzhi Zhao, Jiaxin Liu, Liyuan Shao, Jiong Shi, Meihua Ye, Xianglei He, Jianping Jin, Bin Zhao, Jun Huang, Stephanie Roessler, Xin Zheng, Junfang Ji
Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal biliary epithelial cancer in the liver. Here, Laminin subunit gamma-2 (LAMC2) with important oncogenic roles in iCCA is discovered. In a total of 231 cholangiocarcinoma patients (82% of iCCA patients) across four independent cohorts, LAMC2 is significantly more abundant in iCCA tumor tissue compared to normal bile duct and non-tumor liver. Among 26.3% of iCCA patients, LAMC2 gene is amplified, contributing to its over-expression. Functionally, silencing LAMC2 significantly blocks tumor formation in orthotopic iCCA mouse models...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38523988/a-rare-case-of-hepatic-schwannoma-in-the-setting-of-schwannomatosis
#4
Minh-Anh Le, Rachel Shi, Justin Geraghty, Vania Zayat, Jignesh Parikh
Schwannomas are benign nerve sheath tumors commonly found in the head, neck, vestibular system, and extremities. Primary hepatic schwannomas are exceptionally rare, with 34 cases reported to date according to our review of the literature. This case report describes a 79-year-old man with a medical history of skin and thyroid cancer, who presented with no clinical symptoms and underwent a follow-up MRI due to an initial scan indicating a suspicious hepatic mass resembling an atypical hemangioma. The MRI revealed a 3...
February 2024: Curēus
https://read.qxmd.com/read/38522890/multimodal-treatment-with-endoscopic-ablation-and-systemic-therapy-for-cholangiocarcinoma
#5
REVIEW
Zaheer Nabi, Michał Żorniak, D Nageshwar Reddy
Cholangiocarcinoma (CCA) are primary malignancies of biliary system and usually unresectable at the time of diagnosis. As a consequence, majority of these cases are candidates for palliative care. With the advances in chemotherapeutic agents and multidisciplinary care, the survival rate has improved in cases with inoperable malignant biliary obstruction. As a consequence, there is a need to provide effective and durable palliative care in these patients. The main role of endoscopic palliation in the vast majority of CCA includes biliary stenting for obstructive jaundice...
February 2024: Best Practice & Research. Clinical Gastroenterology
https://read.qxmd.com/read/38520582/recurrent-intrahepatic-cholangiocarcinoma-a-10-point-score-to-predict-post-recurrence-survival-and-guide-treatment-of-recurrence
#6
JOURNAL ARTICLE
Diamantis I Tsilimigras, Yutaka Endo, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W Bauer, Irinel Popescu, George A Poultsides, Shishir K Maithel, Hugo P Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, François Cauchy, Bas Groot Koerkamp, Itaru Endo, Timothy M Pawlik
INTRODUCTION: Although up to 50-70% of patients with intrahepatic cholangiocarcinoma (ICC) recur following resection, data to predict post-recurrence survival (PRS) and guide treatment of recurrence are limited. METHODS: Patients who underwent resection of ICC between 2000 and 2020 were identified from an international, multi-institutional database. Data on primary disease as well as laboratory and radiologic data on recurrent disease were collected. Factors associated with PRS were examined and a novel scoring system to predict PRS (PRS score) was developed and internally validated...
March 23, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38519993/the-crosstalk-between-cholangiocytes-and-hepatic-stellate-cells-promotes-the-progression-of-epithelial-mesenchymal-transition-and-periductal-fibrosis-during-clonorchis-sinensis-infection
#7
JOURNAL ARTICLE
Junyeong Yi, Ji Hoon Jeong, Jihee Won, Seok Chung, Jhang Ho Pak
UNLABELLED: ABSTRACT: BACKGROUND: Clonorchis sinensis infection is one of the risk factors that provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis and even cholangiocarcinoma (CCA). Disrupted or aberrant intercellular communication among liver-constituting cells leads to pathological states that cause various hepatic diseases. This study was designed to investigate the pathological changes caused by C. sinensis excretory-secretory products (ESPs) in non-cancerous human cell lines (cholangiocytes [H69 cell line] and human hepatic stellate cells [LX2 cell line]) and their intercellular crosstalk, as well the pathological changes in infected mouse liver tissues...
