Wei Sang, Cong Zhang, Dianzheng Zhang, Ying Wang, Cai Sun, Mingshan Niu, Xiaoshen Sun, Cui Zhou, Lingyu Zeng, Bin Pan, Wei Chen, Dongmei Yan, Feng Zhu, Qingyun Wu, Jiang Cao, Kai Zhao, Chong Chen, Zhenyu Li, Depeng Li, Thomas P Loughran, Kailin Xu
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a valuable therapeutic strategy for a wide variety of diseases. Acute graft-versus-host disease (aGVHD) is a major complication in up to 75% of allo-HSCT. The absence of a reliable predicative marker for aGVHD onset prevents preemptive treatment and impedes widespread and successful application of this therapy. In this study we found that after allo-HSCT, the levels of miR-181a were reduced significantly prior to the onset of aGVHD. More importantly, the degree of its reduction correlated with the severity of aGVHD...
November 2015: American Journal of Hematology