Md Shahjalal H Khan, Sora Q Kim, Robert C Ross, Florina Corpodean, Redin A Spann, Diana A Albarado, Sun O Fernandez-Kim, Blaise Clarke, Hans-Rudolf Berthoud, Heike Münzberg, David H McDougal, Yanlin He, Sangho Yu, Vance L Albaugh, Paul Soto, Christopher D Morrison
Dietary protein restriction induces adaptive changes in food preference, increasing protein consumption over carbohydrates or fat. We investigated whether motivation and reward signaling underpin these preferences. In an operant task, protein-restricted male mice increased their responding for liquid protein rewards, but not carbohydrate, fat, or sweet rewards. The protein restriction-induced increase in operant responding for protein was absent in Fgf21 -KO mice and mice with neuron-specific deletion of the FGF21 co-receptor beta-Klotho ( Klb Cam2ka ) mice...
May 13, 2024: bioRxiv