Christophe Duvoux, Lorraine Blaise, Jean-Jacques Matimbo, Francky Mubenga, Norbert Ngongang, Monika Hurtova, Alexis Laurent, Jérémy Augustin, Julien Calderaro, Edouard Reizine, Alain Luciani, Anoosha Habibi, Dora Bachir, Geoffroy Vole, Justine Gellen-Dautremer, Vincent Leroy, Eric Levesque, Pablo Bartolucci
Liver involvement in SCD patients is frequent but often misdiagnosed or underestimated, except in case of advanced liver diseases. Because of so far poorly recognized forms of chronic SCD-related vascular injury that can silently evolved towards end stages or facilitate ACLF, any persisting liver function tests abnormalities should be carefully investigated, following the above proposed algorithm. Work up and management must be considered multidisciplinary in relationship with a Hepatologist. Early SCD hepatopathy should prompt revision of SCD management to prevent further liver injury and decompensation, discussing transfusion exchanges and hydro urea when not yet initiated, and control for any cofactor of liver injury...
December 2023: La Presse Médicale