March 22, 2024: Parasites & Vectors
https://read.qxmd.com/read/38519311/survival-outcomes-of-surgical-resection-in-perihilar-cholangiocarcinoma-in-endemic-area-of-o-%C3%A2-viverrini-northeast-thailand
#8
JOURNAL ARTICLE
Poowanai Sarkhampee, Sunhawit Junrungsee, Apichat Tantraworasin, Pongserath Sirichindakul, Weeris Ouransatien, Satsawat Chansitthichok, Nithi Lertsawatvicha, Paiwan Wattanarath
BACKGROUND: Perihilar cholangiocarcinoma (pCCA) is an intractable malignancy and remains the most challenge for surgeon. This study aims to investigate survival outcomes and prognostic factors in pCCA patient. METHODS: From October 2013 to December 2018, 240 consecutive patients with pCCA underwent surgical exploration were retrospectively reviewed. The clinicopathological parameters and surgical outcomes were extracted. Patients were divided into two groups: unresectable and resectable group...
March 21, 2024: Asian Journal of Surgery
https://read.qxmd.com/read/38517613/major-hepatectomy-for-perihilar-cholangiocarcinoma-taking-sides
#9
EDITORIAL
Kjetil Soreide
No abstract text is available yet for this article.
March 22, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38517592/en%C3%A2-bloc-groin-node-resection-reconstructed-with-external-oblique-flap-for-solitary-metastatic-cholangiocarcinoma-a-case-report
#10
JOURNAL ARTICLE
Chalisa Suwanprinya, Vor Luvira, Kengkart Winaikosol, Palakorn Surakunprapha, Pattama Punyavong, Kamonwan Jenwitheesuk, Ake Pugkhem, Chawalit Pairojkul
Cholangiocarcinoma requires complete surgical resection for cure. Even so, the recurrence and metastasis rates are high, and further treatment is typically through palliative systemic chemotherapy. Curative-intent resection of metastatic site may provide survival benefit in selected cases. However, there were no previous reports of groin node dissection in cholangiocarcinoma. We have reported the first case of intrahepatic mass-forming cholangiocarcinoma with isolated synchronous groin node metastasis, successfully treated with   resection of the liver mass followed by groin node resection, reconstructed with musculofascial flap...
March 22, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38517409/role-of-long-non-coding-rnas-in-cholangiocarcinoma-a-systematic-review-and-meta-analysis
#11
REVIEW
Parnian Shobeiri, Razman Arabzadeh Bahri, Mohamad Mehdi Khadembashiri, Mohamad Amin Khadembashiri, Saba Maleki, Mohammad Eslami, Marzie Khalili Dehkordi, Amir Hossein Behnoush, Nima Rezaei
BACKGROUND: Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non-coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically. METHODS: International databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA...
March 2024: Cancer reports
https://read.qxmd.com/read/38514507/early-detection-of-occupational-cholangiocarcinoma-in-a-high-risk-patient-under-intensive-surveillance-a-case-study
#12
JOURNAL ARTICLE
Naoko Kounami, Sakae Maeda, Akihiro Kitagawa, Hideo Tomihara, Yuki Ushimaru, Nobuyoshi Ohara, Tomohira Takeoka, Mitsunobu Imasato, Ryohei Kawabata, Shingo Noura, Yumiko Yasuhara, Atsushi Miyamoto
BACKGROUND: Occupational cholangiocarcinoma is associated with exposure to organic solvents, such as dichloromethane (DCM) and 1,2-dichloropropane (DCP). This report describes a case of occupational cholangiocarcinoma detected through regularly imaging following the discovery of elevated serum γ-glutamyl trans peptidase (γ-GTP) levels revealed during regular checkup. CASE PRESENTATION: A 43-year-old man who had been working in a printing company with 15 years of exposure to organic solvents presented to our hospital owing to abnormalities found during a routine checkup...
