Jonathan R Dillman, Jean A Tkach, Joel G Fletcher, David H Bruining, Aiming Lu, Subra Kugathasan, Adina L Alazraki, Jack Knight-Scott, Ryan W Stidham, Jeremy Adler, Bruce C Trapnell, Scott D Swanson, Lin Fei, Lucia Qian, Alexander J Towbin, Murat Kocaoglu, Christopher G Anton, Rebecca A Imbus, Jonathan A Dudley, Lee A Denson
BACKGROUND: Despite advances in medical therapy, many children and adults with ileal Crohn's disease (CD) progress to fibrostenosis requiring surgery. We aimed to identify MRI and circulating biomarkers associated with the need for surgical management. METHODS: This prospective, multicenter study included pediatric and adult CD cases undergoing ileal resection and CD controls receiving medical therapy. Noncontrast research MRI examinations measured bowel wall 3-dimensional magnetization transfer ratio normalized to skeletal muscle (normalized 3D MTR), modified Look-Locker inversion recovery (MOLLI) T1 relaxation, intravoxel incoherent motion (IVIM) diffusion-weighted imaging metrics, and the simplified magnetic resonance index of activity (sMaRIA)...
May 13, 2024: Inflammatory Bowel Diseases