Anna Kovilakath, Adolfo G Mauro, Yolander Valentine, Frank Raucci, Maryam Jamil, Christiane Carter, Jeremy Thompson, Qun Chen, Beutner Gisela, Yang Yue, Jeremy Allegood, Xiaoxin X Wang, Jordan Dail, Teja Devarakonda, Komuraiah Myakala, Jolene J Windle, Mark A Subler, David Montefusco, Belinda Willard, Ali Javaheri, Tytus Bernas, Sushil K Mahata, Moshe Levi, Jinze Liu, George A Porter, Edward J Lesnefsky, Fadi N Salloum, L Ashley Cowart
BACKGROUND: Dysregulated metabolism of bioactive sphingolipids, including ceramides and sphingosine-1-phosphate, has been implicated in cardiovascular disease, although the specific species, disease contexts, and cellular roles are not completely understood. Sphingolipids are produced by the serine palmitoyltransferase enzyme, canonically composed of 2 subunits, SPTLC1 (serine palmitoyltransferase long chain base subunit 1) and SPTLC2 (serine palmitoyltransferase long chain base subunit 2)...
April 25, 2024: Circulation