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JOURNAL ARTICLE
Yahong Wu, Cindy G Boer, Amy Hofman, Dieuwke Schiphof, Marienke van Middelkoop, Ingrid A Szilagyi, Bahar Sedaghati-Khayat, Sita M A Bierma-Zeinstra, Trudy Voortman, Joyce B J van Meurs
IMPORTANCE: It has been demonstrated that total physical activity is not associated with risk of osteoarthritis. However, the association of different types of physical activity with incident knee osteoarthritis remains unclear. OBJECTIVE: To determine whether weight-bearing recreational physical activities are associated with increased risk of incident knee osteoarthritis. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study used data from the Rotterdam Study (1996 to 2009), including participants with knee x-ray measurements at baseline and follow-up examinations...
April 1, 2024: JAMA Network Open
#22
REVIEW
Suprabhat Giri, Prajna Anirvan, Arun Vaidya, Dibya Lochan Praharaj
Infection by dengue virus is common in tropical countries. Hepatic involvement in dengue can range from asymptomatic elevation of transaminases to life-threatening acute liver failure (ALF). Dengue-related ALF (DALF) is responsible for significant morbidity and mortality, especially in Southeast Asia. However, there is a scarcity of literature on DALF, necessitating a thorough examination of its clinical determinants and management strategies. All relevant studies related to DALF were reviewed until December 2023...
April 30, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#23
JOURNAL ARTICLE
Camila Heloise Dos Santos, Emanuele Cristina Gustani, Luciana Paes de Barros Machado, Rogério Pincela Mateus
The ability of an organism to respond to nutritional stress can be a plastic character under the action of natural selection, affecting several characteristics, including life history and energy storage. The genus Drosophila (Diptera; Drosophilidae) presents high variability regarding natural resource exploration. However, most works on this theme have studied the model species D. melanogaster Meigen, 1830 and little is known about Neotropical drosophilids. Here we evaluate the effects of three diets, with different carbohydrate-to-protein ratios, on life history (viability and development time) and metabolic pools (triglycerides, glycogen, and total soluble protein contents) of three Neotropical species of Drosophila: D...
April 30, 2024: Neotropical Entomology
#24
JOURNAL ARTICLE
Miriam Pepponi, Valentina Berti, Elsa Fasciglione, Flavio Montanini, Letizia Canu, Fabrice Hubele, Elisabetta Abenavoli, Vittorio Briganti, Elena Rapizzi, Anne Charpiot, David Taieb, Karel Pacak, Bernard Goichot, Alessio Imperiale
PURPOSE: To investigate the [68 Ga]DOTATOC PET radiomic profile of head and neck paragangliomas (HNPGLs) and identify radiomic characteristics useful as predictors of succinate dehydrogenase genes (SDHx) pathogenic variants. METHODS: Sporadic and SDHx HNPGL patients, who underwent [68 Ga]DOTATOC PET/CT, were retrospectively included. HNPGLs were analyzed using LIFEx software, and extracted features were harmonized to correct for batch effects and confronted testing for multiple comparison...
April 30, 2024: European Journal of Nuclear Medicine and Molecular Imaging
#25
JOURNAL ARTICLE
Răzvan Alexandru Radu, Vincent Costalat, Michele Romoli, Basel Musmar, James E Siegler, Sherief Ghozy, Jane Khalife, Hamza Salim, Hamza Shaikh, Nimer Adeeb, Hugo H Cuellar-Saenz, Ajith J Thomas, Ramanathan Kadirvel, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Robert W Regenhardt, Joshua D Bernstock, Aman B Patel, James D Rabinov, Christopher J Stapleton, Nicole M Cancelliere, Thomas R Marotta, Vitor Mendes Pereira, Kareem El Naamani, Abdelaziz Amllay, Stavropoula I Tjoumakaris, Pascal Jabbour, Lukas Meyer, Jens Fiehler, Tobias D Faizy, Helena Guerreiro, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Charbel Mounayer, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Takahiro Ota, Shogo Dofuku, Leonard L L Yeo, Benjamin Yq Tan, Anil Gopinathan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Lina M Chervak, Achala Vagal, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, Andrea M Alexandre, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Ymd, Jessica Jesser, Charlotte Weyland, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Cheng-Yang Hsieh, David S Liebeskind, Illario Tancredi, Robert Fahed, Boris Lubicz, Muhammed Amir Essibayi, Amanda Baker, David Altschul, Luca Scarcia, Erwah Kalsoum, Adam A Dmytriw, Adrien Guenego
BACKGROUND: Optimal anesthetic strategy for the endovascular treatment of stroke is still under debate. Despite scarce data concerning anesthetic management for medium and distal vessel occlusions (MeVOs) some centers empirically support a general anesthesia (GA) strategy in these patients. METHODS: We conducted an international retrospective study of MeVO cases. A propensity score matching algorithm was used to mitigate potential differences across patients undergoing GA and conscious sedation (CS)...
