Manuel Scimeca, Julia Bischof, Rita Bonfiglio, Elisabetta Nale, Valerio Iacovelli, Marco Carilli, Matteo Vittori, Massimiliano Agostini, Valentina Rovella, Francesca Servadei, Erica Giacobbi, Eleonora Candi, Yufang Shi, Gerry Melino, Alessandro Mauriello, Pierluigi Bove
The increasing incidence of urothelial bladder cancer is a notable global concern, as evidenced by the epidemiological data in terms of frequency, distribution, as well as mortality rates. Although numerous molecular alterations have been linked to the occurrence and progression of bladder cancer, currently there is a limited knowledge on the molecular signature able of accurately predicting clinical outcomes. In this report, we present a case of a pT3b high-grade infiltrating urothelial carcinoma with areas of squamous differentiation characterized by very high tumor mutational burden (TMB), with up-regulations of immune checkpoints...
April 30, 2024: Cell Death Discovery