Miklos Z Molnar, Vishnu S Potluri, Douglas E Schaubel, Meghan E Sise, Beatrice P Concepcion, Rachel C Forbes, Emily Blumberg, Roy D Bloom, David Shaffer, Raymond T Chung, Ian A Strohbehn, Nahel Elias, Ambreen Azhar, Mital Shah, Deirdre Sawinski, Laura A Binari, Manish Talwar, Vasanthi Balaraman, Anshul Bhalla, James D Eason, Behdad Besharatian, Jennifer Trofe-Clark, David S Goldberg, Peter P Reese
Kidney transplantation (KT) from deceased donors with hepatitis C virus (HCV) into HCV-negative recipients has become more common. However, the risk of complications such as BK polyomavirus (BKPyV) remains unknown. We assembled a retrospective cohort at four centers. We matched recipients of HCV-viremic kidneys to highly similar recipients of HCV-aviremic kidneys on established risk factors for BKPyV. To limit bias, matches were within the same center. The primary outcome was BKPyV viremia ≥1000 copies/ml or biopsy-proven BKPyV nephropathy; a secondary outcome was BKPyV viremia ≥10 000 copies/ml or nephropathy...
February 2022: American Journal of Transplantation