April 30, 2024: Clinical Neuroradiology
#26
JOURNAL ARTICLE
Laurens Winkelmeier, Máté Maros, Fabian Flottmann, Christian Heitkamp, Gerhard Schön, Götz Thomalla, Jens Fiehler, Uta Hanning
PURPOSE: Randomized controlled trials (RCTs) demonstrated a treatment effect of endovascular thrombectomy in acute ischemic stroke with large infarct, commonly defined as an Alberta Stroke Program Early CT Score (ASPECTS) of 3-5. However, data on endovascular thrombectomy in patients with very low ASPECTS of 0-2 remain scarce. METHODS: We conducted a systematic review and meta-analysis of RCTs comparing endovascular thrombectomy versus medical treatment alone in acute ischemic anterior circulation stroke with very large infarct, defined as ASPECTS of 0-2...
April 30, 2024: Clinical Neuroradiology
#27
JOURNAL ARTICLE
Domenico A Gattozzi, Ufuk Erginoglu, Omaditya Khanna, Patrick W Hosokawa, Rafael Martinez-Perez, Mustafa K Baskaya, A Samy Youssef
PURPOSE: Proximity to critical neurovascular structures can create significant obstacles during surgical resection of foramen magnum meningiomas (FMMs) to the detriment of treatment outcomes. We propose a new classification that defines the tumor's relationship to neurovascular structures and assess correlation with postoperative outcomes. METHODS: In this retrospective review, 41 consecutive patients underwent primary resection of FMMs through a far lateral approach...
April 30, 2024: Acta Neurochirurgica
#28
JOURNAL ARTICLE
Alberto Zani, Serena Messali, Antonella Bugatti, Matteo Uggeri, Alessandro Rondina, Leonardo Sclavi, Francesca Caccuri, Arnaldo Caruso
HIV-1 matrix protein p17 variants (vp17s), characterized by amino acid insertions at the COOH-terminal region of the viral protein, have been recently identified and studied for their biological activity. Different from their wild-type counterpart (refp17), vp17s display a potent B cell growth and clonogenic activity. Recent data have highlighted the higher prevalence of vp17s in people living with HIV-1 (PLWH) with lymphoma compared with those without lymphoma, suggesting that vp17s may play a key role in lymphomagenesis...
April 2024: Journal of General Virology
#29
JOURNAL ARTICLE
Ming-Han H Lee, Ebony J Smith, Thomas G Hardy, Nicole Graf, Krishna Tumuluri
PURPOSE: Juvenile xanthogranuloma (JXG) is a subtype of histiocytosis characterised histologically by foamy non-Langerhan cells with Touton giant cells. It typically manifests as a single self-limiting cutaneous nodule in the paediatric population. Orbital JXG is extremely rare, and its clinical course and management are not well understood or defined. Herein we present 3 cases of orbital JXG and provide a detailed literature review. METHODS: Review of 3 cases with orbital JXG and literature review of all published cases...