March 22, 2024: Surgical Case Reports
https://read.qxmd.com/read/38514067/a-rare-autopsy-case-of-aggressive-combined-hepatocellular-cholangiocarcinoma-in-59-year-old-female
#13
JOURNAL ARTICLE
Ahmed A Ahmed, Brandon Gehris, Michelle McDonald, Suhair Al Salihi, L Maximilian Buja
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a liver tumor with features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). It consists of intermingled malignant biliary and hepatic tissue and thus a distinct entity, rather than two separate coexisting malignancies. A 59-year-old female with a history of hepatitis C and cirrhosis presented with abdominal pain and altered mental status. She developed hematemesis, and despite extensive interventions, she expired one day after her initial presentation...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38513779/a-metabolomics-approach-reveals-metabolic-disturbance-of-human-cholangiocarcinoma-cells-after-parthenolide-treatment
#14
JOURNAL ARTICLE
Yongping He, Qianxue Yu, Xiaoyu Ma, Diya Lv, Hui Wang, Weian Qiu, Xiao Fei Chen, Yang Jiao, Yue Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Tanacetum parthenium (L.) Schultz-Bip, commonly known as feverfew, has been traditionally used to treat fever, migraines, rheumatoid arthritis, and cancer. Parthenolide (PTL), the main bioactive ingredient isolated from the shoots of feverfew, is a sesquiterpene lactone with anti-inflammatory and antitumor properties. Previous studies showed that PTL exerts anticancer activity in various cancers, including hepatoma, cholangiocarcinoma, acute myeloid leukemia, breast, prostate, and colorectal cancer...
March 19, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38509930/low-expression-of-rack1-is-associated-with-metastasis-and-worse-prognosis-in-cholangiocarcinoma
#15
JOURNAL ARTICLE
Zhihui Gao, Wentao Sun, Xiaojian Ni, Wenze Wan, Tao Suo, Xiaoling Ni, Han Liu, Na Li, Sheng Shen, Houbao Liu
BACKGROUND: Cholangiocarcinoma is a poorly prognostic malignant tumor, and the metastatic stage of cancer is not an early stage when diagnosed. Lymph node metastasis is common in the early stage. Ribosomal receptor for activated C-kinase 1 (RACK1) has found involved in the oncogenesis of various tumors and in the epithelial-mesenchymal transition (EMT). Nevertheless, its role in cholangiocarcinoma remains unknown. MATERIAL AND METHODS: The possible correlation between RACK1 and tumor prognosis was analyzed in cholangiocarcinoma patients...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509498/tumor-burden-score-and-carcinoembryonic-antigen-predict-outcomes-in-patients-with-intrahepatic-cholangiocarcinoma-following-liver-resection-a-multi%C3%A2-institutional-analysis
#16
MULTICENTER STUDY
Jun Fu, Lifang Zheng, Shicuan Tang, Kongying Lin, Shuguo Zheng, Xinyu Bi, Jianming Wang, Wei Guo, Fuyu Li, Jian Wang, Kui Wang, Haitao Li, Yongyi Zeng
BACKGROUND: The prognostic significance of tumor burden score (TBS) in relation to carcinoembryonic antigen (CEA) has not been investigated among patients undergoing hepatectomy for intrahepatic cholangiocarcinoma (ICC). This study aimed to develop and validate a simplified model, a combination of TBS and CEA (CTC grade), for predicting the long-term outcomes of postoperative ICC patients. METHODS: Patients who underwent curative - intent resection of ICC between 2011 and 2019 were identified from a large multi - institutional database...
March 20, 2024: BMC Cancer
https://read.qxmd.com/read/38508738/analysis-of-the-clinical-course-in-a-population-of-patients-with-biliary-tract-cancer-diagnosed-as-unresectable-after-portal-vein-embolization-a-case-series
#17
JOURNAL ARTICLE
Hajime Imamura, Tomohiko Adachi, Hajime Matsushima, Hideki Ishimaru, Masayuki Fukumoto, Kyohei Yoshino, Kunihiro Matsuguma, Ryo Matsumoto, Takanobu Hara, Akihiko Soyama, Masaaki Hidaka, Susumu Eguchi
Portal vein embolization (PVE) is recommended as a preoperative procedure for patients with biliary tract cancer scheduled to undergo hepatic resection of more than 50%-60% of the liver. However, details and/or information regarding the follow-up of unresectable cases are often lacking, and the clinical course of unresectable cases is not well analyzed and reported. This study aimed to clarify the clinical prognosis of patients with unresectable biliary tract cancer after PVE. We retrospectively analyzed the clinical backgrounds of patients with biliary tract cancer who underwent PVE without subsequent resection between January 2011 and October 2022...