April 29, 2024: Ophthalmic Plastic and Reconstructive Surgery
#30
JOURNAL ARTICLE
Hyungdon Kook, Ho Eun Gwag, So Yun Park, Narang Hong, Jung-Ho Lee, Hye Jung Jung, Mi Youn Park, Yu Sung Choi, Hyun Je Kim, Stephan Weidinger, Jiyoung Ahn
BACKGROUND: Trials and real-life studies demonstrated clinically meaningful improvements of disease activity in the majority of patients with moderate to severe atopic dermatitis (AD) treated with the anti-IL-4RA-antibody dupilumab. However, misdiagnosis or confounding skin diseases in particular cutaneous T-cell lymphoma (CTCL) may lead to inadequate response. OBJECTIVE: To investigate the clinical and pathological features of patients with AD who showed insufficient response to dupilumab...
April 30, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#31
JOURNAL ARTICLE
Madison L Schanz, Abigail M Bitters, Kamryn E Zadeii, Dana Joulani, Angela K Chamberlain, Américo H López-Yglesias
To defend against intracellular pathogens such as Toxoplasma gondii, the host generates a robust type 1 immune response. Specifically, host defense against T. gondii is defined by an IL-12-dependent IFN-γ response that is critical for host resistance. Previously, we demonstrated that host resistance is mediated by T-bet-dependent ILC-derived IFN-γ by maintaining IRF8+ conventional type 1 dendritic cells during parasitic infection. Therefore, we hypothesized that innate lymphoid cells are indispensable for host survival...
April 1, 2024: ImmunoHorizons
#32
JOURNAL ARTICLE
Giulia Collatuzzo, Monireh Sadat Seyyedsalehi, Hamideh Rashidian, Maryam Hadji, Roya Safari-Faramani, Abbas Rezaianzadeh, Reza Malekzadeh, Kazem Zendehdel, Paolo Boffetta
BACKGROUND: We aimed to study the risk factors of early-onset colorectal cancer (CRC) incidence in the Iranian population. Early onset CRC in Iran is a relevant health issue that deserves further epidemiological efforts to be defined and controlled as far as possible. Early age screening of low-tract of the intestine would be particularly useful in families of colorectal cancer patients. METHODS: We analyzed data from a multicenter hospital-based case-control study in Iran (The Iranian Study of Opium and Cancer)...
April 29, 2024: European Journal of Cancer Prevention
#33
JOURNAL ARTICLE
Alastair J McGinness, Susan A Brooks, Richard Strasser, Jennifer Schoberer, Verena Kriechbaumer
Plant cells are a capable system for producing economically and therapeutically important proteins for a variety of applications, and are considered a safer production system than some existing hosts such as bacteria or yeasts. However, plants do not perform protein modifications in the same manner as mammalian cells do. This can impact on protein functionality for plant-produced human therapeutics. This obstacle can be overcome by creating a plant-based system capable of 'humanising' proteins of interest resulting in a glycosylation profile of synthetic plant-produced proteins as it would occur in mammalian systems...
April 30, 2024: Journal of Microscopy
#34
MULTICENTER STUDY
Bina Choi, Alejandro A Díaz, Ruben San José Estépar, Nicholas Enzer, Victor Castro, MeiLan K Han, George R Washko, Raúl San José Estépar, Samuel Y Ash
Background Acute respiratory disease (ARD) events are often thought to be airway-disease related, but some may be related to quantitative interstitial abnormalities (QIAs), which are subtle parenchymal abnormalities on CT scans associated with morbidity and mortality in individuals with a smoking history. Purpose To determine whether QIA progression at CT is associated with ARD and severe ARD events in individuals with a history of smoking. Materials and Methods This secondary analysis of a prospective study included individuals with a 10 pack-years or greater smoking history recruited from multiple centers between November 2007 and July 2017...
April 2024: Radiology
#35
JOURNAL ARTICLE
Mischa Vance Bandet, Ian Robert Winship
Despite substantial progress in mapping the trajectory of network plasticity resulting from focal ischemic stroke, the extent and nature of changes in neuronal excitability and activity within the peri-infarct cortex of mice remains poorly defined. Most of the available data have been acquired from anesthetized animals, acute tissue slices, or infer changes in excitability from immunoassays on extracted tissue, and thus may not reflect cortical activity dynamics in the intact cortex of an awake animal. Here, in vivo two-photon calcium imaging in awake, behaving mice was used to longitudinally track cortical activity, network functional connectivity, and neural assembly architecture for 2 months following photothrombotic stroke targeting the forelimb somatosensory cortex...
April 30, 2024: ELife
#36
JOURNAL ARTICLE
Sheng H Wang, Gabriele Arnulfo, Lino Nobili, Vladislav Myrov, Paul Ferrari, Philippe Ciuciu, Satu Palva, J Matias Palva
OBJECTIVE: Postsurgical seizure freedom in drug-resistant epilepsy (DRE) patients varies from 30% to 80%, implying that in many cases the current approaches fail to fully map the epileptogenic zone (EZ). We aimed to advance a novel approach to better characterize epileptogenicity and investigate whether the EZ encompasses a broader epileptogenic network (EpiNet) beyond the seizure zone (SZ) that exhibits seizure activity. METHODS: We first used computational modeling to test putative complex systems-driven and systems neuroscience-driven mechanistic biomarkers for epileptogenicity...
April 30, 2024: Epilepsia
#37
JOURNAL ARTICLE
Philip Ball
The problem with defining "life" has bedeviled biology throughout its history, and still there is no agreed resolution. But one of the best ways to characterize living entities is not through any of the features or properties usually considered to define it, such as replication, metabolism, or evolution. Rather, living entities are generators of meaning.
April 30, 2024: Annals of the New York Academy of Sciences
#38
JOURNAL ARTICLE
Kristy Ng, Samantha Morais, Michel D Wissing, Ann N Burchell, Pierre-Paul Tellier, François Coutlée, Tim Waterboer, Mariam El-Zein, Eduardo L Franco
Given low seroconversion rates following human papillomavirus (HPV) infection, fixed external cutoffs may lead to errors in estimating HPV seroprevalence. We evaluated finite mixture modeling (FMM) and group-based trajectory modeling (GBTM) among unvaccinated, sexually active, HPV-exposed women to determine study-specific HPV16 and HPV18 seropositivity thresholds. We included 399 women (aged 18-24 years) enrolled in the HPV Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) cohort study between 2005 and 2011 in Montreal, Canada...
April 30, 2024: Microbiology Spectrum
#39
JOURNAL ARTICLE
Carly G K Ziegler, Anna H Owings, Michelle Galeas-Pena, Samuel W Kazer, Vincent N Miao, Andrew W Navia, Ying Tang, Joshua D Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley B Williams, Micayla George, Riley S Drake, Yilianys Pride, George E Abraham, Michal Senitko, Tanya O Robinson, Gill Diamond, Michail S Lionakis, Alex K Shalek, Jose Ordovas-Montanes, Bruce H Horwitz, Sarah C Glover
UNLABELLED: Recent case reports and epidemiological data suggest that fungal infections represent an underappreciated complication among people with severe COVID-19. However, the frequency of fungal colonization in patients with COVID-19 and associations with specific immune responses in the airways remain incompletely defined. We previously generated a single-cell RNA-sequencing data set characterizing the upper respiratory microenvironment during COVID-19 and mapped the relationship between disease severity and the local behavior of nasal epithelial cells and infiltrating immune cells...
April 30, 2024: Microbiology Spectrum
#40
JOURNAL ARTICLE
Antonio Dono, Ping Zhu, Takeshi Takayasu, Octavio Arevalo, Roy Riascos, Nitin Tandon, Leomar Y Ballester, Yoshua Esquenazi
BACKGROUND AND OBJECTIVES: Maximizing the extent of resection (EOR) improves outcomes in glioblastoma (GBM). However, previous GBM studies have not addressed the EOR impact in molecular subgroups beyond IDH1/IDH2 status. In the current article, we evaluate whether EOR confers a benefit in all GBM subtypes or only in particular molecular subgroups. METHODS: A retrospective cohort of newly diagnosed GBM isocitrate dehydrogenase (IDH)-wildtype undergoing resection were prospectively included in a database (n = 138)...
April 30, 2024: Neurosurgery
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