March 19, 2024: Kurume Medical Journal
https://read.qxmd.com/read/38508240/fasn-mediated-fatty-acid-biosynthesis-remodels-immune-environment-in-clonorchis-sinensis-infection-related-intrahepatic-cholangiocarcinoma
#18
JOURNAL ARTICLE
Lixia Xu, Ying Zhang, Zhilong Lin, Xinlang Deng, Xiaoxue Ren, Mingle Huang, Shangru Li, Qianying Zhou, Fei Fang, Qingxia Yang, Gaomin Zheng, Zebin Chen, Zhongdao Wu, Xi Sun, Jie Lin, Jingxian Shen, Jianping Guo, Xiaoxing Li, Tianchen Xue, Jing Tan, Xiaoxuan Lin, Li Tan, Hong Peng, Shunli Shen, Sui Peng, Shaoqiang Li, Lijian Liang, James M Cleary, Jiaming Lai, Yubin Xie, Ming Kuang
BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer with high lethality. Clonorchis sinensis (C. sinensis) infection is an important risk factor for ICC. Here we investigated the clinical impact and underlying molecular characteristics of C. sinensis-infected ICC. METHODS: We performed single-cell RNA sequencing, whole exome sequencing, RNA-sequencing, metabolomics and spatial transcriptomics in 251 ICC patients from three medical centers...
March 18, 2024: Journal of Hepatology
https://read.qxmd.com/read/38507173/laparoscopic-liver-resection-as-a-treatment-option-for-intrahepatic-cholangiocarcinoma
#19
JOURNAL ARTICLE
Kyeong Deok Kim, Ji Eun Lee, Jongman Kim, Junsoo Ro, Jinsoo Rhu, Gyu-Seong Choi, Jin Seok Heo, Jae-Won Joh
Laparoscopic liver resection (LLR) remains controversial in the treatment of intrahepatic cholangiocarcinoma (ICC). The aim of the present study is to investigate the outcomes of LLR for ICC compared to open liver resection (OLR). We retrospectively reviewed patients who underwent surgery for ICC between January 2013 and February 2020. OLR and LLR were compared after propensity score matching (PSM). Overall survival (OS) and recurrence-free survival (RFS) were compared between the matched groups. During the study period, 219 patients met the inclusion criteria (OLR = 170 patients, 77...
March 20, 2024: Updates in Surgery
https://read.qxmd.com/read/38504335/association-of-glucose-lowering-drug-target-and-risk-of-gastrointestinal-cancer-a-mendelian-randomization-study
#20
JOURNAL ARTICLE
Yi Yang, Bo Chen, Chongming Zheng, Hao Zeng, Junxi Zhou, Yaqing Chen, Qing Su, Jingxian Wang, Juejin Wang, Yurong Wang, Hongli Wang, Ruxue Jin, Zhiyuan Bo, Gang Chen, Yi Wang
BACKGROUND & AIMS: Glucose-lowering drug is associated with various cancers, but the causality with gastrointestinal cancer risk is rarely reported. We aimed to explore the causality between them in this Mendelian randomization (MR) study. METHODS: Two-sample MR, summary-data-based (SMR), mediation MR, and colocalization analyses was employed. Ten glucose-lowering drug targets (PPARG, DPP4, GLP1R, INSR, SLC5A2, ABCC8, KCNJ11, ETFDH, GPD2, PRKAB1) and seven types of gastrointestinal cancer (anal carcinoma, cardia cancer, gastric cancer, hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), pancreatic cancer, rectum cancer) were included...
March 19, 2024: Cell & Bioscience
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